메뉴 건너뛰기




Volumn 1, Issue 4, 2008, Pages 559-571

β-lactams against emerging 'superbugs': Progress and pitfalls

Author keywords

Lactamase inhibitor; Anti methicilin resistant staphylococcus aureus carbapenems; Ceftaroline; Ceftobiprole; Doripenem; Methicilin resistant staphylococcus aureus; Multidrug resistant acinetobacter; NXL 104; Pseudomonas aeruginosa

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEFALEXIN; CEFTAROLINE FOSAMIL; CEFTOBIPROLE MEDOCARIL; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CEPHALOSPORINASE; CILASTATIN PLUS IMIPENEM; CP 5609; DORIBAX; DORIPENEM; EXTENDED SPECTRUM BETA LACTAMASE; LEVOFLOXACIN; LINEZOLID; ME 1036; MINOCYCLINE; OUTER MEMBRANE PROTEIN; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; PORIN; PPI 0903M; PZ 601; SM 216601; SMP 216601; SMP 601; T 91825; TIGECYCLINE; TOMOPENEM; UNINDEXED DRUG; VANCOMYCIN;

EID: 49449109243     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/17512433.1.4.559     Document Type: Review
Times cited : (2)

References (113)
  • 1
    • 37849048632 scopus 로고    scopus 로고
    • Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia
    • Kim SH, Kim KH, Kim HB et al. Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia. Antimicrob. Agents Chemother. 52(1), 192-197 (2008).
    • (2008) Antimicrob. Agents Chemother , vol.52 , Issue.1 , pp. 192-197
    • Kim, S.H.1    Kim, K.H.2    Kim, H.B.3
  • 2
    • 33846140488 scopus 로고    scopus 로고
    • Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    • Stryjewski ME, Szczech LA, Benjamin DKJ et al. Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin. Infect. Dis. 44(2), 190-196 (2007).
    • (2007) Clin. Infect. Dis , vol.44 , Issue.2 , pp. 190-196
    • Stryjewski, M.E.1    Szczech, L.A.2    Benjamin, D.K.J.3
  • 3
    • 4644366894 scopus 로고    scopus 로고
    • The basis for resistance to β-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus
    • Fuda C SM, Vakulenko SB, Mobashery S. The basis for resistance to β-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J. Biol. Chem. 279(39), 40802-40806 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.39 , pp. 40802-40806
    • Fuda, C.S.1    Vakulenko, S.B.2    Mobashery, S.3
  • 4
    • 34548816157 scopus 로고    scopus 로고
    • Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: Epidemiological and molecular aspects
    • Martins A, Cunha ML. Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: epidemiological and molecular aspects. Microbiol. Immunol. 51(9), 787-795 (2007).
    • (2007) Microbiol. Immunol , vol.51 , Issue.9 , pp. 787-795
    • Martins, A.1    Cunha, M.L.2
  • 5
    • 45149119170 scopus 로고    scopus 로고
    • Restoration of susceptibility of methicillin-resistant staphylococcus aureus (MRSA) to β-lactam antibiotics by acidic PH: Role of penicillin-binding protein 2A (PBP 2A)
    • Lemaire S, Fuda C, Van Bambeke F, Tulkens PM, Mobashery S. Restoration of susceptibility of methicillin-resistant staphylococcus aureus (MRSA) to β-lactam antibiotics by acidic PH: role of penicillin-binding protein 2A (PBP 2A). J. Biol. Chem. 283(19), 12769-12776 (2008).
    • (2008) J. Biol. Chem , vol.283 , Issue.19 , pp. 12769-12776
    • Lemaire, S.1    Fuda, C.2    Van Bambeke, F.3    Tulkens, P.M.4    Mobashery, S.5
  • 6
    • 0036829003 scopus 로고    scopus 로고
    • Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus
    • Lim D, Strynadka NC. Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat. Struct: Biol. 9(11), 870-876 (2002).
    • (2002) Nat. Struct: Biol , vol.9 , Issue.11 , pp. 870-876
    • Lim, D.1    Strynadka, N.C.2
  • 7
    • 0028235806 scopus 로고
    • Purification, properties, and kinetics of enzymatic acylation with β-lactams of soluble penicillin-binding protein 2a. A major factor in methicillin-resistant Staphylococcus aureus
    • Roychoudhury S, Dotzlaf JE, Ghag S, Yeh WK. Purification, properties, and kinetics of enzymatic acylation with β-lactams of soluble penicillin-binding protein 2a. A major factor in methicillin-resistant Staphylococcus aureus. J. Biol. Chem. 269(16), 12067-12073 (1994).
