Regulation of de novo ceramide synthesis: The role of dihydroceramide desaturase and transcriptional factors NFATC and Hand2 in the hypoxic mouse heart

DNA and Cell Biology

Volumn 32, Issue 6, 2013, Pages 310-319

  Azzam, Raed ^a   Hariri, Fadi ^a   El Hachem, Nehmé ^a   Kamar, Amina ^a   Dbaibo, Ghassan ^a   Nemer, Georges ^a   Bitar, Fadi ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIHYDROCERAMIDE DESATURASE; ENZYME; MESSENGER RNA; TRANSCRIPTION FACTOR HAND 2; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HEART MUSCLE ISCHEMIA; HYPOXIA; IMMUNOPRECIPITATION; IN VIVO STUDY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SYNTHESIS;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELL LINE; CERAMIDES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART VENTRICLES; HUMANS; MEMBRANE PROTEINS; MICE; MYOCARDIUM; NFATC TRANSCRIPTION FACTORS; OXIDOREDUCTASES; PROMOTER REGIONS, GENETIC;

MUS;

EID: 84878432481     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2013.1993     Document Type: Article

References (27)

1. Adrogue, J. V., Sharma, S., Ngumbela, K., Essop, M. F., and Taegtmeyer, H. (2005). Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle. Mol Cell Biochem 278, 71-78.
2. Bruneau, B. G., Nemer, G., Schmitt, J. P., Charron, F., Robitaille, L., Caron, S., Conner, D. A., Gessler, M., Nemer, M., Seidman, C. E., et al. (2001) A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106, 709-721.
3. de Frutos, S., Nitta, C. H., Caldwell, E., Friedman, J., and Gonzalez Bosc, L. V. (2009). Regulation of soluble guanylyl cyclasealpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. Am J Physiol Lung Cell Mol Physiol 297, L475-L486.
4. de Frutos, S., Spangler, R., Alo, D., and Bosc, L. V. (2007). NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. J Biol Chem 282, 15081-15089.
5. Geley, S., Hartmann, B. L., and Kofler, R. (1997). Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 400, 15-18.
6. Georges, R., Nemer, G., Morin, M., Lefebvre, C., and Nemer, M. (2008). Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation. Mol Cell Biol 28, 4052-4067.
7. Giordano, F. J. (2005). Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115, 500-508.
8. Kang, M. S., Ahn, K. H., Kim, S. K., Jeon, H. J., Ji, J. E., Choi, J. M., Jung, K. M., Jung, S. Y., and Kim, D. K. (2010). Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase. Cell Signal 22, 610-618.
9. Kraveka, J. M., Li, L., Szulc, Z. M., Bielawski, J., Ogretmen, B., Hannun, Y. A., Obeid, L. M., and Bielawska, A. (2007). Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 282, 16718-16728.
10. Lepple-Wienhues, A., Belka, C., Laun, T., Jekle, A., Walter, B., Wieland, U., Welz, M., Heil, L., Kun, J., Busch, G., et al. (1999). Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci U S A 96, 13795-13800.
11. Melchert, R. B., Joseph, J., and Kennedy, R. H. (2002). Interaction of xenobiotics with myocardial signal transduction pathways. Cardiovasc Toxicol 2, 1-23.
12. Menuz, V., Howell, K. S., Gentina, S., Epstein, S., Riezman, I., Fornallaz-Mulhauser, M., Hengartner, M. O., Gomez, M., Riezman, H., andMartinou, J. C. (2009). Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 324, 381-384.
13. Mizutani, Y., Kihara, A., and Igarashi, Y. (2005). Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 390, 263-271.
14. Molkentin, J. D., Lu, J. R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., and Olson, E. N. (1998). A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228.
15. Morin, S., Charron, F., Robitaille, L., and Nemer, M. (2000). GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J 19, 2046-2055.
16. Nemer, G., and Nemer, M. (2001). Regulation of heart development and function through combinatorial interactions of transcription factors. Ann Med 33, 604-610.
17. Nemer, G., and Nemer, M. (2002). Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 129, 4045-4055.
18. Nemer, G., and Nemer, M. (2003). Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and-6. Dev Biol 254, 131-148.
19. Noureddine, L., Azzam, R., Nemer, G., Bielawski, J., Nasser, M., Bitar, F., and Dbaibo, G. S. (2008). Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages. Prostaglandins Other Lipid Mediat 86, 49-55.
20. Perry, D. K., Carton, J., Shah, A. K., Meredith, F., Uhlinger, D. J., and Hannun, Y. A. (2000). Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275, 9078-9084.
21. Schiffmann, S., Hartmann, D., Fuchs, S., Birod, K., Ferreiros, N., Schreiber, Y., Zivkovic, A., Geisslinger, G., Grosch, S., and Stark, H. (2012). Inhibitors of specific ceramide synthases. Biochimie 94, 558-565.
22. Schulz, A., Mousallem, T., Venkataramani, M., Persaud-Sawin, D. A., Zucker, A., Luberto, C., Bielawska, A., Bielawski, J., Holthuis, J. C., Jazwinski, S. M., et al. (2006). The CLN9 protein, a regulator of dihydroceramide synthase. J Biol Chem 281, 2784-2794.
23. Schulze, H., Michel, C., and van Echten-Deckert, G. (2000). Dihydroceramide desaturase. Methods Enzymol 311, 22-30.
24. Shimoda, L. A., Wang, J., and Sylvester, J. T. (2006). Ca2 + channels and chronic hypoxia. Microcirculation 13, 657-670.
25. Sridevi, P., Alexander, H., Laviad, E. L., Pewzner-Jung, Y., Hannink, M., Futerman, A. H., and Alexander, S. (2009). Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta 1793, 1218-1227.
26. Thattaliyath, B. D., Livi, C. B., Steinhelper, M. E., Toney, G. M., and Firulli, A. B. (2002). HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Biochem Biophys Res Commun 297, 870-875.
27. Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H., and Webster, K. A. (2001). Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem 276, 12645-12653.