Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells

Molecular and Cellular Biochemistry

Volumn 379, Issue 1-2, 2013, Pages 37-42

  Iwayama, Hideyuki ^a   Ueda, Norishi ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Public Central Hospital of Matto Ishikawa   (Japan)

Author keywords

Bax; Caspases; Ceramide; Epidermal growth factor; Mitogen activated protein kinases; Renal proximal tubules

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CERAMIDE; EPIDERMAL GROWTH FACTOR; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE INHIBITORS; CASPASES; CELL LINE; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY TUBULES, PROXIMAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; SPHINGOSINE;

EID: 84878425543     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1624-8     Document Type: Article

References (32)

1. Morales A, Lee H, Goñi FM, Kolesnick R, Fernandez-Checa JC (2007) Sphingolipids and cell death. Apoptosis 12:923-939
2. Ueda N, Kaushal GP, Hong X, Shah SV (1998) Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Kidney Int 54:399-406
3. Ueda N, Camargo SM, Hong X, Basnakian AG, Walker PD, Shah SV (2001) Role of ceramide synthase in oxidant injury to renal tubular epithelial cells. J Am Soc Nephrol 12:2384-2391
4. Basnakian AG, Ueda N, Hong X, Galitovsky VE, Yin X, Shah SV (2005) Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Am J Physiol Renal Physiol 288:F308-F314
5. Autret A, Martin SJ (2009) Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol Cell 36:355-363
6. Zhang TH, Liu JF, Zhang Y, Li YL, Lu HT, Murata NM, Yamakawa T (2007) Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. Acta Pharmacol Sin 28:439-445
7. Kim HJ, Oh JE, Kim SW, Chun YJ, Kim MY (2008) Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer Lett 260:88-95
8. Blázquez C, Galve-Roperh I, Guzmán M (2000) De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J 14:2315-2322
9. Willaime S, Vanhoutte P, Caboche J, Lemaigre-Dubreuil Y, Mariani J, Brugg B (2001) Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. Eur J Neurosci 13:2037-2046
10. Oh HL, Seok JY, Kwon CH, Kang SK, Kim YK (2006) Role of MAPK in ceramide-induced cell death in primary cultured astrocytes from mouse embryonic brain. Neurotoxicology 27:31-38
11. Jarvis WD, Fornari FA Jr, Auer KL, Freemerman AJ, Szabo E, Birrer MJ, Johnson CR, Barbour SE, Dent P, Grant S (1997) Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol Pharmacol 52:935-947
12. Stoica BA, Movsesyan VA, Knoblach SM, Faden AI (2005) Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci 29:355-371
13. Kong JY, Klassen SS, Rabkin SW (2005) Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis. Mol Cell Biochem 278:39-51
14. Falluel-Morel A, Aubert N, Vaudry D, Basille M, Fontaine M, Fournier A, Vaudry H, Gonzalez BJ (2004) Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. J Neurochem 91:1231-1243
15. Qiu L, Zhou C, Sun Y, Di W, Scheffler E, Healey S, Wanebo H, Kouttab N, Chu W, Wan Y (2006) Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. Oncol Rep 16:907-913
16. Willaime-Morawek S, Brami-Cherrier K, Mariani J, Caboche J, Brugg B (2003) c-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. Neuroscience 119:387-397
17. Donato NJ, Klostergaard J (2004) Distinct stress and cell destruction pathways are engaged by TNF and ceramide during apoptosis of MCF-7 cells. Exp Cell Res 294:523-533
18. Henson ES, Gibson SB (2006) Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal 18:2089-2097
19. Sheng G, Guo J, Warner BW (2007) Epidermal growth factor receptor signaling modulates apoptosis via p38α MAPK-dependent activation of Bax in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 293:G599-G606
20. Iwayama H, Sakamoto T, Nawa A, Ueda N (2011) Crosstalk between Smad and MAPKs for the regulation of apoptosis in cyclosporine A-induced renal tubular injury. Nephron Extra 1:178-189
21. Ganesan V, Colombini M (2010) Regulation of ceramide channels by Bcl-2 family proteins. FEBS Lett 584:2128-2134
22. Martinou JC, Youle RJ (2011) Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21:92-101
23. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139:1281-1292
24. Er E, Oliver L, Cartron PF, Juin P, Manon S, Vallette FM (2006) Mitochondria as the target of the pro-apoptotic protein Bax. Biochim Biophys Acta 1757:1301-1311
25. Düssmann H, Rehm M, Concannon CG, Anguissola S, Würstle M, Kacmar S, Völler P, Huber HJ, Prehn JH (2010) Single-cell quantification of Bax activation and mathematical modeling suggest pore formation on minimal mitochondrial Bax accumulation. Cell Death Differ 17:278-290
26. Leber B, Lin J, Andrews DW (2007) Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis 12:897-911
27. Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Nozawa Y (2000) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells. Oncogene 19:3508-3520
28. Sawai H, Kawai S, Domae N (2004) Reduced expression of Bax in ceramide-resistant HL-60 subline. Biochem Biophys Res Commun 319:46-49
29. Poppe M, Reimertz C, Münstermann G, Kögel D, Prehn JH (2002) Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. J Neurochem 82:482-494
30. Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fucks Z, Kolesnick R (2011) Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. Plos One 6:e19783
31. Tikhomirov O, Carpenter G (2005) Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci 118:5681-5690
32. Payne SG, Brindley DN, Guilbert LJ (1999) Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. J Cell Physiol 180:263-270