메뉴 건너뛰기




Volumn 31, Issue 4-5, 2013, Pages 673-682

Upregulation of peptide transporters PEPT1 and PEPT2 by Janus kinase JAK2

Author keywords

Energy depletion; Intestine; JAK2 inhibitor AG490; Nutrient transport; Peptide transport

Indexed keywords

COMPLEMENTARY RNA; DIPEPTIDE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; BREFELDIN A;

EID: 84878421247     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000350086     Document Type: Article
Times cited : (46)

References (57)
  • 2
    • 77950356668 scopus 로고    scopus 로고
    • Narrative review: Thrombocytosis, polycythemia vera, and JAK2 mutations: The phenotypic mimicry of chronic myeloproliferation
    • Spivak JL: Narrative review: Thrombocytosis, polycythemia vera, and JAK2 mutations: The phenotypic mimicry of chronic myeloproliferation. Ann Intern Med 2010;152:300-306.
    • (2010) Ann Intern Med , vol.152 , pp. 300-306
    • Spivak, J.L.1
  • 4
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • Morris DL, Rui L: Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 2009;297:E1247-E1259.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Morris, D.L.1    Rui, L.2
  • 6
    • 77955921088 scopus 로고    scopus 로고
    • The growth hormone receptor: Mechanism of activation and clinical implications
    • Brooks AJ, Waters MJ: The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol 2010;6:515-525.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 515-525
    • Brooks, A.J.1    Waters, M.J.2
  • 7
    • 70350440089 scopus 로고    scopus 로고
    • JAK redux: A second look at the regulation and role of JAKs in the heart
    • Kurdi M, Booz GW: JAK redux: a second look at the regulation and role of JAKs in the heart. Am J Physiol Heart Circ Physiol 2009;297:H1545-H1556.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Kurdi, M.1    Booz, G.W.2
  • 11
    • 84856019851 scopus 로고    scopus 로고
    • Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene
    • Venkitachalam S, Chueh FY, Yu CL: Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun 2012;417:1058-1062.
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 1058-1062
    • Venkitachalam, S.1    Chueh, F.Y.2    Yu, C.L.3
  • 14
    • 79951510594 scopus 로고    scopus 로고
    • JAK2 inhibitors: What's the true therapeutic potential?
    • Santos FP, Verstovsek S: JAK2 inhibitors: What's the true therapeutic potential? Blood Rev 2011;25:53-63.
    • (2011) Blood Rev , vol.25 , pp. 53-63
    • Santos, F.P.1    Verstovsek, S.2
  • 16
    • 78650664262 scopus 로고    scopus 로고
    • The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors
    • Baskin R, Majumder A, Sayeski PP: The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors. Curr Med Chem 2010;17:4551-4558.
    • (2010) Curr Med Chem , vol.17 , pp. 4551-4558
    • Baskin, R.1    Majumder, A.2    Sayeski, P.P.3
  • 17
    • 79955675817 scopus 로고    scopus 로고
    • JAK2 Translocations in hematological malignancies: Review of the literature
    • Ho K, Valdez F, Garcia R, Tirado CA: JAK2 Translocations in hematological malignancies: Review of the literature. J Assoc Genet Technol 2010;36:107-109.
    • (2010) J Assoc Genet Technol , vol.36 , pp. 107-109
    • Ho, K.1    Valdez, F.2    Garcia, R.3    Tirado, C.A.4
  • 18
    • 77953529304 scopus 로고    scopus 로고
    • JAK2 V617F and beyond: Role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms
    • Oh ST, Gotlib J: JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms. Expert Rev Hematol 2010;3:323-337.
    • (2010) Expert Rev Hematol , vol.3 , pp. 323-337
    • Oh, S.T.1    Gotlib, J.2
  • 19
    • 77954581139 scopus 로고    scopus 로고
    • Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    • Tefferi A: Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010;24:1128-1138.
    • (2010) Leukemia , vol.24 , pp. 1128-1138
