Neurobiological Consequences of Sleep Deprivation

Current Neuropharmacology

Volumn 11, Issue 3, 2013, Pages 231-249

  Alkadhi, Karim ^a   Zagaar, Munder ^a   Alhaider, Ibrahim ^b   Salim, Samina ^a   Aleisa, Abdulaziz ^c  

^a UNIVERSITY OF HOUSTON   (United States)

^b KING FAISAL UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Anxiety; Electrophysiology; Exercise; Ltd; Ltp; Modified multipleplatform; Neurogenesis; Nicotine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; CAFFEINE; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; METYRAPONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

ANXIETY; BRAIN FUNCTION; ELECTROENCEPHALOGRAPHY; EXERCISE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; LEARNING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MAZE TEST; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; NONHUMAN; POLYSOMNOGRAPHY; POSITRON EMISSION TOMOGRAPHY; REM SLEEP DEPRIVATION; REVIEW; SLEEP DEPRIVATION; SLEEP PATTERN; TREADMILL ERGOMETRY; ULTRADIAN RHYTHM; WAKEFULNESS;

EID: 84878630455     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/1570159X11311030001     Document Type: Review

References (290)

1. Orzel-Gryglewska, J. Consequences of sleep deprivation. Int. J. Occup. Med. Environ Health, 2010, 23, 95-114.
2. Kalia, M. Neurobiology of sleep. Metabolism, 2006, 55, S2-S6.
3. Luppi, P.H. Neurochemical aspects of sleep regulation with specific focus on slow-wave sleep. World J. Biol.Psychiatry, 2010, 11 Suppl 1, 4-8.
4. Lucero, M.A. Lengthening of REM sleep duration consecutive to learning in the rat. Brain Res., 1970, 20, 319-22.
5. Smith, C., Kitahama, K., Valatx, J.L., Jouvet, M. Increased paradoxical sleep in mice during acquisition of a shock avoidance task. Brain Res., 1974, 77(2), 221-30.
6. Smith, C., Lapp, L. Increases in number of REMS and REM density in humans following an intensive learning period. Sleep, 1991, 14(4), 325-30.
7. Timo-Iaria, C., Negrao, N., Schmidek, W.R., Hoshino, K., Lobato, de Menezes, C.E., Leme da Rocha, T. Phases and states of sleep in the rat. Physiol. Behav., 1970, 5, 1057-62.
8. Cantero, J.L., Atienza, M., Stickgold, R., Kahana, M., Madsen, J.R., Kocsis, B. Sleep-dependent theta oscillations in the human hippocampus and neocortex. J. Neurosci., 2003, 23, 10897-10903.
9. Bryson, D., Schacher, S. Behavioral analysis of mammalian sleep and learning. Perspect Biol. Med 1969; 13: 71-79.
10. Diekelmann S, Born, J. The memory function of sleep. Nat. Rev. Neurosci., 2010, 11, 114-26.
11. Diekelmann S., Born, J. The memory function of sleppe. Nat. Rev. Neurosci., 2010, 11, 144-126.
12. Walker, MP. Stickgold, R. Sleep-dependent learning and memory consolidation. Neuron, 2004, 44, 121-33.
13. Rauchs, G., Desgranges, B., Foret, J., Eustache, F. The relationships between memory systems and sleep stages. J. Sleep Res., 2005, 14, 123-40.
14. Gais, S., Albouy, G., Boly, M., Dang-Vu, T.T., Darsaud, A., Desseilles, M., Rauchs, G., Schabus, M., Sterpenich, V., Vandewalle, G., Maquet, P., Peigneux, P. Sleep transforms the cerebral trace of declarative memories. Proc. Natl. Acad. Sci. USA, 2007, 104, 18778-83.
15. Orban, P., Rauchs, G., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., Peigneux, P. Sleep after spatial learning promotes covert reorganization of brain activity. Proc. Natl. Acad. Sci. U.S.A., 2006, 103, 7124-29.
16. Walker, M.P. Stickgold R. Sleep, memory, and plasticity. Annu. Rev. Psychol. 2006, 57, 139-166.
17. Yoo, S. S., Hu, P. T., Gujar, N., Jolesz, F. A. and Walker, M. P. A deficit in the ability to form new human memories without sleep. Nat. Neurosci., 2007, 10, 385-392.
18. Errara M, Iaria G, Tempesta D, et al. Sleep to find your way: the role of sleep in the consolidation of memory for navigation in humans. Hippocampus, 2008, 18, 844-851.
19. Burgess, N., Maguire, E.A., O'Keefe, J. The human hippocampus and spatial and episodic memory. Neuron, 2002, 35, 625-641.
20. Cohen, N.J., Squire, L.R. Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that. Sci. NY 1980, 210, 207-10.
21. Kirwan, C.B., Gilbert, P.E., Kesner, R.P. The role of the hippocampus in the retrieval of a spatial location. Neurobiol. Learn Mem., 2005, 83, 65-71.
22. Faraut, B., Boudjeltia, K.Z., Vanhamme, L., Kerkhofs, M. Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery.Sleep Med. Rev., 2012, 16, 137-49
23. Aldabal, L., Bahammam, A.S. Metabolic, endocrine, and immune consequences of sleep deprivation. Open Respir. Med. J. 2011, 5, 31-43.
24. Stones, M.J. Memory performance after arousal from different sleep stages. Br. J. Psychol., 1977, 68, 177-181.
25. Smith C. Sleep states and memory processes. Behav. Brain Res. 1995, 69, 137-45.
26. Stenberg, D. Neuroanatomy and neurochemistry of sleep. Cell Mol. Life Sci., 2007, 64, 1187-1204.
27. McCarley, R.W. Neurobiology of REM and NREM sleep. Sleep Med., 2007, 8, 302-330.
28. Lesku, J.R.N., Amlaner, C. The Evolution of Sleep: A Phylogenetic Approach. In: Sleep: A Comprehensive Handbook, vol. 1 Lee-Chiong, T., ed, p 1038 Hoboken, New Jersey: John Wiley & Sons, Inc. 2006.
29. Elgar, M.A., Pagel, M.D., Harvey, P.H. Sleep in mammals. Anim Behav., 1988, 36, 1407-1419.
30. Rattenborg, N.C., Amlaner, C.J., Lima, S.L. Behavioral, neurophysiological and evolutionary perspectives on unihemispheric sleep. Neurosci. Biobehav. Rev., 2000, 24, 817-42.
31. McEwen BS. Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. Metabolism, 2006, 55, S20-S23.
32. Samkoff, J.S., Jacques, C.H. A review of studies concerning effects of sleep deprivation and fatigue on residents' performance. Acad. Med., 1991, 66, 687-93.
33. Blissitt, P. A. Sleep, memory, and learning. J. Neurosci. Nurs., 2001, 33, 208-15.
34. Peigneux, P., Laureys S., Delbeuck, X., Maquet, P. Sleeping brain, learning brain. The role of sleep for memory systems. Neuroreport, 2001, 1218, A111-24.
35. McDermott, C.M., LaHoste, G.J., Chen, C., Musto, A., Bazan, N.G., Magee, J.C. sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J. Neurosci., 2003, 23: 9687-9695.
