메뉴 건너뛰기




Volumn 21, Issue 6, 2013, Pages 1182-1194

Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NANOPARTICLE; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

EID: 84878560006     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.42     Document Type: Article
Times cited : (79)

References (50)
  • 1
    • 84755161651 scopus 로고    scopus 로고
    • A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Management strategies and economic impact
    • Jensen, SB, Pedersen, AM, Vissink, A, Andersen, E, Brown, CG, Davies, AN et al.; Salivary Gland Hypofunction/Xerostomia Section; Oral Care Study Group; Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). (2010). A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer 18: 1061-1079.
    • (2010) Support Care Cancer , vol.18 , pp. 1061-1079
    • Jensen, S.B.1    Pedersen, A.M.2    Vissink, A.3    Andersen, E.4    Brown, C.G.5    Davies, A.N.6
  • 2
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D and Rossi, JJ (2009). The promises and pitfalls of RNA-interference-based therapeutics. Nature 457: 426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 3
    • 31444440290 scopus 로고    scopus 로고
    • Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
    • Shen, J, Samul, R, Silva, RL, Akiyama, H, Liu, H, Saishin, Y et al. (2006). Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 13: 225-234.
    • (2006) Gene Ther , vol.13 , pp. 225-234
    • Shen, J.1    Samul, R.2    Silva, R.L.3    Akiyama, H.4    Liu, H.5    Saishin, Y.6
  • 5
    • 9644278021 scopus 로고    scopus 로고
    • Salivary glands: Novel target sites for gene therapeutics
    • Baum, BJ, Voutetakis, A and Wang, J (2004). Salivary glands: novel target sites for gene therapeutics. Trends Mol Med 10: 585-590.
    • (2004) Trends Mol Med , vol.10 , pp. 585-590
    • Baum, B.J.1    Voutetakis, A.2    Wang, J.3
  • 6
    • 80053442737 scopus 로고    scopus 로고
    • Gene delivery in salivary glands: From the bench to the clinic
    • Samuni, Y and Baum, BJ (2011). Gene delivery in salivary glands: from the bench to the clinic. Biochim Biophys Acta 1812: 1515-1521.
    • (2011) Biochim Biophys Acta 1812 , pp. 1515-1521
    • Samuni, Y.1    Baum, B.J.2
  • 7
    • 36349032232 scopus 로고    scopus 로고
    • Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands
    • Cotrim, A P, Sowers, A, Mitchell, JB and Baum, BJ (2007). Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther 15: 2101-2106.
    • (2007) Mol Ther , vol.15 , pp. 2101-2106
    • Cotrim, A.P.1    Sowers, A.2    Mitchell, J.B.3    Baum, B.J.4
  • 8
    • 10744223777 scopus 로고    scopus 로고
    • Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome
    • Kok, MR, Yamano, S, Lodde, BM, Wang, J, Couwenhoven, RI, Yakar, S et al. (2003). Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. Hum Gene Ther 14: 1605-1618.
    • (2003) Hum Gene Ther , vol.14 , pp. 1605-1618
    • Kok, M.R.1    Yamano, S.2    Lodde, B.M.3    Wang, J.4    Couwenhoven, R.I.5    Yakar, S.6
  • 9
    • 80053553412 scopus 로고    scopus 로고
    • A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome
    • Pauley, KM, Gauna, AE, Grichtchenko, II, Chan, EK and Cha, S (2011). A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome. Arthritis Rheum 63: 3116-3125.
    • (2011) Arthritis Rheum , vol.63 , pp. 3116-3125
    • Pauley, K.M.1    Gauna, A.E.2    Grichtchenko, I.I.3    Chan, E.K.4    Cha, S.5
  • 10
    • 70349157576 scopus 로고    scopus 로고
    • SiRNA-mediated gene silencing in the salivary gland using in vivo microbubble-enhanced sonoporation
    • Sakai, T, Kawaguchi, M and Kosuge, Y (2009). siRNA-mediated gene silencing in the salivary gland using in vivo microbubble-enhanced sonoporation. Oral Dis 15: 505-511.
