Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells

Molecular Biology Reports

Volumn 40, Issue 3, 2013, Pages 2617-2625

  Arabsolghar, Rita ^a   Azimi, Tayebeh ^a   Rasti, Mozhgan ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

DNMT1; ESR1; HDAC1; MDA MB 468 cells; MeCP2; p53

Indexed keywords

DNA METHYLTRANSFERASE 1; ESTROGEN RECEPTOR ALPHA; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; METHYL CPG BINDING PROTEIN 2; MUTANT PROTEIN; PROTEIN P53; SMALL INTERFERING RNA;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DOWN REGULATION; ENZYME ACTIVITY; ESR1 GENE; GENE; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR MECHANICS; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION;

BREAST NEOPLASMS; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE 1; HUMANS; MCF-7 CELLS; METHYL-CPG-BINDING PROTEIN 2; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84878402803     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2348-7     Document Type: Article

References (43)

1. Sui M, Zhang H, Fan W (2011) The role of estrogen and estrogen receptors in chemoresistance. Curr Med Chem 18:4674-4683
2. Giacinti L, Claudio PP, Lopez M, Giordano A (2006) Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist 11:1-8
3. Lo PK, Sukumar S (2008) Epigenomics and breast cancer. Pharmacogenomics 9:1879-1902
4. Yan L, Yang X, Davidson NE (2001) Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer. J Mammary Gland Biol Neoplasia 6:183-192
5. Sharma D, Blum J, Yang X et al (2005) Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells. Mol Endocrinol 19:1740-1751
6. Yan L, Nass SJ, Smith D et al (2003) Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines. Cancer Biol Ther 2:552-556
7. Tajima S, Suetake I (1998) Regulation and function of DNA methylation in vertebrates. J Biochem 123:993-999
8. Chedin F, Lieber MR, Hsieh CL (2002) The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci USA 99:16916-16921
9. Ferguson AT, Lapidus RG, Baylin SB, Davidson NE (1995) Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res 55:2279-2283
10. Dobosy JR, Selker EU (2001) Emerging connections between DNA methylation and histone acetylation. Cell Mol Life Sci 58:721-727
11. Yang X, Ferguson AT, Nass SJ et al (2000) Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. Cancer Res 60:6890-6894
12. Keen JC, Yan L, Mack KM et al (2003) A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine. Breast Cancer Res Treat 81:177-186
13. Zhou Q, Atadja P, Davidson NE (2007) Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol Ther 6:64-69
14. Robertson KD, Ait-Si-Ali S, Yokochi T et al (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25:338-342
15. Rountree MR, Bachman KE, Baylin SB (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 25:269-277
16. Qin W, Leonhardt H, Pichler G (2011) Regulation of DNA methyltransferase 1 by interactions and modifications. Nucleus 2:392-402
17. Kimura H, Shiota K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem 278:4806-4812
18. Angeloni SV, Martin MB, Garcia-Morales P et al (2004) Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. J Endocrinol 180:497-504
19. Goh AM, Coffill CR, Lane DP (2011) The role of mutant p53 in human cancer. J Pathol 223:116-126
20. Akaogi K, Nakajima Y, Ito I et al (2009) KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalpha. Oncogene 28:2894-2902
21. Shirley SH, Rundhaug JE, Tian J et al (2009) Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells. Cancer Res 69:3405-3414
22. Rasti M, Arabsolghar R, Khatooni Z, Mostafavi-Pour Z (2012) p53 Binds to estrogen receptor 1 promoter in human breast cancer cells. Pathol Oncol Res 18:169-175
23. Suzuki M, Sunaga N, Shames DS et al (2004) RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res 64:3137-3143
24. Keshelava N, Davicioni E, Wan Z et al (2007) Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide. J Natl Cancer Inst 99:1107-1119
25. Rasti M, Grand RJ, Mymryk JS et al (2005) Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A. J Virol 79:5594-5605
26. Rasti M, Tavasoli P, Monabati A, Entezam M (2009) Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients. Iran Biomed J 13:199-206
27. Lapidus RG, Nass SJ, Butash KA et al (1998) Mapping of ER gene CpG island methylation-specific polymerase chain reaction. Cancer Res 58:2515-2519
28. Hoque MO, Prencipe M, Poeta ML et al (2009) Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression. Cancer Epidemiol Biomarkers Prev 18:2694-2700
29. Zhao L, Wang L, Jin F et al (2009) Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer. Breast Cancer Res Treat 117:253-259
30. Saxena NK, Sharma D (2010) Epigenetic reactivation of estrogen receptor: promising tools for restoring response to endocrine therapy. Mol Cell Pharmacol 2:191-202
31. Vinyals A, Peinado MA, Gonzalez-Garrigues M et al (1999) Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein. Gene Ther 6:22-33
32. Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247-257
33. Yang X, Phillips DL, Ferguson AT et al (2001) Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res 61:7025-7029
34. Ng HH, Bird A (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9:158-163
35. Harms K, Nozell S, Chen X (2004) The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61:822-842
36. Ho JS, Ma W, Mao DY, Benchimol S (2005) p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol 25:7423-7431
37. Esteve PO, Chin HG, Pradhan S (2005) Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters. Proc Natl Acad Sci USA 102:1000-1005
38. Juan LJ, Shia WJ, Chen MH et al (2000) Histone deacetylases specifically down-regulate p53-dependent gene activation. J Biol Chem 275:20436-20443
39. Le Gac G, Esteve PO, Ferec C, Pradhan S (2006) DNA damage-induced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1. J Biol Chem 281:24161-24170
40. Lai JC, Cheng YW, Goan YG et al (2008) Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53. DNA Repair (Amst) 7:1352-1363
41. Lim LY, Vidnovic N, Ellisen LW, Leong CO (2009) Mutant p53 mediates survival of breast cancer cells. Br J Cancer 101:1606-1612
42. Dhar G, Banerjee S, Dhar K et al (2008) Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. Cancer Res 68:4580-4587
43. Böhlig L, Rother K (2011) One function-multiple mechanisms: the manifold activities of p53 as a transcriptional repressor. J Biomed Biotechnol 2011:464916