Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes

European Journal of Clinical Pharmacology

Volumn 65, Issue 5, 2009, Pages 457-464

  Chen, Mei Fang ^a,b   Li, Yuan Jian ^b   Yang, Tian Lun ^a   Lou, Bin ^c   Xie, Xiu Mei ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Asymmetric dimethylarginine (ADMA); Interleukin 8 (IL 8); Losartan; Monocyte chemoattractant protein 1 (MCP 1); Nuclear factor kappaB (NF B)

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LOSARTAN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G),N(G) DIMETHYLARGININE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ARGININE; CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-8; LOSARTAN; MONOCYTES; NF-KAPPA B; RECEPTORS, CHEMOKINE; RNA, MESSENGER; TIME FACTORS;

EID: 67349281215     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0607-2     Document Type: Article

References (36)

1. N Ayabe VR Babaev Y Tang T Tanizawa AB Fogo MF Linton I Ichikawa S Fazio V Kon 2006 Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice Atherosclerosis 184 312 321
2. 2 is increased in hypercholesterolemia. Differential effects of plasma lipoproteins on monocyte function J Lipid Res 40 1053 1063
3. F Dol G Martin B Staels AM Mares C Cazaubon D Nisato JP Bidouard P Janiak P Schaeffer JM Herbert 2001 Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice J Cardiovasc Pharmacol 38 395 405
4. 2 in atherosclerosis Immunol Res 21 129 137
5. YN Nabah T Mateo R Estelles M Mata J Zagorski H Sarau J Cortijo EJ Morcillo PJ Jose MJ Sanz 2004 Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines Circulation 110 3581 3586
6. K Sydow E Schwedhelm N Arakawa SM Bode-Boger D Tsikas B Hornig JC Frolich RH Boger 2003 ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins Cardiovasc Res 57 244 252
7. DJ Jiang SJ Jia Z Dai YJ Li 2006 Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells J Mol Cell Cardiol 40 529 539
8. Q Yuan DJ Jiang QQ Chen S Wang HY Xin HW Deng YJ Li 2007 Role of asymmetric dimethylarginine in homocysteine-induced apoptosis of vascular smooth muscle cells Biochem Biophys Res Commun 356 880 885
9. IV Smirnova M Kajstura T Sawamura MS Goligorsky 2004 Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation Am J Physiol Heart Circ Physiol 287 H782 790
10. C Delles MP Schneider S John M Gekle RE Schmieder 2002 Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G),N(G)-dimethylarginine in human essential hypertension Am J Hypertens 15 590 593
11. A Ito K Egashira T Narishige K Muramatsu A Takeshita 2002 Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus Circ J 66 811 815
12. JW Chen NW Hsu TC Wu SJ Lin MS Chang 2002 Long-term angiotensin- converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X Am J Cardiol 90 974 982
13. MF Chen XM Xie TL Yang YJ Wang XH Zhang BL Luo YJ Li 2007 Involvement of asymmetric dimethylarginine in inflammatory reaction by angiotensin II J Vasc Res 44 391 402
14. F Scalera J Borlak B Beckmann J Martens-Lobenhoffer T Thum M Täger SM Bode-Böger 2004 Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence Arterioscler Thromb Vasc Biol 24 1816 1822
15. B Wojciak-Stothard B Torondel LY Tsang I Fleming B Fisslthaler JM Leiper P Vallance 2007 The ADMA/DDAH pathway is a critical regulator of endothelial cell motility J Cell Sci 120 929 942
16. H Miyazaki H Matsuoka JP Cooke M Usui S Ueda S Okuda T Imaizumi 1999 Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis Circulation 99 1141 1146
17. K Furuki H Adachi M Enomoto M Otsuka A Fukami S Kumagae H Matsuoka Y Nanjo T Kakuma T Imaizumi 2008 Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography Hypertens Res 31 6 1185 1189
18. C Iribarren G Husson K Sydow BY Wang S Sidney JP Cooke 2007 Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study Eur J Cardiovasc Prev Rehabil 14 222 229
19. TM Lu YA Ding SJ Lin WS Lee HC Tai 2003 Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention Eur Heart J 24 1912 1919
20. VP Valkonen H Paiva JT Salonen TA Lakka T Lehtimaki J Laakso R Laaksonen 2001 Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine Lancet 358 2127 2128
21. A Meinitzer U Seelhorst B Wellnitz G Halwachs-Baumann BO Boehm BR Winkelmann W März 2007 Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study) Clin Chem 53 273 283
22. RJ Nijveldt T Teerlink B van der Hoven MP Siroen DJ Kuik JA Rauwerda PA van Leeuwen 2003 Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality Clin Nutr 22 23 30
23. RH Boger SM Bode-Boger PS Tsao PS Lin JR Chan JP Cooke 2002 An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes J Am Coll Cardiol 36 2287 2295
24. JR Chan RH Boger SM Bode-Boger O Tangphao PS Tsao TF Blaschke JP Cooke 2000 Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans Arterioscler Thromb Vasc Biol 20 1040 1046
25. 2 increase with age and alter vascular smooth muscle cell function Arterioscler Thromb Vasc Biol 24 1397 1402
26. E Bush N Maeda WA Kuziel TC Dawson JN Wilcox H DeLeon WR Taylor 2000 CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension Hypertension 36 360 363
27. M Ishibashi K Hiasa Q Zhao S Inoue K Ohtani S Kitamoto M Tsuchihashi T Sugaya IF Charo S Kura T Tsuzuki T Ishibashi A Takeshita K Egashira 2004 Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling Circ Res 94 1203 1210
28. Y Abe M Fornage CY Yang NA Bui-Thanh V Wise HH Chen G Rangaraj CM Ballantyne 2007 L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion Atherosclerosis 192 56 66
29. 2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase Cardiovasc Res 53 524 532
30. SM Wells A Holian 2007 Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells Am J Respir Cell Mol Biol 36 520 528
31. K Hasegawa S Wakino S Tatematsu K Yoshioka K Homma N Sugano M Kimoto K Hayashi H Itoh 2007 Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2 Circ Res 101 e2 10
32. O Suda M Tsutsui T Morishita H Tasaki S Ueno S Nakata T Tsujimoto Y Toyohira Y Hayashida Y Sasaguri Y Ueta Y Nakashima N Yanagihara 2004 Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress Arterioscler Thromb Vasc Biol 24 1682 1688
33. MI Yilmaz M Saglam A Sonmez K Caglar E Cakir Y Kurt T Eyileten M Tasar C Acikel Y Oguz A Vural M Yenicesu 2007 Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan Blood Purif 25 327 335
34. RH Böger E Schwedhelm R Maas S Quispe-Bravo C Skamira 2005 ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study Vasc Med 10 S97 102
35. C Napoli V Sica F de Nigris O Pignalosa M Condorelli LJ Ignarro A Liguori 2004 Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension Am Heart J 148 e5
36. JL Jiang S Wang NS Li XH Zhang HW Deng YJ Li 2007 The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells Biochem Cell Biol 85 66 77