    • (2009) Oral Dis , vol.15 , pp. 505-511
    • Sakai, T.1    Kawaguchi, M.2    Kosuge, Y.3
  • 11
    • 84857784900 scopus 로고    scopus 로고
    • Progress toward in vivo use of siRNAs-II
    • Rettig, GR and Behlke, MA (2012). Progress toward in vivo use of siRNAs-II. Mol Ther 20: 483-512.
    • (2012) Mol Ther , vol.20 , pp. 483-512
    • Rettig, G.R.1    Behlke, M.A.2
  • 12
    • 84859613225 scopus 로고    scopus 로고
    • Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures
    • Arany, S, Xu, Q, Hernady, E, Benoit, DS, Dewhurst, S and Ovitt, CE (2012). Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. J Cell Biochem 113: 1955-1965.
    • (2012) J Cell Biochem , vol.113 , pp. 1955-1965
    • Arany, S.1    Xu, Q.2    Hernady, E.3    Benoit, D.S.4    Dewhurst, S.5    Ovitt, C.E.6
  • 13
    • 77950571073 scopus 로고    scopus 로고
    • PH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1
    • Benoit, DS, Henry, SM, Shubin, AD, Hoffman, AS and Stayton, PS (2010). pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1. Mol Pharm 7: 442-455.
    • (2010) Mol Pharm , vol.7 , pp. 442-455
    • Benoit, D.S.1    Henry, S.M.2    Shubin, A.D.3    Hoffman, A.S.4    Stayton, P.S.5
  • 16
    • 0034282653 scopus 로고    scopus 로고
    • Severe impairment of salivation in Na+/K+/2Cl-cotransporter (NKCC1)-defcient mice
    • Evans, RL, Park, K, Turner, RJ, Watson, GE, Nguyen, HV, Dennett, MR et al. (2000). Severe impairment of salivation in Na+/K+/2Cl-cotransporter (NKCC1)-defcient mice. J Biol Chem 275: 26720-26726.
    • (2000) J Biol Chem , vol.275 , pp. 26720-26726
    • Evans, R.L.1    Park, K.2    Turner, R.J.3    Watson, G.E.4    Nguyen, H.V.5    Dennett, M.R.6
  • 18
    • 0033516666 scopus 로고    scopus 로고
    • Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells
    • Reyland, ME, Anderson, SM, Matassa, AA, Barzen, KA and Quissell, DO (1999). Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. J Biol Chem 274: 19115-19123.
    • (1999) J Biol Chem , vol.274 , pp. 19115-19123
    • Reyland, M.E.1    Anderson, S.M.2    Matassa, A.A.3    Barzen, K.A.4    Quissell, D.O.5
  • 20
    • 78449309070 scopus 로고    scopus 로고
    • Effcient and targeted delivery of siRNA in vivo
    • Shim, MS and Kwon, YJ (2010). Effcient and targeted delivery of siRNA in vivo. FEBS J 277: 4814-4827.
    • (2010) FEBS J , vol.277 , pp. 4814-4827
    • Shim, M.S.1    Kwon, Y.J.2
  • 21
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identifcation and therapeutic application
    • Jackson, AL and Linsley, PS (2010). Recognizing and avoiding siRNA off-target effects for target identifcation and therapeutic application. Nat Rev Drug Discov 9: 57-67.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 22
    • 77954385672 scopus 로고    scopus 로고
    • The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
    • Kedmi, R, Ben-Arie, N and Peer, D (2010). The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials 31: 6867-6875.
    • (2010) Biomaterials , vol.31 , pp. 6867-6875
    • Kedmi, R.1    Ben-Arie, N.2    Peer, D.3
  • 23
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, AD, Sood, V, Shaw, JR, Fang, D, McClintock, K and MacLachlan, I (2005). Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462.
