Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

European Journal of Pharmacology

Volumn 713, Issue 1-3, 2013, Pages 68-77

  Pekarova, Michaela ^a   Kubala, Lukas ^a   Martiskova, Hana ^a   Bino, Lucia ^a   Twarogova, Michaela ^a   Klinke, Anna ^b   Rudolph, Tanja K ^b   Kuchtova, Zdenka ^c   Kolarova, Hana ^a   Ambrozova, Gabriela ^a   Kuchta, Radek ^c   Kadlec, Jaroslav ^c   Lojek, Antonin ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c BRNO UNIVERSITY OF TECHNOLOGY   (Czech Republic)

Author keywords

Asymmetric dimethylarginine; Inducible nitric oxide synthase; Macrophage; Methylarginine; Nitric oxide; Symmetric dimethylarginine

Indexed keywords

6 N,N' DIMETHYLARGININE; CYTOCHROME C; DIMETHYLARGININASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DENSITOMETRY; DNA SYNTHESIS; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SYNTHESIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ARGININE; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MACROPHAGES, PERITONEAL; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDES;

EID: 84878330413     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.001     Document Type: Article

References (57)

1. W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition Biochem. J. 357 2001 593 615
2. J.P. Andrew, and B. Mayer Enzymatic function of nitric oxide synthases Cardiovasc. Res. 43 1999 521 531
3. J. Beltowski, and A. Kedra Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy Pharomacol. Rep. 58 2006 159 178
4. R.G. Bogle, R.J. MacAllister, G.S. Whitley, and P. Vallance Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthase? Am. J. Physiol. 269 1995 C750 C756
5. R.H. Boger Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide sythase, explains the "L-arginine paradox" and act as a novel cardiovascular risk factor J. Nutr. 134 2004 2842S 2847S
6. R.H. Boger, S.M. Bode-Boger, K. Sydow, D.D. Heistad, and S.R. Lentz Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia Arterioscler. Thromb. Vasc. Biol. 20 2000 1557 1564
7. V. Bronte, and P. Zanovello Regulation of immune responses by L-arginine metabolism Immunology 5 2005 641 654
8. J.R. Chan, R.H. Boger, S.M. Bode-Boger, O. Tangphao, P.S. Tsao, T.F. Blascheke, and J.P. Cooke Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans Arterioscler. Thromb. Vasc. Biol. 20 2000 1040 1046
9. M.F. Chen, Y.J. Li, T.L. Yang, B. Lou, and X.M. Xie Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes Eur. J. Clin. Pharmacol. 65 2009 457 464
10. + carrier hCAT-2B Nitric Oxide 1 1997 65 73
11. L. Connelly, M. Palacios-Callender, C. Ameixa, S. Moncada, and A.J. Hobbs Biphasic regulation of NF-kappaB activity underlies the pro- and anti-inflammatory actions of nitric oxide J. Immunol. 166 2001 3873 3881
12. S. Dikalov Cross talk between mitochondria and NADPH oxidases Free Radical Biol. Med 51 2011 1289 1301
13. L.J. Druhan, S.P. Forbes, A.J. Pope, C.A. Chen, J.L. Zweier, and A.J. Cardounel Regulation of eNOS-derived superoxide by endogenous methylarginines Biochemistry 47 2008 7256 7263
14. G-dimethylarginine Acta Physiol. Scand. 167 1999 145 150
15. G. Gloire, S. Legrand-Poels, and J. Piette NF-κB activation by reactive oxygen species: fifteen years later Biochem. Pharmacol. 72 2006 1493 1505
16. R. Hyde, P.M. Taylor, and H.S. Hundal Amino acid transporters: roles in amino acid sensing and signaling in animal cells Biochem. J. 373 2003 1 18
17. A.T. Jacobs, and L.J. Ignarro Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages J. Biol. Chem. 276 2001 47950 47957
