Covalent inhibition of serine β-lactamases by novel hydroxamic acid derivatives

Biochemistry

Volumn 52, Issue 21, 2013, Pages 3712-3720

  Tilvawala, Ronak ^a   Pratt, R F ^a  

^a WESLEYAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC ACTIVITY; ENZYME ACTIVE SITES; ENZYME PHOSPHORYLATION; FREE SOLUTIONS; HYDROXAMIC ACIDS; LEAVING GROUPS; MEDICAL PRACTICE; STRUCTURE-ACTIVITY;

AMIDES; AMINO ACIDS; ANTIBIOTICS; HYDROLYSIS; MASS SPECTROMETRY; PHOSPHORYLATION;

ENZYMES;

(O PHENOXYCARBONYL) 1 BENZYL 3 HYDROXYUREA; ANTIBIOTIC AGENT; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; N (BENZYLOXYCARBONYL) O (PHENYLPHOSPHORYL) HYDROXYLAMINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROSS LINKING; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HYDROLYSIS; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BETA-LACTAMASES; ENZYME INHIBITORS; HYDROXAMIC ACIDS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SERINE;

EID: 84878312151     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4003887     Document Type: Article

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