The effects of flumazenil, RO 15-4513 and β-CCM on the behaviour of control and stressed mice in the plus-maze test

Journal of Physiology and Pharmacology

Volumn 48, Issue 2, 1997, Pages 253-261

  Pokk, P ^a   Zharkovsky, A ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

CCM; Flumazenil; Plus maze; Ro 15 4513; Sleep deprivation; Stress

Indexed keywords

8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; FLUMAZENIL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BEHAVIOR MODIFICATION; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; EYE MOVEMENT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MAZE TEST; MOUSE; NONHUMAN; REM SLEEP; SLEEP DEPRIVATION; STRESS;

ANIMALS; ANXIETY; AZIDES; BEHAVIOR, ANIMAL; BENZODIAZEPINES; CARBOLINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA MODULATORS; LIGANDS; MALE; MICE; STRESS, PSYCHOLOGICAL;

EID: 0030803381     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Biggio G, Concas A, Corda MG, Giorgi O, Sanna E, Serra M. GABAergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. Pharmac Ther 1990; 48: 121-142.
2. 3H]muscimol binding in rats that do not develop stress-induced behavioral depression. Brain Res 1993; 631: 270-276.
3. Drugan RC, Basile AS, Ha J-L, Ferland RJ. The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists. Brain Res 1994; 661: 127-136.
4. Boix F, Fernandez-Teruel A, Tobena A. The anxiolytic action of benzodiazepines is not present in handling-habituated rats. Pharmacol Biochem Behav 1989; 31: 541-546.
5. Conti LH, Maciver CR, Ferkany JW, Abreu ME. Footschock-induced freezing behavior in rats as a model of assessing anxiolytics. Psychopharmacol 1990; 102: 492-497.
6. Charrier D, Dangoumau L, Puech AJ, Hamon M, Thiebot M-H. Failure of CCK receptor ligands to modify anxiety-related behavioural suppression in an operant conflict paradigm in rats. Psychopharmal 1995; 121: 127-134.
7. Stone EA, Manavalan SJ, Zhang Y, Quatermain D. Beta adrenoceptor blockade mimics effects of stress on motor activity in mice. Neuropsychopharmacol 1995; 12: 65-71.
8. Ferretti C, Blengio M, Gamalero SR, Ghi P. Biochemical and behavioural changes induced by acute stress in a chronic variate stress model of depression: the effect of amitryptilline. Eur J Pharmacol 1995; 280: 19-26.
9. Andrews N, File SE. Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety. Eur J Pharmacol 1993; 235: 109-112.
10. McBlane JW, Handley SL. Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT. Psychopharmacol 1994, 116: 173-182.
11. Armario A, Gil M, Marti J, Pol O, Balasch J. Influence of various acute stressors on the activity of adult male rats in a hole-board and in the forced swim test. Pharmacol Biochem Behav 1991; 39: 373-377.
12. Willner P, Lappas S, Cheeta S, Muscat R. Reversal of stress-induced anhedonia by the dopamine receptor agonist, pramipexole. Psychopharmacol 1994; 115: 454-462.
13. Monleon S, D'Aquila P, Parra A, Simon VM, Brain PF, Willner P. Attenuation of sucrose consumption in mice by chronic stress and its restoration by imipramine. Psyhopharmacol 1995; 117: 453-457.
14. Moreau J-L, Scherschlicht R, Jenck F, Martin JR. Chronic mild stress-induced anhedonia model of depression: sleep abnormalities and curative effects of electroshock treatment. Behav Pharmacol 1995; 6: 682-687.
15. Cheeta S, Broekkamp C, Willner P. Stereospecific reversal of stress-induced anhedonia by mianserin and its (+)-enantiomer. Psychopharmacol 1994; 116: 523-528.
16. Morden B, Mitchell G, Dement W. Selective REM sleep deprivation and compensation phenomena in the rat. Brain Res 1967; 5: 339-349.
17. Mark J, Heiner L, Mandel P, Godin Y. Norepinephrine turnover in brain and stress reactions in rats during paradoxical sleep deprivation. Life Sci 1969; 8: 1085-1093.
18. Fratta W, Collu M, Marcelotta MC, Pichiri M, Muntoni F, Gessa GL. Stress induced insomnia: opioid-dopamine interactions. Eur J Pharmacol 1987; 142: 437-440.
19. Fratta W, Fadda P, Marcelotta MC, Gessa GL. Dopamine and neuropeptides interactions in sleep deprivation. Clin Neuropharmacol 1990; 13: 386-388.
20. Moore JD, Hayes C, Hicks RA. REM sleep deprivation increases preference for novelty in rats. Physiol Behav 1979; 23: 975-976.
21. Pokk P, Zharkovsky A. The effects of drugs acting at GABA-Benzodiazepine-Barbiturate receptor complex on the behaviour of sleep deprived mice. Pharmacol Toxicol 1995; 76: 23-28.
22. Pokk, P, Kivastik T, Sobol D, Liljequist S, Zharkovsky A. Is upregulation of benzodiazepine receptors a compensatory reaction to reduced GABAergic tone in the brain of stressed mice? Naunyn-Schmied Arch Pharmacol 1996; 354: 703-708.
23. Pokk P, Zharkovsky A. Ro 15-4513 potentiates, instead of antagonizes, ethanol-induced sleep in mice exposed to small platform stress. Eur J Pharmacol 1996; 317: 15-20.
24. Vale NB, Leite JR. Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation. Psychopharmacol 1988; 94: 138-140.
25. Asakura W, Matsumoto K, Ohta H, Watanabe H. Involvement of dopamine D2 receptor mechanism in the REM sleep deprivation-induced increase in swimming activity in the forced swimming test. Pharmacol Biochem Behav 1994; 48: 43-46.
26. File SE, Wilks LJ, Mabbutt PS. Withdrawal, tolerance and sensitization after a single dose of lorazepam. Pharmacol Biochem Behav 1989; 31: 937-940.
27. Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacol 1987; 92: 180-185.
28. Dawson GR, Crawford SP, Collinson N, Iversen SD, Tricklebank MD. Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity. Psychopharmacol 1995; 118: 316-323.
29. File SE. The anxiogenic action of benzodiazepine antagonists. Neuropharmacol 1982; 21: 1033-1037.
30. Crawley JN, Skolnick P, Paul SM. Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse. Neuropharmacol 1984; 23: 531-537.
31. File SE, Pellow S. Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacol 1986; 88: 1-11.
32. File SE, Baldwin HA, Hitchcott PK. Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat. Psychopharmacol 1989; 98: 262-264.
33. Urbancic M, Gadek MA, Marczynski TJ. Chronic exposure to flumazenil: anxiolytic effect and increased exploratory behavior. Pharmacol Biochem Behav 1990; 35: 503-509.
34. Ferre P, Fernandez Teruel A, Escorihuela RM, Garcia E, Zapata A, Tobena A. Struggling and flumazenil effects in the swimming test are related to the level of anxiety in mice. Neuropsychobiology 1994; 29: 23-27.
35. Kapczinski F, Curran HV, Gray J, Lader M. Flumazenil has an anxiolytic effect in simulated stress. Psychopharmacol 1994; 114: 187-189.
36. Belzung C, Misslin R, Vogel E, Dodd RH, Chapouthier G. Anxiogenic effects of methyl-β-carboline-3-carboxylate in a light/dark choice situation. Pharmacol Biochem Behav 1987; 28: 29-33.
37. Nicholls B, Mellanby J, Smith S. The effect of Ro 15-4513, an inverse agonist at the benzodiazepine receptor, on the exploratory response to novelty in the playground maze. J. Psychopharmacol 1994; 8: 32-39.