Interval exercise alters feed intake as well as leptin and ghrelin concentrations in Standardbred mares

Equine Veterinary Journal

Volumn 38, Issue SUPPL.36, 2006, Pages 596-605

  Gordon, M E ^a   Mckeever, K H ^a   Bokman, S ^a   Betros, C L ^a   Manso Filho, H ^a   Liburt, N ^a   Streltsova, J ^a  

^a The State University of New Jersey   (United States)

Author keywords

Appetite; Endocrine; Energy homeostasis; Horse; Training

Indexed keywords

EQUIDAE;

EID: 84878468816     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2006.tb05611.x     Document Type: Article

References (50)

1. Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L. and Considine, R. V. (1996). Leptin: the tale of an obesity gene. Diabetes 45, 1455-1462.
2. Cartmill, J. A., Thompson, D. L., Storer, W. A., Huff, N. K. and Walker, R. E. (2003) Effect of dexamethasone or feeding time on plasma leptin in stallions. In: Proceedings of the 19th Equine Nutrition and Physiology Society Symposium. pp 82-83.
3. Considine, R. V., Sinha, M. K. Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J. and Bauer, T. L. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Eng. J. Med. 334, 292-295.
4. Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E. and Weigle, D. S. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714-1719.
5. Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R. and Chapelot, D. (2004) Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am. J. Physiol. Endocrin. Metab. 287, E297-E304.
6. Dall, R., Kanaley, J., Hansen, T. K., Moller, N., Christiansen, J. S., Hosoda, H., Kangawa, K. and Jorgensen, J. O. (2002) Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients. Eur. J. Endocrinol. 147, 65-70.
7. Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K. and Nakazato, M. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinol. 141, 4255-4261.
8. Freestone, J. F., Wolfsheimer, K. J., Kamerling, S. G., Church, G., Hamra, J. and Bagwell, C. (1991) Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. Equine vet. J. 23, 219-223.
9. Geor, R. J., Hinchcliff, K. W. and Sams, R. A. (2000) Beta-adrenergic blockade augments glucose utilization in horses during graded exercise. J. appl. Physiol. 89, 1086-1098.
10. Gordon, M. E. and McKeever, K. H. (2005a) Diurnal variation of ghrelin, leptin, and adiponectin in Standardbred mares. J. anim. Sci. 83, 6365-6371, 2005.
11. Gordon, M. E. and McKeever, K. H. (2005b) Oral and IV nutrient challenges decrease active ghrelin concentrations and alter hormones related to energy balance in horses. J. anim. Sci. 84, 1982. 1690.
12. Gordon, M. E., McKeever, K. H., Betros, C. L. and Manso Filho, H. C. (2005a) Plasma leptin, ghrelin and adiponectin concentrations in fit versus unfit racehorses. Vet. J. (In press, doi:10.1016/j.tvjl.2005.11.004).
13. Gordon, M. E., McKeever, K. H., Betros, C. L. and Manso, H. C. (2006a) Exercise-induced alterations in plasma glucose, insulin, cortisol, leptin, and ghrelin concentration in horses. Vet. J. (In press, doi:10.1016/j.tvjl.2006.01.003).
14. Gordon, M. E., McKeever, C. L., Betros, C. L., Liburt, N. R., Streltsova, J. M. and Manso Filho, H. C. (2006) Training-induced energy balance mismatch in Standardbred mares. Equine comp. Exerc. Physiol. 3, 73-82.
15. Hammond, C. J., Mason, D. K. and Watkins, K. L. (1986) Gastric ulceration in mature TB horses. Equine vet. J. 18, 284-287.
16. Havel, P. J. (2001) Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Expt. Biol. Med. (Maywood) 226, 963-977.
17. Hodgson, D. R. and Rose, R. J. (1994) Hematology and biochemistry. In: The Athletic Horse: Principle and Practice of Equine Sports Medicine. Eds: D. R. Hodgson and R. J. Rose, W. B. Saunders Company, Philadelphia. pp 63-78.
18. Houpt, KA. (1990) Ingestive behavior. Vet. Clin. N. Am. Equine Pract. 6, 319-337.
19. Jose-Cunilleras, E., Hinchcliff, K. W., Sams, R. A., Devor, S. T. and Linderman, J. K. (2002) Glycemic index of a meal fed before exercise alters substrate use and glucose flux in exercising horses. J. appl. Physiol. 92, 117-28.
20. Kallio, J., Pesonen, U., Karvonen, M. K., Kojima, M., Hosoda, H., Kangawa, K. and Koulu, M. (2001) Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY. J. Clin. Endocrinol. Metab. 86, 5348-5352.
21. Kearns, C. F., McKeever, K. H., Roegner, V., Brady, S. M. and Malinowski, K. (2005) Adiponectin and leptin are related to fat mass in horses. Vet. J. (In Press, doi:10.1016/j.tvjl.2005.05.002).
22. Kraemer, R. R., Acevedo, E. O., Synovitz, L. B., Hebert, E. P., Gimpel, T. and Castracane, V. D. (2001) Leptin and steroid hormone responses to exercise in adolescent female runners over a 7-week season. Eur. J. appl. Physiol. 86, 85-91.
23. Kraemer, R. R., Durand, R. J., Acevedo, E. O., Johnson, L. G., Kraemer, G. R., Hebert, E. P. and Castracane, V. D. (2004) Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin. Expt. Biol. Med. 229, 240-246.
