메뉴 건너뛰기




Volumn 52, Issue 3, 2013, Pages 234-240

Aging decreases antioxidant effects and increases lipid peroxidation in the Apolipoprotein E deficient mouse

Author keywords

Aging; Apolipoprotein E; Lipid peroxidation; Senescence; TBARS

Indexed keywords

APOLIPOPROTEIN E; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE 1; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 84878314988     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.12-85     Document Type: Article
Times cited : (19)

References (47)
  • 1
    • 34447129492 scopus 로고    scopus 로고
    • Demographic factors associated with the diet quality of older US men: Baseline data from the Osteoporotic Fractures in Men (MrOS) study
    • DOI 10.1017/S1368980007258604, PII S1368980007258604
    • Shannon J, Shikany JM, Barrett-Connor E, et al. Demographic factors associated with the diet quality of older US men: baseline data from the Osteoporotic Fractures in Men (MrOS) study. Public Health Nutr 2007; 10: 810-818. (Pubitemid 47038201)
    • (2007) Public Health Nutrition , vol.10 , Issue.8 , pp. 810-818
    • Shannon, J.1    Shikany, J.M.2    Barrett-Connor, E.3    Marshall, L.M.4    Bunker, C.H.5    Chan, J.M.6    Stone, K.L.7    Orwoll, E.8
  • 2
    • 70349161604 scopus 로고    scopus 로고
    • Implementation of an active aging model in Mexico for prevention and control of chronic diseases in the elderly
    • Mendoza-Núñez VM, Martínez-Maldonado Mde L, Correa-Muñoz E. Implementation of an active aging model in Mexico for prevention and control of chronic diseases in the elderly. BMC Geriatr 2009; 9: 40.
    • (2009) BMC Geriatr , vol.9 , pp. 40
    • Mendoza-Núñez, V.M.1    Martínez-Maldonado, Mde.L.2    Correa-Muñoz, E.3
  • 4
    • 0036860219 scopus 로고    scopus 로고
    • A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice
    • DOI 10.1016/S0047-6374(02)00091-X, PII S004763740200091X
    • Hosokawa M. A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice. Mech Ageing Dev 2002; 123: 1553-1561. (Pubitemid 35449219)
    • (2002) Mechanisms of Ageing and Development , vol.123 , Issue.12 , pp. 1553-1561
    • Hosokawa, M.1
  • 5
    • 79959745884 scopus 로고    scopus 로고
    • Increased lipid accumulation in liver and white adipose tissue in aging in the SAMP10 mouse
    • Honma T, Yanaka M, Tsuduki T, Ikeda I. Increased lipid accumulation in liver and white adipose tissue in aging in the SAMP10 mouse. J Nutr Sci Vitaminol (Tokyo) 2011; 57: 123-129.
    • (2011) J Nutr Sci Vitaminol (Tokyo) , vol.57 , pp. 123-129
    • Honma, T.1    Yanaka, M.2    Tsuduki, T.3    Ikeda, I.4
  • 6
    • 79951552825 scopus 로고    scopus 로고
    • Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice
    • Tsuduki T, Honma T, Nakagawa K, Ikeda I, Miyazawa T. Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice. Nutrition 2011; 27: 334-337.
    • (2011) Nutrition , vol.27 , pp. 334-337
    • Tsuduki, T.1    Honma, T.2    Nakagawa, K.3    Ikeda, I.4    Miyazawa, T.5
  • 9
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258: 468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 10
    • 59849086386 scopus 로고    scopus 로고
    • Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification
    • Maizel J, Six I, Slama M, et al. Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification. Circulation 2009; 119: 306-313.
    • (2009) Circulation , vol.119 , pp. 306-313
    • Maizel, J.1    Six, I.2    Slama, M.3
  • 11
    • 46949111807 scopus 로고    scopus 로고
    • Apolipoprotein E, an important player in longevity and age-related diseases
    • Ang LS, Cruz RP, Hendel A, Granville DJ. Apolipoprotein E, an important player in longevity and age-related diseases. Exp Gerontol 2008; 43: 615-622.
    • (2008) Exp Gerontol , vol.43 , pp. 615-622
    • Ang, L.S.1    Cruz, R.P.2    Hendel, A.3    Granville, D.J.4
  • 12
    • 0037115049 scopus 로고    scopus 로고
    • Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation
    • Buttini M, Yu GQ, Shockley K, et al. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci 2002; 22: 10539-10548. (Pubitemid 36005128)
    • (2002) Journal of Neuroscience , vol.22 , Issue.24 , pp. 10539-10548
