Bioavailability through PepT1: The role of computer modelling in intelligent drug design

Current Computer-Aided Drug Design

Volumn 6, Issue 1, 2010, Pages 68-78

  Foley, David W ^a   Rajamanickam, Jeyaganesh ^b   Bailey, Patrick D ^a   Meredith, David ^b  

^a KEELE UNIVERSITY   (United Kingdom)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

Drug absorption; Homology modelling; Membrane transport; Pharmacophore; SLC15A1; Structure function relationship; Substrate binding

Indexed keywords

ACTIVATION ANALYSIS; ANTIBIOTICS; BIOCHEMISTRY; CONTROLLED DRUG DELIVERY; CRYSTAL STRUCTURE; MAMMALS; PHARMACODYNAMICS; PROTEINS; TARGETED DRUG DELIVERY;

COMPUTER MODELS; DI-PEPTIDES; DRUG ABSORPTION; DRUG DESIGN; HOMOLOGY MODELING; MEMBRANE TRANSPORT; PHARMACOPHORES; SLC15A1; STRUCTURE-FUNCTION RELATIONSHIP; SUBSTRATE-BINDING;

SUBSTRATES;

PEPTIDE TRANSPORTER 1; COTRANSPORTER; DIPEPTIDE; DRUG; PROTEIN BINDING;

BINDING AFFINITY; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DESIGN; MEMBRANE TRANSPORT; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; ANIMAL; BIOAVAILABILITY; COMPUTER SIMULATION; HUMAN; METABOLISM; SYNTHESIS;

ANIMALS; BIOLOGICAL AVAILABILITY; COMPUTER SIMULATION; DIPEPTIDES; DRUG DESIGN; HUMANS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; SYMPORTERS;

EID: 77950543534     PISSN: 15734099     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340910790980133     Document Type: Review

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