Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients

Iranian Biomedical Journal

Volumn 13, Issue 4, 2009, Pages 133-140

  Rasti, Mozhgan ^a   Tavasoli, Parastoo ^a   Monabati, Ahmad ^a   Entezam, Mona ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Breast cancer; Hypermethylated in cancer (HIC1); Methylation; Methylene tetrahydrofolate dehydrogenase (MTHFD1); Ras associated domain family 1 (RASSF1A)

Indexed keywords

ALANINE; GLYCINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ADULT; ARTICLE; BREAST CARCINOMA; BREAST TUMOR; CANCER GROWTH; CANCER INVASION; CLINICAL FEATURE; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; DNA POLYMORPHISM; EPIGENETICS; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IRAN; MAJOR CLINICAL STUDY; METASTASIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; TUMOR VOLUME;

EID: 74549210096     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Mousavi, S.M., Gouya, M.M., Ramazani, R., Davanlou, M., Hajsadeghi, N. and Seddighi, Z. (2009) Cancer incidence and mortality in Iran. Ann. Oncol. 20 (3): 556-563.
2. Agrawal, A., Murphy, R.F. and Agrawal, D.K. (2007) DNA methylation in breast and colorectal cancers. Mod. Pathol. 20 (7): 711-721.
3. Yang, X., Yan,L., and Davidson, N.E. (2001) DNA methylation in breast cancer. Endocr. Relat. Cancer 8 (2): 115-127.
4. Widschwendter, M. and Jones, P.A. (2002) DNA methylation and breast carcinogenesis. Oncogene 21: 5462-5482.
5. Burbee, D.G., Forgacs, E., Zochbauer-Muller, S., Shivakumar, L., Fong, K., Gao, B., Randle, D., Kondo, M., Virmani, A., Bader, S., Sekido, Y., Latif, F., Milchgrub, S., Toyooka, S., Gazdar, A.F., Lerman, M.I., Zabarovsky, E., White, M. and Minna, J.D. (2001) Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. 93 (9): 691-699.
6. Kim, S.T., Lim, D.S., Canman, C.E. and Kastan, M.B. (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274 (53): 37538-37543.
7. Deltour, S., Pinte, S., Guerardel, C., Wasylyk, B. and Leprince, D. (2002) The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol. Cell Biol. 22 (13): 4890-4901.
8. Wales, M.M., Biel, M.A., El Deiry, W., Nelkin, B.D., Issa, J.P., Cavenee, W.K., Kuerbitz, S.J. and Baylin, S.B. (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat. Med. 1 (6): 570-577.
9. Fujii, H., Biel, M.A., Zhou, W., Weitzman, S.A., Baylin, S.B. and Gabrielson, E. (1998) Methylation of the HIC1 candidate tumor suppressor gene in human breast cancer. Oncogene 16 (16): 2159-2164.
10. Li, S.Y., Rong, M. and Iacopetta, B. (2006) Germline variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer. Oncol. Rep. 15 (1): 221-225.
11. Hum, D.W., Bell, A.W., Rozen, R. and MacKenzie, R.E. (1988) Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetra-hydrofolate synthetase. J. Biol. Chem. 263 (31): 15946-15950.
12. Herman, J.G., Graff, J.R., Myohanen, S., Nelkin, B.D. and Baylin, S.B. (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93 (18): 9821-9826.
13. Dong, S.M., Kim, H.S., Rha, S.H. and Sidransky, D. (2001) Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res. 7 (7): 1982-1986.
14. Dietrich, D., Lesche, R., Tetzner, R., Krispin, M., Dietrich, J., Haedicke, W., Schuster, M. and Kristiansen,G. (2009) Analysis of DNA methylation of multiple genes in microdissected cells From formalin-fixed and paraffin-embedded tissues. J. Histochem. Cytochem. 57 (5): 477-489.
15. Flanagan, J.M., Munoz-Alegre, M., Henderson, S., Tang, T., Sun, P., Johnson, N., Fletcher, O., Dos Santos Silva, I., Peto, J., Boshoff, C., Narod, S. and Petronis, A. (2009) Gene Body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum. Mol. Genet. 18 (7): 1332-1342.
16. Li, Y., Wei, Q., Cao, F., and Cao, X. (2008) Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. Oncol. Rep. 19 (5): 1149-1153.
17. Yeo, W., Wong, W.L., Wong, N., Law, B.K., Tse, G.M. and Zhong, S. (2005) High frequency of promoter hypermethylation of RASSF1A in tumorous and non-tumorous tissue of breast cancer. Pathology 37 (2): 125-130.
