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Volumn 133, Issue 2, 2013, Pages 234-247

Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling

Author keywords

Biological modeling; Biomarkers; Dose response; Endocrine disruptors; Nonmammalian species

Indexed keywords

AROMATASE; ESTRADIOL; FADROZOLE; FOLLITROPIN; LUTEINIZING HORMONE; MESSENGER RNA;

EID: 84878476519     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft067     Document Type: Article
Times cited : (21)

References (41)
  • 3
    • 84857935925 scopus 로고    scopus 로고
    • A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows
    • Ankley, G. T., Cavallin, J. E., Durhan, E. J., Jensen, K. M., Kahl, M. D., Makynen, E. A., Thomas, L. M., Wehmas, L. C., and Villeneuve, D. L. (2012). A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows. Aquat. Toxicol. 114-115, 88-95.
    • (2012) Aquat. Toxicol. , vol.114-115 , pp. 88-95
    • Ankley, G.T.1    Cavallin, J.E.2    Durhan, E.J.3    Jensen, K.M.4    Kahl, M.D.5    Makynen, E.A.6    Thomas, L.M.7    Wehmas, L.C.8    Villeneuve, D.L.9
  • 4
    • 0031768461 scopus 로고    scopus 로고
    • A model for pharmacokinetics and physiological feedback among hormones of the testicular-pituitary axis in adult male rats: A framework for evaluating effects of endocrine active compounds
    • Barton, H. A., and Andersen, M. E. (1998). A model for pharmacokinetics and physiological feedback among hormones of the testicular-pituitary axis in adult male rats: A framework for evaluating effects of endocrine active compounds. Toxicol. Sci. 45, 174-187.
    • (1998) Toxicol. Sci. , vol.45 , pp. 174-187
    • Barton, H.A.1    Andersen, M.E.2
  • 5
    • 34249722064 scopus 로고    scopus 로고
    • Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds
    • Breen, M. S., Villeneuve, D. L., Breen, M., Ankley, G. T., and Conolly, R. B. (2007). Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds. Ann. Biomed. Eng. 35, 970-981.
    • (2007) Ann. Biomed. Eng. , vol.35 , pp. 970-981
    • Breen, M.S.1    Villeneuve, D.L.2    Breen, M.3    Ankley, G.T.4    Conolly, R.B.5
  • 7
    • 0031049261 scopus 로고    scopus 로고
    • Endocrine disruptors and reproductive development: A weight-of-evidence overview
    • Cooper, R. L., and Kavlock, R. J. (1997). Endocrine disruptors and reproductive development: A weight-of-evidence overview. J. Endocrinol. 152, 159-166.
    • (1997) J. Endocrinol. , vol.152 , pp. 159-166
    • Cooper, R.L.1    Kavlock, R.J.2
  • 8
    • 0042242581 scopus 로고    scopus 로고
    • Uncertainties for endocrine disrupters: Our view on progress
    • Daston, G. P., Cook, J. C., and Kavlock, R. J. (2003). Uncertainties for endocrine disrupters: Our view on progress. Toxicol. Sci. 74, 245-252.
    • (2003) Toxicol. Sci. , vol.74 , pp. 245-252
    • Daston, G.P.1    Cook, J.C.2    Kavlock, R.J.3
  • 10
    • 33746730199 scopus 로고    scopus 로고
    • Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment
    • Hutchinson, T. H., Ankley, G. T., Segner, H., and Tyler, C. R. (2006). Screening and testing for endocrine disruption in fish-biomarkers as "signposts," not "traffic lights," in risk assessment. Environ. Health Perspect. 114(Suppl. 1), 106-114.
    • (2006) Environ. Health Perspect. , vol.114 , Issue.SUPPL. 1 , pp. 106-114
    • Hutchinson, T.H.1    Ankley, G.T.2    Segner, H.3    Tyler, C.R.4
  • 11
    • 33744966609 scopus 로고    scopus 로고
    • Modeling the brain-pituitarygonad axis in salmon