    • Buttini, M.1    Yu, G.-Q.2    Shockley, K.3    Huang, Y.4    Jones, B.5    Masliah, E.6    Mallory, M.7    Yeo, T.8    Longo, F.M.9    Mucke, L.10
  • 13
    • 4344715276 scopus 로고    scopus 로고
    • Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a cunjugated triene system, via lipid peroxidation
    • DOI 10.1093/carcin/bgh109
    • Tsuzuki T, Tokuyama Y, Igarashi M, Miyazawa T. Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis 2004; 25: 1417-1425. (Pubitemid 39162707)
    • (2004) Carcinogenesis , vol.25 , Issue.8 , pp. 1417-1425
    • Tsuzuki, T.1    Tokuyama, Y.2    Igarashi, M.3    Miyazawa, T.4
  • 14
    • 41849148974 scopus 로고    scopus 로고
    • Tumor angiogenesis suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via peroxisome proliferator- activated receptor gamma
    • DOI 10.1093/carcin/bgm298
    • Tsuzuki T, Kawakami Y. Tumor angiogenesis suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via peroxisome proliferator-activated receptor gamma. Carcinogenesis 2008; 29: 797-806. (Pubitemid 351494168)
    • (2008) Carcinogenesis , vol.29 , Issue.4 , pp. 797-806
    • Tsuzuki, T.1    Kawakami, Y.2
  • 15
    • 84861461087 scopus 로고    scopus 로고
    • High-fat diet intake accelerates aging, increases expression of Hsd11b1, and promotes lipid accumulation in liver of SAMP10 mouse
    • Honma T, Shinohara N, Ito J, et al. High-fat diet intake accelerates aging, increases expression of Hsd11b1, and promotes lipid accumulation in liver of SAMP10 mouse. Biogerontology 2012; 13: 93-103.
    • (2012) Biogerontology , vol.13 , pp. 93-103
    • Honma, T.1    Shinohara, N.2    Ito, J.3
  • 16
    • 84860660557 scopus 로고    scopus 로고
    • Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo
    • Shinohara N, Tsuduki T, Ito J, et al. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta 2012; 1821: 980-988.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 980-988
    • Shinohara, N.1    Tsuduki, T.2    Ito, J.3
  • 17
    • 0017065248 scopus 로고
    • A simple fluorometric assay for lipoperoxide in blood plasma
    • Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976; 15: 212-216.
    • (1976) Biochem Med , vol.15 , pp. 212-216
    • Yagi, K.1
  • 18
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • DOI 10.1016/0003-2697(79)90738-3
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358. (Pubitemid 9194347)
    • (1979) Analytical Biochemistry , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 19
    • 33846198704 scopus 로고    scopus 로고
    • Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis
    • Qi X, Hauswirth WW, Guy J. Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis. Mol Vis 2007; 13: 1-11. (Pubitemid 46092245)
    • (2007) Molecular Vision , vol.13 , pp. 1-11
    • Qi, X.1    Hauswirth, W.W.2    Guy, J.3
  • 20
    • 77952294953 scopus 로고    scopus 로고
    • Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
    • Wirth EK, Conrad M, Winterer J, et al. Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J 2010; 24: 844-852.
    • (2010) FASEB J , vol.24 , pp. 844-852
    • Wirth, E.K.1    Conrad, M.2    Winterer, J.3
  • 21
    • 76649086338 scopus 로고    scopus 로고
    • RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    • Kawase-Koga Y, Low R, Otaegi G, et al. RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci 2010; 123: 586-594.
    • (2010) J Cell Sci , vol.123 , pp. 586-594
    • Kawase-Koga, Y.1    Low, R.2    Otaegi, G.3
  • 23
    • 33846045643 scopus 로고    scopus 로고
    • Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells
    • Tsuzuki T, Kambe T, Shibata A, Kawakami Y, Nakagawa K, Miyazawa T. Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells. Biochim Biophys Acta 2007; 1771: 20-30.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 20-30
    • Tsuzuki, T.1    Kambe, T.2    Shibata, A.3    Kawakami, Y.4    Nakagawa, K.5    Miyazawa, T.6
  • 24
    • 79959557384 scopus 로고    scopus 로고
    • Increased monocytic adhesion by senescence in human umbilical vein endothelial cells
    • Yanaka M, Honma T, Sato K, et al. Increased monocytic adhesion by senescence in human umbilical vein endothelial cells. Biosci Biotechnol Biochem 2011; 75: 1098-1103.
