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Volumn 29, Issue 1, 2012, Pages 88-94

Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells

Author keywords

AICAR; AMP activated protein kinase; Metabolic profiling; NMR spectroscopy

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALANINE; ASPARTIC ACID; BETAINE; CHOLINE; CREATINE; CREATINE PHOSPHATE; ETHANOLAMINE; FAT DROPLET; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHOETHANOLAMINE; SATURATED FATTY ACID;

EID: 84855179327     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.802     Document Type: Article
Times cited : (9)

References (31)
  • 3
    • 33745225026 scopus 로고    scopus 로고
    • AMP-activated protein kinase - Development of the energy sensor concept
    • DOI 10.1113/jphysiol.2006.108944
    • Hardie DG, Hawley SA and Scott JW: AMP-activated protein kinase: development of the energy sensor concept. J Physiol 574: 7-15, 2006. (Pubitemid 43905792)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 7-15
    • Hardie, D.G.1    Hawley, S.A.2    Scott, J.W.3
  • 4
    • 0035665594 scopus 로고    scopus 로고
    • Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
    • Bergeron R, Ren JM, Cadman KS, et al.: Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 281: E1340-E1346, 2001.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Bergeron, R.1    Ren, J.M.2    Cadman, K.S.3
  • 6
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • Lim CT, Kola B and Korbonits M: AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44: 87-97, 2010.
    • (2010) J Mol Endocrinol , vol.44 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 7
    • 77949683134 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A stress-responsive kinase with implications for cardiovascular disease
    • Li C and Keaney JF Jr: AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease. Curr Opin Pharmacol 10: 111-115, 2010.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 111-115
    • Li, C.1    Keaney Jr., J.F.2
  • 8
    • 85047689953 scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
    • Corton JM, Gillespie JG, Hawley SA and Hardie DG: 5-Aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229: 558-565, 1995.
    • (1995) Eur J Biochem , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 9
    • 0041413142 scopus 로고    scopus 로고
    • The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle
    • DOI 10.1096/fj.02-1125com
    • Lemieux K, Konrad D, Klip A and Marette A: The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle. FASEB J 17: 1658-1665, 2003. (Pubitemid 37100067)
    • (2003) FASEB Journal , vol.17 , Issue.12 , pp. 1658-1665
    • Lemieux, K.1    Konrad, D.2    Klip, A.3    Marette, A.4
  • 10
    • 41549084644 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation by 5-aminoimidazole-4- carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression
    • Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ and Park SY: AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J Pharmacol Sci 106: 394-403, 2008.
    • (2008) J Pharmacol Sci , vol.106 , pp. 394-403
    • Kim, J.E.1    Kim, Y.W.2    Lee, I.K.3    Kim, J.Y.4    Kang, Y.J.5    Park, S.Y.6
  • 11
    • 77953817830 scopus 로고    scopus 로고
    • Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells
    • Li H, Thali RF, Smolak C, et al.: Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol 299: F167-F177, 2010.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Li, H.1    Thali, R.F.2    Smolak, C.3
  • 12
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
    • Hardie DG and Carling D: The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur J Biochem 246: 259-273, 1997. (Pubitemid 27232500)
    • (1997) European Journal of Biochemistry , vol.246 , Issue.2 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 13
    • 0037083768 scopus 로고    scopus 로고
    • Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
    • DOI 10.1042/0264-6021:3620097
    • Houweling M, Klein W and Geelen MJ: Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). Biochem J 362: 97-104, 2002. (Pubitemid 34174466)
    • (2002) Biochemical Journal , vol.362 , Issue.1 , pp. 97-104
    • Houweling, M.1    Klein, W.2    Geelen, M.J.H.3
  • 14
    • 4043165350 scopus 로고
    • Removal of dipolar broadening of NMR spectra of solids by specimen rotation
    • Andrew ER and Eades RG: Removal of dipolar broadening of NMR spectra of solids by specimen rotation. Nature 183: 1802-1803, 1959.
    • (1959) Nature , vol.183 , pp. 1802-1803
    • Andrew, E.R.1    Eades, R.G.2
  • 15
    • 49049139340 scopus 로고
    • Magic-angle sample spinning of liquids
    • Garroway AN: Magic-angle sample spinning of liquids. J Magn Reson 49: 168-171, 1982.
    • (1982) J Magn Reson , vol.49 , pp. 168-171
    • Garroway, A.N.1
  • 16
    • 0031884049 scopus 로고    scopus 로고
    • Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells
