Identification of thymosins β4 and β10 in paediatric craniopharyngioma cystic fluid

Child's Nervous System

Volumn 29, Issue 6, 2013, Pages 951-960

  Desiderio, Claudia ^a   Martelli, Claudia ^b   Rossetti, Diana Valeria ^b   Di Rocco, Concezio ^c   D'Angelo, Luca ^b,c   Caldarelli, Massimo ^c   Tamburrini, Gianpiero ^c   Iavarone, Federica ^b   Castagnola, Massimo ^a,b   Messana, Irene ^d   Cabras, Tiziana ^d   Faa, Gavino ^d  

^a CNR   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Craniopharyngioma; Intracystic fluid; Liquid chromatography; Mass spectrometry; Thymosin 10; Thymosin 4; Top down proteomics

Indexed keywords

CHLOROFORM; THYMOSIN BETA10; THYMOSIN BETA4;

ACIDIFICATION; ADOLESCENT; AMELOBLASTOMA; AMINO ACID SEQUENCE; ARTICLE; CEREBROSPINAL FLUID; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CRANIOPHARYNGIOMA; CYST FLUID; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOELECTRIC POINT; LIQUID LIQUID EXTRACTION; MALE; MOLECULAR WEIGHT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRANIOPHARYNGIOMA; ENDOSCOPY; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; MULTIPROTEIN COMPLEXES; PITUITARY NEOPLASMS; THYMOSIN;

EID: 84878560274     PISSN: 02567040     EISSN: 14330350     Source Type: Journal    
DOI: 10.1007/s00381-013-2069-9     Document Type: Article

References (55)

