Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas)

Toxicological Sciences

Volumn 67, Issue 1, 2002, Pages 121-130

  Ankley, G T ^a   Kahl, M D ^a   Jensen, K M ^a   Hornung, M W ^a   Korte, J J ^a   Makynen, E A ^a   Leino, R L ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aromatase inhibitor; Endocrinology; Fish; Reproduction; Steroids; Vitellogenin

Indexed keywords

11 OXOTESTOSTERONE; ANDROGEN; AROMATASE; AROMATASE INHIBITOR; CYTOCHROME P450; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FADROZOLE; TESTOSTERONE; VITELLOGENIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ECOTOXICITY; ENDOCRINE FUNCTION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FERTILITY; FISH; MALE; NONHUMAN; OOCYTE; OVARY; OVARY FOLLICLE ATRESIA; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; SPERM; TESTIS;

ANIMALS; AROMATASE INHIBITORS; BRAIN; CYPRINIDAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN ANTAGONISTS; FADROZOLE; FEMALE; FERTILITY; MALE; OVARY; TESTIS; TESTOSTERONE; TOXICITY TESTS; VITELLOGENINS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; CYPRINIFORMES; PHOXINUS PHOXINUS; PIMEPHALES; PIMEPHALES PROMELAS; VERTEBRATA;

EID: 0036091601     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/67.1.121     Document Type: Article

References (54)

1. Effects of the aromatase inhibitor fadrozole on plasma sex steroid secretion and ovulation rate in female coho salmon, Onchorhynchus kisutch, close to final maturation
2. Effects of the aromatase inhibitor fadrozole on reproductive steroids and spermiation in male coho salmon (Oncorhynchus kisutch) during sexual maturation
3. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas)
4. Development of a research strategy for assessing the ecological risk of endocrine disruptors
5. Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife
6. Morphological and behavioral characters in mosquito fish as potential bioindication of exposure to kraft mill effluent
7. Aromatase, its inhibitors, and their use in breast cancer treatment
8. Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system
9. Two CYP19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain
10. Identification of estrogenic chemicals in STW effluent: I. Chemical fractionation and in vitro biological screening
11. Aromatase enzyme activity and sex determination in chickens
12. Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant
13. Quantitative histology of the seasonal changes in the gonads of summer whiting, Sillago ciliata
14. Cloning and molecular characterization of an ovarian-derived (brain-like) P450 aromatase cDNA and development of a competitive RT-PCR assay to quantify its expression in the fathead minnow (Pimephales promelas)
15. Development of a reproductive performance test for endocrine disrupting chemicals using pair-breeding fathead minnows (Pimephales promelas)
16. Inhibition of central nervous system aromatase activity: A mechanism for fenarimol-induced infertility in the male rat
17. Identification of androstenedione in a river containing paper mill effluent
18. Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas)
19. Distinct cytochrome P450 aromatase isoforms in zebra fish (Danio rerio) brain and ovary are differentially programmed and estrogen-regulated during early development
20. Aromatase inhibitor and 17α-methyltestosterone cause sex-reversal from genetic females to phenotypic males and suppression of P450 aromatase gene expression in Japanese flounder (Paralichthys olivaceus)
21. Fathead minnow vitellogenin: Complementary DNA sequence and messenger RNA and protein expression after 17β-estradiol treatment
22. Reproductive impairment and induction of alkaline-labile phosphate, a biomarker of estrogen exposure, in fathead minnows (Pimephales promelas) exposed to waterborne 17β-estradiol
23. More male fish embryos near a pulp mill
24. Pesticides: Multiple mechanisms of demasculinization
25. Reproductive characteristics of the ruffe, Gymnocephalus cernuus, in the St. Louis River estuary on western Lake Superior: A histological examination of the ovaries over one annual cycle
26. Multiple effects of acid and aluminum on brood stock and progeny of fathead minnows, with emphasis on histopathology
27. Effects of the mammalian antiandrogen vinclozolin on the development and reproduction of the fat-head minnow (Pimephales promelas)
28. Imidazole antimycotics: Selective inhibitors of steroid aromatization and progesterone hydroxylation
29. An epidemiological evaluation of the biochemical basis for steroid hormonal depressions in fish exposed to industrial wastes
30. Sexual dimorphism of brain aromatase activity in medaka: Induction of a female phenotype by estradiol
31. Effects of waterborne exposure of 17β-estradiol on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas)
32. Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas)
33. Aromatase inhibitors and breast cancer
34. Effects of exposure to municipal wastewater in situ on the reproductive physiology of the fathead minnow (Pimephales promelas)
35. Evidence for endocrine disruption in perch (Perca fluviatilis) and roach (Rutilus rutilus) in a remote Swedish lake in the vicinity of a public refuse dump
36. Utility of a juvenile fathead minnow-screening assay for detecting (anti)-estrogenic substances
37. Adverse reproductive effects in male fathead minnows (Pimephales promelas) exposed to environmentally relevant concentrations of the natural oestrogens, oestradiol and oestrone
38. Fathead minnow (Pimephales promelas) vitellogenin: Purification, characterization, and quantitative immunoassay for the detection of estrogenic compounds
39. Masculinization of female mosquitofish in Kraft mill effluent-contaminated Fenholloway River water is associated with androgen receptor agonist activity
40. Effects of flavonoids on aromatase activity, an in vitro study
41. Estrogenic effects of effluents from sewage treatment works
42. CGS 16949A, a new nonsteroidal aromatase inhibitor: Effects on hormone-dependent and -independent tumors in vivo
43. Gametogenesis in Fundulus heteroclitus
44. Vitellogenesis in fishes: Status and perspectives
45. In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A
46. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment
47. Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary
48. Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione
49. An in vivo testing system for endocrine disruptors in fish early-life stages using induction of vitellogenin
50. Endocrine disrupter screening and testing advisory committee (EDSTAC) report
51. A short-term test method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas)
52. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro
53. Studies on the disposition of fadrozole hydrochloride (CGS 16949A): (I). Absorption, distribution, metabolism and excretion after a single oral administration to rats
54. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes