JNK pathway may be involved in isoflurane-induced apoptosis in the hippocampi of neonatal rats

Neuroscience Letters

Volumn 545, Issue , 2013, Pages 17-22

  Li, Yujuan ^a   Wang, Fei ^a   Liu, Chuiliang ^b   Zeng, Minting ^a   Han, Xue ^a   Luo, Tao ^c   Jiang, Wei ^c   Xu, Jie ^c   Wang, Huaqiao ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b ChanCheng Central Hospital   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Anesthetics volatile isoflurane; Apoptosis; C Jun N terminal kinase; Caspase 3; Hippocampus

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; DIMETHYL SULFOXIDE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOFLURANE; PROTEIN BCL XL; PROTEIN C JUN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPOSURE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; INTRACELLULAR SIGNALING; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT;

ANESTHETICS, INHALATION; ANIMALS; ANIMALS, NEWBORN; ANTHRACENES; APOPTOSIS; DRUG INTERACTIONS; HIPPOCAMPUS; ISOFLURANE; MAP KINASE KINASE 4; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84878530808     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.04.008     Document Type: Article

References (36)

1. Behrens A., Sibilia M., Wagner E.F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 1999, 21:326-329.
2. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., Anderson D.W. S.P600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:13681-13686.
3. Bickler P.E., Fahlman C.S. The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia. Anesth. Analg. 2006, 103:419-429.
4. Bickler P.E., Zhan X., Fahlman C.S. Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling. Anesthesiology 2005, 103:532-539.
5. Brambrink A.M., Evers A.S., Avidan M.S., Farber N.B., Smith D.J., Zhang X., Dissen G.A., Creeley C.E., Olney J.W. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010, 112:834-841.
6. Cheng Y., Gidday J.M., Yan Q., Shah A.R., Holtzman D.M. Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann. Neurol. 1997, 41:521-529.
7. Choi C.H., Lee B.H., Ahn S.G., Oh S.H. Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3beta. Biochem. Biophys. Res. Commun. 2012, 418:759-764.
8. Chu R., Upreti M., Ding W.X., Yin X.M., Chambers T.C. Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochem. Pharmacol. 2009, 78:241-248.
9. Fan J., Xu G., Nagel D.J., Hua Z., Zhang N., Yin G. A model of ischemia and reperfusion increases JNK activity, inhibits the association of BAD and 14-3-3, and induces apoptosis of rabbit spinal neurocytes. Neurosci. Lett. 2010, 473:196-201.
10. Fornoni A., Pileggi A., Molano R.D., Sanabria N.Y., Tejada T., Gonzalez-Quintana J., Ichii H., Inverardi L., Ricordi C., Pastori R.L. Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia 2008, 51:298-308.
11. Guan Q.H., Pei D.S., Zhang Q.G., Hao Z.B., Xu T.L., Zhang G.Y. The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways. Brain Res. 2005, 1035:51-59.
12. Guan Q.H., Pei D.S., Zong Y.Y., Xu T.L., Zhang G.Y. Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways. Neuroscience 2006, 139:609-627.
13. Han J.Y., Jeong E.Y., Kim Y.S., Roh G.S., Kim H.J., Kang S.S., Cho G.J., Choi W.S. C-jun N-terminal kinase regulates the interaction between 14-3-3 and Bad in ethanol-induced cell death. J. Neurosci. Res. 2008, 86:3221-3229.
14. Jeong H.S., Choi H.Y., Choi T.W., Kim B.W., Kim J.H., Lee E.R., Cho S.G. Differential regulation of the antiapoptotic action of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma extra long (Bcl-xL) by c-Jun N-terminal protein kinase (JNK) 1-involved pathway in neuroglioma cells. Biol. Pharm. Bull. 2008, 31:1686-1690.
15. Kalkman C.J., Peelen L., Moons K.G., Veenhuizen M., Bruens M., Sinnema G., de Jong T.P. Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology 2009, 110:805-812.
