Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18808-18813

  Campbell, Andrew D ^a   Cui, Shuaiying ^a   Shi, Lihong ^a   Urbonya, Rebekah ^a   Mathias, Andrea ^a   Bradley, Kori ^a   Bonsu, Kwaku O ^a   Douglas, Rhonda R ^a   Halford, Brittne ^a   Schmidt, Lindsay ^a   Harro, David ^a   Giacherio, Donald ^a   Tanimoto, Keiji ^b   Tanabe, Osamu ^a   Engel, James Douglas ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

thalassemia; NR2C1; NR2C2; Repression; Therapeutic target

Indexed keywords

GAMMA GLOBIN; HEMOGLOBIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROID CELL; GENE EXPRESSION; GENETIC MANIPULATION; HEMATOCRIT; HEMOGLOBIN SYNTHESIS; HEMOLYSIS; HEPATITIS; HEPATOSPLENOMEGALY; LIVER NECROSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REDUCTION KINETICS; RETICULOCYTE; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; ANIMALS; BETA-THALASSEMIA; BONE MARROW CELLS; DISEASE MODELS, ANIMAL; FETAL HEMOGLOBIN; GAMMA-GLOBINS; HUMANS; MICE; MICE, TRANSGENIC; NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 1; NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2; PHENOTYPE; SPLEEN; TRANSGENES;

ANIMALIA; MURINAE; MUS; MUS MUSCULUS;

EID: 81755163577     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104964108     Document Type: Article

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