    • Kim, J., Hayton, W. L., and Schultz, I. R. (2006). Modeling the brain-pituitarygonad axis in salmon. Mar. Environ. Res. 62(Suppl), S426-S432.
    • (2006) Mar. Environ. Res. , vol.62 , Issue.SUPPL.
    • Kim, J.1    Hayton, W.L.2    Schultz, I.R.3
  • 14
    • 79955556512 scopus 로고    scopus 로고
    • A computational model of the hypothalamic:pituitary:gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17a-ethynylestradiol and 17β-trenbolone
    • Li, Z., Kroll, K. J., Jensen, K. M., Villeneuve, D. L., Ankley, G. T., Brian, J. V., Sepúlveda, M. S., Orlando, E. F., Lazorchak, J. M., Kostich, M., et al. (year). A computational model of the hypothalamic:pituitary:gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17a-ethynylestradiol and 17β-trenbolone. BMC Syst. Biol. 5, 63.
    • (2011) BMC Syst. Biol. , vol.5 , pp. 63
    • Li, Z.1    Kroll, K.J.2    Jensen, K.M.3    Villeneuve, D.L.4    Ankley, G.T.5    Brian, J.V.6    Sepúlveda, M.S.7    Orlando, E.F.8    Lazorchak, J.M.9    Kostich, M.10
  • 15
    • 0036241442 scopus 로고    scopus 로고
    • Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors
    • McArdle, C. A., Franklin, J., Green, L., and Hislop, J. N. (2002). Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors. J. Endocrinol. 173, 1-11.
    • (2002) J. Endocrinol. , vol.173 , pp. 1-11
    • McArdle, C.A.1    Franklin, J.2    Green, L.3    Hislop, J.N.4
  • 16
    • 0024064517 scopus 로고
    • Molecular biology of steroid hormone synthesis
    • Miller, W. L. (1988). Molecular biology of steroid hormone synthesis. Endocr. Rev. 9, 295-318.
    • (1988) Endocr. Rev. , vol.9 , pp. 295-318
    • Miller, W.L.1
  • 17
    • 18844367746 scopus 로고    scopus 로고
    • Minireview: Regulation of steroidogenesis by electron transfer
    • Miller, W. L. (2005). Minireview: Regulation of steroidogenesis by electron transfer. Endocrinology 146, 2544-2550.
    • (2005) Endocrinology , vol.146 , pp. 2544-2550
    • Miller, W.L.1
  • 18
    • 0027958076 scopus 로고
    • Localization of two gonadotropin receptors in the salmon gonad by in vitro ligand autoradiography
    • Miwa, S., Yan, L., and Swanson, P. (1994). Localization of two gonadotropin receptors in the salmon gonad by in vitro ligand autoradiography. Biol. Reprod. 50, 629-642.
    • (1994) Biol. Reprod. , vol.50 , pp. 629-642
    • Miwa, S.1    Yan, L.2    Swanson, P.3
  • 19
    • 15944380740 scopus 로고    scopus 로고
    • Modeling vitellogenesis in female fish exposed to environmental stressors: Predicting the effects of endocrine disturbance due to exposure to a PCB mixture and cadmium
    • Murphy, C. A., Rose, K. A., and Thomas, P. (2005). Modeling vitellogenesis in female fish exposed to environmental stressors: Predicting the effects of endocrine disturbance due to exposure to a PCB mixture and cadmium. Reprod. Toxicol. 19, 395-409.
    • (2005) Reprod. Toxicol. , vol.19 , pp. 395-409
    • Murphy, C.A.1    Rose, K.A.2    Thomas, P.3
  • 21
    • 0000238336 scopus 로고
    • A simplex method for function minimization
    • Nelder, J. A., and Mead, R. (1965). A simplex method for function minimization. Comput. J. 7, 308-313.
    • (1965) Comput. J. , vol.7 , pp. 308-313
    • Nelder, J.A.1    Mead, R.2
  • 22
    • 1342310168 scopus 로고    scopus 로고
    • A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I Feeding studies with 2,2',5,5'-tetrachlorobiphenyl
    • Nichols, J. W., Fitzsimmons, P. N., Whiteman, F. W., Dawson, T. D., Babeu, L., and Juenemann, J. (2004). A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. Toxicol. Sci. 77, 206-218.