16. Kong F., Xu L., He D., Zhang X., Lu H. Effects of gestational isoflurane exposure on postnatal memory and learning in rats. Eur. J. Pharmacol. 2011, 670:168-174.
17. Kuan C.Y., Burke R.E. Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Curr. Drug Targets CNS Neurol. Disord. 2005, 4:63-67.
18. Li C., Xing G., Dong M., Zhou L., Li J., Wang G., Zou D., Wang R., Liu J., Niu Y. Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. Eur. J. Pharmacol. 2010, 635:96-102.
19. Li Y., Liang G., Wang S., Meng Q., Wang Q., Wei H. Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. Neuropharmacology 2007, 53:942-950.
20. Li Y., Liu C., Zhao Y., Hu K., Zhang J., Zeng M., Luo T., Jiang W., Wang H. Sevoflurane induces short-term changes in proteins in the cerebral cortices of developing rats. Acta Anaesthesiol. Scand. 2013, 3:380-390.
21. Luo H.R., Hattori H., Hossain M.A., Hester L., Huang Y., Lee-Kwon W., Donowitz M., Nagata E., Snyder S.H. Akt as a mediator of cell death. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:11712-11717.
22. Orliaguet G., Vivien B., Langeron O., Bouhemad B., Coriat P., Riou B. Minimum alveolar concentration of volatile anesthetics in rats during postnatal maturation. Anesthesiology 2001, 95:734-739.
23. Paule M.G., Li M., Allen R.R., Liu F., Zou X., Hotchkiss C., Hanig J.P., Patterson T.A., Slikker W.J., Wang C. Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol. Teratol. 2011, 33:220-230.
24. Shu Y., Zhou Z., Wan Y., Sanders R.D., Li M., Pac-Soo C.K., Maze M., Ma D. Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol. Dis. 2012, 45:743-750.
25. Song G., Ouyang G., Bao S. The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 2005, 9:59-71.
26. Wang W., Shi L., Xie Y., Ma C., Li W., Su X., Huang S., Chen R., Zhu Z., Mao Z., Han Y., Li M. S.P600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neurosci. Res. 2004, 48:195-202.
27. Wang W.Y., Wang H., Luo Y., Jia L.J., Zhao J.N., Zhang H.H., Ma Z.W., Xue Q.S., Yu B.W. The effects of metabotropic glutamate receptor 7 allosteric agonist N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway. Neuroscience 2012, 205:167-177.
28. Wang Y., Cheng Y., Liu G., Tian X., Tu X., Wang J. Chronic exposure of gestation rat to sevoflurane impairs offspring brain development. Neurol. Sci. 2012, 33:535-544.
29. Wei H., Kang B., Wei W., Liang G., Meng Q.C., Li Y., Eckenhoff R.G. Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently. Brain Res. 2005, 1037:139-147.
30. Wilder R.T., Flick R.P., Sprung J., Katusic S.K., Barbaresi W.J., Mickelson C., Gleich S.J., Schroeder D.R., Weaver A.L., Warner D.O. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 2009, 110:796-804.
31. Yeste-Velasco M., Folch J., Casadesus G., Smith M.A., Pallas M., Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience 2009, 159:1135-1147.
32. Yin G., Li L.Y., Qu M., Luo H.B., Wang J.Z., Zhou X.W. Upregulation of AKT attenuates amyloid-beta-induced cell apoptosis. J. Alzheimers Dis. 2011, 25:337-345.
33. Yon J.H., Daniel-Johnson J., Carter L.B., Jevtovic-Todorovic V. Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience 2005, 135:815-827.
34. Zhao H., Yenari M.A., Cheng D., Sapolsky R.M., Steinberg G.K. Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity. J. Neurochem. 2003, 85:1026-1036.
35. Zhao Y., Liang G., Chen Q., Joseph D.J., Meng Q., Eckenhoff R.G., Eckenhoff M.F., Wei H. Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. J. Pharmacol. Exp. Ther. 2010, 333:14-22.
36. Zhao Y.L., Xiang Q., Shi Q.Y., Li S.Y., Tan L., Wang J.T., Jin X.G., Luo A.L. GABAergic excitotoxicity injury of the immature hippocampal pyramidal neurons' exposure to isoflurane. Anesth. Analg. 2011, 113:1152-1160.