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 1098-1103
    • Yanaka, M.1    Honma, T.2    Sato, K.3
  • 25
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 26
    • 29444448615 scopus 로고    scopus 로고
    • Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats
    • DOI 10.1007/s11745-005-1475-0, L9815
    • Tsuzuki T, Kawakami Y, Suzuki Y, Abe R, Nakagawa K, Miyazawa T. Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats. Lipids 2005; 40: 1117-1123. (Pubitemid 43010566)
    • (2005) Lipids , vol.40 , Issue.11 , pp. 1117-1123
    • Tsuzuki, T.1    Kawakami, Y.2    Suzuki, Y.3    Abe, R.4    Nakagawa, K.5    Miyazawa, T.6
  • 27
    • 33746022297 scopus 로고    scopus 로고
    • Conjugated docosahexaenoic acid inhibits lipid accumulation in rats
    • DOI 10.1016/j.jnutbio.2005.09.006, PII S0955286305002548
    • Tsuzuki T, Kawakami Y, Nakagawa K, Miyazawa T. Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. J Nutr Biochem 2006; 17: 518-524. (Pubitemid 44066763)
    • (2006) Journal of Nutritional Biochemistry , vol.17 , Issue.8 , pp. 518-524
    • Tsuzuki, T.1    Kawakami, Y.2    Nakagawa, K.3    Miyazawa, T.4
  • 28
    • 0014779155 scopus 로고
    • Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots
    • Rouser G, Fkeischer S, Yamamoto A. Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970; 5: 494-496.
    • (1970) Lipids , vol.5 , pp. 494-496
    • Rouser, G.1    Fkeischer, S.2    Yamamoto, A.3
  • 30
    • 0035071759 scopus 로고    scopus 로고
    • Effects of high-fat, low-cholesterol diets on hepatic peroxidation and antioxidants in apolipoprotein E-deficient mice
    • DOI 10.1023/A:1007296919243
    • Ferré N, Camps J, Paul A, et al. Effects of high-fat, low-cholesterol diets on hepatic lipid peroxidation and antioxidants in apolipoprotein E-deficient mice. Mol Cell Biochem 2001; 218: 165-169. (Pubitemid 32294147)
    • (2001) Molecular and Cellular Biochemistry , vol.218 , Issue.1-2 , pp. 165-169
    • Ferre, N.1    Camps, J.2    Paul, A.3    Cabre, M.4    Calleja, L.5    Osada, J.6    Joven, J.7
  • 32
    • 84860227456 scopus 로고    scopus 로고
    • Age-related dysfunction of the lacrimal gland and oxidative stress: Evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice
    • Kojima T, Wakamatsu TH, Dogru M, et al. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol 2012; 180: 1879-1896.
    • (2012) Am J Pathol , vol.180 , pp. 1879-1896
    • Kojima, T.1    Wakamatsu, T.H.2    Dogru, M.3
  • 33
    • 33749072055 scopus 로고    scopus 로고
    • MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice
    • DOI 10.1161/01.ATV.0000238347.77590.c9, PII 0004360520061000000026
    • Ohashi M, Runge MS, Faraci FM, Heistad DD. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2006; 26: 2331-2336. (Pubitemid 44465730)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.10 , pp. 2331-2336
    • Ohashi, M.1    Runge, M.S.2    Faraci, F.M.3    Heistad, D.D.4
  • 34
    • 77949752957 scopus 로고    scopus 로고
    • Caloric restric tion shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS
    • Patel BP, Safdar A, Raha S, Tarnopolsky MA, Hamadeh MJ. Caloric restric tion shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. Plos One 2010; 5: e9386.
    • (2010) Plos One , vol.5
    • Patel, B.P.1    Safdar, A.2    Raha, S.3    Tarnopolsky, M.A.4    Hamadeh, M.J.5
  • 35
    • 0034063728 scopus 로고    scopus 로고
    • A mechanism for the neuroprotective effect of apolipoprotein E: Isoform- specific modification by the lipid peroxidation product 4-hydroxynonenal
    • DOI 10.1046/j.1471-4159.2000.0741426.x
    • Pedersen WA, Chan SL, Mattson MP. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J Neurochem 2000; 74: 1426-1433. (Pubitemid 30163962)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.4 , pp. 1426-1433
    • Pedersen, W.A.1    Chan, S.L.2    Mattson, M.P.3
  • 36
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • DOI 10.1016/j.molmed.2004.09.003, PII S1471491404002357
    • Motohashi H, Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004; 10: 549-557. (Pubitemid 39433824)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.11 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 37