1. Prabhu VC, Brown HG (2005) The pathogenesis of craniopharyngiomas. Child's Nerv Syst 21:622-627
2. Ahmadi J, Destian S, Apuzzo MLJ, Segall HD, Zee CS (1992) Cystic fluid in craniopharyngiomas: MR imaging and quantitative analysis. Radiology 182:783-785
3. Caldarelli M, Massimi L, Tamburrini G, Cappa M, Di Rocco C (2005) Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Child's Nerv Syst 21:747-757
4. Thompson D, Phipps K, Hayward R (2005) Chraniopharyngioma in childhood: our evidence-based approach to management. Child's Nerv Syst 21:660-668
5. Cáceres A (2005) Intracavitary therapeutic options in the management of cystic craniopharyngioma. Child's Nerv Syst 21:705-718
6. Cavalheiro S, Dastoli PA, Silva NS, Toledo S, Lederman H, da Silva MC (2005) Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma. Child's Nerv Syst 21:719-724
7. Takahashi H, Yamaguci F, Teramoto A (2005) Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children. Child's Nerv Syst 21:701-704
8. Laffond C, Dellatolas G, Alapetite C, Puget S, Grill J, Habrand JL, Doz F, Chevignard M (2012) Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy. Brain Inj 26:270-281
9. Arefyeva A, Semenova JB, Zubairaev MS, Kondrasheva EA, Moshkin AV (2002) Analysis of fluid in craniopharyngioma-related cysts in children: proteins, lactate and pH. Acta Neurochir 144:551-554
10. Schaub C, Bluet-Pajot MT, Szikla G, Lornet-Videau C, Mounier F, Talairach J (1978) Distribution of beta2-microglobulin in cerebrospinal fluid and in cystic fluid of brain tumors. A preliminary study. Pathol Biol (Paris) 26:381-385
11. Pettorini BL, Inizitari R, Massimi L, Tamburrini G, Caldarelli M, Fanali C, Cabras T, Messana I, Castagnola M, Di Rocco C (2010) The role of inflammation in the genesis of the cystic component of craniopharyngiomas. Child's Nerv Syst 26:1179-1784
12. Han X, Aslanian A, Yates JR III (2008) Mass spectrometry for proteomics. Curr Opin Chem Biol 12:483-490
13. Messana I, Cabras T, Iavarone F, Vincenzoni F, Urbani A, Castagnola M (2013) Unraveling the different proteomic platforms. J Sep Sci 36:128-139
14. Desiderio C, D'Angelo L, Rossetti DV, Iavarone F, Giardina B, Castagnola M, Massimi L, Tamburrini G, Di Rocco C (2012) Cerebrospinal fluid top-down proteomics evidenced the potential biomarker role of LVV- and VV-hemorphin-7 in posterior cranial fossa pediatric brain tumors. Proteomics 12:2158-2166
15. 4 and its posttranslational modifications. Ann N Y Acad Sci 1194:27-35
16. 10. J Sep Sci 32:57-63
17. Honneger J, Mann K, Thierauf P, Zrinzo A, Fahlbusch R (1995) Human chorionic gonadotropin immunoreactivity in cystic intracanical tumors. Clin Endocrinol 42:235-241
18. Honneger J, Rennae C, Fahlbusch R, Adams EF (1997) Progesteron receptor gene expression in craniopharyngiomas and evidence for biological activity. Neurosurgery 41:1359-1364
19. Hannappel E (2007) β-thymosins. Ann N Y Acad Sci 1112:21-37
20. 4 defined by active sites in short peptide sequences. FASEB J 24:2144-2151
21. Mannherz HG, Hannappel E (2009) The β-thymosins: intracellular and extracellular activities of a versatile actin binding protein family. Cell Motil Cytoskel 66:839-851
22. 4: structure, function, and biological properties supporting current and future clinical applications. Ann N Y Acad Sci 1194:179-189
23. 4, a multifunctional tissue repair and regeneration peptide. Ann N Y Acad Sci 1194:81-86
24. 4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 95:1674-1680
25. Huff T, Müller CSG, Otto AM, Netzker R, Hannappel E (2001) β-thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol 33:205-220
26. 4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis 10:229-241
27. Sun LW, Lim H (2007) Neurotrophic roles of the beta-thymosins in the development and regeneration of nervous system. Ann N Y Acad Sci 1112:210-218
28. Van Kesteren RE, Carter C, Dissel HMG, JvMY G, Syed NI, Spencer GE, Smit AB (2006) Local of actin-binding protein beta-thymosin regulates neurite outgrowth. J Neurosci 26:152-157
29. Popoli P, Pepponi R, Martire A, Armida M, Pèzzola A, Galluzzo M, Domenici MR, Potenza RL, Tebano MT, Mollinari C, Merlo D, Garaci E (2007) Neuroprotective effects of thymosin beta4 in experimental models of excitotoxicity. Ann NY Acad Sci 1112:219-224
30. Hardesty WM, Kelley MC, Mi D, Low RL, Caprioli RM (2011) Protein signatures for survival and recurrence in metastatic melanoma. J Proteome 74:1002-1014
31. 4, vascular endothelial growth factor (VEGF), and hypoxia inducible factor (HIF)-1α in early-stage cervical cancers. Pathol Oncol Res 17:493-502
32. 4 expression correlates with lymph node metastasis through hypoxia inducible factor-α induction in breast cancer. Oncol Rep 25:23-31
33. 4 in the regulation of epithelia-mesenchymal transformation in urothelial carcinoma. Urol Oncol 30:167-176
34. 4: a potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr 22:109-116
35. Ryu YK, Lee GH, Song KS, Kim YS, Moon EY (2012) Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. Int J Cancer 131:2067-2077
36. 4 is a novel potential prognostic marker in gastrointestinal stromal tumors. APMIS 120:689-698
37. 4: a new molecular target for antitumour strategies. J Natl Cancer Inst 95:1646-1647
38. 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. Cancer Lett 308:162-171
39. 4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80. Ann N Y Acad Sci 1194:60-71
40. Zhang Y, Feurino LW, Zhai Q, Wang H, Fisher WE, Chen C, Yao Q, Li M (2008) Thymosin beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation. Cancer Biol Ther 7:419-423
41. 4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 26:2781-2790
42. 4 in human NK cells. Immunobiology 216:1155-1162
43. 4 inhibits TNF-α-induced NF-kB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J 25:1815-1826
44. Wang WS, Chen PM, Hsiao HL, Wang HS, Liang WY, Su Y (2004) Overexpression of the thymosin β-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23:6666-6671
45. Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y, Sakamoto M, Hirohashi S (2002) Chranipharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol 161:1997-2001
46. Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrubl F, Hahnen E, Kreutzer J, Fahlbusch R (2005) Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol 109:589-597
47. Gaston-Maussuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP (2011) Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A 108:11482-11487
48. Cani CMG, Matushita H, Carvalho LRS, Soares IC, Brito LP, Almeida MQ, Mendonça BB (2011) PROP1 and CTNNB1expression in adamantinomatous craniopharyngiomas with or without β-catenin mutation. Clinics 66:1849-1854
49. Andoniadou CL, Massuet CG, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacque TS, Pevny LH, Dattani MT, Martinez-Barbera JP (2012) Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol 124:259-271
50. Nemolato S, Restivo A, Cabras T, Coni PP, Zorcolo L, Orrù G, Fanari M, Cau F, Gerosa C, Fanni D, Messana I, Castagnola M, Casula G, Faa G (2012) Thymosin β-4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition. Cancer Biol Ther 13:1-7
51. 4 expression reveals intriguing similarities between fetal and cancer cells. Ann NY Acad Sci 1269:53-60
52. Castagnola M, Inzitari R, Fanali C, Iavarone F, Vitali A, Desiderio C, Vento G, Tirone C, Romagnoli C, Cabras T, Manconi B, Sanna MT, Boi R, Pisano E, Olianas A, Pellegrini M, Nemolato S, Heizmann CW, Faa G, Messana I (2011) The surprising composition of the salivary proteome of preterm human newborn. Mol Cell Proteomics 10:M110.003467
53. 10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions. Cancer Invest 20:1-7
54. 10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PLoS One 7:e35399. doi: 10.1371/journal.pone.0035399
55. Hannappel E, van Kampen M (1987) Determination of thymosin beta 4 in human blood cells and serum. J Chromatogr 397:279-285