    • Tefferi, A.1
  • 25
    • 27144535106 scopus 로고    scopus 로고
    • Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs
    • DOI 10.1016/j.canlet.2004.12.023, PII S0304383504010018
    • Inoue M, Terada T, Okuda M, Inui K: Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Cancer Lett 2005;230:72-80. (Pubitemid 41506962)
    • (2005) Cancer Letters , vol.230 , Issue.1 , pp. 72-80
    • Inoue, M.1    Terada, T.2    Okuda, M.3    Inui, K.-I.4
  • 26
    • 48749131090 scopus 로고    scopus 로고
    • Peptide transporters and their roles in physiological processes and drug disposition
    • Rubio-Aliaga I, Daniel H: Peptide transporters and their roles in physiological processes and drug disposition. Xenobiotica 2008;38:1022-1042.
    • (2008) Xenobiotica , vol.38 , pp. 1022-1042
    • Rubio-Aliaga, I.1    Daniel, H.2
  • 28
    • 77952985477 scopus 로고    scopus 로고
    • PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport
    • Rexhepaj R, Rotte A, Pasham V, Gu S, Kempe DS, Lang F: PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport. Cell Physiol Biochem 2010;25:715-722.
    • (2010) Cell Physiol Biochem , vol.25 , pp. 715-722
    • Rexhepaj, R.1    Rotte, A.2    Pasham, V.3    Gu, S.4    Kempe, D.S.5    Lang, F.6
  • 31
    • 77954371389 scopus 로고    scopus 로고
    • The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase
    • Pieri M, Christian HC, Wilkins RJ, Boyd CA, Meredith D: The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. Am J Physiol Gastrointest Liver Physiol 2010;299:G136-G143.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299
    • Pieri, M.1    Christian, H.C.2    Wilkins, R.J.3    Boyd, C.A.4    Meredith, D.5
  • 32
    • 79951557949 scopus 로고    scopus 로고
    • Diverse roles of leptin in the gastrointestinal tract: Modulation of motility, absorption, growth, and inflammation
    • Yarandi SS, Hebbar G, Sauer CG, Cole CR, Ziegler TR: Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation. Nutrition 2011;27:269-275.
    • (2011) Nutrition , vol.27 , pp. 269-275
    • Yarandi, S.S.1    Hebbar, G.2    Sauer, C.G.3    Cole, C.R.4    Ziegler, T.R.5
  • 33
    • 11844264896 scopus 로고    scopus 로고
    • Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells
    • Alteheld B, Evans ME, Gu LH, Ganapathy V, Leibach FH, Jones DP, Ziegler TR: Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells. J Nutr 2005;135:19-26. (Pubitemid 40094315)
    • (2005) Journal of Nutrition , vol.135 , Issue.1 , pp. 19-26
    • Alteheld, B.1    Evans, M.E.2    Gu, L.H.3    Ganapathy, V.4    Leibach, F.H.5    Jones, D.P.6    Ziegler, T.R.7
  • 42
    • 1242272750 scopus 로고    scopus 로고
    • The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology
    • DOI 10.1007/s00424-003-1101-4, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Daniel H, Kottra G: The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch 2004;447:610-618. (Pubitemid 38241445)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 610-618
    • Daniel, H.1    Kottra, G.2
  • 43
    • 34347379290 scopus 로고    scopus 로고
    • + -coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    • DOI 10.1113/expphysiol.2005.029959
    • Thwaites DT, Anderson CM: H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 2007;92:603-619. (Pubitemid 47024940)
    • (2007) Experimental Physiology , vol.92 , Issue.4 , pp. 603-619
    • Thwaites, D.T.1    Anderson, C.M.H.2
  • 44
    • 56149103172 scopus 로고    scopus 로고
    • Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity
    • Kamal MA, Keep RF, Smith DE: Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity. Drug Metab Pharmacokinet 2008;23:236-242.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 236-242
    • Kamal, M.A.1    Keep, R.F.2    Smith, D.E.3
  • 45
    • 78651253877 scopus 로고    scopus 로고