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 24
    • 20444392027 scopus 로고    scopus 로고
    • Early and late effects of X-irradiation on submandibular gland: A morphological study in mice
    • Urek, MM, Bralic, M, Tomac, J, Borcic, J, Uhac, I, Glazar, I et al. (2005). Early and late effects of X-irradiation on submandibular gland: a morphological study in mice. Arch Med Res 36: 339-343.
    • (2005) Arch Med Res , vol.36 , pp. 339-343
    • Urek, M.M.1    Bralic, M.2    Tomac, J.3    Borcic, J.4    Uhac, I.5    Glazar, I.6
  • 25
    • 0032891583 scopus 로고    scopus 로고
    • Radiation-induced progressive decrease in fuid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling
    • O'Connell, AC, Redman, RS, Evans, RL and Ambudkar, IS (1999). Radiation-induced progressive decrease in fuid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling. Radiat Res 151: 150-158.
    • (1999) Radiat Res , vol.151 , pp. 150-158
    • O'Connell, A.C.1    Redman, R.S.2    Evans, R.L.3    Ambudkar, I.S.4
  • 26
    • 79952156419 scopus 로고    scopus 로고
    • Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation
    • Medina, VA, Prestiflippo, JP, Croci, M, Carabajal, E, Bergoc, RM, Elverdin, JC et al. (2011). Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation. Int J Radiat Biol 87: 284-292.
    • (2011) Int J Radiat Biol , vol.87 , pp. 284-292
    • Medina, V.A.1    Prestiflippo, J.P.2    Croci, M.3    Carabajal, E.4    Bergoc, R.M.5    Elverdin, J.C.6
  • 27
    • 33744817082 scopus 로고    scopus 로고
    • Decreased saliva secretion and down-regulation of AQP5 in submandibular gland in irradiated rats
    • Li, Z, Zhao, D, Gong, B, Xu, Y, Sun, H, Yang, B et al. (2006). Decreased saliva secretion and down-regulation of AQP5 in submandibular gland in irradiated rats. Radiat Res 165: 678-687.
    • (2006) Radiat Res , vol.165 , pp. 678-687
    • Li, Z.1    Zhao, D.2    Gong, B.3    Xu, Y.4    Sun, H.5    Yang, B.6
  • 28
    • 33751562457 scopus 로고    scopus 로고
    • Radiation-induced xerostomia in patients with head and neck cancer: A literature review
    • Dirix, P, Nuyts, S and Van den Bogaert, W (2006). Radiation-induced xerostomia in patients with head and neck cancer: a literature review. Cancer 107: 2525-2534.
    • (2006) Cancer , vol.107 , pp. 2525-2534
    • Dirix, P.1    Nuyts, S.2    Van Den Bogaert, W.3
  • 30
    • 78650159604 scopus 로고    scopus 로고
    • Convenient and reproducible in vivo gene transfer to mouse parotid glands
    • Zheng, C, Shinomiya, T, Goldsmith, CM, Di Pasquale, G and Baum, BJ (2011). Convenient and reproducible in vivo gene transfer to mouse parotid glands. Oral Dis 17: 77-82.
    • (2011) Oral Dis , vol.17 , pp. 77-82
    • Zheng, C.1    Shinomiya, T.2    Goldsmith, C.M.3    Di Pasquale, G.4    Baum, B.J.5
  • 31
    • 0017915802 scopus 로고
    • The infuence of gland size on the fow rate and composition of human parotid saliva
    • Dawes, C, Cross, HG, Baker, CG and Chebib, FS (1978). The infuence of gland size on the fow rate and composition of human parotid saliva. Dent J 44: 21-25.
    • (1978) Dent J , vol.44 , pp. 21-25
    • Dawes, C.1    Cross, H.G.2    Baker, C.G.3    Chebib, F.S.4
  • 32
    • 9044230116 scopus 로고    scopus 로고
    • High-effciency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation
    • Nishi, T, Yoshizato, K, Yamashiro, S, Takeshima, H, Sato, K, Hamada, K et al. (1996). High-effciency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res 56: 1050-1055.