    • (1994) J. Biol. Chem , vol.269 , Issue.16 , pp. 12067-12073
    • Roychoudhury, S.1    Dotzlaf, J.E.2    Ghag, S.3    Yeh, W.K.4
  • 8
    • 0032526053 scopus 로고    scopus 로고
    • Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with β-lactams and acyclic substrates: Kinetics in homogeneous solution
    • Graves-Woodward K, Pratt RF. Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with β-lactams and acyclic substrates: kinetics in homogeneous solution. Biochem. J. 332(Pt 3), 755-761 (1998).
    • (1998) Biochem. J , vol.332 , Issue.PART 3 , pp. 755-761
    • Graves-Woodward, K.1    Pratt, R.F.2
  • 9
    • 0036367233 scopus 로고    scopus 로고
    • Factors influencing methicillin resistance in staphylococci
    • Berger-Bächi B, Rohrer S. Factors influencing methicillin resistance in staphylococci. Arch. Microbiol. 178(3), 165-171 (2002).
    • (2002) Arch. Microbiol , vol.178 , Issue.3 , pp. 165-171
    • Berger-Bächi, B.1    Rohrer, S.2
  • 10
    • 34447254695 scopus 로고    scopus 로고
    • Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
    • Davies TA, Page MG, Shang W, Andrew T, Kania M, Bush K. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51(7), 2621-2624 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.7 , pp. 2621-2624
    • Davies, T.A.1    Page, M.G.2    Shang, W.3    Andrew, T.4    Kania, M.5    Bush, K.6
  • 11
    • 33748575602 scopus 로고    scopus 로고
    • Anti-MRSA β-lactams in development
    • Page MG. Anti-MRSA β-lactams in development. Curr. Opin. Pharmacol. 6(5), 480-485 (2006).
    • (2006) Curr. Opin. Pharmacol , vol.6 , Issue.5 , pp. 480-485
    • Page, M.G.1
  • 12
    • 0000214977 scopus 로고    scopus 로고
    • Vancomycin resistant Staphylococcus aureus - Pennsylvania, 2002
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Vancomycin resistant Staphylococcus aureus - Pennsylvania, 2002. MMWR Morb. Mortal. Wkly Rep. 51(40), 902 (2002).
    • (2002) MMWR Morb. Mortal. Wkly Rep , vol.51 , Issue.40 , pp. 902
  • 14
    • 39749193928 scopus 로고    scopus 로고
    • Vancomycin-resistant Staphylococcus aureus: A perfect but geographically limited storm?
    • Tenover FC. Vancomycin-resistant Staphylococcus aureus: a perfect but geographically limited storm? Clin. Infect. Dis. 46(5), 675-677 (2008).
    • (2008) Clin. Infect. Dis , vol.46 , Issue.5 , pp. 675-677
    • Tenover, F.C.1
  • 15
    • 40749096040 scopus 로고    scopus 로고
    • Changes in serotypes and antimicrobial susceptibility of invasive Streptococcus pneumoniae strains in Cleveland: A quarter century of experience
    • Jacobs MR, Good CE, Beall B, Bajaksouzian S, Windau AR, Whitney CG. Changes in serotypes and antimicrobial susceptibility of invasive Streptococcus pneumoniae strains in Cleveland: a quarter century of experience. J. Clin. Microbiol. 46(3), 982-990 (2008).
    • (2008) J. Clin. Microbiol , vol.46 , Issue.3 , pp. 982-990
    • Jacobs, M.R.1    Good, C.E.2    Beall, B.3    Bajaksouzian, S.4    Windau, A.R.5    Whitney, C.G.6
  • 16
    • 33646948881 scopus 로고    scopus 로고
    • Antimicrobial resistance in Gram-positive bacteria
    • discussion S62-S70
    • Rice LB. Antimicrobial resistance in Gram-positive bacteria. Am. J. Med. 119(6 Suppl. 1), S11-S19; discussion S62-S70 (2006).
    • (2006) Am. J. Med , vol.119 , Issue.6 SUPPL. 1
    • Rice, L.B.1
  • 17
    • 0031800337 scopus 로고    scopus 로고
    • Important and emerging β-lactamase-mediated resistances in hospital-based pathogens: The Amp C enzymes
    • Jones RN. Important and emerging β-lactamase-mediated resistances in hospital-based pathogens: the Amp C enzymes. Diagn. Microbiol. Infect. Dis. 31(3), 461-466 (1998).
    • (1998) Diagn. Microbiol. Infect. Dis , vol.31 , Issue.3 , pp. 461-466
    • Jones, R.N.1
  • 19
    • 33750624074 scopus 로고    scopus 로고
    • Metallo-β-lactamases: Novel weaponry for antibiotic resistance in bacteria
    • Crowder MW, Spencer J, Vila AJ. Metallo-β-lactamases: novel weaponry for antibiotic resistance in bacteria. Acc. Chem. Res. 39(10), 721-728 (2006).
