Butyrate regulation of distinct macrophage subsets: Opposing effects on M1 and M2 macrophages

International Journal of Probiotics and Prebiotics

Volumn 6, Issue 3-4, 2011, Pages 147-158

  Foey, Andrew D ^a  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

Butyrate; Cytokines; Inflammation; Macrophage

Indexed keywords

BUTYRIC ACID; COLECALCIFEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOREGULATION; M1 MACROPHAGE; M2 MACROPHAGE; MACROPHAGE; MONOCYTE; MONOCYTE MACROPHAGE PRECURSOR CELL; NONHUMAN; TH1 CELL;

EID: 84878452809     PISSN: 15551431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Artis, D. (2008). Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nature Reviews Immunology 8:411-420.
2. Beck, P. L. and Wallace, J. L. (1997). Cytokines in inflammatorybowel disease. Mediators of Inflammation 6:95-103.
3. Bocker, U., Nebe, T., Herweck, R, Holt, L., Panja, A., Jobin, C, Rossol, S., Sartor, R. B. and Singer, M. V. (2003). Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. Clinical Experimental Immunology 131:53-60.
4. Bohmig, GA, Krieger, P. M., Saemann, M. D., Wenhardt, C, Pohanka, E. and Zlabinger, G. J. (1997). N-Butyrate downregulates the stimulatory function of peripheral blood-derived antigen presenting cells: a potential mechanism for modulating T-cell responses by short chain fatty acids. Immunology 92:234-243.
5. Bohmig, G. A., Krieger, P. M., Saemann, M. D., Ullrich, R., Karimi, H., Wekerle, T., Muhlbacher, F. and Zlabinger, G. J. (1999). Stable prodrugs of n-butyric acid: suppression of T cell alloresponses in vitro and prolongation of heart allograft survival in a fully allogeneic rat strain combination. Transplantation Immunology 7:221-227.
6. Bondeson, J., Browne, KA, Brennan, EM., Foxwell, B. M. J, and Feldmann, M. (1999). Selective regulation of cytokine induction by adenoviral gene transfer of IkBα into human macrophages: Lipopolysaccharide-induced, but not zymosaninduced, pro-inflammatory cytokines are inhibited, but IL-10 is nuclear factor-kB independent. Journal of Immunology 162:2939-2945.
7. Bonizzi, G. and Karin. M. (2004). The two NF-kB activation pathways and their role in innate and adaptive immunity. Trends in Immunology 25:280-288.
8. Breuer, R. I., Soergel, K. H., Christ, M. L., Hanauer, S. B., Vanagunas, A., Harig, J. M., Keshavarzian, A., Robinson, M., Sellin, J. H., Weinberg, D., Vidican, D. E., Flemal, K. L. and Rademaker, A. W. (1997). Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. Gut 40:485-491.
9. Brouns, E, Kettlitz, B. and Arrgoni, E. (2002). Resistant starch and the butyrate revolution. Trends in Food Science & Technology 13:251-261.
10. Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., Pike, N. B., Strum, J. C., Steplewski, K. M., Murdoch, P. R., Holder, J. C., Marshal, EH., Szekeres, P. G., Wilson, S., Igner, D. M., Foord, S. M., Wise, A. and Dowell, S. J. (2003). The orphan G-protein coupled receptors GPR41 and GPR43 are activated by propionate and other Short chain carboxylic acids. Journal of Biological Chemistry 278:11312-11319.
11. Butzner, J. D., Parmar, R., Bell, C. J. and Dalai, V. (1996). Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat. Gut 38:568-573.
12. Campos, F. G., Waitzberg, D. L., Teixeira, M. G., Mucerino, D. R., Kiss, D. R. and Habr-Gama, A. (2003). Pharmacological nutrition in inflammatory bowel diseases. Nutricion Hospitalaria 18:57-64.
13. Canto, E., Ricart, E., Montford, D., Gonzalez-Juan, D., Balanzo, J., Rodriguez-Sanchez, J. L. and Vidal, S. (2006). TNF-alpha production to TLR2 ligands in active IBD patients. Clinical Immunology 119:156-165.
14. Cavaglieri, C. R., Nishiyama, A., Fernandes, L. C., Curi, R., Miles, E. A. and Calder, P. C. (2003). Differential effects of short-chain fatty acids on proliferation and production of proinflammatory and anti-inflammatory cytokines by cultured lymphocytes. Life Sciences 73:1683-1690.
15. Diakos, C, Prieschl, E. E., Saemann, M. D., Bohmig, G. A., Csong, R., Sobanov, Y., Baumruker, T. and Zlabinger, G. J. (2006). N-Butyrate inhibits Jun. NH (2)-terminal kinase activation and cytokine transcription in mast cells. Biochemical Biophysical Research Communications 349:863-868.