    • (2004) Toxicol. Sci. , vol.77 , pp. 206-218
    • Nichols, J.W.1    Fitzsimmons, P.N.2    Whiteman, F.W.3    Dawson, T.D.4    Babeu, L.5    Juenemann, J.6
  • 23
    • 0025632946 scopus 로고
    • A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish
    • Nichols, J. W., McKim, J. M., Andersen, M. E., Gargas, M. L., Clewell, H. J., 3rd, and Erickson, R. J. (1990). A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish. Toxicol. Appl. Pharmacol. 106, 433-447.
    • (1990) Toxicol. Appl. Pharmacol. , vol.106 , pp. 433-447
    • Nichols, J.W.1    McKim, J.M.2    Andersen, M.E.3    Gargas, M.L.4    Clewell III, H.J.5    Erickson, R.J.6
  • 25
    • 0034146307 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of testosterone and luteinizing hormone suppression by cetrorelix in healthy volunteers
    • Pechstein, B., Nagaraja, N. V., Hermann, R., Romeis, P., Locher, M., and Derendorf, H. (2000). Pharmacokinetic-pharmacodynamic modeling of testosterone and luteinizing hormone suppression by cetrorelix in healthy volunteers. J. Clin. Pharmacol. 40, 266-274.
    • (2000) J. Clin. Pharmacol. , vol.40 , pp. 266-274
    • Pechstein, B.1    Nagaraja, N.V.2    Hermann, R.3    Romeis, P.4    Locher, M.5    Derendorf, H.6
  • 26
    • 72149108995 scopus 로고    scopus 로고
    • Mechanism-based categorization of aromatase inhibitors: A potential discovery and screening tool
    • Petkov, P. I., Temelkov, S., Villeneuve, D. L., Ankley, G. T., and Mekenyan, O. G. (2009). Mechanism-based categorization of aromatase inhibitors: A potential discovery and screening tool. SAR QSAR Environ. Res. 20, 657-678.
    • (2009) SAR QSAR Environ. Res. , vol.20 , pp. 657-678
    • Petkov, P.I.1    Temelkov, S.2    Villeneuve, D.L.3    Ankley, G.T.4    Mekenyan, O.G.5
  • 28
    • 0021279862 scopus 로고
    • A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
    • Ramsey, J. C., and Andersen, M. E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
    • (1984) Toxicol. Appl. Pharmacol. , vol.73 , pp. 159-175
    • Ramsey, J.C.1    Andersen, M.E.2
  • 29
    • 0027078252 scopus 로고
    • A physiologically based pharmacokinetic model for nicotine and cotinine in man
    • Robinson, D. E., Balter, N. J., and Schwartz, S. L. (1992). A physiologically based pharmacokinetic model for nicotine and cotinine in man. J. Pharmacokinet. Biopharm. 20, 591-609.
    • (1992) J. Pharmacokinet. Biopharm. , vol.20 , pp. 591-609
    • Robinson, D.E.1    Balter, N.J.2    Schwartz, S.L.3
  • 30
    • 0035047848 scopus 로고    scopus 로고
    • StAR protein and the regulation of steroid hormone biosynthesis
    • Stocco, D. M. (2001). StAR protein and the regulation of steroid hormone biosynthesis. Annu. Rev. Physiol. 63, 193-213.
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 193-213
    • Stocco, D.M.1
  • 31
    • 34248571909 scopus 로고    scopus 로고
    • Population pharmacokinetic/ pharmacodynamic (PK/PD) modelling of the hypothalamic-pituitary- gonadal axis following treatment with GnRH analogues
    • Tornøe, C. W., Agersø, H., Senderovitz, T., Nielsen, H. A., Madsen, H., Karlsson, M. O., and Jonsson, E. N. (2007). Population pharmacokinetic/ pharmacodynamic (PK/PD) modelling of the hypothalamic-pituitary- gonadal axis following treatment with GnRH analogues. Br. J. Clin. Pharmacol. 63, 648-664.
    • (2007) Br. J. Clin. Pharmacol. , vol.63 , pp. 648-664
    • Tornøe, C.W.1    Agersø, H.2    Senderovitz, T.3    Nielsen, H.A.4    Madsen, H.5    Karlsson, M.O.6    Jonsson, E.N.7
  • 32
    • 0030902159 scopus 로고    scopus 로고