36. Kim, E.Y., Mahmoud, G.S., Grover, L.M. REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus. Neurosci. Lett., 2005, 388, 163-167.
37. Kopp, C., Longordo, F., Nicholson, J.R., Luthi, A. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J. Neurosci., 2006, 26, 12456-12465.
38. McDermott, C.M., Hardy, M, N Bazan, N.G. Magee J.C. Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J. Physiol., 2006, 570 Pt 3, 553-65.
39. Vecsey, C.G., Baillie, G.S., Jaganath, D., Havekes, R., Daniels, A., Wimmer, M., Huang, T., Brown, K.M., Li, X.Y., Descalzi, G., Kim, S.S., Chen, T., Shang, Y.Z., Zhuo, M., Houslay, M.D., Abel, T. Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 2009, 461, 1122-1125.
40. Smith, C., Rose, G.M. Evidence for a paradoxical sleep window for place learning in the Morris water maze. Physiol. Behav., 1996, 59, 93-97.
41. Romcy-Pereira, R., Pavlides, C. Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP. Eur. J. Neurosci., 2004, 20, 3453-3462.
42. Poe GR, Walsh CM, Bjorness, T.E. Cognitive neuroscience of sleep. Prog. Brain Res. 2010, 185, 1-19.
43. Gais, S., Albouy, G., Boly, M., Dang-Vu, T.T., Darsaud, A., Desseilles, M., Rauchs, G., Schabus, M., Sterpenich, V., Vandewalle, G, Maquet P., Peigneux, P. Sleep transforms the cerebral trace of declarative memories. Proc. Natl. Acad. Sci. USA, 2007, 104, 18778-83.
44. Cai, D.J., Shuman, T., Gorman, M.R., Sage, J.R., Anagnostaras, S.G. Sleep selectively enhances hippocampus-dependent memory in mice. Behav. Neurosci., 2009, 123, 713-19.
45. Stickgold, R. Sleep-dependent memory consolidation. Nature, 2005, 437, 1272-78.
46. Harrison, Y., Horne, J.A. The impact of sleep deprivation on decision making: a review. J Exp Psychol Appl 2000; 6: 236-49.
47. Guzman-Marin R., Ying, Z., Suntsova, N., Methippara, M., Bashir, T., Szymusiak, R., Gomez-Pinilla, F., McGinty, D. Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats. J. Physiol., 2006, 575, 807-819.
48. Belenky, G., Wesensten, N.J., Thorne, D.R., Thomas, M.L., Sing, H.C., Redmond, D.P., Russo, M.B., Balkin, T.J. The effects of sleep deprivation on information-integration categorization performance. Sleep, 2009, 32, 1439-1448.
49. Guan, Z., Peng, X., Fang, J. sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Brain Res., 2004, 1018, 38-47.
50. Graves, L.A., Heller, E.A., Pack, A.I., Abel, T. Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning. Learn. Mem 2003, 10, 16876.
51. Belenky, G., Wesensten, N. J., Thorne, D. R., et al. Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J. Sleep Res., 2003, 12, 1-12.
52. Suchecki, D., Tiba, P.A., Machad, R.B. REM Sleep Rebound as an Adaptive Response to Stressful Situations. Front. Neurol. 2012, 3, 41.
53. Vgontzas, A.N., Tsigos, C., Bixler, E.O., Stratakis, C.A., Zachman, K., Kales, A., Vela-Bueno, A., Chrousos, G.P. Chronic insomnia and activity of the stress system: a preliminary study. J. Psychosom. Res., 1998, 45, 21-31.
54. Vgontzas, A N., Bixler E.O., Chrousos, G.P. Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann. N. Y. Acad. Sci., 2006, 1083, 329-344.
55. Stefurak, S.J., Stefurak, M.L., Mendelson, W.B., Gillin, J.C., Wyatt, R.J. A method for sleep depriving rats. Pharmacol. Bochem., Behav., 1977, 6, 137-139.
56. Campbell, I.G., Guinan, M.J, Horowitz JM. sleep deprivation impairs long-term potentiation in rat hippocampal slices. J. Neurophysiol., 2002, 88, 1073-1076.
57. Levitt, R.A. Sleep deprivation in the rat. Science, 1966, 153, 85-87.
58. Guzman-Marin, R., Suntsova, N., Stewart, D.R., Gong H, Szymusiak, R., McGinty, D. sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats. J. Physiol., 2003, 549, 563-571.
59. Webb, W. B., Agnew, H.W. Jr. Sleep deprivation, age, and exhaustion time in the rat. Science, 1962, 136, 1122.
60. O'Callaghan, R.M., Ohle, R, Kelly, A.M. The effects of forced exercise on hippocampal plasticity in the rat, A comparison of LTP, spatial-and non-spatial learning. Behav. Brain Res., 2007, 176, 362-366.
61. Tobler, I., Scherschlicht, R. Sleep and EEG slow-wave activity in the domestic cat, effect of sleep deprivation. Behav. Brain Res., 1990, 37, 109-118.
62. Tobler, I., Franken, P., Scherschlicht, R. Sleep and EEG spectra in the rabbit under baseline conditions and following sleep deprivation. Physiol. Behav., 1990, 48, 121-129.
63. Franken, P., Tobler, I., Borbely, A.A. Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat. Physiol. Behav., 1993, 54, 885-894.
64. Ocampo-Garces, A., Molina, E., Rodriguez, A., Vivaldi, E.A. Homeostasis of REM sleep after total and selective sleep deprivation in the rat. J. Neurophysiol., 2000, 84, 2699-2702.
65. Vyazovskiy, V.V., Borbely, A.A, Tobler, I. Interhemispheric sleep EEG asymmetry in the rat is enhanced by sleep deprivation. J. Neurophysiol., 2002, 88, 2280-2286.
66. Modirrousta, M., Mainville, L., Jones, B.E. Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur. J. Neurosci., 2005, 21, 2807-2816.
67. Li, S., Tian, Y., Ding, Y., Jin X, Yan, C., Shen, X. The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats. Learn Behav., 2009, 37, 246-253.
68. Kopp, C., Longordo, F., Luthi, A. Experience-dependent changes in NMDA receptor composition at mature central synapses. Neuropharmacology, 2007, 53, 1-9.
69. Datta, S., Mavanji, V., Ulloor, J., Patterson, E.H. Activation of phasic pontine-wave generator prevents rapid eye movement sleep deprivation-induced learning impairment in the rat, a mechanism for sleep-dependent plasticity. J. Neurosci., 2004, 24, 1416-1427.
70. Grahnstedt, S., Ursin, R. Platform sleep deprivation affects deep slow wave sleep in addition to REM sleep. Behav. Brain Res., 1985, 18, 233-239.
71. Machado, R.B., Hipolide, D.C., Benedito-Silva, A.A., Tufik, S. sleep deprivation induced by the modified multiple platform technique, quantification of sleep loss and recovery. Brain Res., 2004, 1004, 45-51.
72. Jouvet, D., Vimont, P., Delorme, F, Jouvet, M. Study of Selective Deprivation of the Paradoxal Sleep Phase in the Cat. C R Seances Soc Biol. Fil., 1964, 158, 756-759.
73. Suchecki, D., Lobo, L.L., Hipolide, D.C., Tufik, S. Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation. J. Sleep Res., 1998, 7, 276-81.
74. Coenen, A. M. and Van Hulzen, Z. J. Paradoxical sleep deprivation in animal studies, some methodological considerations. Prog. Brain Res., 1980, 53, 325-330.
75. van Hulzen, Z.J., Coenen, A.M. Paradoxical sleep deprivation and locomotor activity in rats. Physiol. Behav., 1981, 27, 741-744.
76. Suchecki, D., Tufik, S. Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat. Physiol. Behav., 2000, 68, 309-16.
77. Rechtschaffen, A., Bergmann, B.M. Sleep deprivation in the rat, an update of the 1989 paper. Sleep, 2002, 25, 18-24.
78. Medeiros R, Lenneberg-Hoshino, C., Hoshino, K, Tufik, S. Neuroethologic differences in sleep deprivation induced by the single-and multiple-platform methods. Braz. J. Med. Biol. Res. 1998, 31, 675-80.
79. Gulyani, S., Mallick, B.N. Effect of rapid eye movement sleep deprivation on rat brain Na-K ATPase activity. J. Sleep Res., 1993, 2, 45-50.
80. Bentivoglio, M. and Grassi-Zucconi, G. The pioneering experimental studies on sleep deprivation. Sleep, 1997, 20, 570-576.
81. Bast, B. Studies in experimental exhaustion due to lack of sleep. IV. Effect on the nerve cells in the medulla. Am. J. Physiol., 1927, 82, 140-146.
82. Dement, W., Henry, P., Cohen, H., Ferguson, J. Studies on the effect of REM deprivation in humans and in animals. Res. Publ. Assoc. Res. Nerv. Ment. Dis., 1967, 45, 456-468.
83. Dement, W. The effect of dream deprivation. Science, 1960, 131, 1705-1707.
84. Cohen, H.B., Duncan, R.F, 2nd and Dement, W.C. Sleep, the effect of electroconvulsive shock in cats deprived of REM sleep. Science, 1967, 156, 1646-1648.
85. Penev, P.D. Sleep deprivation and energy metabolism: to sleep, perchance to eat? Curr. Opin. Endocrinol. Diabetes Obes., 2007, 14, 374-381.
86. Thomas, M., Sing, H., Belenky, G., Holcomb, H., Mayberg, H., Dannals, R., Wagner, H., Thorne, D., Popp, K., Rowland, L., Welsh, A., Balwinski, S., Redmond, D. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J. Sleep Res., 2000, 9, 335-352.
87. West, L.J., Janszen, H.H., Lester, B.K., Cornelisoon F.S. Jr. The psychosis of sleep deprivation. Ann. N. Y. Acad. Sci., 1962, 96, 66-70.
88. Kollar, E.J., Slater, G.R., Palmer, J.O., Doctor, R.F., Mandell, A.J. Stress in subjects undergoing sleep deprivation. Psychosom. Med., 1966, 28, 101-113.
89. Caldwell, J.A., Prazinko, B., Caldwell, J.L. Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleep-deprived subjects. Clin. Neurophysiol., 2003, 114(1), 23-31.
90. Nicholson, A.N., Stone, B.M. Influence of back angle on the quality of sleep in seats. Ergonomics, 1987, 30, 1033-1041.
91. Dinges, D.F. An overview of sleepiness and accidents. J. Sleep Res., 1995, 4(S2), 4-14.
92. Carskadon, M.A., Dement, W.C. Effects of total sleep loss on sleep tendency. Percept. Mot. Skills. 1979, 48, 495-506.
93. Horne, J.A. Sleep loss and divergent thinking ability. Sleep, 1988, 11(6), 528-536.
94. Gillberg, M., Akerstedt, T. Sleep loss and performance: no safe duration of a monotonous task. Physiol. Behav., 1998, 64, 599-604.
95. Thomas, M.L., Sing, H.C., Belenky, G., Holcomb, H.H., Mayberg, H.S., Dannals, R.F., Wagner, H.N. Jr, Thorne, D.R., Popp, K.A., Rowland, L.M., Welsh, A.B., Balwinski, S.M., Redmond, D.P. Neural basis of alertness and cognitive performance impairments during sleepiness. II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity. Thalamus Related Syst., 2003, 2, 199-229.
96. Drummond, S.P., Gillin, J.C., Brown, G.G. Increased cerebral response during a divided attention task following sleep deprivation. J. Sleep Res., 2001, 10, 85-92.
97. Jin, S.H., Na, S.H., Kim, S.Y., Kim, D.J. Effects of total sleepdeprivation on waking human EEG: functional cluster analysis. Clin. Neurophysiol., 2004, 115, 2825-2833.
98. Szelenberger, W., Piotrowski, T, Dabrowska, A.J. Increased prefrontal event-related current density after sleep deprivation. Acta Neurobiol. Exp. Wars, 2005, 65, 19-28.
99. Yang, R.H., Hu, S.J., Wang Y., Zhang, W.B., Luo, W.J, Chen, J.Y. Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus. Brain Res., 2008, 1230, 224-232.
100. Zagaar, M., Alhaider, I., Dao, A., Levine, A., Alkarawi, A., Alzubaidy, M., Alkadhi, K. The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence. Neurobiol. Dis., 2012, 4, 1153-1162.
101. Hagewoud, R., Havekes, R., Novati, A., Keijser, J.N., Van de Zee, E.A., Meerlo, P. sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. J. Sleep Res., 2010, 19, 280-288
102. Youngblood, B.D., Smagin, G.N., Elkins, P.D., Ryan, D.H., Harris, R.B. The effects of paradoxical sleep deprivation and valine on spatial learning and brain 5-HT metabolism. Physiol. Behav., 1999, 67, 643-649.
103. Ruskin, D.N., Liu, C, Dunn, K.E. Bazan, N.G., LaHoste, G.J. Sleep deprivation impairs hippocampus-mediated contextual learning but not amygdala-mediated cued learning in rats. Eur. J. Neurosci., 2004, 19, 3121-3124.
104. Yoo, S. S., Hu, P. T., Gujar, N., Jolesz, F. A. and Walker, M. P. A deficit in the ability to form new human memories without sleep. Nat. Neurosci., 2007, 10, 385-392.
105. Yang, R.H., Hu, S.J., Wang, Y., Zhang, W.B., Luo, W.J., Chen, J.Y. Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus. Brain Res., 2008, 1230, 224-232.
106. Mograss, M.A., Guillem, F., Brazzini-Poisson, V., Godbout, R. The effects of total sleep deprivation on recognition memory processes, a study of event-related potential. Neurobiol. Learn Mem., 2009, 91, 343-352
107. Ramanathan, L., Hu, S., Frautschy, S.A., Siegel, J.M. Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior. Behav. Brain Res., 2009, 207, 305-309.
108. Wang, G.P., Huang, L.Q., Wu, H.J., Zhang, L., You, Z.D., Zhao, Z.X. Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation. Neuroreport, 2009, 20, 1172-1176.
109. Alhaider, I.A., Aleis, AM, Tran, T.T., Alkadhi, K.A. Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. Eur. J. Neurosci., 2010a, 31, 1368-1376.
