A model for pharmacokinetics and physiological feedback among hormones of the testicular-pituitary axis in adult male rats: A framework for evaluating effects of endocrine active compounds

Toxicological Sciences

Volumn 45, Issue 2, 1998, Pages 174-187

  Barton, Hugh A ^a   Andersen, Melvin E ^a  

^a ICF Kaiser International   (United States)

Author keywords

Antiandrogen; Endocrine active compounds; Endocrine disruption; Feedback regulation; Pharmacokinetic model; Testosterone; Testosterone pharmacokinetics

Indexed keywords

ANTIANDROGEN; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; HORMONAL REGULATION; HORMONE RELEASE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LIGAND BINDING; NEGATIVE FEEDBACK; NONHUMAN; RAT; RISK ASSESSMENT; SPERMATOGENESIS; TESTIS BLOOD FLOW; TESTOSTERONE SYNTHESIS;

ANIMALIA;

EID: 0031768461     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2538     Document Type: Article

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