    • Hijacking solute carriers for proton-coupled drug transport
    • Anderson CM, Thwaites DT: Hijacking solute carriers for proton-coupled drug transport. Physiology (Bethesda ) 2010;25:364-377.
    • (2010) Physiology (Bethesda) , vol.25 , pp. 364-377
    • Anderson, C.M.1    Thwaites, D.T.2
  • 46
    • 0032005174 scopus 로고    scopus 로고
    • An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2
    • Gonzalez DE, Covitz KM, Sadee W, Mrsny RJ: An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res 1998;58:519-525. (Pubitemid 28087417)
    • (1998) Cancer Research , vol.58 , Issue.3 , pp. 519-525
    • Gonzalez, D.E.1    Covitz, K.-M.Y.2    Sadee, W.3    Mrsny, R.J.4
  • 47
    • 61449455434 scopus 로고    scopus 로고
    • Review. The mammalian proton-coupled peptide cotransporter PepT1: Sitting on the transporter-channel fence?
    • Meredith D: Review. The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence? Philos Trans R Soc Lond B Biol Sci 2009;364:203-207.
    • (2009) Philos Trans R Soc Lond B Biol Sci , vol.364 , pp. 203-207
    • Meredith, D.1
  • 48
    • 77950543534 scopus 로고    scopus 로고
    • Bioavailability through PepT1: The role of computer modelling in intelligent drug design
    • Foley DW, Rajamanickam J, Bailey PD, Meredith D: Bioavailability through PepT1: the role of computer modelling in intelligent drug design. Curr Comput Aided Drug Des 2010;6:68-78.
    • (2010) Curr Comput Aided Drug des , vol.6 , pp. 68-78
    • Foley, D.W.1    Rajamanickam, J.2    Bailey, P.D.3    Meredith, D.4
  • 49
    • 80053351510 scopus 로고    scopus 로고
    • Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family
    • Newstead S: Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family. Biochem Soc Trans 2011;39:1353-1358.
    • (2011) Biochem Soc Trans , vol.39 , pp. 1353-1358
    • Newstead, S.1
  • 50
    • 68149161029 scopus 로고    scopus 로고
    • Transport of drugs by proton-coupled peptide transporters: Pearls and pitfalls
    • Brandsch M: Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls. Expert Opin Drug Metab Toxicol 2009;5:887-905.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 887-905
    • Brandsch, M.1
  • 51
    • 47149115766 scopus 로고    scopus 로고
    • Pharmacogenetics of intestinal absorption
    • DOI 10.2174/156720108784911749
    • Nakamura T, Yamamori M, Sakaeda T: Pharmacogenetics of intestinal absorption. Curr Drug Deliv 2008;5:153-169. (Pubitemid 351977879)
    • (2008) Current Drug Delivery , vol.5 , Issue.3 , pp. 153-169
    • Nakamura, T.1    Yamamori, M.2    Sakaeda, T.3
  • 53
    • 56049109562 scopus 로고    scopus 로고
    • Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: Increased transporter affinity and metabolic stability
    • Tsume Y, Hilfinger JM, Amidon GL: Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm 2008;5:717-727.
    • (2008) Mol Pharm , vol.5 , pp. 717-727
    • Tsume, Y.1    Hilfinger, J.M.2    Amidon, G.L.3
  • 54
    • 84873363234 scopus 로고    scopus 로고
    • Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells
    • Tai W, Chen Z, Cheng K: Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells. Mol Pharm 2013;10:477-487.
    • (2013) Mol Pharm , vol.10 , pp. 477-487
    • Tai, W.1    Chen, Z.2    Cheng, K.3
  • 55
  • 57
    • 67649390829 scopus 로고    scopus 로고
    • Epidermal growth factor activates Na+/H+ exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin
    • Coaxum SD, Garnovskaya MN, Gooz M, Baldys A, Raymond JR: Epidermal growth factor activates Na+/H+ exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin. Biochim Biophys Acta 2009;1793:1174-1181.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1174-1181
    • Coaxum, S.D.1    Garnovskaya, M.N.2    Gooz, M.3    Baldys, A.4    Raymond, J.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.