Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis

International Immunopharmacology

Volumn 16, Issue 4, 2013, Pages 414-423

  Chu, Tony L H ^a   Guan, Qiunong ^a   Nguan, Christopher Y C ^a   Du, Caigan ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER COASTAL HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Amino acid starvation; Apoptosis; Halofuginone; Immunosuppressant; Proline; T cell

Indexed keywords

7 AMINODACTINOMYCIN; ALLOANTIGEN; CD3 ANTIBODY; HALOFUGINONE; INTERLEUKIN 2; LIPOCORTIN 5; PROLINE; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CULTURE MEDIUM; CYTOKINE PRODUCTION; FLUORESCENCE ACTIVATED CELL SORTING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MOLECULAR MECHANICS; MOUSE; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; IN SITU NICK-END LABELING; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PIPERIDINES; PROLINE; QUINAZOLINONES; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES;

EID: 84878380313     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.04.031     Document Type: Article

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