A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 8, 2013, Pages 1344-1356

  Cinq Frais, Christel ^a,b   Coatrieux, Christelle ^a   Grazide, Marie Hélène ^a,b   Hannun, Yusuf A ^c   Nègre Salvayre, Anne ^a,b   Salvayre, Robert ^a,b   Augé, Nathalie ^a,b,d  

^a University Hospital of Toulouse   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c STONY BROOK UNIVERSITY   (United States)

^d CHU RANGUEIL   (France)

Author keywords

Hydrogen peroxide; Mitogenic signaling; Neutral sphingomyelinase 2; PDGFR ; Sphingosine 1 phosphate; Sphingosine kinase1

Indexed keywords

CERAMIDE; HYDROGEN PEROXIDE; NEUTRAL SPHINGOMYELINASE 2; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; OXIDIZING AGENT; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; SMPD3 PROTEIN, HUMAN; SMPD3 PROTEIN, MOUSE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL COUNT; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MESENCHYME CELL; MITOGENESIS; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOXICITY TESTING; TRANSACTIVATION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CELL LINE; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; LYSOPHOSPHOLIPIDS; MICE; MICE, MUTANT STRAINS; OXIDANTS; OXIDATIVE STRESS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SRC-FAMILY KINASES;

EID: 84878503654     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.04.014     Document Type: Article

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