Long-Term Exposure to Cigarette Smoke Extract Induces Hypomethylation at the RUNX3 and IGF2-H19 Loci in Immortalized Human Urothelial Cells

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chen, Li Mei ^a   Nergard, Jennifer C ^a   Ni, Liqiang ^b   Rosser, Charles J ^c   Chai, Karl X ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

^c M D ANDERSON CANCER CENTER ORLANDO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; DIHYDROFOLATE REDUCTASE; MESSENGER RNA; SOMATOMEDIN B; TRANSCRIPTION FACTOR RUNX3;

ARTICLE; BLADDER CANCER; CELL IMMORTALIZATION; CONTROLLED STUDY; DIHYDROFOLATE REDUCTASE GENE; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REPRESSION; GENETIC ASSOCIATION; H19 GENE; HAPLOTYPE; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SOMATOMEDIN B GENE; TRANSCRIPTION FACTOR RUNX3 GENE; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; UROTHELIUM CELL;

CELL LINE, TRANSFORMED; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; GENETIC LOCI; HUMANS; INSULIN-LIKE GROWTH FACTOR II; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SERINE ENDOPEPTIDASES; SMOKING; TETRAHYDROFOLATE DEHYDROGENASE; TIME FACTORS; UROTHELIUM;

EID: 84878419580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065513     Document Type: Article

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