Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 57-63

  Wu, Qiong ^a   Fan, Cundong ^b   Chen, Tianfeng ^b   Liu, Chaoran ^b   Mei, Wenjie ^a,b   Chen, Sidong ^a   Wang, Baoguo ^a   Chen, Yunyun ^c   Zheng, Wenjie ^b  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Arene ruthenium complexes; DNA damage; Microwave assisted synthesis; S Phase arrest

Indexed keywords

ANTINEOPLASTIC AGENT; ARENE RUTHENIUM; CYCLIN A; IMIDAZOLE DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; COMET ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DAMAGE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROWAVE IRRADIATION; NITROBLUE TETRAZOLIUM TEST; OSTEOSARCOMA; PROTEIN PHOSPHORYLATION; UPREGULATION; VISCOSITY; X RAY DIFFRACTION;

BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; CYCLIN A; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROCARBONS, AROMATIC; MICROWAVES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NEOPLASMS; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLATION; RUTHENIUM; S PHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84878599170     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.037     Document Type: Article

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