    • (2006) Acc. Chem. Res , vol.39 , Issue.10 , pp. 721-728
    • Crowder, M.W.1    Spencer, J.2    Vila, A.J.3
  • 22
    • 0000908299 scopus 로고
    • AmpC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of β-lactamases of the penicillinase type
    • Jaurin B, Grundström T. AmpC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of β-lactamases of the penicillinase type. Proc. Natl Acad. Sci. USA 78(8), 4897-4901 (1981).
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , Issue.8 , pp. 4897-4901
    • Jaurin, B.1    Grundström, T.2
  • 23
    • 0023446033 scopus 로고
    • Precise insertion of antibiotic resistance determinants into Tn21-like transposons: Nucleotide sequence of the OXA-1 β-lactamase gene
    • Ouellette M, Bissonncrte L, Roy PH. Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 β-lactamase gene. Proc. Natl Acad. Sci. USA 84(21), 7378-7382 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , Issue.21 , pp. 7378-7382
    • Ouellette, M.1    Bissonncrte, L.2    Roy, P.H.3
  • 24
    • 0029071785 scopus 로고
    • A functional classification scheme for β-lactamases and its correlation with molecular structure
    • Bush K, Jacoby GA, Medeiros AA. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39(6), 1211-1233 (1995).
    • (1995) Antimicrob. Agents Chemother , vol.39 , Issue.6 , pp. 1211-1233
    • Bush, K.1    Jacoby, G.A.2    Medeiros, A.A.3
  • 27
    • 33645788333 scopus 로고    scopus 로고
    • Extended-spectrum β-lactamases and clinical outcomes: Current data
    • Ramphal R, Ambrose PG. Extended-spectrum β-lactamases and clinical outcomes: current data. Clin. Infect. Dis. 42(Suppl. 4), S164-S172 (2006).
    • (2006) Clin. Infect. Dis , vol.42 , Issue.SUPPL. 4
    • Ramphal, R.1    Ambrose, P.G.2
  • 28
    • 33751566651 scopus 로고    scopus 로고
    • Bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli in the CTX-M era: A new clinical challenge
    • Rodríguez-Baño J, Navarro MD, Romero L et al. Bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge. Clin. Infect. Dis. 43(11), 1407-1414 (2006).
    • (2006) Clin. Infect. Dis , vol.43 , Issue.11 , pp. 1407-1414
    • Rodríguez-Baño, J.1    Navarro, M.D.2    Romero, L.3
  • 29
    • 33751572498 scopus 로고    scopus 로고
    • Extended-spectrum β-lactainases in multidrug-resistant Escherichia coli: Changing the therapy for hospital-acquired and community-acquired infections
    • Helfand MS, Bonomo RA. Extended-spectrum β-lactainases in multidrug-resistant Escherichia coli: changing the therapy for hospital-acquired and community-acquired infections. Clin. Infect. Dis. 43(11), 1415-1416 (2006).
    • (2006) Clin. Infect. Dis , vol.43 , Issue.11 , pp. 1415-1416
    • Helfand, M.S.1    Bonomo, R.A.2
  • 30
    • 12944331945 scopus 로고    scopus 로고
    • Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York
    • Bratu S, Landman D, Alam M, Tolentino E, Quale J. Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York. Antimicrob. Agents Chemother. 49(2), 776-778 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.2 , pp. 776-778
    • Bratu, S.1    Landman, D.2    Alam, M.3    Tolentino, E.4    Quale, J.5
  • 31
    • 22144436291 scopus 로고    scopus 로고
    • Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: A new threat to our antibiotic armamentarium
    • Bratu S, Landman D, Haag R et al. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch. Intern. Med. 165(12), 1430-1435. (2005).
    • (2005) Arch. Intern. Med , vol.165 , Issue.12 , pp. 1430-1435
    • Bratu, S.1    Landman, D.2    Haag, R.3
  • 32
    • 21444442707 scopus 로고    scopus 로고
    • Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and recommendations for detection
    • Bratu S, Moory M, Nichani S et al. Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob. Agents Chemother. 49(7), 3018-3020. (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.7 , pp. 3018-3020
    • Bratu, S.1    Moory, M.2    Nichani, S.3
  • 33
    • 24044518439 scopus 로고    scopus 로고
    • Bratu S, Tolaney P, Karumudi U et al. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J. Antimicrob. Chemother. 56(1), 128-132 (2005).
    • Bratu S, Tolaney P, Karumudi U et al. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J. Antimicrob. Chemother. 56(1), 128-132 (2005).