110. Aleisa, A.M., Alzoubi, K.H., Alkadhi, K.A. Post-learning REM sleep deprivation impairs long-term memory: Reversal by acute nicotine treatment. Neurosci. Lett., 2011a, 499, 28-31.
111. Samkoff, J.S., Jacques, C.H. A review of studies concerning effects of sleep deprivation and fatigue on residents' performance. Acad. Med., 1991, 66, 687-963.
112. Blissitt, P. A. Sleep, memory, and learning. J. Neurosci. Nurs., 2001, 33, 208-215.
113. Drake, C.L., Roehrs, T., Roth, T. Insomnia causes, consequences, and therapeutics: an overview. Depress Anxiety, 2003, 184, 163-176.
114. Sagaspe, P., Sanchez-Ortuno, M, Charles, A. Effects of sleep deprivation on Color-Word, Emotional, and Specific Stroop interference and on self-reported anxiety. Brain Cogn., 2005, 60, 76-87.
115. Uhde, T.W. Anxiety disorders. In, Kryger, M.H., Roth, T., Demet. W.C, editors. Sleep medicine. 1994 Philadelphia, W.B. Saunders Company, p. 1123-1139. American Psychiatry Association. Diagnostic statistical manual of mental disorders, 4th edn. APA, Washington D.C.
116. Wyatt, R.J., Fram, D.H., Kupfer, D.J., Snyder, F. Total prolonged drug-induced REM sleep suppression in anxious-depressed patients. Arch. Gen. Psychiatry, 1971, 24, 145-155.
117. Peeke, S.C., Callaway, E., Jones, R.T., Stone, G.C., Doyle, J. Combined effects of alcohol and sleep deprivation in normal young adults. Psychopharmacology, 1980, 67, 279-87.
118. Dinges, D.F., Pack, F., Williams, D, et al. Cumulative sleepiness, mood disturbances, and psychomotor vigillance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep, 1997, 20, 267-277.
119. Roy-Byrne, P.P., Uhde, T.W., Post, R.M. Effects of one night's sleep deprivation on mood and behavior in panic disorder. Patients with panic disorder compared with depressed patients and normal controls. Arch. Gen.Psychiatry, 1986, 43, 895-899.
120. Kessler, R.C., Chiu, W.T., Demler, O., Merikangas, K.R., Walters, E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen. Psychiatry, 2005, 62(6), 617-627.
121. Kessler, R.C., Greenberg, P.E. The economic burden of anxiety and stress disorders. Davis, K.L., Charney, D.S., Coyle, J.T., Nemeroff, C., eds. 2002, pp. 981-992. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott Williams and Wilkins.
122. Breslau, N., Roth T., Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders, A longitudinal epidemiological study of young adults. Biol. Psychiatry, 1996, 39, 411-418.
123. Harvey, A.G., Hairston, I.S., Gruber, J., Gershon, A. Anxiety and sleep. In, Antony, M.A.; Stein, M.B., editors. The handbook of anxiety and anxiety disorders. New York, Oxford University Press 2008.
124. Papadimitriou, G.N., Linkowski, P. Sleep disturbance in anxiety disorders. Intk. Rev Psychiatry, 2005, 17, 229-36.
125. Kumar, A., Singh, A., Kumar, P. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behavior modification and oxidative damage in mice. Ind. J. Exp. Biol., 2011, 49, 211-218.
126. Kumar, A., Garg, R. Possible role of trazodone and imipramine in sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. Methods Find. Exp. Clin. Pharmacol., 2009, 3, 383-387.
127. Kumar, A., Singh, A. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundam. Clin. Pharmacol., 2009, 23, 439-48.
128. Xu, A., Sakurai, E., Kuramasu, A., Zhang, J., Li, J., Okamura, N., Zhang, D., Yoshikawa, T., Watanabe, T., Yanai, K. Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats. J. Pharmacol. Sci., 2010, 1144, 444-453.
129. Pokk, P., Zharkovsky, A. The effects of drugs acting at GABAbenzodiazepine-barbiturate receptor complex on the behavior of sleep deprived mice. Pharmacol. Toxicol., 1995, 76, 23-28.
130. Pokk, P., Zharkovsky, A. Small platform stress attenuates the anxiogenic effect of diazepam withdrawal in the plus-maze test. Behav. Brain Res., 1998, 97, 153-157.
131. Pokk, P., Zharkovsky, A. The effects of flumazenil, RO 15-4513 and--CCM on the behaviour of control and stressed mice in the plus-maze test. J. Physiol. Pharmacol., 1997, 48, 253-61.
132. Pokk, P., Liljequist, S., Zharkovsky, A. Ro 15-4513 potentiates, instead of antagonizes, ethanol-induced sleep in mice exposed to small platform stress. Eur. J. Pharmacol., 1996, 317, 15-20.
133. Suchecki, D., Tibamm P A., Tufik, S. Hormonal and behavioral responses of paradoxical sleep-deprived rats to the elevated plus maze. J. Neuroendocrinol., 2002, 14, 549-554.
134. Gessa, G.L., Pani, L., Fadda, P., Fratta, W. Sleep deprivation in the rat: an animal model of mania. Eur. Neuropsychopharmacol., 1995, 5, 89-93.
135. Silva, R.H., Kameda, S.R., Carvalho, R.C. Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice. Psychopharmacology, 2004, 176, 115-122.
136. Pokk, P., Väli, M. Small platform stress increases exploratory activity of mice in staircase test. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2001, 25, 1435-1444.
137. Martinez-Gonzalez, D., Obermeyer, W., Fahy, J.L., Riboh, M., Kalin, N.H., Benca, RM. REM sleep deprivation induces changes in coping responses that are not reversed by amphetamine. Sleep, 2004, 27, 609-617.
138. Mogilnicka, E., Boissard, C.G., Hunn, C., Delini-Stula, A. Suppressant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons. Pharmacol. Biochem. Behav., 1985, 23, 93-97.
139. Meerlo, P., Mistlberger, R., Jacobs, B., Heller, H., McGinty, D. New neurons in the adult brain, the role of sleep and consequences of sleep loss. Sleep Med. Rev., 2009, 13, 187-94.
140. Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., Levine, A., Alkadhi, K., Salim, S. Exercise prevents sleep deprivation-associated anxiety-like behavior in rats, Potential role of oxidative stress mechanisms. Behav. Brain Res., 2011, 224, 233-240.
141. Gopalakrishnan, A., Ji, L.L., Cirelli, C. Sleep deprivation and cellular responses to oxidative stress. Sleep, 2004, 27, 27-35.
142. Kumar, A., Kalonia, H. Protective effect of Withania somnifera Dual on the behavioral and biochemical alterations in sleep disturbed mice grid over water suspended method. Ind. J. Exp. Biol., 200, 45, 524-528.
143. Reimund, E. The free radical theory of sleep. Med. Hypotheses, 1994, 43, 231-33.
144. Ikeda, M., Ikeda-Sagara, M., Okada, T. Brain oxidation is an initial process in sleep induction. Neuroscience, 2005, 130, 1029-1040.
145. Honda K, Kamoda Y, Inoue S. Oxidized glutathione regulates physiological sleep in unrestrained rats. Brain Res., 1994, 636, 253-58.