18. D.J. Jiang, Y. Cao, H.Y. Xin, X.H. Li, Z.Q. Luo, and Y.J. Li Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: role in acute coronary syndromes Atherosclerosis 205 2009 554 560
19. D. Krejcova, M. Pekarova, B. Safrankova, and L. Kubala The effect of different molecular weight hyaluronan on macrophage physiology Neuro. Endocrinol. Lett. 30 2009 106 111
20. T.K. Krempl, R. Maas, K. Sydow, T. Meinertz, R.H. Boger, and J. Kahler Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events Eur. Heart J. 26 2005 1846 1851
21. M.B.P. Landim, A.C. Filho, and A.C.P. Chagas Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implication for atherogenesis Clinics 64 2009 471 478
22. J. Leiper, J. Murray-Rust, N. McDonald, and P. Vallance S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enyzme activity: further interactions between nitric oxide sythase and dimethylarginine dimethylaminohydrolase PNAS 99 2002 13527 13532
23. J. Leiper, M. Nandi, B. Torondel, J. Murray-Rust, M. Malaki, B. O'Hara, S. Rossiter, S. Anthony, M. Madhani, D. Selwood, C. Smith, B. Wojciak-Stothard, A. Rudiger, R. Stidwill, N.Q. McDonald, and P. Vallance Disruption of methylarginine metabolism impairs vascular homeostasis Nat. Med. 13 2007 198 203
24. J.M. Leiper, J. Santa Maria, A. Chubb, R.J. MacAllinster, I.G. Charles, G.J. Whitley, and P. Vallance Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases Biochem. J. 343 1999 209 214
25. J. Leiper, and P. Vallance Biological significance of endogenous methylarginines that inhibit nitric oxide synthases Cardiovasc. Res. 43 1999 542 548
26. H. Lum, and K.A. Roebuck Oxidant stress and endothelial cell dysfunction Am. J. Physiol. Cell Physiol. 280 2001 C719 C741
27. R.J. Macallister, H. Parry, M. Kimoto, T. Ogawa, R.J. Russell, H. Hodson, G.S. Whitley, and P. Vallance Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase Br. J. Pharmacol. 119 1996 1533 1540
28. R.J. Macallister, G.S.J. Whitley, and P. Vallance Effects of guanidine and uremic compounds on nitric oxide pathways Kidney Int. 45 1994 737 742
29. H. Masuda Significance of nitric oxide and its modulation mechanisms endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction Int. J. Urol. 15 2008 128 134
30. B. Mayer, and B. Hemmens Biosynthesis and action of nitric oxide in mammalian cells Trends Biochem. Sci. 22 1997 477 481
31. M. Mori, and T. Gotoh Regulation of nitric oxide production by arginine metabolic enzymes Biochem. Biophys. Res. Commun. 275 2000 715 719
32. D.M. Mosser The many faces of macrophage activation J. Leukocyte Biol. 73 2003 209 212
33. M. Pekarova, J. Kralova, L. Kubala, M. Ciz, A. Lojek, C. Gregor, and J. Hrbac Continuous electrochemical monitoring of nitric oxide production in murine macrophage cell line RAW 264.7 Anal. Bioanal. Chem. 394 2009 1497 1504
34. M. Pekarova, J. Kralova, L. Kubala, M. Ciz, I. Papezikova, T. Macickova, J. Pecivova, R. Nosal, and A. Lojek Carvedilol and adrenergic agonists suppress the lipopolysaccharide-induced NO production in RAW 264.7 macrophages via the adrenergic receptors J. Physiol. Pharmacol. 60 2009 143 150
35. M. Pekarova, A. Lojek, H. Martiskova, O. Vasicek, L. Bino, A. Klinke, D. Lau, R. Kuchta, J. Kadlec, R. Vrba, and L. Kubala New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages Sci. World J. 11 2011 2443 2457
36. F. Palm, M.L. Onotato, Z. Luo, and C.S. Wilcox Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems Am. J. Physiol. Heart Circ. Physiol 293 2007 H3227 H3245