  • 36
    • 0034725405 scopus 로고    scopus 로고
    • The first structural and mechanistic insights for class D β-lactamases: Evidence for a novel catalytic process for turnover of β-lactam antibiotics
    • Golemi D, Maveyraud L, Vakulenko S et al. The first structural and mechanistic insights for class D β-lactamases: evidence for a novel catalytic process for turnover of β-lactam antibiotics. J. Am. Chem. Soc. 122, 6132 (2000).
    • (2000) J. Am. Chem. Soc , vol.122 , pp. 6132
    • Golemi, D.1    Maveyraud, L.2    Vakulenko, S.3
  • 37
    • 41449096190 scopus 로고    scopus 로고
    • Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 β-lactamase: Raman crystallographic eidence
    • Totir MA, Cha J, Ishiwata A et al. Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 β-lactamase: Raman crystallographic eidence. Biochemistry 47(13), 4094-4101 (2008).
    • (2008) Biochemistry , vol.47 , Issue.13 , pp. 4094-4101
    • Totir, M.A.1    Cha, J.2    Ishiwata, A.3
  • 41
    • 45349083156 scopus 로고    scopus 로고
    • Prevalence of extended spectrum β-lactamase producers (ESBLs) and fluoroquinolone-resistant isolates from phase 3 trials of complicated urinary tract infections (UTIs) including pyelonephritis
    • Presented at:, Chicago, IL, USA, 16 September
    • Kaniga K, Redman R, Llorens L, Friedland I. Prevalence of extended spectrum β-lactamase producers (ESBLs) and fluoroquinolone-resistant isolates from phase 3 trials of complicated urinary tract infections (UTIs) including pyelonephritis. Presented at: 47th Intencience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • (2007) 47th Intencience Conference on Antimicrobial Agents and Chemotherapeutics
    • Kaniga, K.1    Redman, R.2    Llorens, L.3    Friedland, I.4
  • 42
    • 19544371927 scopus 로고    scopus 로고
    • In vitro activity of doripenem (S-4661) against multidrug-resistant Gram-negative bacilli isolated from patients with cystic fibrosis
    • Chen Y, Garber E, Zhao Q et al. In vitro activity of doripenem (S-4661) against multidrug-resistant Gram-negative bacilli isolated from patients with cystic fibrosis. Antimicrob. Agents Chemother. 49(6), 2510-2511 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.6 , pp. 2510-2511
    • Chen, Y.1    Garber, E.2    Zhao, Q.3
  • 43
    • 31944435623 scopus 로고    scopus 로고
    • In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients
    • Traczewski MM, Brown SD. In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients. Antimicrob. Agents Chemother. 50(2), 819-821 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.2 , pp. 819-821
    • Traczewski, M.M.1    Brown, S.D.2
  • 44
    • 38649113256 scopus 로고    scopus 로고
    • In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds
    • Goldstein EJ, Citron DM, Merriam CV, Warren YA, Tyrrell KL, Fernandez HT. In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds. Antimicrob. Agents Chemother. 52(2), 761-766 (2008).
    • (2008) Antimicrob. Agents Chemother , vol.52 , Issue.2 , pp. 761-766
    • Goldstein, E.J.1    Citron, D.M.2    Merriam, C.V.3    Warren, Y.A.4    Tyrrell, K.L.5    Fernandez, H.T.6
  • 45
    • 21244474420 scopus 로고    scopus 로고
    • Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: Tentative disc diffusion criteria and quality control
    • Brown SD, Traczewski MM. Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: tentative disc diffusion criteria and quality control. J. Antimicrob. Chemother. 55 (6), 944-949 (2005).
    • (2005) J. Antimicrob. Chemother , vol.55 , Issue.6 , pp. 944-949
    • Brown, S.D.1    Traczewski, M.M.2
  • 46
    • 3342905057 scopus 로고    scopus 로고
    • Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential
    • Mushtaq S, Ge Y, Livermore DM. Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential. Antimicrob. Agents Chemother. 48(8), 3086-3092 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.8 , pp. 3086-3092
    • Mushtaq, S.1    Ge, Y.2    Livermore, D.M.3
  • 47
    • 33744950954 scopus 로고    scopus 로고
    • Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: The high potency of a new carbapenem doripenem
    • Sakyo S, Tomita H, Tanimoto K, Fujimoto S, Ike Y. Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: the high potency of a new carbapenem doripenem. J. Antibiot. (Tokyo) 59(4), 220-228 (2006).