18. Bagadi, S.A., Prasad, C.P., Kaur, J., Srivastava, A., Prashad, R., Gupta, S.D. and Ralhan, R. (2008) Clinical significance of promoter hypermethylation of RASSF1A, RARbeta2, BRCA1 and HOXA5 in breast cancers of Indian patients. Life Sci. 82 (25-26): 1288-1292.
19. Parrella, P., Poeta, M.L., Gallo, A.P., Prencipe, M., Scintu, M., Apicella, A., Rossiello, R., Liguoro, G., Seripa, D., Gravina, C., Rabitti, C., Rinaldi, M., Nicol, T., Tommasi, S., Paradiso, A., Schittulli, F., Altomare, V. and Fazio, V.M. (2004) Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors. Clin. Cancer Res. 10 (16): 5349-5354.
20. Parrella, P., Scintu, M., Prencipe, M., Poeta, M.L., Gallo, A.P., Rabitti, C., Rinaldi, M., Tommasi, S., Paradiso, A., Schittulli, F., Valori, V.M., Toma, S., Altomare, V. and Fazio, V.M. (2005) HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast. Cancer Lett. 222 (1): 75-81.
21. Zhao, L., Wang, L., Jin, F., Ma, W., Ren, J., Wen, X., He, M., Sun, M., Tang, H. and Wei, M. (2008) Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer. Breast Cancer Res. Treat. 117 (2): 253-259.
22. Chen, J., Kyte, C., Valcin, M., Chan, W., Wetmur, J.G., Selhub, J., Hunter, D.J. and Ma, J. (2004) Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int. J. Cancer 110 (4): 617-620.
23. Derwinger, K., Wettergren, Y., Odin, E., Carlsson, G. and Gustavsson, B. (2009) A study of the MTHFR gene polymorphism C677T in colorectal cancer. Clin. Colorectal Cancer 8 (1): 43-48.
24. Sharp, L. and Little, J. (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia. Am. J. Epidemiol. 159 (5): 423-443.
25. Dammann, R., Schagdarsurengin, U., Seidel, C., Strunnikova, M., Rastetter, M., Baier, K. and Pfeifer, G.P. (2005) The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol. Histopathol. 20 (2): 645-663.
26. Taback, B., Giuliano, A.E., Lai, R., Hansen, N., Singer, F.R., Pantel, K. and Hoon, D.S. (2006) Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients. Ann. N.Y. Acad. Sci. 1075: 211-221.
27. Tan, S.H., Ida, H., Lau, Q.C., Goh, B.C., Chieng, W.S., Loh, M. and Ito, Y. (2007) Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol. Rep. 18 (5): 1225-1230.
28. Skvortsova, T.E., Rykova, E.Y., Tamkovich, S.N., Bryzgunova, O.E., Starikov, A.V., Kuznetsova, N.P., Vlassov, V.V. and Laktionov, P.P. (2006) Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation. Br. J. Cancer 94 (10): 1492-1495.
29. Sunami, E., Shinozaki, M., Sim, M.S., Nguyen, S.L., Vu, A.T., Giuliano, A.E., and Hoon, D.S. (2008) Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors. Breast Cancer Res. 10 (3): R46.
30. Euhus, D.M., Bu, D., Milchgrub, S., Xie, X.J., Bian, A., Leitch, A.M. and Lewis, C.M. (2008) DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 17 (5): 1051-1059.
31. Lewis, C.M., Cler, L.R., Bu, D.W., Zochbauer-Muller, S., Milchgrub, S., Naftalis, E.Z., Leitch, A.M., Minna, J.D. and Euhus, D.M. (2005) Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. Clin. Cancer Res. 11 (1): 166-172.
32. Papadopoulou, E., Davilas, E., Sotiriou, V., Georgakopoulos, E., Georgakopoulou, S., Koliopanos, A., Aggelakis, F., Dardoufas, K., Agnanti, N.J., Karydas, I. and Nasioulas, G. (2006) Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer. Ann. N.Y. Acad. Sci. 1075: 235-243.
33. Lee, J.S., Lo, P.K., Fackler, M.J., Argani, P., Zhang, Z., Garrett-Mayer, E. and Sukumar, S. (2007) A comparative study of Korean with Caucasian breast cancer reveals frequency of Methylation in Multiple Genes Correlates with Breast Cancer in Young, ER, PR-negative Breast cancer in Korean women. Cancer Biol. Ther. 6 (7): 1114-1120.
34. Honorio, S., Agathanggelou, A., Schuermann, M., Pankow, W., Viacava, P., Maher, E.R. and Latif, F. (2003) Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients. Oncogene 22 (1): 147-150.