16. Di Sabatino, A., Morera, R., Ciccocioppo, R., Cazzola, P. Gotti, S., Tinozzi, F. P., Tinozzi, S. and Corazza, G. R. (2005). Oral butyrate for mildly to moderately active Crohn's disease. Alimentary Pharmacological Therapy 22:789-794.
17. Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M. and O'Garra, A. (1991). IL-10 inhibits cytokine production by activated macrophages. Journal of Immunology 147:3815-3822.
18. Foey, A. D., Parry, S. L., Williams, L. M., Feldmann, M., Foxwell, B. M. J, and Brennan, EM. (1998). Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNFα: role of the p38 and p42/44 mitogen-activated protein kinases. Journal of Immunology 160:920-928.
19. Foey, A. D., Feldmann, M. and Brennan, EM. (2000). Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression. Cytokine 12:1496-1505.
20. Huuskonen, J., Suuronen, T., Nuutinen, T., Kyrylenko, S. and Salminen, A. (2004). Regulation of microglial inflammatory response by sodium butyrate and shortchain fatty acids. British Journal of Pharmacology 141:874-880.
21. Klampfer, L., Huang, J., Sasazuki, T., Shirasawa, S. and Augenlicht, L. (2003). Inhibition of interferon? signalling by the short chain fatty acid butyrate. Molecular Cancer Research 1:855-862.
22. Lawrence, T., Gilroy, D. W, Colville-Nash, PR. and Willoughby, D. A. (2001). Possible new role for NF-[kappa]B in the resolution of inflammation. Nature Medicine 7:1291-1297.
23. Lawrence, T. and Fong, C. (2010). The resolution of inflammation: anti-inflammatory roles for NF-kB. International Journal of Biochemistry & Cellular Biology 42:519-523.
24. Luhrs, H., Gerke, T, Muller, J. G., Melcher, R., Schauber, E, Boxberger, E, Scheppach, W and Menzel, T. (2002). Butyrate inhibits NF-kB activation in lamina propria macrophages of patients with ulcerative colitis. Scandinavian Journal of Gastroenterology 27:458-466.
25. Maa M, Chang, M. Hsier M., Chen, Y., Yang, C., Chen, Z., Li Y., Yen. C., Wu, R. and Leu. T. (2010). Butyrate reduced Lipopolysaccharidemediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. Journal of Nutritional Biochemistry 21:1186-1192.
26. Mahida, Y. R. (2000). The key role of macrophages in the immunopathogenesis of inflammatory bowel disease. Inflammatory Bowel Diseases 6:21-33.
27. Mahida, Y. R. and Rolfe, V. E. (2004). Host-bacterial interactions in inflammatory bowel disease. Clinical Sciences 107:331-341.
28. Millard, A. J, Mertes, P. M., Ittelet, D., Villard, E, Jeannesson, P. and Bernard, J. (2002). Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages. Clinical & Experimental Immunology 130:245-255.
29. Miller, S. J., Zaloga, G. P., Hoggatt, A. M., Labarrere, C. and Faulk, W. P. (2005). Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules. Nutrition 21:740-748.
30. Mills, CD., Kincaid, K., Alt, J. M., Heilman, M. J. and Hill, AM. (2000). M-1/M-2 macrophages and the Thl/Th2 paradigm. Journal of Immunology 164:6166-6173.
31. Mosser, D. M. and Edwards, J. P. (2008). Exploring the full spectrum of macrophage activation. Nature Reviews Immunology 8:958-969.
32. Neurath, M. F., Becker, C. and Barbulescu, K. (1998). Role of NF-kB in immune and inflammatory responses in the gut. Gut 43:856-860.
33. Park, J.-S., Lee, E.-J., Lee, J.-C., Kim, W.-K. and Kim, H.-S. (2007). Anti-inflammatory effects of short chain fatty acids in IFNγ stimulated RAW 264.7 murine macrophage cells: involvement of NFkB and ERK signalling pathways. International Immunopharmacology 7:70-77.
34. Platt, AM. and Mowat, AM. (2008). Mucosal macrophages and the regulation of immune responses in the intestine. Immunology Letters. 119:22-31.
35. Rhee, K.-J., Sethupathi, P., Driks, A, Lanning, D. K. and Knight, K. L (2004). Role of commensal bacteria in the development of gut-associated lymphoid tissues and preimmune antibody repertoire. Journal of Immunology 172:1118-1124.
36. Roediger, W. E. (1980). The colonic epithelium in ulcerative colitis: an essential energy deficiency disease? Lancet 36:712-715.
37. Saccani, A, Schioppa, T., Porta, G, Biswas, S. K., Nebuloni, M., Vago, L., Bottazzi, B., Colombo, M. P., Mantovani, A. and Sica, A (2006). p50 nuclear factor-kappaB overexpression in tumour-associated macrophages inhibits M1 inflammatory responses and anti-tumour resistance. Cancer Research 66:11432-11440.