    • (2006) J. Antibiot. (Tokyo) , vol.59 , Issue.4 , pp. 220-228
    • Sakyo, S.1    Tomita, H.2    Tanimoto, K.3    Fujimoto, S.4    Ike, Y.5
  • 48
    • 33745278218 scopus 로고    scopus 로고
    • Delayed resistance selection for doripenem when passaging Pseudomonas aeruginosa isolates with doripenem plus an aminoglycoside
    • Huynh HK, Biedenbach DJ, Jones RN. Delayed resistance selection for doripenem when passaging Pseudomonas aeruginosa isolates with doripenem plus an aminoglycoside. Diagn. Microbiol. Infect. Dis. 55(3), 241-243 (2006).
    • (2006) Diagn. Microbiol. Infect. Dis , vol.55 , Issue.3 , pp. 241-243
    • Huynh, H.K.1    Biedenbach, D.J.2    Jones, R.N.3
  • 49
    • 25844432417 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem
    • Ueda Y, Kanazawa K, Eguchi K, Takemoto K, Eriguchi Y, Sunagawa M. In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem. Antimicrob. Agents Chemother. 49(10), 4185-4196 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.10 , pp. 4185-4196
    • Ueda, Y.1    Kanazawa, K.2    Eguchi, K.3    Takemoto, K.4    Eriguchi, Y.5    Sunagawa, M.6
  • 51
    • 49449085339 scopus 로고    scopus 로고
    • PZ-601 (SMP-601) susceptibility against Gram-negative pathogens with known resistance mechanisms
    • Presented at:, Chicago, IL, USA, 16 September
    • Lolans K, Quinn JP. PZ-601 (SMP-601) susceptibility against Gram-negative pathogens with known resistance mechanisms. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics
    • Lolans, K.1    Quinn, J.P.2
  • 52
    • 49449102472 scopus 로고    scopus 로고
    • Paterson DL, Adams J, Doi Y. In vitro activity of PZ-601 (SMP-601), a novel carbapenem, against extended spectrum β-lactmase producing organisms. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Paterson DL, Adams J, Doi Y. In vitro activity of PZ-601 (SMP-601), a novel carbapenem, against extended spectrum β-lactmase producing organisms. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 53
    • 49449085724 scopus 로고    scopus 로고
    • Fujimoto K, Kanazawa K, Pace J, Xerri L. In vitro activity of SMP-601 (PZ-601) in combination with other antimicrobial agents against SMP-intermediate/resistant Acinetobacter baumannii. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Fujimoto K, Kanazawa K, Pace J, Xerri L. In vitro activity of SMP-601 (PZ-601) in combination with other antimicrobial agents against SMP-intermediate/resistant Acinetobacter baumannii. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 55
    • 44449167059 scopus 로고    scopus 로고
    • Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    • Kihara R, Yanagihara K, Morinaga Y et al. Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob. Agents Chemother. 52(6), 2163-2168 (2008).
    • (2008) Antimicrob. Agents Chemother , vol.52 , Issue.6 , pp. 2163-2168
    • Kihara, R.1    Yanagihara, K.2    Morinaga, Y.3
  • 56
    • 3342977844 scopus 로고    scopus 로고
    • In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci
    • Kurazono M, Ida T, Yamada K et al. In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 48(8), 2831-2837 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.8 , pp. 2831-2837
    • Kurazono, M.1    Ida, T.2    Yamada, K.3
  • 57
    • 40549135961 scopus 로고    scopus 로고
    • Sader HS, Fritsche TR, Jones RN. Antimicrobial activity of ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Antimicrob. Agents Chemother. (2008).
    • Sader HS, Fritsche TR, Jones RN. Antimicrobial activity of ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Antimicrob. Agents Chemother. (2008).
  • 58
    • 23044515843 scopus 로고    scopus 로고
    • Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus
    • Nagura J, Kijima K, Kurazono M et al. Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49(8), 3526-3528 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.8 , pp. 3526-3528
    • Nagura, J.1    Kijima, K.2    Kurazono, M.3
  • 59
    • 34147160821 scopus 로고    scopus 로고
    • Anti-MRSA β-lactams in development, with a focus on ceftobiprole: The first anti-MRSA β-lactam to demonstrate clinical efficacy
    • Bush K, Heep M, Macielag MJ, Noel GJ. Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy. Expert Opin. Investig. Drugs 16(4), 419-429 (2007).
    • (2007) Expert Opin. Investig. Drugs , vol.16 , Issue.4 , pp. 419-429
    • Bush, K.1    Heep, M.2    Macielag, M.J.3    Noel, G.J.4
  • 60
    • 49449084163 scopus 로고    scopus 로고
    • J&J antibiotic hits roadblock
    • Wang SS. J&J antibiotic hits roadblock. Wall St J. D8 (2008).
    • (2008) Wall St J , vol.D8
    • Wang, S.S.1
  • 61
    • 39749117473 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections
    • Noel GJ, Bush K, Bagchi P, Ianus J, Strauss RS. A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin. Infect. Dis. 46(5), 647-655 (2008).
