Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region

Acta Neuropathologica

Volumn 109, Issue 6, 2005, Pages 589-597

  Buslei, Rolf ^a   Nolde, Michael ^a   Hofmann, Bernd ^a   Meissner, Stephan ^a   Eyupoglu, Ilker Y ^a   Siebzehnrübl, Florian ^a   Hahnen, Eric ^b   Kreutzer, Jürgen ^a   Fahlbusch, Rudolf ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Catenin; Adenomatous polyposis coli; Carcinogenesis; Nuclear accumulation; Wnt signalling

Indexed keywords

APC PROTEIN; BETA CATENIN; WNT PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN ARACHNOID CYST; CHILD; COLON POLYPOSIS; CRANIOPHARYNGIOMA; EXON; FEMALE; GENE DELETION; GENETIC CODE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RATHKE CLEFT CYST; SIGNAL TRANSDUCTION; XANTHOGRANULOMA;

ADOLESCENT; ADULT; AGED; BASE SEQUENCE; BETA CATENIN; CHILD; CHILD, PRESCHOOL; CRANIOPHARYNGIOMA; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; FEMALE; GENES, APC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PITUITARY NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SELLA TURCICA; TRANS-ACTIVATORS;

EID: 22144442760     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-005-1004-x     Document Type: Article

References (40)

1. Behrens J, Lustig B (2004) The Wnt connection to tumorigenesis. Int J Dev Biol 48:477-487
2. Brabletz T, Kirchner T (2003) [Morphogenetic aspects of colorectal cancer]. Pathologe 24:44-48
3. Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC (1991) Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE. Am J Hum Genet 48:137-144
4. Dahia PL, Aguiar RC, Honegger J, Fahlbusch R, Jordan S, Lowe DG, Lu X, Clayton RN, Besser GM, Grossman AB (1998) Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours. Oncogene 16:69-76
5. Fahlbusch R, Honegger J, Paulus W, Huk W, Buchfelder M (1999) Surgical treatment of craniopharyngiomas: Experience with 168 patients. J Neurosurg 90:237-250
6. Fodde R (2002) The APC gene in colorectal cancer. Eur J Cancer 38:867-871
7. Friedrich A, Kullmann F (2003) [Familial adenomatous polyposis syndrome (FAP): Pathogenesis and molecular mechanisms]. Med Klin (Munich) 98:776-782
8. Gorski GK, McMorrow LE, Donaldson MH, Freed M (1992) Multiple chromosomal abnormalities in a case of craniopharyngioma. Cancer Genet Cytogenet 60:212-213
9. Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003) Beta-catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol 120:732-736
10. He TC, Sparks AB, Rago C, Hermeking H, Zawel L,Costa LT da, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512
11. Herman V, Drazin NZ, Gonsky R, Melmed S (1993) Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab 77:50-55
12. Huelsken J, Birchmeier W (2001) New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11:547-553
13. Karga HJ, Alexander JM, Hedley-Whyte ET, Klibanski A, Jameson JL (1992) Ras mutations in human pituitary tumors. J Clin Endocrinol Metab 74:914-919
14. Kato K, Nakatani Y, Kanno H, Inayama Y, Ijiri R, Nagahara N, Miyake T, Tanaka M, Ito Y, Aida N, Tachibana K, Sekido K, Tanaka Y (2004) Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. J Pathol 203:814-821
15. Kirchner T, Brabletz T (2000) Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol 157:1113-1121
16. Koch A, Denkhaus D, Albrecht S, Leuschner I, Schweinitz D von, Pietsch T (1999) Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. Cancer Res 59:269-273
17. Kratochwil K, Dull M, Farinas I, Galceran J, Grosschedl R (1996) Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev 10:1382-1394
18. Kratochwil K, Galceran J, Tontsch S, Roth W, Grosschedl R (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev 16:3173-3185
19. McCabe CJ, Gittoes NJ (1999) PTTG - A new pituitary tumour transforming gene. J Endocrinol 162:163-166
20. Moreno-Bueno G, Gamallo C, Perez-Gallego L, Contreras F, Palacios J (2001) Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles. Br J Dermatol 145:576-581
21. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787-1790
22. Nagase H, Nakamura Y (1993) Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat 2:425-434
23. Nakatani Y, Masudo K, Miyagi Y, Inayama Y, Kawano N, Tanaka Y, Kato K, Ito T, Kitamura H, Nagashima Y, Yamanaka S, Nakamura N, Sano J, Ogawa N, Ishiwa N, Notohara K, Resl M, Mark EJ (2002) Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: Up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules. Mod Pathol 15:617-624
24. Paulus W, Honegger J, Keyvani K, Fahlbusch R (1999) Xanthogranuloma of the sellar region: A clinicopathological entity different from adamantinomatous craniopharyngioma. Acta Neuropathol 97:377-382
25. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851
26. Sarubi JC, Bei H, Adams EF, Boson WL, Friedman E, Brandao K, Kalapothakis E, Miranda D, Valle FL, Sarquis MS, De Marco L (2001) Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsalpha and Gi2alpha genes. Neurosci Lett 310:5-8
27. Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y, Sakamoto M, Hirohashi S (2002) Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol 161:1997-2001
28. Sekine S, Sato S, Takata T, Fukuda Y, Ishida T, Kishino M, Shibata T, Kanai Y, Hirohashi S (2003) Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol 163:1707-1712
29. Sekine S, Takata T, Shibata T, Mori M, Morishita Y, Noguchi M, Uchida T, Kanai Y, Hirohashi S (2004) Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: Evidence for its odontogenic epithelial differentiation. Histopathology 45:573-579
30. Semba S, Han SY, Ikeda H, Horii A (2001) Frequent nuclear accumulation of beta-catenin in pituitary adenoma. Cancer 91:42-48
31. Shimon I, Yan X, Ray DW, Melmed S (1997) Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion. J Clin Invest 100:357-363
32. Tanaka Y, Kato K, Notohara K, Nakatani Y, Miyake T, Ijiri R, Nishimata S, Ishida Y, Kigasawa H, Ohama Y, Tsukayama C, Kobayashi Y, Horie H (2003) Significance of aberrant (cytoplasmic/nuclear) expression of beta-catenin in pancreatoblastoma. J Pathol 199:185-190
33. Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422-426
34. Thapar K, Kovacs K (1998) Neoplasms of the sellar region. In: Bigner DD, McLendon RE, Bruner JM (eds) Russell and Rubinstein's pathology of tumors of the nervous system, 6th edn. Arnold, London, pp 629-680
35. Tsang WY (2004) Only adamantinomatous but not papillary type of craniopharyngioma is associated with beta-catenin mutation. Adv Anat Pathol 11:223
36. Tziortzioti V, Ruebel KH, Kuroki T, Jin L, Scheithauer BW, Lloyd RV (2001) Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues. Endocr Pathol 12:125-136
37. Vallar L, Spada A, Giannattasio G (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330:566-568
38. Wikramanayake AH, Hong M, Lee PN, Pang K, Byrum CA, Bince JM, Xu R, Martindale MQ (2003) An ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation. Nature 426:446-450
39. Xin W, Rubin MA, McKeever PE (2002) Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Arch Pathol Lab Med 126:1174-1178
40. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (1999) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84:761-767