The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models

Planta Medica

Volumn 72, Issue 4, 2006, Pages 376-378

  Shin, Yong Wook ^a   Bae, Eun Ah ^a   Kim, Sung Soo ^b   Lee, Young Chul ^b   Lee, Boo Young ^c   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

^b Korea Food Research Institute   (South Korea)

^c CHA University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPSORIASIS AGENT; CYCLOOXYGENASE 2; GINSENOSIDE; GINSENOSIDE RE; GINSENOSIDE RH1; INTERLEUKIN 1BETA; OXAZOLONE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DERMATITIS; DRUG EFFECT; EXPERIMENTAL MODEL; MOUSE; NONHUMAN; PSORIASIS; SWELLING;

ADMINISTRATION, CUTANEOUS; ANIMALS; DERMATITIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GINSENOSIDES; KERATOLYTIC AGENTS; MICE; MICE, INBRED ICR; OXAZOLONE; PANAX; PHYTOTHERAPY; PLANT ROOTS; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA; PANAX GINSENG;

EID: 33645499384     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916217     Document Type: Article

References (15)

1. Nicoloff BJ. The cytokine network in psoriasis. Arch Dermatol 1991; 127: 871-84
2. Hernandez GL, Volpert OV, Iniguez MA, Lorenzo E, Martinez-Martinez S, Grau R et al. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med 2001; 193: 607-20
3. Reynolds NJ, Voorhees JJ, Fisher GH. Cyclsoporin A inhibits 12-O-tetradecanoylphorbol 13-acetate-induced cutaneous inflammation in severe combined immunodeficient mice that lack functional lymphocytes. Br J Dermatol 1998; 139: 16-22
4. Fujii Y, Takeuchi H, Tanaka K, Sakuma S, Ohkubo Y, Mutoh S. Effects of FK-506 (tacrolimus hydrate) on chronic oxazolone-induced dermatitis in rats. Eur J Pharmacol 2002; 456: 115-21
5. Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T. Panaxadiol, a sapongenin of ginseng roots (1). Chem Pharm Bull 1963; 11: 759-64
6. Wu JY, Gardner BH, Murphy CI, Seals JR, Kensil CR, Recchia J et al. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J Immunol 1992; 148: 1519-25
7. Choo MK, Park EK, Han MJ, Kim DH. Antiallergic activity of ginseng and its ginsenoside. Planta Med 2003; 69: 518-22
8. Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004; 133: 113-20
9. Wakabayashi C, Hasegawa H, Murata J, Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1998; 9: 411-7
10. Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1988; 50: 1155-60
11. Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M. Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 2003; 31: 1065-71
12. Hasegawa H, Sung JH, Matsumiya S, Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1966; 62: 453-7
13. Schafer-Korting M, Schmid MH, Korting HC. Topical glucocorticoids with improved risk-benefit ratio. Drug Saf 1996; 14: 375-85
14. Park BK, Heo MY, Pak H, Kim HP. Inhibition of TPA-induced cyclooxygenase-2 and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur J Pharmacol 2001; 425: 53-8
15. Shin YW, Bae EA, Kim SS, Lee YC, Kim DH. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. Int Immunopharmacol 2005; 5: 1183-91