38. Saemann, M. D., Bohmig, G. A., Osterreicher, C. H., Burtscher, H., Parolini, O., Diakos, C, Stockl, J., Horl, W. H. and Zlabinger, G. J. (2000). Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB Journal 14:2380-2382.
39. Schenk, M. and Mueller, C. (2007). Adaptations of intestinal macrophages to an antigen-rich environment. Seminars in Immunology 19:84-93.
40. Scheppach, W., Bartram, H. P. and Richter, F. (1995). Role of SCFA in prevention of colorectal cancer. European Journal of Cancer 31 A: 1077-1080.
41. Schwab, M., Reynersb, V., Shastin, Y., Loitsch, S., Stein, J., and Schroder, O. (2007). Role of nuclear hormone receptors in butyrate up regulation of antimicrobial peptide cathelicidin in epithelial colorectal cells. Molecular Immunology 44:2107-2114.
42. Segain, J. P., Raingeard Dela Blentiere, D., Boureille, A., Leray, V., Gerrois, N., Rosales, C., Ferner, L., Bonnet, C., Ferner, L., Bonnet, C, Blottiere, H. M. and Galmiche, J. P. (2000). Butyrate inhibits inflammatory responses through NFkβ; implications for Crohn's disease. Gut 47:397-403.
43. Simpson, E. J., Chapman, M. A. S., Dawson, J., Berry, D., MacDonald, IA and Cole, A. (2000). In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis. Gut 46:73-77.
44. Smith, P. D., Smythies X., Mosteller-Barnum, M., Sibley. D., Russell, M., Merger, M., Sellers. S., Orenstein, J., Shimada, T., Graham, M. and Kubagawa, H. (2001). Intestinal macrophages lack CD 14 and CD89 and consequently downregulated for LPS- and IgA-mediated activities. Journal of Immunology 167:2651-2656.
45. Smythies, L. E., Sellers, M., Clements, R. H., Mosteller-Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M. and Smith, P. D. (2005). Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. Journal of Clinical Investigation 115:66-75.
46. Soderberg, L. S., Boger, S., Fifer, E. K. and Gilbert, K. M. (2004). Macrophage production of inflammatory mediators is potently inhibited by butyric acid derivative demonstrated to inactivate antigen-stimulated T cells. International Immunopharmacology 4:1231-1239.
47. Stallmach, A, Schafer, E, Hoffman, S., Weber, S., Muller-Molaian, I., Schneider, T, Kohne, G., Ecker, K. W., Feifel, G. and Zeltz, M. (1998). Increased state of activation of CD4 positive T cells and elevated interferon gamma production in pouchitis. Gut 43:499-505.
48. Takk, P. P. and Firestein, G. S. (2001). NFkB: a key role in inflammatory diseases. Journal of Clinical Investigation 107:7-11.
49. Van Nuenen, M. H. M. C, Deligt, R. A. F., Doornbos, R. P., Van Der Woude, J. C. J., Kuipers, E. J. and Venema, K. (2005). The influence of microbial metabolites on intestinal epithelial cells and macrophage in vitro. FEMS Immunology and Medical Microbiology 45:183-189.
50. Venkatraman, A, Ramakrishna, B. S., Pulimood, A, Patra, S. and Murthy, S. (2000). Increased permeability in dextran sulphate colitis in rats: time course of development and effect of butyrate. Scandinavian Journal of Gastroenterology 35:1053-1059.
51. Venkatraman, A., Ramakrishna, B. S., Shaji, R. V., Nanda Kumar, N. S., Pulimood, A. and Patra, S. (2003). Amelioration of dextran sulphate colitis by butyrate: role of heat shock protein 70 and NF-kB. American Journal of Physiology Gastrointestinal & Liver Physiology 285:G177-G184.
52. Willemsen, L. E. M., Koetsier, M. A., Van Deventer, S. J. and Van Tol, E. A. E (2003). Short chain fatty acids stimulate epithelial mucin expression through differential effects on PGE1 and 2 production by intestinal myofibroblasts. Gut 52:1442-1447.
53. Yin, L., Laevsky, G. and Giardina, C. (2001). Butyrate suppression of colonocyte NFkB activation and cellular proteosome activity. Journal of Biological Chemistry 276:44641-44646.
54. Zapolska-Downar, D., Siennicka, A., Kaczmarczyk, M., Kolodziej, B. and Naruszewicz, M. (2004). Butyrate inhibits cytokine-induced VCAM and ICAM-1 expression in cultured endothelial cells. Journal of Nutritional Biochemistry 15:220-228.
55. Zareie M., Singh, P. K., Irvine E. J., Sherman, P. M., McKay, D. M. and Perdue, M. H. (2001). Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn's disease. American Journal of Pathology 158:1101-1109.
56. Ziegler-Heitbrock, L. (2001). The p50-homodimer mechanism in tolerance to LPS. Journal of Endotoxin Research 7:219-222.