    • (2008) Clin. Infect. Dis , vol.46 , Issue.5 , pp. 647-655
    • Noel, G.J.1    Bush, K.2    Bagchi, P.3    Ianus, J.4    Strauss, R.S.5
  • 62
    • 39749190058 scopus 로고    scopus 로고
    • Ceftobiprole: A new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus
    • Widmer AF. Ceftobiprole: a new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 46(5), 656-658 (2008).
    • (2008) Clin. Infect. Dis , vol.46 , Issue.5 , pp. 656-658
    • Widmer, A.F.1
  • 63
    • 25844470484 scopus 로고    scopus 로고
    • Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporin
    • Bogdanovich T, Ednie LM, Shapiro S, Appelbaum PC. Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporin. Antimicrob. Agents Chemother. 49(10), 4210-4219 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.10 , pp. 4210-4219
    • Bogdanovich, T.1    Ednie, L.M.2    Shapiro, S.3    Appelbaum, P.C.4
  • 64
    • 33746871153 scopus 로고    scopus 로고
    • Denis O, Deplano A, Nonhoff C et al. In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals. Antimicrob. Agents Chemother. 50(8), 2680-2685 (2006).
    • Denis O, Deplano A, Nonhoff C et al. In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals. Antimicrob. Agents Chemother. 50(8), 2680-2685 (2006).
  • 65
    • 34347339330 scopus 로고    scopus 로고
    • Rouse MS, Steckelberg JM, Patel R. In vitro activity of ceftobiprole, daptomycin, linezolid, and vancomycin against methicillin-resistant staphylococci associated with endocarditis and bone and joint infection. Diagn. Microbiol. Infect. Dis. 58(3), 363-365 (2007).
    • Rouse MS, Steckelberg JM, Patel R. In vitro activity of ceftobiprole, daptomycin, linezolid, and vancomycin against methicillin-resistant staphylococci associated with endocarditis and bone and joint infection. Diagn. Microbiol. Infect. Dis. 58(3), 363-365 (2007).
  • 66
    • 36549043372 scopus 로고    scopus 로고
    • Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees
    • Yun HC, Ellis MW, Jorgensen JH. Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees. Diagn. Microbiol. Infect. Dis. 59(4), 463-466. (2007).
    • (2007) Diagn. Microbiol. Infect. Dis , vol.59 , Issue.4 , pp. 463-466
    • Yun, H.C.1    Ellis, M.W.2    Jorgensen, J.H.3
  • 68
    • 25844481076 scopus 로고    scopus 로고
    • Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes
    • von Eiff C, Friedrich AW, Becker K, Peters G. Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes. Antimicrob. Agents Chemother. 49(10), 4372-4374 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.10 , pp. 4372-4374
    • von Eiff, C.1    Friedrich, A.W.2    Becker, K.3    Peters, G.4
  • 70
    • 66249083925 scopus 로고    scopus 로고
    • Intraphagocytic activities of ceftobiprole vs. conventional cephalosporins against methicillin-sensitive (MSSA) and methicillin-resistant S. aureus (MRSA)
    • Presented at:, Chicago, IL, USA, 16 September
    • Lemaire S, Van Bambeke F, Glupczynski Y, Tulkens PM. Intraphagocytic activities of ceftobiprole vs. conventional cephalosporins against methicillin-sensitive (MSSA) and methicillin-resistant S. aureus (MRSA). Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics
    • Lemaire, S.1    Van Bambeke, F.2    Glupczynski, Y.3    Tulkens, P.M.4
  • 71
    • 49449087835 scopus 로고    scopus 로고
    • Banerjee R, Chambers HF. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Banerjee R, Chambers HF. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 72
    • 34447281484 scopus 로고    scopus 로고
    • Identification and phenotypic characterization of a β-lactam-dependent, methicillin-resistant Staphylococcus aureus strain
    • Goldstein F, Perutka J, Cuirolo A et al. Identification and phenotypic characterization of a β-lactam-dependent, methicillin-resistant Staphylococcus aureus strain. Antimicrob. Agents Chemother. 51(7), 2514-2522 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.7 , pp. 2514-2522
    • Goldstein, F.1    Perutka, J.2    Cuirolo, A.3
  • 73
    • 40049097830 scopus 로고    scopus 로고
    • In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent Gram-positive and Gram-negative isolates of European origin
    • Pillar CM, Aranza MK, Shah D, Sahm DF. In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent Gram-positive and Gram-negative isolates of European origin. J. Antimicrob. Chemother. (2008).