146. Horne, J.A. A review of the biological effects of total sleep deprivation in man. Biol. Psychol., 1978, 7, 55-102.
147. Taylor, A.H. Physical activity, anxiety, and stress. In, Physical activity and psychological well-being.; Biddle SJH, Fox KR, Boutcher, C.H, eds, pp 10-45. 2000 New York, Routledge.
148. Salmon, P. Effects of physical exercise on anxiety, depression, and sensitivity to stress, a unifying theory. Clin. Psychol. Rev., 2001, 21, 33-61.
149. Fasting, K., Gronningsaeter, H. Unemployment, trait-anxiety and physical exercise. Scandinavian J. Sports Sci., 1986, 8, 99-103.
150. Roth DL, Holmes DS. Influence of aerobic exercise training and relaxation on physical and psychologic health following stressful life events. Psychosomatic Med., 1987, 49, 355-365.
151. Simons, C.W., Birkimer, J.C. An exploration of factors predicting the effects of aerobic conditioning on mood state. J. Psychosomatic Res., 1988, 32, 63-75.
152. Williams, P, Lord, S.R. Effects of group exercise on cognitive functioning and mood in older women. Australian and New Zealand J. Public Health, 1997, 21, 45-52.
153. Abrous, D.N., Koehl, M., Le Moa, I.M. Adult neurogenesis: from precursors to network and physiology. Physiol. Rev., 2005, 85, 523-569.
154. Ming, G.L., Song, H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci., 2005, 28, 223-250.
155. Lledo, P.M., Alonso, M., Grubb, M.S. Adult neurogenesis and functional plasticity in neuronal circuits. Nat. Rev. Neurosci., 2006; 7, 179-193.
156. Kaplan, M.S., Hinds, J.W. Neurogenesis in the adult rat, electron microscopic analysis of light radioautographs. Science, 1977, 197, 1092-1094.
157. Eriksson PS, Perfilieva, E., Bjork-Eriksson, T., Alborn, A.M., Nordborg, C., Peterson, D.A., Gage, H. Neurogenesis in the adult human hippocampus. Nat. Med. 1998, 4, 1313-17.
158. Kornack, D.R., Rakic, P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl. Acad. Sci. USA, 1999, 96, 5768-73.
159. Becker, S., Wojtowicz, J.M. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn. Sci., 2007, 11, 70-76.
160. Sahay, A., Hen, R. Adult hippocampal neurogenesis in depression. Nat. Neurosci., 2007, 10, 1110-1115.
161. Samuels, B.A., Hen, R. Neurogenesis and affective disorders. Eur. J. Neurosci., 2011, 33, 1152-59.
162. Winner, B., Kohl, Z., Gage, F.H. Neurodegenerative disease and adult neurogenesis. Eur. J. Neurosci., 2011, 33, 1139-51.
163. Kempermann, G., Kuhn, H.G., Gage, F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature, 1997, 386, 493-495.
164. van Praag, H., Kempermann, G., Gage, F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci., 1999, 2, 266-270.
165. van Praag, H., Schinder, A.F., Christie, B.R., Toni, N., Palmer, T.D., Gage, F.H. Functional neurogenesis in the adult hippocampus. Nature 2002, 415, 1030-34.
166. Nakashiba, T., Cushman, J.D., Pelkey, K.A., Renaudineau, S., Buhl, D.L., McHugh, T.J., Rodriguez, B. V., Chittajallu, R., Iwamoto, K.S., McBain, C.J., Fanselow, M.S., Tonegawa, S.Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell, 2012, 149(1), 188-201.
167. Hairston, I.S., Little, M.T., Scanlon, M.D., Barakat, M.T., Palmer, T.D., Sapolsky, R.M., Heller, H.C. Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning. J. Neurophysiol., 2005, 94, 4224-4233.
168. Lucassen, P.J., Meerlo, P., Naylor, A.S., van Dam, A.M., Dayer, A.G., Fuchs, E., Oomen, C.A., Czéh, B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation, implications for depression and antidepressant action. Eur. Neuropsychopharmacol., 2010, 20, 1-17.
169. Guzman-Marin, R., Suntsova, N., Methippara, M., Greiffenstein, R., Szymusiak, R., McGinty, D. Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats. Eur. J. Neurosci., 2005, 22, 2111-16.
170. Kitabatake, Y., Sailor, K.A., Ming, G.L., Song, H. Adult neurogenesis and hippocampal memory function, new cells, more plasticity, new memories? Neurosurg. Clin. N. Am., 2007, 18, 105-13.
171. Mueller, A., Pollock, M.S., Lieblich, S.E., Epp, J.R., Galea, L.A., Mistlberger, R.E. sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2008, 294, R1693-R1703.
172. Tung, A., Takase, L., Fornal, C., Jacobs, B. Effects of sleep deprivation and recovery sleep upon cell proliferation in adult rat dentate gyrus. Neuroscience, 2005, 134, 721-723.
173. Roman, V., Van der Borght, K., Leemburg S.A., Van der Zee E.A., Meerlo, P. Sleep restriction by forced activity reduces hippocampal cell proliferation. Brain Res., 2005a, 1065, 53-59.
174. Roman, V., Walstra, I., Luiten, P.G., Meerlo, P. Too little sleep gradually desensitizes the serotonin 1A receptor system. Sleep, 2005b, 28, 1505-10.
175. Mirescu, C., Gould, E. Stress and adult neurogenesis. Hippocampus, 2006a, 16, 233-238.
176. Mirescu, C., Peters, J.D., Noiman, L., Gould, E. sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proc. Natl. Acad. Sci. USA., 2006b, 103, 19170-19175.
177. van der Borght, K., Ferrari, F., Klauke, K., Roman, V., Havekes, R., Sgoifo, A., van der Zee, E.A., Meerlo, P. Hippocampal cell proliferation across the day, increase by running wheel activity, but no effect of sleep and wakefulness. Behav. Brain Res., 2006, 167, 36-41.
178. Grassi, Z. G., Cipriani, S., Balgkouranidou, I., Scattoni, R. "One night" sleep deprivation stimulates hippocampal neurogenesis. Brain Res. Bull., 2006, 69, 375-381.
179. Junek, A., Rusak, B., Semb, K. Short-term sleep deprivation may alter the dynamics of hippocampal cell proliferation in adult rats. Neuroscience, 2010, 170, 1140-1152.
180. Bain, M.J., Dwyer, S.M., Rusak, B. Restraint stress affects hippocampal cell proliferation differently in rats and mice. Neurosci. Lett., 2004; 368, 7-10.
181. Wakamatsu, H., Yoshinobu, Y., Aida, R., Moriya, T., Akiyama, M., Shibata, S. Restricted-feeding-induced anticipatory activity rhythm is associated with a phase-shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice. Eur. J. Neurosci., 2001, 13, 119096.
182. Amir, S., Harbour, V.L., Robinson, B. Pinealectomy does not affect diurnal PER2 expression in the rat limbic forebrain. Neurosci. Lett., 2006, 399, 147-50.
183. Jilg, A., Lesny, S., Peruzki, N., Schwegler, H., Selbach, O., Dehghani, F., Stehle, J.H. Temporal dynamics of mouse hippocampal clock gene expression support memory processing. Hippocampus, 2010, 20, 377-388.