37. E. Peranzoni, I. Marigo, L. Dolcetti, S. Ugel, N. Sonda, E. Taschin, B. Mantelli, V. Bronte, and P. Zanovello Role of arginine metabolism in immunity and immunopathology Immunobiology 212 2008 795 812
38. S. Pfeiffer, A. Lass, K. Schmidt, and B. Mayer Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite FASEB J. 15 2001 2355 2364
39. A.J. Pope, K. Karuppiah, and A.J. Cardounel Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production Pharmacol. Res. 60 2009 461 465
40. J. Prochazkova, L. Kubala, H. Kotasova, I. Gudernova, Z. Sramkova, M. Pekarova, B. Sarkadi, and J. Pachernik ABC transporters affect the detection of intracellular oxidants by fluorescent probes Free Radical Res 45 2011 779 787
41. A. Rawlingson Nitric oxide, inflammation and acute burn injury Burns 29 2003 631 640
42. K. Saksela, and D. Baltimore Negative regulation of immunoglobin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element Mol. Cell. Biol. 13 1993 3698 3705
43. E. Schepers, G. Glorieux, A. Dhondt, L. Leybaert, and R. Vanholder Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes Nephrol. Dial. Transplant. 24 2009 1429 1435
44. S. Schildknecht, C. Karreman, A. Daiber, C. Zhao, J. Hamacher, D. Perlman, B. Jung, B. van der Loo, P. O'Connor, M. Leist, and M.M. Bachschmid Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages Antioxid. Redox Signal. 17 2012 1393 1406
45. I.V. Smirnova, M. Kajstura, T. Sawamura, and M.S. Goligorsky Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation Am. J. Physiol. Heart Circ. Physiol 287 2004 H782 H790
46. J.C. Sullivan, and J.S. Pollock Coupled and uncoupled NOS: separate but equal? Uncoupled NOS in endothelial cell sis a critical pathway for intracellular signaling Circ. Res. 98 2006 717 719
47. K. Sydow, and T. Munzel ADMA and oxidative stress Atheroscler. Suppl. 4 2003 41 51
48. C.T.L. Tran, J.M. Leiper, and P. Vallance The DDAH/ADMA/NOS pathway Atheroscler. Suppl. 4 2003 33 40
49. S. Ueda, S. Kato, H. Matsuoka, M. Kimoto, S. Okuda, M. Morimatsu, and T. Imaizumi Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase Circ. Res. 92 2003 226 233
50. D. Viackova, M. Pekarova, T. Crhak, M. Bucsaiova, J. Matiasovic, A. Lojek, and L. Kubala Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin Immunobiology 216 2010 457 465
51. E.C. von Leitner, A. Klinke, D. Atzler, J.L. Slocum, N. Lund, J.T. Kielstein, R. Maas, R. Schmidt-Haupt, M. Pekarova, O. Hellwinkel, D. Tsikas, L.G. D'Alecy, D. Lau, S. Willems, L. Kubala, H. Ehmke, T. Meinertz, S. Blankenberg, E. Schwedhelm, C.A. Gadegbeku, R.H. Boger, S. Baldus, and K. Sydow Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase Circulation 124 2011 2735 2745
52. S. Wells, and A. Holian Asymetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells Am. J. Respir. Cell. Mol. Biol. 36 2007 520 528
53. G. Wu, and S.M. Morris Jr. Arginine metabolism: nitric oxide and beyond Biochem. J. 336 1998 1 17
54. R.D. Ye Regulation of nuclear factor kB activation by G-protein coupled receptors J. Leukocyte Biol. 70 2001 839 848
55. D. Zakrzewicz, and O. Eickelberg From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases BMC Pulm. Med. 9 2009 5
56. G.G. Zhang, Y.P. Bai, M.F. Chen, R.Z. Shi, D.J. Jiang, Q.M. Fu, G.S. Tan, and Y.J. Li Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C. Vasc. Pharmacol. 48 2008 115 121
57. Z.D. Zhu, Z. Yu, X. Zhang, Y.J. Wang, and D.H. Wang Effect of asymmetric dimethylarginine on MIF expression and TNF-α and IL-8 secretion in THP-1 monocytes-derived macrophages Nan Fang Yi Ke Da Xue Xue Bao 31 2011 1 4