메뉴 건너뛰기




Volumn 304, Issue 8, 2013, Pages

AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat

Author keywords

5 aminoimidazole 4 carboxamide 3 ribonucleoside; Angiogenic balance; Hypertension; Preeclampsia

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CATALASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; DRUG DERIVATIVE; FLT1 PROTEIN, RAT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; RIBONUCLEOTIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

EID: 84878427460     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00903.2012     Document Type: Article
Times cited : (33)

References (39)
  • 1
    • 76149144326 scopus 로고    scopus 로고
    • Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial
    • Agarwal N, Rice SPL, Bolusani H, Luzio SD, Dunseath G, Ludgate M, Rees DA. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial. J Clin Endocrinol Metab 95: 722-730, 2010.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 722-730
    • Agarwal, N.1    Rice, S.P.L.2    Bolusani, H.3    Luzio, S.D.4    Dunseath, G.5    Ludgate, M.6    Rees, D.A.7
  • 3
    • 84866388606 scopus 로고    scopus 로고
    • Timing of ischemic insult alters fetal growth trajectory, maternal angiogenic balance and markers of renal oxidative stress in the pregnant rat
    • Banek CT, Bauer AJ, Gingery A, Gilbert JS. Timing of ischemic insult alters fetal growth trajectory, maternal angiogenic balance and markers of renal oxidative stress in the pregnant rat. Am J Physiol Regul Integr Comp Physiol 303: R658-R664, 2012.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303
    • Banek, C.T.1    Bauer, A.J.2    Gingery, A.3    Gilbert, J.S.4
  • 4
    • 80053257228 scopus 로고    scopus 로고
    • Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect
    • Bosselaar M, Smits P, van Loon LJC, Tack CJ. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. J Clin Pharmacol 51: 1449-1458, 2012.
    • (2012) J Clin Pharmacol , vol.51 , pp. 1449-1458
    • Bosselaar, M.1    Smits, P.2    van Loon, L.J.C.3    Tack, C.J.4
  • 5
  • 6
    • 0036307179 scopus 로고    scopus 로고
    • Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
    • Buhl ES, Jessen N, Pold R, Ledet T, Flyvbjerg A, Pedersen SB, Pedersen O, Schmitz O, Lund S. Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes 51: 2199-2206, 2002.
    • (2002) Diabetes , vol.51 , pp. 2199-2206
    • Buhl, E.S.1    Jessen, N.2    Pold, R.3    Ledet, T.4    Flyvbjerg, A.5    Pedersen, S.B.6    Pedersen, O.7    Schmitz, O.8    Lund, S.9
  • 8
    • 0025863078 scopus 로고
    • AICA-riboside: Safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent
    • Dixon R, Gourzis J, McDermott D, Fujitaki J, Dewland P, Gruber H. AICA-riboside: safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent. J Clin Pharmacol 31: 342-347, 1991.
    • (1991) J Clin Pharmacol , vol.31 , pp. 342-347
    • Dixon, R.1    Gourzis, J.2    McDermott, D.3    Fujitaki, J.4    Dewland, P.5    Gruber, H.6
  • 10
    • 84858702507 scopus 로고    scopus 로고
    • AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats
    • Ford RJ, Teschke SR, Reid EB, Durham KK, Kroetsch JT, Rush JW. AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats. J Hypertens 30: 725-733, 2012.
    • (2012) J Hypertens , vol.30 , pp. 725-733
    • Ford, R.J.1    Teschke, S.R.2    Reid, E.B.3    Durham, K.K.4    Kroetsch, J.T.5    Rush, J.W.6
  • 11
    • 78651285381 scopus 로고    scopus 로고
    • Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent
    • Ford RJ, Rush JWE. Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent. Am J Physiol Heart Circ Physiol 300: H64-H75, 2011.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Ford, R.J.1    Rush, J.W.E.2
  • 13
    • 84862609102 scopus 로고    scopus 로고
    • Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet
    • Frier BC, Wan Z, Williams DB, Stefanson AL, Wright DC. Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet. Am J Physiol Cell Physiol 302: C1772-C1779, 2012.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Frier, B.C.1    Wan, Z.2    Williams, D.B.3    Stefanson, A.L.4    Wright, D.C.5
  • 14
    • 78649873524 scopus 로고    scopus 로고
    • Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants
    • George EM, Cockrell K, Adair TH, Granger JP. Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants. Am J Physiol Regul Integr Comp Physiol 299: R1629-R1633, 2010.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299
    • George, E.M.1    Cockrell, K.2    Adair, T.H.3    Granger, J.P.4
  • 16
    • 36448996940 scopus 로고    scopus 로고
    • Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble Fms-like tyrosine kinase-1 expression
    • Gilbert JS, Babcock SA, Granger JP. Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble Fms-like tyrosine kinase-1 expression. Hypertension 50: 1142-1147, 2007.
    • (2007) Hypertension , vol.50 , pp. 1142-1147
    • Gilbert, J.S.1    Babcock, S.A.2    Granger, J.P.3
  • 17
    • 84870243564 scopus 로고    scopus 로고
    • Exercise training attenuates placental ischemia induced hypertension and angiogenic imbalance in the rat
    • Gilbert JS, Banek CT, Bauer AJ, Gingery A, Needham KM. Exercise training attenuates placental ischemia induced hypertension and angiogenic imbalance in the rat. Hypertension 60: 1545-1551, 2012.
    • (2012) Hypertension , vol.60 , pp. 1545-1551
    • Gilbert, J.S.1    Banek, C.T.2    Bauer, A.J.3    Gingery, A.4    Needham, K.M.5
  • 18
    • 74949100277 scopus 로고    scopus 로고
    • Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placental ischemia-induced hypertension
    • Gilbert JS, Verzwyvelt J, Colson D, Arany M, Karumanchi SA, Granger JP. Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placental ischemia-induced hypertension. Hypertension 55: 380-385, 2009.
    • (2009) Hypertension , vol.55 , pp. 380-385
    • Gilbert, J.S.1    Verzwyvelt, J.2    Colson, D.3    Arany, M.4    Karumanchi, S.A.5    Granger, J.P.6
  • 20
    • 3042685726 scopus 로고    scopus 로고
    • Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy
    • Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod 19: 1323-1330, 2004.
    • (2004) Hum Reprod , vol.19 , pp. 1323-1330
    • Glueck, C.J.1    Goldenberg, N.2    Pranikoff, J.3    Loftspring, M.4    Sieve, L.5    Wang, P.6
  • 21
    • 77953731921 scopus 로고    scopus 로고
    • Chronic placental ischemia alters amniotic fluid milieu and results in impaired glucose tolerance, insulin resistance and hyperleptinemia in young rats
    • Heltemes A, Gingery A, Soldner EL, Bozadjieva N, Jahr KN, Johnson BK, Gilbert JS. Chronic placental ischemia alters amniotic fluid milieu and results in impaired glucose tolerance, insulin resistance and hyperleptinemia in young rats. Exp Biol Med (Maywood) 235: 892-899, 2010.
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 892-899
    • Heltemes, A.1    Gingery, A.2    Soldner, E.L.3    Bozadjieva, N.4    Jahr, K.N.5    Johnson, B.K.6    Gilbert, J.S.7
  • 22
    • 0037379283 scopus 로고    scopus 로고
    • Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles
    • Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S. Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. J Appl Physiol 94: 1373-1379, 2003.
    • (2003) J Appl Physiol , vol.94 , pp. 1373-1379
    • Jessen, N.1    Pold, R.2    Buhl, E.S.3    Jensen, L.S.4    Schmitz, O.5    Lund, S.6
  • 23
    • 70350668791 scopus 로고    scopus 로고
    • The 5= adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
    • Karagounis LG, Hawley JA. The 5= adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics. Int J Biochem Cell Biol 41: 2360-2363, 2009.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 2360-2363
    • Karagounis, L.G.1    Hawley, J.A.2
  • 24
    • 0041413142 scopus 로고    scopus 로고
    • The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle
    • Lemieux K, Konrad D, Klip A, Marette A. The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle. FASEB J 17: 1658-1665, 2003.
    • (2003) FASEB J , vol.17 , pp. 1658-1665
    • Lemieux, K.1    Konrad, D.2    Klip, A.3    Marette, A.4
  • 25
    • 84863673300 scopus 로고    scopus 로고
    • A model of preeclampsia in rats: The reduced uterine perfusion pressure (RUPP) model
    • Li J, LaMarca B, Reckelhoff JF. A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model. Am J Physiol Heart Circ Physiol 303: H1-H8, 2012.
    • (2012) Am J Physiol Heart Circ Physiol , vol.303
    • Li, J.1    LaMarca, B.2    Reckelhoff, J.F.3
  • 28
    • 17844372519 scopus 로고    scopus 로고
    • Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia
    • Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA. Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatr Res 57: 1R-7R, 2005.
    • (2005) Pediatr Res , vol.57
    • Maynard, S.E.1    Venkatesha, S.2    Thadhani, R.3    Karumanchi, S.A.4
  • 29
    • 83155181554 scopus 로고    scopus 로고
    • Threshold of soluble fms-like tyrosine kinase 1/placental growth factor ratio for the imminent onset of preeclampsia
    • Ohkuchi A, Hirashima C, Matsubara S, Takahashi K, Matsuda Y, Suzuki M. Threshold of soluble fms-like tyrosine kinase 1/placental growth factor ratio for the imminent onset of preeclampsia. Hypertension 58: 859-866, 2011.
    • (2011) Hypertension , vol.58 , pp. 859-866
    • Ohkuchi, A.1    Hirashima, C.2    Matsubara, S.3    Takahashi, K.4    Matsuda, Y.5    Suzuki, M.6
  • 32
    • 0037341925 scopus 로고    scopus 로고
    • Summary of the NHLBI working group on research on hypertension during pregnancy
    • Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertension 41: 437-445, 2003.
    • (2003) Hypertension , vol.41 , pp. 437-445
    • Roberts, J.M.1    Pearson, G.2    Cutler, J.3    Lindheimer, M.4
  • 33
  • 34
    • 0033820422 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes
    • Salt IP, Connell JM, Gould GW. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 49: 1649-1656, 2000.
    • (2000) Diabetes , vol.49 , pp. 1649-1656
    • Salt, I.P.1    Connell, J.M.2    Gould, G.W.3
  • 36
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43: 647-654, 1994.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 38
    • 79251477152 scopus 로고    scopus 로고
    • Metformin improves cardiac function in rats via activation of AMP-activated protein kinase
    • Wang XF, Zhang JY, Li L, Zhao XY, Tao HL, Zhang L. Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. Clin Exp Pharmacol Physiol 38: 94-101, 2011.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 94-101
    • Wang, X.F.1    Zhang, J.Y.2    Li, L.3    Zhao, X.Y.4    Tao, H.L.5    Zhang, L.6
  • 39
    • 57649180479 scopus 로고    scopus 로고
    • AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
    • Zwetsloot KA, Westerkamp LM, Holmes BF, Gavin TP. AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise. J Physiol 586: 6021-6035, 2008.
    • (2008) J Physiol , vol.586 , pp. 6021-6035
    • Zwetsloot, K.A.1    Westerkamp, L.M.2    Holmes, B.F.3    Gavin, T.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.