184. Kang, H., Schuman, E.M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science, 1995, 267, 1658-62.
185. Crews, K., Nixon, D., Kim, J., Joseph, B., Shukitt-Hale, L., Qin, Zou, J. BHT blocks NF-kappaB activation and ethanol-induced brain damage. Alcohol. Clin. Exp. Res., 2006, 30, 1938-1949.
186. Nixon, K., Crews, F.T. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J. Neurochem., 2002, 83, 1087-1093.
187. Herrera, D.G., Yague, A.G., Johnsen-Soriano, S., Bosch-Morell, F., Collado-Morente, L., Muriach, M., Romero, F.J., Garcia-Verdugo, J.M. Selective impairment of hippocampal neurogenesis by chronic alcoholism, protective effects of an antioxidant. Proc. Natl. Acad. Sci. USA. 2003, 100, 7919-24.
188. Salim, S., Sarraj, N., Taneja, M., Saha, K., Tejada-Simon, M.V., Chugh, C. Moderate treadmill exercise prevents oxidative stressinduced anxiety-like behavior in rats. Behav. Brain Res., 2010, 208, 545-552.
189. Vgontzas, A.N., Papanicolaou, D.A., Bixler, E.O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.L., Licinio, J., Gold, P.W., Hermida, R.C., Mastorakos, G., Chrousos, G.P. Circadian interleukin-6 secretion and quantity and depth of sleep. J. Clin. Endocrinol. Metab., 1999, 84, 2603-2607.
190. Rock, R.B., Gekker, G., Hu, S., Sheng, W.S., Cheeran, M., Lokensgard, J.R., Peterson, P.K. Role of Microglia in Central Nervous System Infections. Clin. Microbiol. Rev., 200, 17, 942-964.
191. Behrens, M.M., Ali, S.S., Dugan, L.L. Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J. Neurosci., 2008, 28, 13957-13966.
192. Brown, G.C. Mechanisms of inflammatory neurodegeneration, iNOS and NADPH oxidase. Biochem. Soc. Trans., 2007, 35, 1119-1121.
193. Voloboueva, L.A., Giffard, R.G. Inflammation, Mitochondria, and the Inhibition of Adult Neurogenesis. J. Neurosci. Res., 2011, 89, 1989-1996.
194. Van Cauter, E., Spiegel, K., Tasali, E., Leproult, R. Metabolic consequences of sleep and sleep loss. Sleep Med., 2008, 9 Suppl 1: S23-S28.
195. Mullington, J.M., Simpson, N.S., Meier-Ewert, H.K., Haack, M. Sleep loss and inflammation. Best Pract. Res. Clin. Endocrinol. Metab. 2010, 24, 775-784.
196. Opp, M.R. Cytokines and sleep. Sleep Med. Rev., 2005, 9, 355-364.
197. Motivala, S.J., Irwin, M.R. Sleep and immunity, cytokine pathways linking sleep and health outcomes. Curr. Dir. Psychol. Sci., 2007, 16, 21-26
198. Mortensen, R.F. C-reactive protein, inflammation, and innate immunity. Immunol. Res., 2001, 24, 163-176.
199. Zimmerman, M.A., Selzman, C.H., Cothren, C., Sorensen, A.C., Raeburn, C.D., Harken, A.H. Diagnostic implications of Creactive protein. Arch. Surg, 2003, 138, 220-224.
200. Meier-Ewert, H.K., Ridker, P.M., Rifai, N., Price, N, Dinge, D.F., Mullington, J.M. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin. Chem., 2001, 47, 426-430.
201. Meier-Ewert, H.K., Ridker, P.M., Rifai, N. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am. Coll. Cardiol., 2004, 43, 678-683.
202. Rief, W., Mills, P.J., Ancoli-Israel, S., Ziegler, M.G., Pung, M.A., Dimsdale, J.E. Overnight changes of immune parameters and catecholamines are associated with mood and stress. Psychosom. Med., 2010, 72(8), 755-762.
203. Salim, S., Asghar, M., Taneja, M., Hovatta, I, Chugh, G., Vollert, C., Vu, A. Potential Contribution of Oxidative Stress and Inflammation to Anxiety and Hypertension. Brain Res., 2011, 1404, 63-71.
204. Bliss, T.V., Collingridge, G.L. A synaptic model of memory, longterm potentiation in the hippocampus. Nature, 1993, 361(6407), 31-39.
205. Smith, C.T., Conway, J.M., Rose, G.M. Brief paradoxical sleep deprivation impairs reference, but not working, memory in the radial arm maze task. Neurobiol. Learn Mem., 1998, 69, 211-217.
206. Davis, C.J., Harding, J.W., Wright, J.W. REM sleep deprivationinduced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus. Brain Res., 2003, 973, 293-297.
207. Tiba, A., Oliveira, M.G., Rossi, V.C., Tufik, S., Suchecki, D. Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments. Sleep, 2008; 31, 505-515.
208. Ruskin, D.N., Dunn, K.E., Billiot, I., Bazan, N.G., LaHoste, G.J. Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze. Life Sci., 2006, 78, 2833-2838.
209. Alhaider, I.A., Aleisa, A.M., Tran, T.T., Alkadhi, K.A. Sleep deprivation prevents stimulation-induced increases of levels of PCREB and BDNF: protection by caffeine. Mol. Cell. Neurosci., 2010b, 46, 742-751.
210. Alhaider, I.A., Aleisa, A.M., Tran, T.T., Alzoubi, K.H., Alkadhi, K.A. Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep, 2011, 33, 437-444
211. Aleisa, A.M., Helal, G., Alhaider, I.A., Alzoubi, K.H., Srivareerat, M., Tran, T.T., Al-Rejaie, S.S., Alkadhi, K.A. Acute nicotine treatment prevents REM sleep deprivation-induced learning and memory impairment in rat. Hippocampus, 2011b, 21, 899-909.
212. Yang, Z., Zhang, W., Wang, M., Ruan, D., Chen, J. Effects of daytime, night and sleep pressure on long-term depression in the hippocampus in vivo. Neurosci. Lett., 2012, 5112, 106-109.
213. Tadavarty, R., Rajput, P.S., Wong, J.M., Kumar, U., Sastry, B.R. Sleep-deprivation induces changes in GABAB and mGlu receptor expression and has consequences for synaptic long-term depression. PLoS One, 2011; 6: e24933.
214. Tadavarty, R., Kaan, T.K., Sastry, B.R. Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation. Exp. Neurol., 2009, 216, 239-242
215. Tartar, J.L., Ward, C.P., McKenna, J.T, et al. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur. J. Neurosci., 2006, 23, 2739-2748.
216. Marks, C.A., Wayner, M.J. Effects of sleep disruption on rat dentate granule cell LTP in vivo. Brain Res Bull 2005, 66, 114-119.
217. Ishikawa, A., Kanayama, Y., Matsumura, H., Tsuchimochi, H., Ishida, Y., Nakamura, S. Selective rapid eye movement sleep deprivation impairs the maintenance of long-term potentiation in the rat hippocampus. Eur. J. Neurosci., 2006, 24, 243-48.