    • (1996) Cancer Res , vol.56 , pp. 1050-1055
    • Nishi, T.1    Yoshizato, K.2    Yamashiro, S.3    Takeshima, H.4    Sato, K.5    Hamada, K.6
  • 33
    • 73449125182 scopus 로고    scopus 로고
    • Expression of plasmid DNA in the salivary gland epithelium: Novel approaches to study dynamic cellular processes in live animals
    • Sramkova, M, Masedunskas, A, Parente, L, Molinolo, A and Weigert, R (2009). Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol, Cell Physiol 297: C1347-C1357.
    • (2009) Am J Physiol, Cell Physiol , vol.297
    • Sramkova, M.1    Masedunskas, A.2    Parente, L.3    Molinolo, A.4    Weigert, R.5
  • 34
    • 0035839635 scopus 로고    scopus 로고
    • PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells
    • Matassa, AA, Carpenter, L, Biden, TJ, Humphries, MJ and Reyland, ME (2001). PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells. J Biol Chem 276: 29719-29728.
    • (2001) J Biol Chem , vol.276 , pp. 29719-29728
    • Matassa, A.A.1    Carpenter, L.2    Biden, T.J.3    Humphries, M.J.4    Reyland, M.E.5
  • 35
    • 84866620547 scopus 로고    scopus 로고
    • Protein kinase cd in apoptosis: A brief overview
    • Zhao, M, Xia, L and Chen, GQ (2012). Protein kinase cd in apoptosis: a brief overview. Arch Immunol Ther Exp (Warsz) 60: 361-372.
    • (2012) Arch Immunol Ther Exp (Warsz) , vol.60 , pp. 361-372
    • Zhao, M.1    Xia, L.2    Chen, G.Q.3
  • 36
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan, GI and Vousden, KH (2001). Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 37
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe, SW and Lin, AW (2000). Apoptosis in cancer. Carcinogenesis 21: 485-495.
    • (2000) Carcinogenesis , vol.21 , pp. 485-495
    • Lowe, S.W.1    Lin, A.W.2
  • 38
    • 77951753647 scopus 로고    scopus 로고
    • Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to highdose gamma-irradiation
    • Yu, H, Shen, H, Yuan, Y, XuFeng, R, Hu, X, Garrison, SP et al. (2010). Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to highdose gamma-irradiation. Blood 115: 3472-3480.
    • (2010) Blood , vol.115 , pp. 3472-3480
    • Yu, H.1    Shen, H.2    Yuan, Y.3    Xufeng, R.4    Hu, X.5    Garrison, S.P.6
  • 39
    • 77953121698 scopus 로고    scopus 로고
    • Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    • Sotiropoulou, PA, Candi, A, Mascré, G, De Clercq, S, Youssef, KK, Lapouge, G et al. (2010). Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol 12: 572-582.
    • (2010) Nat Cell Biol , vol.12 , pp. 572-582
    • Sotiropoulou, P.A.1    Candi, A.2    Mascré, G.3    De Clercq, S.4    Youssef, K.K.5    Lapouge, G.6
  • 40
    • 58149326850 scopus 로고    scopus 로고
    • Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis
    • Avila, JL, Grundmann, O, Burd, R and Limesand, KH (2009). Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis. Int J Radiat Oncol Biol Phys 73: 523-529.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 523-529
    • Avila, J.L.1    Grundmann, O.2    Burd, R.3    Limesand, K.H.4
  • 43
    • 77957330752 scopus 로고    scopus 로고
    • Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis
    • Knox, SM, Lombaert, IM, Reed, X, Vitale-Cross, L, Gutkind, JS and Hoffman, MP (2010). Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science 329: 1645-1647.
