The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways

Journal of Biological Inorganic Chemistry

Volumn 13, Issue 7, 2008, Pages 1149-1155

  Chatterjee, Soumya ^a   Kundu, Subhadip ^a   Bhattacharyya, Arindam ^a   Hartinger, Christian G ^b   Dyson, Paul J ^b  

^a UNIVERSITY OF KALYANI   (India)

^b EPFL   (Switzerland)

Author keywords

Anticancer research; Apoptosis; Bioorganometallics; p53; Ruthenium

Indexed keywords

CASPASE 9; CYCLIN E; CYTOCHROME C; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; REGULATOR PROTEIN; RUTHENIUM DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER MODEL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; EHRLICH ASCITES TUMOR; EHRLICH ASCITES TUMOR CELL; ENZYME ACTIVATION; ENZYME DEGRADATION; FLOW CYTOMETRY; GROWTH INHIBITION; LD 50; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, EHRLICH TUMOR; CASPASE 9; CELL CYCLE; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CYTOCHROMES C; DNA; GENE EXPRESSION REGULATION, NEOPLASTIC; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOCHONDRIA; ORGANOMETALLIC COMPOUNDS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS;

EID: 51849085127     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-008-0400-9     Document Type: Article

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