218. Park, H.J., Kang, W.S., Paik, J.W., Kim, J.W. Effect of Valproic Acid Through Regulation of NMDA Receptor-ERK Signaling in Sleep Deprivation Rats. J. Mol. Neurosci., 2011, Nov 19.[Epub ahead of print]
219. Novati, A., Hulshof, H.J., Granic, I, Meerlo, P. Chronic partial sleep deprivation reduces brain sensitivity to glutamateN-methyl-daspartate receptor-mediated neurotoxicity. J. Sleep Res., 2012, 21, 3-9.
220. Hagewoud, R., Havekes, R., Novati, A, Keijser, J.N., Van der Zee, E.A., Meerlo, P. Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. J. Sleep Res., 2010, 19, 280-288.
221. Chen, C., Hardy, M., Zhang, J., LaHoste, G.J., Bazan, N.G. Altered NMDA receptor trafficking contributes to sleep deprivationinduced hippocampal synaptic and cognitive impairments. Biochem. Biophys. Res. Commun., 2006, 340, 435-440.
222. Ravassard, P., Pachoud, B., Comte, J.C, et al. Paradoxical REM sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus. Sleep, 2009, 32, 227-240.
223. Vecsey, C.G., Baillie, G.S., Jaganath, D., Havekes, R., Daniels, A., Wimmer, M., Huang, T., Brown, K.M., Li, X.Y., Descalzi, G., Kim, S.S., Chen, T., Shang, Y.Z., Zhuo, M., Houslay, M.D., Abel, T. Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 2009, 461, 1122-1125.
224. Gerges, N.Z., Alzoubi, K.H and Alkadhi, K.A. Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus. Hippocampus, 2005, 15, 480-490.
225. Aleisa, A.M., Alzoubi, K.H., Gerges N.Z., Alkadhi, K.A. Nicotine blocks stress-induced impairment of spatial memory and LTP of the CA1 region. Int. J. Neuropsychopharmacol., 2006a, 9, 417-426
226. Aleisa, A.M., Alzoubi, K.H., Gerges, N.Z., Alkadhi, K.A. Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF. Neurobiol. Dis., 2006b, 22, 453-462.
227. Srivareerat, M., Tran, T.T., Alzoubi, K.H., Alkadhi, K.A. Chronic psychosocial stress exacerbates impairment of cognition and LTP in a A-rat model of Alzheimer's disease. Biol. Psychiatry, 2009, 65 (11), 918-926.
228. Malenka, R.C., Kauer, J.A., Perkel, D.J., Mauk, M.D., Kelly, P.T., Nicoll, R.A., Waxham, M.N. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature, 1989, 340, 554-557.
229. Pettit, D.L., Perlman, S., Malinow, R. Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Sci. N.Y., 1994, 266, 1881-1885.
230. Lledo, P.M., Hjelmstad, G.O., Mukherji, S., Soderling, T.R. Malenka RC, Nicoll RA. Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc. Natl. Acad. Sci. USA., 1995, 92, 11175-11179.
231. Giese, K.P., Fedorov, N.B., Filipkowski, R.K., Silva, A.J. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science, 1998, 279, 870-873.
232. Mulkey, R.M., Herron, C.E., Malenka, R.C. An essential role for protein phosphatases in hippocampal long-term depression. Science, 1993, 261, 1051-55.
233. Mulkey, R.M., Endo, S., Shenolikar, S., Malenka, R.C. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature, 1994, 369, 486-88.
234. Wang, J.H., Kelly, PT. The balance between postsynaptic Ca2+-dependent protein kinase and phosphatase activities controlling synaptic strength. Learn. Mem., 1996, 3, 170-181.
235. Winder, D.G., Mansuy, I.M., Osman, M., Moallem, T.M., Kandel, E.R. Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 1998, 92, 25-37.
236. Linnarsson, S., Bjorklund, A., Ernfors, P. Learning deficit in BDNF mutant mice. Eur. J. Neurosci., 1997, 9, 2581-2587.
237. Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., Bonhoeffer, T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA., 1995, 92, 8856-8860.
238. Patterson, S.L. Abel, T., Deuel, T.A., Martin, K.C., Rose, J.C., Kandel, E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron, 1996, 16, 1137-1145.
239. Mizuno., Yamada, K., Olariu, A., Nawa, H., Nabeshima, T. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J. Neurosci., 2000, 20, 7116-7121.
240. Gooney, M., Shaw, K., Kelly, A., O'Mara, S.M., Lynch, M.A. Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signalregulated kinase ERK in the dentate gyrus, evidence for a role for brain-derived neurotrophic factor. Behav. Neurosci., 2002, 116, 455-463.
241. Patterson, SL., Grover, L.M., Schwartzkroin, P.A., Bothwell, M. Neurotrophin expression in rat hippocampal slices, a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron, 1992, 9, 1081-1088.
242. Castren, E., Pitkanen, M, Sirvio, J, et al. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport, 1993, 4, 895-898.
243. Dragunow, M., Beilharz, E, Mason B, Lawlor, P., Abraham, W., Gluckman, P. Brain-derived neurotrophic factor expression after long-term potentiation. Neurosci. Lett., 1993, 160, 232-236.
244. Springer, J.E., Gwag, B.J., Sessler, F.M. Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle. Brain Res. Mol. Brain Res., 1994, 23, 135-143.
245. Morimoto, K., Sato, K., Sato, S., Yamada, N., Hayabara, T. Timedependent changes in neurotrophic factor mRNA expression after kindling and long-term potentiation in rats. Brain Res. Bul., 1998, 45, 599-605.
246. Finkbeiner, S., Tavazoie, S.F., Maloratsky, A., Jacobs, K.M., Harris, K.M., Greenberg, M.E. CREB, a major mediator of neuronal neurotrophin responses. Neuron, 1997, 19, 1031-1047.
247. Boulanger L, Poo MM. Gating of BDNF-induced synaptic potentiation by cAMP. Science, 1999, 284, 1982-1984.
248. Blanquet, P.R., Lamour, Y. Brain-derived neurotrophic factor increases Ca2+/calmodulin-dependent protein kinase 2 activity in hippocampus. J. Biol. Chem., 1997, 272, 24133-24136.
249. Minichiello, L., Calella, A.M., Medina, D.L., Bonhoeffer, T., Klein, R., Korte, M. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron, 2002, 36, 121-137.
250. Yin, J.C., Wallach, J.S., Del Vecchio, M., et al. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell, 1994, 79, 49-58.
251. Tully, T. Regulation of gene expression and its role in long-term memory and synaptic plasticity. Proc. Natl. Acad. Sci. USA., 1997, 94, 4239-4241.
252. Abel, T., Kandel, E Positive and negative regulatory mechanisms that mediate long-term memory storage. Brain Res. Brain Res. Rev., 1998, 26, 360-378.
253. Abel, T., Martin, K.C., Bartsch, D., Kandel, E.R. Memory suppressor genes inhibitory constraints on the storage of long-term memory. Science, 1998, 279, 338-341.
254. Yin, J.C., Del Vecchio, M, Zhou, H, Tully, T. CREB as a memory modulator, induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 1995, 81, 107-115.
255. Jensen, K.F., Ohmstede, C.A., Fisher, R.S., Sahyoun, N. Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex. Proc. Natl. Acad. Sci. USA, 1991a, 88, 2850-53.