    • (2008) J. Antimicrob. Chemother
    • Pillar, C.M.1    Aranza, M.K.2    Shah, D.3    Sahm, D.F.4
  • 74
    • 38349146133 scopus 로고    scopus 로고
    • In vitro activity of ceftobiprole against Burkholderia pseudomallei
    • Thamlikitkul V, Trakulsomboon S. In vitro activity of ceftobiprole against Burkholderia pseudomallei. J. Antimicrob. Chemother. 61(2), 460-461. (2008).
    • (2008) J. Antimicrob. Chemother , vol.61 , Issue.2 , pp. 460-461
    • Thamlikitkul, V.1    Trakulsomboon, S.2
  • 76
    • 49449103212 scopus 로고    scopus 로고
    • Kresken M, Brauers J, Korber-Irrgang B, Menke A, Romfeld C. In vitro activities of ceftobiprole combined with amikacin or levofloxacin against Pseudamonas aeruginosa by time kill methodology. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Kresken M, Brauers J, Korber-Irrgang B, Menke A, Romfeld C. In vitro activities of ceftobiprole combined with amikacin or levofloxacin against Pseudamonas aeruginosa by time kill methodology. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 77
    • 49449090517 scopus 로고    scopus 로고
    • Queenan AM, Bush K. More rapid penetrability of ceftobiprole and cefepime compared to ceftazidime into Escherichia coli and Enterobacter cloacae. Presented at: 47 th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Queenan AM, Bush K. More rapid penetrability of ceftobiprole and cefepime compared to ceftazidime into Escherichia coli and Enterobacter cloacae. Presented at: 47 th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 78
    • 37849009009 scopus 로고    scopus 로고
    • Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by Gram-positive bacteria
    • Noel GJ, Strauss RS, Amsler K, Heep M, Pypstra R, Solomkin JS. Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by Gram-positive bacteria. Antimicrob. Agents Chemother. 52(1), 37-44 (2008).
    • (2008) Antimicrob. Agents Chemother , vol.52 , Issue.1 , pp. 37-44
    • Noel, G.J.1    Strauss, R.S.2    Amsler, K.3    Heep, M.4    Pypstra, R.5    Solomkin, J.S.6
  • 79
    • 24144435354 scopus 로고    scopus 로고
    • Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus
    • Vaudaux P, Gjinovci A, Bento M, Li D, Schrenzel J, Lew DP. Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49(9), 3789-3793 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.9 , pp. 3789-3793
    • Vaudaux, P.1    Gjinovci, A.2    Bento, M.3    Li, D.4    Schrenzel, J.5    Lew, D.P.6
  • 80
    • 14744278669 scopus 로고    scopus 로고
    • Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    • Chambers HF. Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob. Agents Chemother. 49(3), 884-888 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.3 , pp. 884-888
    • Chambers, H.F.1
  • 81
    • 20944431809 scopus 로고    scopus 로고
    • Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin
    • Kosowska K, Hoellman DB, Clark C et al. Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin. Antimicrob. Agents Chemother. 49(5), 1932-1942 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.5 , pp. 1932-1942
    • Kosowska, K.1    Hoellman, D.B.2    Clark, C.3
  • 82
    • 33744485266 scopus 로고    scopus 로고
    • Activities of ceftobiprole, a novel broad-spectrum cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis
    • Bogdanovich T, Clark C, Ednie LM et al. Activities of ceftobiprole, a novel broad-spectrum cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis. Antimicrob. Agents Chemother. 50(6), 2050-2057 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.6 , pp. 2050-2057
    • Bogdanovich, T.1    Clark, C.2    Ednie, L.M.3
  • 83
    • 34250172067 scopus 로고    scopus 로고
    • Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including β-lactamase-producing and vancomycin-resistant isolates
    • Arias CA, Singh KV, Panesso D, Murray BE. Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including β-lactamase-producing and vancomycin-resistant isolates. Antimicrob. Agents Chemother. 51(6), 2043-2047 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.6 , pp. 2043-2047
    • Arias, C.A.1    Singh, K.V.2    Panesso, D.3    Murray, B.E.4
  • 84
    • 34548118782 scopus 로고    scopus 로고
    • Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model
    • Arias CA, Singh KV, Panesso D, Murray BE. Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model. J. Antimicrob. Chemother. 60(3), 594-598. (2007).
    • (2007) J. Antimicrob. Chemother , vol.60 , Issue.3 , pp. 594-598
    • Arias, C.A.1    Singh, K.V.2    Panesso, D.3    Murray, B.E.4
  • 85
    • 34247863918 scopus 로고    scopus 로고
    • Amtianaerobe activity of ceftobiprole, a new broad-spectrum cephalosporin
    • Ednie LM, Shapiro S, Appelbaum PC. Amtianaerobe activity of ceftobiprole, a new broad-spectrum cephalosporin. Diagn. Microbiol. Infect. Dis. 58(1), 133-136. (2007).
