Fetal globin expression is regulated by Friend of Prmt1

Blood

Volumn 116, Issue 20, 2010, Pages 4349-4352

  Van Dijk, Thamar Bryn ^a   Gillemans, Nynke ^a   Pourfarzad, Farzin ^a   Van Lom, Kirsten ^a   Von Lindern, Marieke ^a   Grosveld, Frank ^a   Philipsen, Sjaak ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FRIEND OF PRMT1; GAMMA GLOBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA THALASSEMIA; CHROMATIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 78549244494     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-274399     Document Type: Article

References (22)

1. Schechter AN. Hemoglobin research and the origins of molecular medicine. Blood. 2008;112(10): 3927-3938.
2. Bank A. Regulation of human fetal hemoglobin: new players, new complexities. Blood. 2006;107(2): 435-443. (Pubitemid 43076362)
3. Sankaran VG, Menne TF, Xu J, et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008;322(5909):1839-1842.
4. Uda M, Galanello R, Sanna S, et al. Genomewide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A. 2008;105(5):1620-1625.
5. Menzel S, Garner C, Gut I, et al. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet. 2007;39(10):1197-1199.
6. Thein SL, Menzel S, Peng X, et al. Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci U S A. 2007;104(27):11346-11351. (Pubitemid 47175143)
7. Lettre G, Sankaran VG, Bezerra MA, et al. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008;105(33):11869-11874.
8. Thein SL, Menzel S, Lathrop M, Garner C. Control of fetal hemoglobin: new insights emerging from genomics and clinical implications. Hum Mol Genet. 2009;18(R2):R216-R223.
9. de Krom M, van de Corput M, von Lindern M, Grosveld F, Strouboulis J. Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited. Mol Cell. 2002;9(6):1319-1326.
10. von Lindern M, Deiner EM, Dolznig H, et al. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene. 2001;20(28): 3651-3664.
11. Leberbauer C, Boulme F, Unfried G, Huber J, Beug H, Mullner EW. Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors. Blood. 2005;105(1):85-94. (Pubitemid 40053068)
12. Wijgerde M, Gribnau J, Trimborn T, et al. The role of EKLF in human beta-globin gene competition. Genes Dev. 1996;10(22):2894-2902.
13. Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods. 2006;3(9):715-719.
14. Follenzi A, Sabatino G, Lombardo A, Boccaccio C, Naldini L. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum Gene Ther. 2002;13(2): 243-260. (Pubitemid 34164109)
15. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol. 1997;15(9):871-875. (Pubitemid 27391780)
16. van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Lowenberg B, von Lindern M. Stem cell factor induces phosphatidylinositol 3′-kinase- dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood. 2000;96(10):3406-3413.
17. van Dijk TB, Gillemans N, Stein C, et al. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol. 2010;30(1):260-272.
18. Zullo AJ, Michaud M, Zhang W, Grusby MJ. Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. J Biol Chem. 2009;284(18):12504- 12511.
19. Xu J, Sankaran VG, Ni M, et al. Transcriptional silencing of γ-globin by BCL11A involves longrange interactions and cooperation with SOX6. Genes Dev. 2010;24(8):783-798.
20. Huang S, Litt M, Felsenfeld G. Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev. 2005;19(16): 1885-1893.
21. Zhao Q, Rank G, Tan YT, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009;16(3): 304-311.
22. Li X, Hu X, Patel B, et al. H4R3 methylation facilitates β-globin transcription by regulating histone acetyltransferase binding and H3 acetylation. Blood. 2010;115(10):2028-2037.