256. Jensen KF, Ohmstede, C.A, Fisher RS, Olin JK, Sahyoun N. Acquisition and loss of a neuronal Ca2+/calmodulin-dependent protein kinase during neuronal differentiation. Proc. Natl. Acad. Sci. USA, 1991b, 88, 4050-4053.
257. Bito, H., Deisseroth, K, Tsien, R.W. CREB phosphorylation and dephosphorylation: a Ca2+-and stimulus duration-dependent switch for hippocampal gene expression. Cell, 1996, 87, 1203-14.
258. Tokuda, M., Ahmed, B.Y., Lu, Y.F., Matsui, H., Miyamoto, O., Yamaguchi, F., Konishi, R., Hatase, O. Involvement of calmodulindependent protein kinases-I and-IV in long-term potentiation. Brain Res., 1997, 755, 162-166.
259. Ho, N., Liauw, J.A., Blaeser, F., Wei, F., Hanissian, S., Muglia, L.M., Wozniak, D.F., Nardi, A., Arvin, K.L., Holtzman, D.M., Linden, D.J., Zhuo, M., Muglia, L.J., Chatila, T.A. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J. Neurosci., 2000, 20, 6459-72.
260. Kang, H., Sun, L.D., Atkins, CM, Soderling, T.R., Wilson, M.A., Tonegawa, S. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell, 2001, 106, 771-783.
261. Srivareerat, M., Tran, T.T., Salim, S., Aleisa, A.M., Alkadhi, K.A. Chronic nicotine restores normal A-levels and prevents short-term memory and E-LTP impairment in a-rat model of Alzheimer's disease. Neurobiol. Aging, 2011, 32, 834-844.
262. Mansvelder, H.D., McGehee, D.S. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron, 2000, 27, 349-357.
263. Ji, D., Lape, R., Dani, J.A. Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron, 2001, 31, 131-141.
264. Alkondon, M., Braga, M.F., Pereira, E.F., Maelicke, A., Albuquerque EX. alpha7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus. Eur. J. Pharmacol., 2000, 393, 59-67.
265. Fujii, S., Ji, Z., Morita, N, Sumikawa K. Acute and chronic nicotine exposure differentially facilitate the induction of LTP. Brain Res., 1999, 846, 137-143.
266. French, S.J., Humby, T, Horner, C.H., Sofroniew, M.V., Rattray, M. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Brain Res. Mol. Brain Res., 1999, 67, 124-136.
267. Nehlig, A., Daval, J.L., Debry, G. Caffeine and the central nervous system, mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res. Brain Res. Rev., 1992, 17, 139-170.
268. Angelucci, M.E. Cesario, C, Hiroi, R.H., Rosalen, P.L., Da Cunha, C. Effects of caffeine on learning and memory in rats tested in the Morris water maze. Braz. J. Med. Biol. Rest., 2002, 35, 1201-1208.
269. Dall'Igna, O.P., Fett, P., Gomes, M.W., Souza, D.O., Cunha, R.A., Lara, D.R. Caffeine and adenosine A2a receptor antagonists prevent beta-amyloid 25-35-induced cognitive deficits in mice. Exp. Neurol. 2007, 203, 241-245.
270. Gevaerd, M.S., Takahashi, R.N., Silveira, R., Da Cunha, C. Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats. Brain Res. Bull., 2001, 55, 101-106.
271. Prediger, R.D., Pamplona, F.A., Fernandes, D., Takahashi, R.N. Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder ADHD--the spontaneously hypertensive rat SHR. Int. J. Neuropsychopharmacol., 2005, 8, 583-594.
272. Riedel, W.J., Jolles, J. Cognition enhancers in age-related cognitive decline. Drugs Aging, 1996, 8, 245-74.
273. Riedel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., Jolles, J. Caffeine attenuates scopolamine-induced memory impairment in humans. Psychopharmacol. Berl., 1995, 122, 158-168.
274. Fredholm, B.B. Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol. Toxicol., 1995, 76, 93-101.
275. de Mendonca, A, Ribeiro, J.A. Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience, 1994, 62, 385-390.
276. de Mendonca, A., Sebastiao, A.M, Ribeiro, J.A. Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurons by adenosine A1 receptor activation. Neuroreport, 1995, 6, 1097-1100.
277. Dunwiddie, T.V., Masino, S.A. The role and regulation of adenosine in the central nervous system. Ann. Rev. Neurosci., 2001, 24, 31-55.
278. Kalinchuk, A.V., McCarley, R.W., Porkka-Heiskanen, T., Basheer, R. The time course of adenosine, nitric oxide NO and inducible NO synthase changes in the brain with sleep loss and their role in the non-rapid eye movement sleep homeostatic cascade. Neurochemistry. 2011, 116, 260-272.
279. Ding, Y.H., Luan, X.D., Li, J., Rafols, J.A., Guthinkonda, M., Diaz, F.G., Ding, Y. Exercise-induced overexpression of angiogenic factors and reduction of ischemia/reperfusion injury in stroke. Curr. Neurovasc. Res., 2004, 1, 411-420.
280. Sim YJ, Kim SS, Kim JY, Shin MS, Kim CJ. Treadmill exercise improves short-term memory by suppressing ischemia-induced apoptosis of neuronal cells in gerbils. Neurosci Lett 2004; 372: 256-261.
281. Toldy, A., Atalay, M., Stadler, K., Sasvári, M., Jakus, J., Jung, K.J., Chung, H.Y., Nyakas, C., Radák, Z. The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat. J. Nutr. Biochem., 2009, 20, 974-981.
282. Garcia-Capdevila, S., Portell-Cortes, I., Torras-Garcia, M., Coll-Andreu, M., Costa-Miserachs, D. Effects of long-term voluntary exercise on learning and memory processes, dependency of the task and level of exercise. Behav. Brain Res., 2009, 202, 162-170.
283. Nichol, K. E., Parachikova, A. I. and Cotman, C. W. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav. Brain Res., 2007184, 124-132.
284. Kim, S.E., Ko, I.G., Kim, B.K., Shin, M.S., Cho, S., Kim, C.J., Kim, S.H., Baek, S.S., Lee, E.K., Jee, Y.S. Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp. Gerontol., 2010, 45, 357-365.
285. Radak, Z., Toldy, A., Szabo, Z., Siamilis, S., Nyakas, C., Silye, G., Jakus, J., Goto, S. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem. Int., 2006, 49, 387-392.
286. Radak, Z., Chung, H.Y., Koltai, E, Taylor, A.W., Goto, S. Exercise, oxidative stress and hormesis. Ageing Res. Rev., 2008, 7, 34-42.
287. Akaneya, Y., Tsumoto, T., Kinoshita, S., Hatanaka, H. Brainderived neurotrophic factor enhances long-term potentiation in rat visual cortex. J. Neurosci., 1997, 17, 6707-16.
288. Gomez-Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G. Exercise impacts brain-derivedneurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. Eur. J. Neurosci., 2010, 33, 383-390.
289. Gerges, N.Z. and Alkadhi, K.A. Hypothyroidism impairs late LTP in CA1 region but not in dentate gyrus of the intact rat hippocampus: MAPK involvement. Hippocampus, 2004, 14, 40-45.
290. Gerges, N.Z., Stringer, J.L., Alkadhi, K.A. Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats. Brain Res., 2001, 922, 250-226.