HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages

PLoS Genetics

Volumn 9, Issue 5, 2013, Pages

  Barneda Zahonero, Bruna ^a   Román González, Lidia ^a   Collazo, Olga ^a   Rafati, Haleh ^b   Islam, Abul B M M K ^c,f   Bussmann, Lars H ^d   di Tullio, Alessandro ^d   de Andres, Luisa ^d   Graf, Thomas ^d,e   López Bigas, Núria ^c,e   Mahmoudi, Tokameh ^b   Parra, Maribel ^a  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^f UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 7; MYOCYTE ENHANCER FACTOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MEF2C; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL FUNCTION; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; MACROPHAGE; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MYELOID GENE; NONLYMPHOID GENE; PHAGOCYTOSIS; PRE B LYMPHOCYTE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REPRESSOR GENE;

B-LYMPHOCYTES; BINDING SITES; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSDIFFERENTIATION; DOWN-REGULATION; HISTONE DEACETYLASES; HUMANS; LYMPHOPOIESIS; MACROPHAGES; MADS DOMAIN PROTEINS; MYELOID CELLS; MYOGENIC REGULATORY FACTORS; PRECURSOR CELLS, B-LYMPHOID; PROMOTER REGIONS, GENETIC;

EID: 84878489387     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003503     Document Type: Article

References (36)

1. Parra M, (2009) Epigenetic events during B lymphocyte development. Epigenetics 4: 462-468.
2. Mercer EM, Lin YC, Murre C, (2011) Factors and networks that underpin early hematopoiesis. Semin Immunol 23: 317-325.
3. Adolfsson J, Mansson R, Buza-Vidas N, Hultquist A, Liuba K, et al. (2005) Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121: 295-306.
4. Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K, (2006) Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol 7: 382-391.
5. Stehling-Sun S, Dade J, Nutt SL, DeKoter RP, Camargo FD, (2009) Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol 10: 289-296.
6. Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, et al. (1994) E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79: 885-892.
7. Bain G, Robanus Maandag EC, te Riele HP, Feeney AJ, Sheehy A, et al. (1997) Both E12 and E47 allow commitment to the B cell lineage. Immunity 6: 145-154.
8. Zhuang Y, Soriano P, Weintraub H, (1994) The helix-loop-helix gene E2A is required for B cell formation. Cell 79: 875-884.
9. Lin H, Grosschedl R, (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376: 263-267.
10. Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, et al. (2008) Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 9: 1388-1398.
11. Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M, (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79: 901-912.
12. Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, et al. (2006) Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24: 269-281.
13. Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, et al. (2007) Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27: 49-63.
14. Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J Immunol 180: 1719-1728.
15. Parra M, Verdin E, (2010) Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol 10: 454-460.
16. Martin M, Kettmann R, Dequiedt F, (2009) Class IIa histone deacetylases: conducting development and differentiation. Int J Dev Biol 53: 291-301.
17. Bussmann LH, Schubert A, Vu Manh TP, De Andres L, Desbordes SC, et al. (2009) A robust and highly efficient immune cell reprogramming system. Cell Stem Cell 5: 554-566.
18. Di Tullio A, Manh TP, Schubert A, Mansson R, Graf T, (2011) CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation. Proc Natl Acad Sci U S A 108: 17016-17021.
19. Rodriguez-Ubreva J, Ciudad L, Gomez-Cabrero D, Parra M, Bussmann LH, et al. (2011) Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. Nucleic Acids Res.
20. Perez-Llamas C, Lopez-Bigas N, (2011) Gitools: analysis and visualisation of genomic data using interactive heat-maps. PLoS ONE 6: e19541 doi:10.1371/journal.pone.0019541.
21. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, et al. (2010) A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol 11: 635-643.
22. Swanson BJ, Jack HM, Lyons GE, (1998) Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes. Mol Immunol 35: 445-458.
23. Wilker PR, Kohyama M, Sandau MM, Albring JC, Nakagawa O, et al. (2008) Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol 9: 603-612.
24. Khiem D, Cyster JG, Schwarz JJ, Black BL, (2008) A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A 105: 17067-17072.
25. Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, et al. (2009) Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood 113: 3461-3471.
26. Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, et al. (2003) HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 18: 687-698.
27. Kasler HG, Verdin E, (2007) Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes. Mol Cell Biol 27: 5184-5200.
28. Kasler HG, Young BD, Mottet D, Lim HW, Collins AM, et al. (2011) Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol 186: 4782-4793.
29. Dequiedt F, Van Lint J, Lecomte E, Van Duppen V, Seufferlein T, et al. (2005) Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J Exp Med 201: 793-804.
30. Navarro MN, Goebel J, Feijoo-Carnero C, Morrice N, Cantrell DA, (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12: 352-361.
31. Parra M, Kasler H, McKinsey TA, Olson EN, Verdin E, (2005) Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem 280: 13762-13770.
32. Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, et al. (2011) Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol 9: e1001206 doi:10.1371/journal.pbio.1001206.
33. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
34. Gautier L, Cope L, Bolstad BM, Irizarry RA, (2004) affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20: 307-315.
35. Kauffmann A, Gentleman R, Huber W, (2009) arrayQualityMetrics-a bioconductor package for quality assessment of microarray data. Bioinformatics 25: 415-416.
36. Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.