Oxidative stress and cell senescence combine to cause maximal renal tubular epithelial cell dysfunction and loss in an in vitro model of kidney disease

Nephron - Experimental Nephrology

Volumn 122, Issue 3-4, 2013, Pages 123-130

  Small, David M ^a   Bennett, Nigel C ^a   Roy, Sandrine ^a   Gabrielli, Brian G ^a   Johnson, David W ^a,b   Gobe, Glenda C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Apoptosis; Cell senescence; Chronic kidney disease; Mitochondria; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; APIGENIN; BETA GALACTOSIDASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL XL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL AGING; CELL DAMAGE; CELL DEATH; CELL LOSS; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; KIDNEY TUBULE EPITHELIUM; KIDNEY TUMOR; LIPID PEROXIDATION; MITOSIS; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE REGENERATION;

ACETYLCYSTEINE; APIGENIN; APOPTOSIS; CELL AGING; CELL LINE; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; KIDNEY; KIDNEY TUBULES; LIPID PEROXIDATION; MITOCHONDRIA; OXIDATIVE STRESS; REGENERATION; RENAL INSUFFICIENCY, CHRONIC;

EID: 84878345904     PISSN: None     EISSN: 16602129     Source Type: Journal    
DOI: 10.1159/000350726     Document Type: Article

References (33)

1. Inagami T: Mitochondrial angiotensin receptors and aging. Circ Res 2011; 109: 1323-1324.
2. Finkel T, Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
3. Singh DK, Winocour P, Farrington K: Oxidative stress in early diabetic nephropathy: fueling the fire. Nat Rev Endocrinol 2011; 7: 176- 184.
4. Carnicer R, Crabtree MJ, Sivakumaran V, Casadei B, Kass DA: Nitric oxide synthases in heart failure. Antioxid Redox Signal 2012, Epub ahead of print.
5. Cuttle L, Zhang XJ, Endre ZH, Winterford C, Gobe GC: Bcl-x(l) translocation in renal tubular epithelial cells in vitro protects distal cells from oxidative stress. Kidney Int 2001; 59: 1779-1788. (Pubitemid 32336792)
6. Vay L, Hernandez-SanMiguel E, Lobaton CD, Moreno A, Montero M, Alvarez J: Mitochondrial free [Ca2+] levels and the permeability transition. Cell Calcium 2009; 45: 243-250.
7. Madesh M, Hajnoczky G: Vdac-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 2001; 155: 1003-1015. (Pubitemid 34286251)
8. Soubannier V, McBride HM: Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta 2009; 1793: 154-170.
9. Rieg T, Vallon V: Atp and adenosine in the local regulation of water transport and homeostasis by the kidney. Am J Physiol Regul Integr Comp Physiol 2009; 296:R419-R427.
10. Hall AM, Unwin RJ, Parker N, Duchen MR: Multiphoton imaging reveals differences in mitochondrial function between nephron segments. J Am Soc Nephrol 2009; 20: 1293- 1302.
11. St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD: Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002; 277: 44784-44790. (Pubitemid 36159072)
12. Melk A: Senescence of renal cells: molecular basis and clinical implications. Nephrol Dial Transplant 2003; 18: 2474-2478. (Pubitemid 37483777)
13. Jiao S, Meng F, Zhang J, Yang X, Zheng X, Wang L: Stat1 mediates cellular senescence induced by angiotensin II and H 2 O 2 in human glomerular mesangial cells. Mol Cell Biochem 2012; 365: 9-17.
14. Stenvinkel P, Larsson TE: Chronic kidney disease: a clinical model of premature aging. Am J Kidney Dis 2013, E-pub ahead of print.
15. Campisi J, d'Adda FF: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8: 729-740. (Pubitemid 47312822)
16. Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O: Subcytotoxic H 2 O 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 2001; 276: 2531-2537.
17. Glotin AL, Debacq-Chainiaux F, Brossas JY, Faussat AM, Treton J, Zubielewicz A, Toussaint O, Mascarelli F: Prematurely senescent ARPE-19 cells display features of age-related macular degeneration. Free Radic Biol Med 2008; 44: 1348-1361.
18. Stein GH, Drullinger LF, Soulard A, Dulic V: Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999; 19: 2109-2117. (Pubitemid 29098269)
19. Ryu SW, Woo JH, Kim YH, Lee YS, Park JW, Bae YS: Downregulation of protein kinase CKII is associated with cellular senescence. FEBS Lett 2006; 580: 988-994. (Pubitemid 43152324)
20. Pat BK, Cuttle L, Watters D, Yang T, Johnson DW, Gobe GC: Fibrogenic stresses activate different mitogen-activated protein kinase pathways in renal epithelial, endothelial or fibroblast cell populations. Nephrology (Carlton) 2003; 8: 196-204. (Pubitemid 36995090)
21. Hughes J, Gobe G: Identification and quantification of apoptosis in the kidney using morphology, biochemical and molecular markers. Nephrology (Carlton) 2007; 12: 452-458. (Pubitemid 47366651)
22. Chen Q, Ames BN: Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 1994; 91: 4130-4134. (Pubitemid 24143386)
23. Wang XQ, Gabrielli BG, Milligan A, Dickinson JL, Antalis TM, Ellem KA: Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay. Cancer Res 1996; 56: 2510-2514.
24. Lagoa R, Graziani I, Lopez-Sanchez C, Garcia- Martinez V, Gutierrez-Merino C: Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. Biochim Biophys Acta 2011; 1807: 1562-1572.
25. Liu LZ, Fang J, Zhou Q, Hu X, Shi X, Jiang BH: Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol 2005; 68: 635-643. (Pubitemid 41206017)
26. Percy CJ, Brown L, Power DA, Johnson DW, Gobe GC: Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mech Ageing Dev 2009; 130: 129-138.
27. Vogetseder A, Picard N, Gaspert A, Walch M, Kaissling B, Le Hir M: Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am J Physiol Cell Physiol 2008; 294:C22-C28.
28. Zheng PW, Chiang LC, Lin CC: Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sci 2005; 76: 1367-1379.
29. Shukla S, Gupta S: Molecular targets for apigenin- induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol Cancer Ther 2006; 5: 843-852. (Pubitemid 43724583)
30. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR: The bcl-2 family reunion. Mol Cell 2010; 37: 299-310.
31. Ye J, Li J, Yu Y, Wei Q, Deng W, Yu L: L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regul Pept 2010; 161: 58-66.
32. Alonso A, Lau J, Jaber BL, Weintraub A, Sarnak MJ: Prevention of radiocontrast nephropathy with N-acetylcysteine in patients with chronic kidney disease: a meta-analysis of randomized, controlled trials. Am J Kidney Dis 2004; 43: 1-9. (Pubitemid 38049429)
33. Quiroz Y, Ferrebuz A, Vaziri ND, Rodriguez- Iturbe B: Effect of chronic antioxidant therapy with superoxide dismutase-mimetic drug, tempol, on progression of renal disease in rats with renal mass reduction. Nephron Exp Nephrol 2009; 112:e31-e42.