24. Malmstrom, R., Taskinen, M.R., Karonen, S. L. and Yki-Jarvinen, H. (1996) Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39, 993-996.
25. McClure, S. R., Glickman, L. T. and Glickman, N. W. (1999) Prevalence of gastric ulcers in show horses. J. Am. vet. med. Assoc. 215, 1130-1133.
26. McKeever, K. H. (2002) The endocrine system and the challenge of exercise. Vet. Clin. N. Am.: Equine Pract. 18, 321-353.
27. McKeever, K. H. and Malinowski K. (1997) Exercise capacity in young and old mares. Am. J. vet. Res. 58, 1468-1472.
28. McManus, C. J. and Fitzgerald, B. P. (2000) Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares. Domest. Anim. Endocrinol. 19, 1-13.
29. Meier, U. and Gressner, A. M. (2004) Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin and resistin. Clin. Chem. 50, 1511-1525.
30. Minokoski, Y. and Kahn, B. B. (2003) Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem. Soc. Trans. 31, 196-201.
31. Murdolo, G., Lucidi, P., Di Loreto, C., Parlanti, N. de Cicco, A., Fatone, C., Fanelli, C. G., Bolli, G. B., Santeusanio, F. and de Feo, P. (2003) Insulin is required for prandial ghrelin suppression in humans. Diabetes 52, 2923-2927.
32. Murray, M. J., Grodinsky, C., Anderson, C. W., Radue, P. F. and Schmidt, G. R. (1989) Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine vet. J., Suppl. 7, 68-72.
33. Murray, M. J., Schusser, G. F., Pipers, F. S. and Gross, S. J. (1996) Factors associated with gastric lesions in Thoroughbred race horses. Equine vet. J. 28, 368-374.
34. Olive, J. L. and Miller, G. D. (2001) Differential effects of maximal- and moderate-intensity runs on plasma leptin in healthy trained subjects. Nutrition 17, 365-369.
35. Otto, B., Tschop, M., Heldwein, W., Pfeiffer, A. F., and Diederich, S. (2004) Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur. J. Endocrinol. 151, 113-117.
36. Pagan, J. D. and Hintz, H. F. (1986a) Equine energetics. I. Relationship between body weight and energy requirements in horses. J. Anim. Sci. 63, 815-821.
37. Pagan, J. D. and Hintz, H. F. (1986b) Equine energetics. II. Energy expenditure in horses during submaximal exercise. J. Anim. Sci. 63, 822-830.
38. Perusse, L., G. Collier, J. Gagnon, A. S. Leon, D. C. Rao, J. S. Skinner, J. H. Wilmore, A. Nadeau, P. Z. Zimmet and C. Bouchard (1997) Acute and chronic effects of exercise on leptin levels in humans. J. appl. Physiol. 83, 5-10.
39. Rose, R. J., Knight, P. K. and Bryden, W. L. (1991) Energy use and cardiorespiratory responses to prolonged submaximal exercise. In: Equine Exercise Physiology 3. Eds: S. Persson, A. Lindholm and L. B. Jeffcott ICEEP Publications, Davis. pp 281-287.
40. Schmidt, A., Maier, C., Schaller, G., Nowotny, P., Bayerle-Eder, M., Buranyi, B., Luger, A. and Wolzt, M. (2004) Acute exercise has no effect on ghrelin plasma concentrations. Horm. Metab. Res. 36, 174-177.
41. Schwartz, M. W., Woods, S. C., Porte Jr, D., Seeley, R. J. and Baskin, D. G. (2000) Central nervous system control of food intake. Nature 404, 661-671.
42. Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M. S., Tanaka, M., Nozoe, S., Hosoda, H., Kangawa, K. and Matsukura, S. (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J. Clin. Endocrinol. Metab. 87, 240-244.
43. Sugino, T., Hasegawa, Y. Kikkawa, Y., Yamaura, J., Yamagishi, M., Kurose, Y., Kojima, M., Kangawa, K. and Terashima, Y. (2002a) A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep. Biochem. Biophys. Res. Commun. 295, 255-260.
44. Sugino, T., Yamaura, J., Yamagishi, M., Ogura, A., Hayashi, R., Kurose, Y., Kojima, M., Kangawa, K., Hasegawa, Y. and Terashima, Y. (2002b) A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem. Biophys. Res. Commun. 298, 785-788.
45. Tschop, M., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, E. and Heiman, M. L. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707-709.
46. Vatistas, N. J., Snyder, J. R., Carlson, G., Johnson, B., Arthur, R. M., Thurmond, M., Zhou, H. and Lloyd, K. L. (1999) Cross-sectional study of gastric ulcers of the squamous mucosa in thoroughbred racehorses. Equine vet. J., Suppl. 29, 34-39.
47. Weltman, A., Pritzlaff, C. J., Wideman, L., Considine, R. V., Fryburg, D. A., Gutgesell, M. E., Hartman, M. L. and Veldhuis J. D. (2000) Intensity of acute exercise does not affect serum leptin concentrations in young men. Med. Sci. Sports Exerc. 32, 1556-1561.
48. Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G., Ghatei, M. A. and Bloom, S. R. (2000) The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinol. 141, 4325-4328.
49. Wren, A. M., Small, C. J., Abbott, C. R., Dhillo, W. S., Seal, L. J., Cohen, M. A., Batterham, R. L., Taheri, S., Stanley, S. A., Ghatei, M. A. and Bloom, S. R. (2001a) Ghrelin causes hyperphagia and obesity in rats. Diabetes 50, 2540-2547.
50. Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A. and Bloom, S. R. (2001b) Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 5992.