Evaluation of thymosin β4 in the regulation of epithelial-mesenchymal transformation in urothelial carcinoma

Urologic Oncology: Seminars and Original Investigations

Volumn 30, Issue 2, 2012, Pages 167-176

  Wang, Zhi Yu ^a   Zeng, Fu Qing ^a   Zhu, Zhao Hui ^a   Jiang, Guo Song ^a   Lv, Lei ^a   Wan, Feng ^a   Dong, Rui ^a   Xiao, Xing Yuan ^a   Xing, Shi An ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Catenin; E cadherin; Epithelial mesenchymal transition; ILK; TCC; Thymosin 4

Indexed keywords

BETA CATENIN; DNA DIRECTED RNA POLYMERASE III; INTEGRIN LINKED KINASE; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; THYMOSIN BETA4; UVOMORULIN;

ARTICLE; CANCER INVASION; CELL MOTILITY; CELL STRAIN BIU 87; CELL STRAIN T24; CONTROLLED STUDY; CYTOSOL; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION; TRANSITIONAL CELL CARCINOMA; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

AGED; BETA CATENIN; BLOTTING, WESTERN; CADHERINS; CARCINOMA, TRANSITIONAL CELL; CASE-CONTROL STUDIES; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMOSIN; TUMOR CELLS, CULTURED; URINARY BLADDER; URINARY BLADDER NEOPLASMS; WOUND HEALING;

EID: 84857654849     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2010.02.009     Document Type: Article

References (37)

1. Savagner P. Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition. BioEssays 2001, 23:912-923.
2. Thiery J.P. Epithelial-mesenchymal transitions in tumor progression. Nat Rev Cancer 2002, 2:442-454.
3. Vernon A.E., LaBonne C. Tumor metastasis: A new twist on epithelial-mesenchymal transitions. Curr Biol 2004, 14:719-721.
4. Fuchs I.B., Lichtenegger W., Buehler H., et al. The prognostic significance of epithelial-mesenchymal transition in breast cancer. Anticancer Res 2002, 22:3415-3419.
5. Baumgart E., Cohen M.S., Silva Neto B., et al. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Clin Cancer Res 2007, 13:1685-1694.
6. Kang Y., Massague J. Epithelial-mesenchymal transitions: Twist in development and metastasis. Cell 2004, 118:277-279.
7. Batlle E., Sancho E., Franci C., et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells. Nat Cell Biol 2000, 2:84-89.
8. Bolos V., Peinado H., Perez-Moreno M.A., et al. The transcription factor slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors. J Cell Sci 2003, 116:499-511.
9. Eger A., Aigner K., Sonderegger S., et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 2005, 24:2375-2385.
10. Perez-Moreno M.A., Locascio A., Rodrigo I., et al. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 2001, 276:24-31.
11. Artsock A., Nelson W.J. Adherens and tight junctions: Structure, function, and connections to the actin cytoskeleton. Biochim Biophys Acta 2008, 1778:660-669.
12. Brembeck F.H., Rosario M., Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of β-catenin. Curr Opin Genet Dev 2006, 16:51-59.
13. Wu C., Knightly S.Y., Leung-Hagesteijn C., et al. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 1998, 273:528-536.
14. Hannigan G., Troussard A.A., Dedhar S. Integrin-linked kinase: A cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005, 5:51-63.
15. Sanders M.C., Goldstein A.L., Wang Y.L. Thymosin β4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci USA 1992, 89:4678-4682.
16. Dyson H.J., Wright P.E. Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 2005, 6:197-208.
17. Goldstein A.L., Hannappel E., Kleinman H.K. Thymosin β4: Actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med 2005, 11:421-429.
18. Philp D., Goldstein A.L., Kleinman H.K. Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev 2004, 125:113-115.
19. Wang W.S., Chen P.M., Hsiao H.L., et al. Overexpression of the thymosin β4 gene is associated with malignant progression of SW480 colon carcinoma cells. Oncogene 2003, 22:3297-3306.
20. Wang W.S., Chen P.M., Hsiao H.L., et al. Overexpression of the thymosin β4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 2004, 23:6666-6671.
21. Bock-Marquette I., Saxena A., White M.D., et al. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and cardiac repair. Nature 2004, 432:466-472.
22. Yu L.Z., Gu F.L., Huang Y.L., et al. Establishment of epithelial cell line BIU-87 from a human bladder transitional cell Carcinoma and its biological characteristics. Chin J Urol 1989, 10:131-136.
23. Bubenick J., Baresora M., Viklicky V., et al. Established cell line of urinary bladder carcinoma (T24) containing tumor-specific antigen. Int J Cancer 1973, 11:765-773.
24. Sobin D.H., Witteking C. TNM Classification of Malignant Tumors 2003, Wiley-Liss, New York. 6th ed.
25. Sosne G., Szliter E.A., Barrett R., et al. Thymosin β4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res 2002, 74:293-299.
26. Wang L., Zhou G.B., Liu P., et al. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA 2008, 12:4826-4831.
27. Huang H.C., Hu C.H., Tang M.C., et al. Thymosin 4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 2007, 26:2781-2790.
28. Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003, 15:740-746.
29. Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-142.
30. Potter E., Bergwitz C., Brabant G. The cadherin-catenin system: Implications for growth and differentiation of endocrine tissues. Endocr Rev 1999, 20:207-239.
31. Nummela P., Yin M., Kielosto M., et al. Thymosin β4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts. Cancer Res 2006, 66:701-712.
32. Wu X.R. Urothelial tumorigenesis: A tale of divergent pathways. Nat Rev Cancer 2005, 5:713-725.
33. Suda K., Rothen-Rutishauser B., Günthert M., et al. Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: Endothelial vs. epithelial features. In Vitro Cell Dev Biol Anim 2001, 37:505-514.
34. Cano A., Perez-Moreno M.A., Rodrigo I., et al. Metastasis and angiogenesis. Nat Cell Biol 2000, 2:76-83.
35. Hajra K.M., Chen D.Y., Fearon E.R. The SLUG zinc finger protein represses E-cadherin in breast cancer. Cancer Res 2002, 62:1613-1618.
36. Peinado H., Portillo F., Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 2004, 48:365-375.
37. Moreno-Bueno G., Cubillo E., Sarrió D., et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for snail, slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res 2006, 66:9543-9556.