Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I. Data generation in a small fish model

Toxicological Sciences

Volumn 133, Issue 2, 2013, Pages 225-233

  Villeneuve, Daniel L ^a   Breen, Miyuki ^b   Bencic, David C ^a   Cavallin, Jenna E ^a   Jensen, Kathleen M ^a   Makynen, Elizabeth A ^a   Thomas, Linnea M ^c   Wehmas, Leah C ^d   Conolly, Rory B ^a   Ankley, Gerald T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c US Fish and Wildlife Service   (United States)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

Alternative species; Compensation; Endocrine disruption; Reproduction; Steroidogenesis; Time course

Indexed keywords

ESTRADIOL; FADROZOLE; FOLLITROPIN RELEASING FACTOR; VITELLOGENIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; NONHUMAN; PIMEPHALES PROMELAS; PREDICTIVE VALUE; PROTEIN EXPRESSION; STEROIDOGENESIS; VERTEBRATE;

ALTERNATIVE SPECIES; COMPENSATION; ENDOCRINE DISRUPTION; REPRODUCTION; STEROIDOGENESIS; TIME COURSE.;

ADAPTATION, PHYSIOLOGICAL; ANIMAL TESTING ALTERNATIVES; ANIMALS; AROMATASE INHIBITORS; CYPRINIDAE; ESTRADIOL; ESTROGEN ANTAGONISTS; FADROZOLE; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; OVARY; PREDICTIVE VALUE OF TESTS; TIME FACTORS; VITELLOGENINS;

PIMEPHALES PROMELAS; VERTEBRATA;

EID: 84878504196     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft068     Document Type: Article

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