A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows

Aquatic Toxicology

Volumn 114-115, Issue , 2012, Pages 88-95

  Ankley, Gerald T ^a   Cavallin, Jenna E ^a   Durhan, Elizabeth J ^a   Jensen, Kathleen M ^a   Kahl, Michael D ^a   Makynen, Elizabeth A ^a   Thomas, Linnea M ^a   Wehmas, Leah C ^a   Villeneuve, Daniel L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Fish; Fungicide; Mechanisms; Steroid synthesis; Toxicity

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; ESTRADIOL; FADROZOLE; KETOCONAZOLE; PROCHLORAZ; TESTOSTERONE; TRILOSTANE; VITELLOGENIN;

CONCENTRATION (COMPOSITION); ENDOCRINE DISRUPTOR; EXPERIMENTAL STUDY; FISH; FUNGICIDE; INHIBITOR; PLASMA; POLLUTION EFFECT; POLLUTION EXPOSURE; STEROID; TESTOSTERONE; TIME SERIES ANALYSIS; TOXICITY TEST;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYP11A GENE; CYP17 GENE; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; ESTRADIOL BLOOD LEVEL; EX VIVO STUDY; FEMALE; FSHR GENE; GENDER; GENE; GENE EXPRESSION; GONAD; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; NONHUMAN; PIMEPHALES PROMELAS; PRIORITY JOURNAL; SEXUAL MATURATION; STAR GENE; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; TIME COURSE ANALYSIS; UPREGULATION;

14-ALPHA DEMETHYLASE INHIBITORS; ANIMALS; CYPRINIDAE; DRUG ADMINISTRATION SCHEDULE; ENDOCRINE DISRUPTORS; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; KETOCONAZOLE; MALE; REPRODUCTION; TIME FACTORS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; PIMEPHALES PROMELAS; VERTEBRATA;

EID: 84857935925     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2012.02.012     Document Type: Article

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