    • (2010) Science , vol.329 , pp. 1645-1647
    • Knox, S.M.1    Lombaert, I.M.2    Reed, X.3    Vitale-Cross, L.4    Gutkind, J.S.5    Hoffman, M.P.6
  • 44
    • 84865315279 scopus 로고    scopus 로고
    • Transplantation of side population cells restores the function of damaged exocrine glands through clusterin
    • Mishima, K, Inoue, H, Nishiyama, T, Mabuchi, Y, Amano, Y, Ide, F et al. (2012). Transplantation of side population cells restores the function of damaged exocrine glands through clusterin. Stem Cells 30: 1925-1937.
    • (2012) Stem Cells , vol.30 , pp. 1925-1937
    • Mishima, K.1    Inoue, H.2    Nishiyama, T.3    Mabuchi, Y.4    Amano, Y.5    Ide, F.6
  • 45
    • 77957858210 scopus 로고    scopus 로고
    • Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFa prevents radiation-induced fbrosis
    • Nawroth, I, Alsner, J, Behlke, MA, Besenbacher, F, Overgaard, J, Howard, KA et al. (2010). Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFa prevents radiation-induced fbrosis. Radiother Oncol 97: 143-148.
    • (2010) Radiother Oncol , vol.97 , pp. 143-148
    • Nawroth, I.1    Alsner, J.2    Behlke, M.A.3    Besenbacher, F.4    Overgaard, J.5    Howard, K.A.6
  • 46
    • 0033578605 scopus 로고    scopus 로고
    • Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf
    • Flagella, M, Clarke, LL, Miller, ML, Erway, LC, Giannella, RA, Andringa, A et al. (1999). Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem 274: 26946-26955.
    • (1999) J Biol Chem , vol.274 , pp. 26946-26955
    • Flagella, M.1    Clarke, L.L.2    Miller, M.L.3    Erway, L.C.4    Giannella, R.A.5    Andringa, A.6
  • 47
    • 33645110519 scopus 로고    scopus 로고
    • Toxicity and biodistribution of a frst-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland
    • Zheng, C, Voutetakis, A, Kok, MR, Goldsmith, CM, Smith, GB, Elmore, S et al. (2006). Toxicity and biodistribution of a frst-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. Oral Dis 12: 137-144.
    • (2006) Oral Dis , vol.12 , pp. 137-144
    • Zheng, C.1    Voutetakis, A.2    Kok, M.R.3    Goldsmith, C.M.4    Smith, G.B.5    Elmore, S.6
  • 48
    • 48649085911 scopus 로고    scopus 로고
    • Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, infamed, atrophic and regenerative states
    • Silver, N, Cotroneo, E, Proctor, G, Osailan, S, Paterson, KL and Carpenter, GH (2008). Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, infamed, atrophic and regenerative states. BMC Mol Biol 9: 64.
    • (2008) BMC Mol Biol , vol.9 , pp. 64
    • Silver, N.1    Cotroneo, E.2    Proctor, G.3    Osailan, S.4    Paterson, K.L.5    Carpenter, G.H.6
  • 49
    • 4444382738 scopus 로고    scopus 로고
    • Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis
    • Epperly, MW, Carpenter, M, Agarwal, A, Mitra, P, Nie, S and Greenberger, JS (2004). Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In Vivo 18: 401-410.
    • (2004) Vivo , vol.18 , pp. 401-410
    • Epperly, M.W.1    Carpenter, M.2    Agarwal, A.3    Mitra, P.4    Nie, S.5    Greenberger, J.S.6
  • 50
    • 1542410323 scopus 로고    scopus 로고
    • Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages
    • Hisatomi, Y, Okumura, K, Nakamura, K, Matsumoto, S, Satoh, A, Nagano, K et al. (2004). Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages. Hepatology 39: 667-675.
    • (2004) Hepatology , vol.39 , pp. 667-675
    • Hisatomi, Y.1    Okumura, K.2    Nakamura, K.3    Matsumoto, S.4    Satoh, A.5    Nagano, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.