    • 80051548161 scopus 로고    scopus 로고
    • Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells
    • Um HC, Jang JH, Kim DH, Lee C, Surh YJ. Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells. Nitric Oxide 2011; 25: 161-168.
    • (2011) Nitric Oxide , vol.25 , pp. 161-168
    • Um, H.C.1    Jang, J.H.2    Kim, D.H.3    Lee, C.4    Surh, Y.J.5
  • 38
    • 0026493679 scopus 로고
    • High density lipoprotein is the major carrier of lipid hydroperoxides in human blood-plasma from fasting donors
    • Bowry VW, Stanley KK, Stocker R. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood-plasma from fasting donors. Proc Natl Acad Sci U S A 1992; 89: 10316-10320.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10316-10320
    • Bowry, V.W.1    Stanley, K.K.2    Stocker, R.3
  • 40
    • 0030598932 scopus 로고    scopus 로고
    • In vitro oxidised HDL exerts a cytotoxic effect on macrophages
    • DOI 10.1016/0021-9150(96)05840-6
    • Hurtado I, Fiol C, Gracia V, Caldu P. In vitro oxidised HDL exerts a cytotoxic effect on macrophages. Atherosclerosis 1996; 125: 39-46. (Pubitemid 26267120)
    • (1996) Atherosclerosis , vol.125 , Issue.1 , pp. 39-46
    • Hurtado, I.1    Fiol, C.2    Gracia, V.3    Caldu, P.4
  • 41
    • 0032890194 scopus 로고    scopus 로고
    • Possible role of high susceptibility of high-density lipoprotein to lipid peroxidative modification and oxidized high-density lipoprotein in genesis of coronary artery spasm
    • DOI 10.1016/S0021-9150(98)00235-4, PII S0021915098002354
    • Ohmura H, Watanabe Y, Hatsumi C, et al. Possible role of high susceptibility of high-density lipoprotein to lipid peroxidative modification and oxidized high-density lipoprotein in genesis of coronary artery spasm. Atherosclerosis 1999; 142: 179-184. (Pubitemid 28551823)
    • (1999) Atherosclerosis , vol.142 , Issue.1 , pp. 179-184
    • Ohmura, H.1    Watanabe, Y.2    Hatsumi, C.3    Sato, H.4    Daida, H.5    Mokuno, H.6    Yamaguchi, H.7
  • 42
    • 84860389880 scopus 로고    scopus 로고
    • Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice
    • Karavia EA, Papachristou DJ, Kotsikogianni I, Giopanou I, Kypreos KE. Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice. FEBS J 2011; 278: 3119-3129.
    • (2011) FEBS J , vol.278 , pp. 3119-3129
    • Karavia, E.A.1    Papachristou, D.J.2    Kotsikogianni, I.3    Giopanou, I.4    Kypreos, K.E.5
  • 43
    • 78049523857 scopus 로고    scopus 로고
    • Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity
    • Bowman TA, Ramakrishnan SK, Kaw M, et al. Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. Endocrinology 2010; 151: 5157-5164.
    • (2010) Endocrinology , vol.151 , pp. 5157-5164
    • Bowman, T.A.1    Ramakrishnan, S.K.2    Kaw, M.3
  • 44
    • 79959891977 scopus 로고    scopus 로고
    • Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice
    • Kosinska W, Khmelnitsky M, Kim JH, Zhao ZL, Guttenplan JB. Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice. Environ Mol Mutagen 2011; 52: 502-509.
    • (2011) Environ Mol Mutagen , vol.52 , pp. 502-509
    • Kosinska, W.1    Khmelnitsky, M.2    Kim, J.H.3    Zhao, Z.L.4    Guttenplan, J.B.5
  • 45
    • 80052593219 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidative stress responses of salmon fed a diet containing perfluorooctane sulfonic- or perfluorooctane carboxylic acids
    • Arukwe A, Mortensen AS. Lipid peroxidation and oxidative stress responses of salmon fed a diet containing perfluorooctane sulfonic- or perfluorooctane carboxylic acids. Comp Biochem Physiol C Toxicol Pharmacol 2011; 154: 288-295.
    • (2011) Comp Biochem Physiol C Toxicol Pharmacol , vol.154 , pp. 288-295
    • Arukwe, A.1    Mortensen, A.S.2
  • 46
    • 84862289956 scopus 로고    scopus 로고
    • Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B1-induced liver carcinogenesis in rats
    • Kumar M, Verma V, Nagpal R, et al. Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B1-induced liver carcinogenesis in rats. Br J Nutr 2012; 107: 1006-1016.
    • (2012) Br J Nutr , vol.107 , pp. 1006-1016
    • Kumar, M.1    Verma, V.2    Nagpal, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.