    • Neuroendocrine regulation of gonadotrophin II release and gonadal growth in the goldfish, Carassius auratus
    • Trudeau, V. L. (1997). Neuroendocrine regulation of gonadotrophin II release and gonadal growth in the goldfish, Carassius auratus. Rev. Reprod. 2, 55-68.
    • (1997) Rev. Reprod. , vol.2 , pp. 55-68
    • Trudeau, V.L.1
  • 33
    • 84878504196 scopus 로고    scopus 로고
    • Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I Data generation in a small fish model
    • Villeneuve, D. L., Breen M., Bencic, D. C., Cavallin, J. E., Jensen, K. M., Makynen, E. A., Thomas, L. M., Wehmas, L. C., Conolly, R. B., Ankley, G. T. (2013). Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: I. Data generation in a small fish model. Toxicol. Sci.133, 225-233.
    • (2013) Toxicol. Sci. , vol.133 , pp. 225-233
    • Villeneuve, D.L.1    Breen, M.2    Bencic, D.C.3    Cavallin, J.E.4    Jensen, K.M.5    Makynen, E.A.6    Thomas, L.M.7    Wehmas, L.C.8    Conolly, R.B.9    Ankley, G.T.10
  • 34
    • 32644468916 scopus 로고    scopus 로고
    • Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas)
    • Villeneuve, D. L., Knoebl, I., Kahl, M. D., Jensen, K. M., Hammermeister, D. E., Greene, K. J., Blake, L. S., and Ankley, G. T. (2006). Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas). Aquat. Toxicol. 76, 353-368.
    • (2006) Aquat. Toxicol. , vol.76 , pp. 353-368
    • Villeneuve, D.L.1    Knoebl, I.2    Kahl, M.D.3    Jensen, K.M.4    Hammermeister, D.E.5    Greene, K.J.6    Blake, L.S.7    Ankley, G.T.8
  • 36
    • 0034106868 scopus 로고    scopus 로고
    • Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro
    • Vinggaard, A. M., Hnida, C., Breinholt, V., and Larsen, J. C. (2000). Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol. In Vitro 14, 227-234.
    • (2000) Toxicol. In Vitro , vol.14 , pp. 227-234
    • Vinggaard, A.M.1    Hnida, C.2    Breinholt, V.3    Larsen, J.C.4
  • 37
    • 34547552220 scopus 로고    scopus 로고
    • What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas
    • Watanabe, K. H., Jensen, K. M., Orlando, E. F., and Ankley, G. T. (2007). What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 146, 348-356.
    • (2007) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.146 , pp. 348-356
    • Watanabe, K.H.1    Jensen, K.M.2    Orlando, E.F.3    Ankley, G.T.4
  • 39
    • 0002931420 scopus 로고
    • Endocrine control of gametogenesis and spawning induction in the carp
    • Yaron, Z. (1995). Endocrine control of gametogenesis and spawning induction in the carp. Aquaculture 129, 49-73.
    • (1995) Aquaculture , vol.129 , pp. 49-73
    • Yaron, Z.1
  • 40
    • 0031804204 scopus 로고    scopus 로고
    • Identification and assessment of endocrine disruptors: Limitations of in vivo and in vitro assays
    • Zacharewski, T. (1998). Identification and assessment of endocrine disruptors: Limitations of in vivo and in vitro assays. Environ. Health Perspect. 106(Suppl. 2), 577-582.
    • (1998) Environ. Health Perspect. , vol.106 , Issue.SUPPL. 2 , pp. 577-582
    • Zacharewski, T.1
  • 41
    • 0034925290 scopus 로고    scopus 로고
    • Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes
    • Zhao, J., Mak, P., Tchoudakova, A., Callard, G., and Chen, S. (2001). Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. Gen. Comp. Endocrinol. 123, 180-191.
    • (2001) Gen. Comp. Endocrinol. , vol.123 , pp. 180-191
    • Zhao, J.1    Mak, P.2    Tchoudakova, A.3    Callard, G.4    Chen, S.5


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