Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior

Behavioural Brain Research

Volumn 207, Issue 2, 2010, Pages 305-309

  Ramanathan, Lalini ^a,b   Hu, Shuxin ^a,b   Frautschy, Sally A ^a,b,c   Siegel, Jerome M ^a,b  

^a VA Greater Los Angeles Healthcare System   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antioxidant responses; Metabolic activity; Rat; Total sleep deprivation; Y maze

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEXOKINASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CEREBELLUM; COGNITIVE DEFECT; CONTROLLED STUDY; DETERIORATION; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; FOREBRAIN; GLUCOSE METABOLISM; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP DEPRIVATION; SPONTANEOUS ALTERNATION BEHAVIOR; TASK PERFORMANCE; TIME; TOTAL SLEEP DEPRIVATION; WORKING MEMORY;

ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BRAIN; EXPLORATORY BEHAVIOR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEXOKINASE; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; SLEEP DEPRIVATION; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 74449088944     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.10.014     Document Type: Article

References (31)

1. Albert I., Cicala G.A., and Siegel J. The behavioral effects of REM sleep deprivation in rats. Psychophysiology 6 (1970) 550-560
2. Cirelli C. Cellular consequences of sleep deprivation in the brain. Sleep Med Rev 10 (2006) 307-321
3. Cruz-Aguado R., Almaguer-Melian W., Diaz C.M., Lorigados L., and Bergado J. Behavioral and biochemical effects of glutathione depletion in the rat brain. Brain Res Bull 55 (2001) 327-333
4. D'Almeida V., Lobo L.L., Hipólide D.C., de Oliveira A.C., Nobrega J.N., and Tufik S. Sleep deprivation induces brain region-specific decreases in glutathione levels. Neuroreport 9 (1998) 2853-2856
5. Dean O., Bush A.I., Berk M., Copolov D.L., and van den Buuse M. Glutathione depletion in the brain disrupts short-term spatial memory in the Y maze in rats and mice. Behav Brain Res 198 (2009) 258-262
6. Eiland M.M., Ramanathan L., Gulyani S., Gilliland M., Bergmann B.M., Rechtschaffen A., et al. Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation. Brain Res 945 (2002) 1-8
7. Everson C.A., Laatsch C.D., and Hogg N. Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 288 (2005) R374-R383
8. Giordano F.J. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 15 (2005) 500-508
9. Gip P., Hagiwara G., Sapolsky R.M., Cao V.H., Heller H.C., and Ruby N.F. Glucocorticoids influence brain glycogen levels during sleep deprivation. Am J Physiol Regul Integr Comp Physiol 286 (2004) R1057-R1062
10. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106 (1980) 207-212
11. Guan Z., Peng X., and Fang J. Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Brain Res 1018 (2004) 38-47
12. Harris E.D. Regulation of antioxidant enzymes. FASEB J 6 (1992) 2675-2683
13. Hughes R.N. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Behav Rev 28 (2004) 497-505
14. Ikeda M., Ikeda-Sagara M., Okada T., Clement P., Urade Y., Nagai T., et al. Brain oxidation is an initial process in sleep induction. Neuroscience 130 (2005) 1029-1040
15. Knull H.R., Taylor W.F., and Wells W.W. Effects of energy metabolism on in vivo distribution of hexokinase in brain. J Biol Chem 248 (1973) 5414-5417
16. Mayer R.J., Shakespeare P., and Hübscher G. Glucose metabolism in the mucosa of the small intestine. Changes of hexokinase activity during perfusion of the proximal half of rat small intestine. Biochem J 116 (1970) 43-48
17. Misra H.P., and Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247 (1972) 3170-3175
18. Morton R.K. Methods of extraction of enzymes from animal tissues. Methods Enzymol 1 (1955) 25-51
19. Pierard C., Liscia P., Philippin J.N., Mons N., Lafon T., Chauveau F., et al. Modafinil restores memory performance and neural activity impaired by sleep deprivation. Pharmacol Biochem Behav 88 (2007) 55-63
20. Ramanathan L., Gulyani S., Nienhuis R., and Siegel J.M. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Neuroreport 13 (2002) 1387-1390
21. Reimund E. The free radical flux theory of sleep. Med Hypotheses 43 (1994) 231-233
22. Scharf M.T., Naidoo N., Zimmerman J.E., and Pack A.I. The energy hypothesis of sleep revisited. Prog Neurobiol 86 (2008) 264-280
23. Silva R.H., Abílio V.C., Takatsu A.L., Kameda S.R., Grassl C., Chehin A.B., et al. Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice. Neuropharmacology 46 (2004) 895-903
24. Singh R., Kiloung J., Singh S., and Sharma D. Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats. Biogerontology 9 (2008) 53-62
25. Smith C., and Rose G.M. Posttraining paradoxical sleep in rats is increased after spatial learning in the Morris water maze. Behav Neurosci 111 (1997) 1197-1204
26. Somani S.M., and Husain K. Interaction of exercise training and chronic ethanol ingestion on antioxidant system of rat brain regions. J Appl Toxicol 17 (1997) 329-336
27. Tartar J.L., Ward C.P., McKenna J.T., Thakkar M., Arrigoni E., McCarley R.W., et al. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci 23 (2006) 2739-2748
28. Tartar J.L., Ward C.R., Cordeira J.W., Legare S.L., Blanchette A.J., McCarley R.W., et al. Experimental sleep fragmentation and sleep deprivation in rats increases exploration in an open field test of anxiety while increasing plasma corticosterone levels. Behav Brain Res 197 (2009) 450-453
29. Thakkar M., and Mallick B.N. Rapid eye movement sleep-deprivation-induced changes in glucose metabolic enzymes in rat brain. Sleep 16 (1993) 691-694
30. Tobler I., and Borbely A.A. The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat. Behav Brain Res 36 (1990) 73-78
31. Yang R.H., Hu S.J., Wang Y., Zhang W.B., Luo W.J., and Chen J.Y. Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus. Brain Res 1230 (2008) 224-232