    • Weybright P, Millis K, Campbell N, Cory DG and Singer S: Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells. Magn Reson Med 39: 337-345, 1998.
    • (1998) Magn Reson Med , vol.39 , pp. 337-345
    • Weybright, P.1    Millis, K.2    Campbell, N.3    Cory, D.G.4    Singer, S.5
  • 17
    • 0036792396 scopus 로고    scopus 로고
    • Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy
    • Griffin JL, Bollard M, Nicholson JK and Bhakoo K: Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed 15: 375-384, 2002.
    • (2002) NMR Biomed , vol.15 , pp. 375-384
    • Griffin, J.L.1    Bollard, M.2    Nicholson, J.K.3    Bhakoo, K.4
  • 18
    • 51649124711 scopus 로고    scopus 로고
    • Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling
    • Monleon D, Morales JM, Gonzalez-Darder J, et al.: Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling. J Proteome Res 7: 2882-2888, 2008.
    • (2008) J Proteome Res , vol.7 , pp. 2882-2888
    • Monleon, D.1    Morales, J.M.2    Gonzalez-Darder, J.3
  • 19
    • 78649712613 scopus 로고    scopus 로고
    • Protective effects of AMP-activated protein kinase in the cardiovascular system
    • Xu Q and Si LY: Protective effects of AMP-activated protein kinase in the cardiovascular system. J Cell Mol Med 14: 2604-2613, 2010.
    • (2010) J Cell Mol Med , vol.14 , pp. 2604-2613
    • Xu, Q.1    Si, L.Y.2
  • 20
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
    • Jaffe EA, Nachman RL, Becker CG and Minick CR: Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756, 1973.
    • (1973) J Clin Invest , vol.52 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, R.L.2    Becker, C.G.3    Minick, C.R.4
  • 21
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto Encyclopedia of Genes and Genomes
    • Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30, 2000. (Pubitemid 30047706)
    • (2000) Nucleic Acids Research , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 23
    • 0344528589 scopus 로고    scopus 로고
    • The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells
    • Barba I, Cabanas ME and Arus C: The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells. Cancer Res 59: 1861-1868, 1999. (Pubitemid 29186158)
    • (1999) Cancer Research , vol.59 , Issue.8 , pp. 1861-1868
    • Barba, I.1    Cabanas, M.E.2    Arus, C.3
  • 24
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC and Holmes E: 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181-1189, 1999.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 25
    • 77955429547 scopus 로고    scopus 로고
    • Metabolic preconditioning of cells with AICAR-riboside: Improved cryopreservation and cell-type specific impacts on energetics and proliferation
    • Menze MA, Chakraborty N, Clavenna M, et al.: Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and proliferation. Cryobiology 61: 79-88, 2010.
    • (2010) Cryobiology , vol.61 , pp. 79-88
    • Menze, M.A.1    Chakraborty, N.2    Clavenna, M.3
  • 26
    • 0033547339 scopus 로고    scopus 로고
    • The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells
    • Dagher Z, Ruderman N, Tornheim K and Ido Y: The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun 265: 112-115, 1999.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 112-115
    • Dagher, Z.1    Ruderman, N.2    Tornheim, K.3    Ido, Y.4
  • 27
    • 0034014002 scopus 로고    scopus 로고
    • Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro
    • Ojuka EO, Nolte LA and Holloszy JO: Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro. J Appl Physiol 88: 1072-1075, 2000. (Pubitemid 30154913)
    • (2000) Journal of Applied Physiology , vol.88 , Issue.3 , pp. 1072-1075
    • Ojuka, E.O.1    Nolte, L.A.2    Holloszy, J.O.3
  • 28
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG and Winder WW: AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273: E1107-E1112, 1997.
    • (1997) Am J Physiol , vol.273
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 29
    • 84855161459 scopus 로고    scopus 로고
    • AMPK and vasculoprotection
    • November 25, Epub ahead of print
    • Ewart MA and Kennedy S: AMPK and vasculoprotection. Pharmacol Ther: November 25, 2010 (Epub ahead of print).
    • (2010) Pharmacol Ther
    • Ewart, M.A.1    Kennedy, S.2
  • 30
    • 23844454317 scopus 로고    scopus 로고
    • Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism
    • Hallows KR: Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens 14: 464-471, 2005.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 464-471
    • Hallows, K.R.1
  • 31
    • 0037328989 scopus 로고    scopus 로고
    • A molecular approach to the concerted action of kinases involved in energy homoeostasis
    • Neumann D, Schlattner U and Wallimann T: A molecular approach to the concerted action of kinases involved in energy homoeostasis. Biochem Soc Trans 31: 169-174, 2003. (Pubitemid 36241421)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.1 , pp. 169-174
    • Neumann, D.1    Schlattner, U.2    Wallimann, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.