Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle

Molecular and Cellular Biochemistry

Volumn 278, Issue 1-2, 2005, Pages 71-78

  Adrogue, Julia V ^a   Sharma, Saumya ^a   Ngumbela, Kholiswa ^b   Essop, M Faadiel ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Gene expression; Hypertrophy; Hypoxia; Right ventricle

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FATTY ACID; GLUCOSE; ISOPROTEIN; MYOSIN HEAVY CHAIN; OXYGEN;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENVIRONMENTAL EXPOSURE; FATTY ACID METABOLISM; GENE EXPRESSION; GLUCOSE METABOLISM; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE OVERLOAD; HISTOPATHOLOGY; HYPOBARISM; ISOLATED HEART; LONG TERM EXPOSURE; MALE; NONHUMAN; RAT; SARCOMERE; TRANSCRIPTION REGULATION;

ACCLIMATIZATION; AIR PRESSURE; ANIMALS; ANOXIA; ATRIAL NATRIURETIC FACTOR; CARBOHYDRATE METABOLISM; HEART VENTRICLES; LIPID METABOLISM; MALE; MUSCLE PROTEINS; RATS; RATS, WISTAR; TIME FACTORS; TRANSCRIPTION, GENETIC;

RATTUS NORVEGICUS;

EID: 26444480274     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-6629-5     Document Type: Article

References (26)

1. Hochachka P: Mechanism and evolution of hypoxia-tolerance in humans. J Exp Biol 201: 1243-1254, 1998 9510535
2. Hochachka PW, Lutz PL: Mechanism, origin, and evolution of anoxia tolerance in animals. Comp Biochem Physiol B Biochem Mol Biol 130: 435-459, 2001
3. Sharma S, Taegtmeyer H, Adrogue J, Razeghi P, Sen S, Ngumbela K, Essop MF: Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy. Am J Cardiol Heart Circ Physiol 286: H1185-H1192, 2004 10.1152/ajpheart.00916.2003
4. Ngumbela KC, Sack MN, Essop MF: Counter-regulatory effects of incremental hypoxia on the transcription of a cardiac fatty acid oxidation enzyme-encoding gene. Mol Cell Biochem 250: 151-158, 2003 10.1023/A:1024921329885
5. Bancroft JD, Stevens A (eds): Theory of Histological Techniques. Churchill and Livingstone, London, UK, 1991, pp 165-166
6. Depre C, Shipley GL, Chen W, Han Q, Doenst T, Moore ML, Stepkowski S, Davies PJA, Taegtmeyer H: Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature Medicine 4: 1269-1275, 1998 10.1038/3253
7. Young ME, Razeghi P, Taegtmeyer H: Clock genes in the heart: characterization and attenuation with hypertrophy. Circ Res 88: 1142-1150, 2001 11397780
8. Torsoni A, Constancio S, Nadruz WJ, Hanks S, Franchini K: Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res 93: 140-147, 2003 10.1161/ 01.RES.0000081595.25297.1B
9. Barger PM, Kelly DP: PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 10: 238-245, 2000 10.1016/ S1050-1738(00)00077-3
10. Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP: Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest 105: 1723-1730, 2000 10862787
11. Razeghi P, Young ME, Abbasi S, Taegtmeyer H: Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun 287: 5-10, 2001 10.1006/bbrc.2001.5541
12. Young ME, Laws FA, Goodwin GW, Taegtmeyer H: Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 276: 44390-44395, 2001 10.1074/jbc.M103826200
13. Sugden MC, Langdown ML, Harris RA, Holness MJ: Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: Role of thyroid hormone status and lipid supply. Biochem J 352: 731-738, 2000 10.1042/0264-6021:3520731
14. Depre C, Vanoverschelde JLJ, Taegtmeyer H: Glucose for the heart. Circulation 99: 578-588, 1999 9927407
15. Santalucia T, Camps M, Castello A, Munoz P, Nuel A, Testar X, Palacin M, Zorzano A: Developmental regulation of GLUT-1 (Erythroid/HepG2) and GLUT-4 (Muscle/Fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue. Endocrinology 130: 837-846, 1992 1370797
16. Pope B, Hoh JF, Weeds A: The ATPase activities of rat cardiac myosin isoenzymes. FEBS Lett 118: 205-208, 1980 10.1016/0014-5793(80)80219-5
17. Morkin E: Control of cardiac myosin heavy chain gene expression. Microsc Res Tech 50: 522-531, 2000 10.1002/ 1097-0029(20000915)50:6<522::AID-JEMT9>3.0.CO;2-U
18. Bers DM: Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Front Biosci 7: D1697-d1711, 2002 12086924
19. 2+ content in isolated failing and nonfailing human myocardium. Circ Res 85: 38-46, 1999 10400909
20. Johnson D, Tetzke T, Cheung C: Gene expression of atrial natriuretic factor in ovine fetal heart during development. J Soc Gynecol Investig 1: 14-18, 1994 9419740
21. Razeghi P, Young ME, Alcorn JL, Moravec CS, Frazier OH, Taegtmeyer H: Metabolic gene expression in fetal and failing human heart. Circulation 104: 2923-2931, 2001 11739307
22. Sack MN, Disch DL, Rockman HA, Kelly DP: A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophy growth program. Proc Natl Acad Sci USA 94: 6438-6443, 1997 10.1073/pnas.94.12.6438
23. Singer D: Neonatal toleraAce to hypoxia: a comparative-physiological approach. Comp Biochem Physiol A Mol Integr Physiol 123: 221-234, 1999 10.1016/S1095-6433(99)00057-4
24. Reed T, Babu G, Ji Y, Zilberman A, Ver Heyen M, Wuytack F, Periasamy M: The expression of SR calcium transport ATPase and the Na(+)/ Ca(2+)Exchanger are antithetically regulated during mouse cardiac development and in Hypo/hyperthyroidism. J Mol Cell Cardiol 32: 453-464, 2000 10731444
25. Izumo S, Nadal-Ginard B, Mahdavi V: Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 85: 339-343, 1988 2963328
26. Schneider M, Roberts R, Parker T: Modulation of cardiac genes by mechanical stress. The oncogene signalling hypothesis. Mol Biol Med 8: 167-183, 1991 1839641