    • (2007) Diagn. Microbiol. Infect. Dis , vol.58 , Issue.1 , pp. 133-136
    • Ednie, L.M.1    Shapiro, S.2    Appelbaum, P.C.3
  • 86
    • 35948961490 scopus 로고    scopus 로고
    • Interactions of ceftobiprole with β-lactamases from molecular classes A to D
    • Queenan AM, Shang W, Kania M, Page MG, Bush K. Interactions of ceftobiprole with β-lactamases from molecular classes A to D. Antimicrob. Agents Chemother. 51(9), 3089-3095. (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.9 , pp. 3089-3095
    • Queenan, A.M.1    Shang, W.2    Kania, M.3    Page, M.G.4    Bush, K.5
  • 87
    • 3843081646 scopus 로고    scopus 로고
    • In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599
    • Iizawa Y, Nagai J, Ishikawa T et al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. J. Infect. Chemother. 10(3), 146-156 (2004).
    • (2004) J. Infect. Chemother , vol.10 , Issue.3 , pp. 146-156
    • Iizawa, Y.1    Nagai, J.2    Ishikawa, T.3
  • 88
    • 23044471735 scopus 로고    scopus 로고
    • Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
    • Sader HS, Fritsche TR, Kaniga K, Ge Y, Jones RN. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrob. Agents Chemother. 49(8), 3501-3512 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.8 , pp. 3501-3512
    • Sader, H.S.1    Fritsche, T.R.2    Kaniga, K.3    Ge, Y.4    Jones, R.N.5
  • 89
    • 34547841550 scopus 로고    scopus 로고
    • In vitro activity of ceftaroline (PPI-0903M, T-91825) against bacteria with defined resistance mechanisms and phenotypes
    • Mushtaq S, Warner M, Ge Y, Kaniga K, Livermore DM. In vitro activity of ceftaroline (PPI-0903M, T-91825) against bacteria with defined resistance mechanisms and phenotypes. J. Antimicrob. Chemother. 60(2), 300-311 (2007).
    • (2007) J. Antimicrob. Chemother , vol.60 , Issue.2 , pp. 300-311
    • Mushtaq, S.1    Warner, M.2    Ge, Y.3    Kaniga, K.4    Livermore, D.M.5
  • 90
    • 33645766499 scopus 로고    scopus 로고
    • Pharmacodynamics of a new cephalosporin PPI-0903 active against methicillin resistant Staphylococcus aureus in routine thigh and lung infection models: Identification of an in vivo pharmacokinetic-pharmacodynamic target
    • Andes D, Craig WA. Pharmacodynamics of a new cephalosporin PPI-0903 active against methicillin resistant Staphylococcus aureus in routine thigh and lung infection models: identification of an in vivo pharmacokinetic-pharmacodynamic target. Antimicrob. Agents Chemother. 50(4), 1376-1383 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.4 , pp. 1376-1383
    • Andes, D.1    Craig, W.A.2
  • 91
    • 35948962693 scopus 로고    scopus 로고
    • In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model
    • Jacqueline C, Caillon J, Le Mabecque V et al. In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. Antimicrob. Agents Chemother. 51(9), 3397-3400 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.9 , pp. 3397-3400
    • Jacqueline, C.1    Caillon, J.2    Le Mabecque, V.3
  • 92
    • 34948854764 scopus 로고    scopus 로고
    • Phase 2 study of ceftaroline versus standard therapy in treatment of complicated skin and skin structure infections
    • 5100, 3612-3616
    • Talbot GH, Thye D, Das A, Ge Y. Phase 2 study of ceftaroline versus standard therapy in treatment of complicated skin and skin structure infections. Antimicrob. Agents Chemother. 5100), 3612-3616 (2007).
    • (2007) Antimicrob. Agents Chemother
    • Talbot, G.H.1    Thye, D.2    Das, A.3    Ge, Y.4
  • 94
    • 49449089780 scopus 로고    scopus 로고
    • Miossec C, Poirel L, Livermore DM et al. In vitro activity of the new β-lactamase inhibitor NXL 104: restoration of ceftazidime efficacy against carbapenem-resistant Enterobacteriaciae stains. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Miossec C, Poirel L, Livermore DM et al. In vitro activity of the new β-lactamase inhibitor NXL 104: restoration of ceftazidime efficacy against carbapenem-resistant Enterobacteriaciae stains. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 97
    • 84877015121 scopus 로고    scopus 로고
    • Safety, single dose pharmacokinetics and pharmacodynamics of β-lactamase inhibitor NXL 104 in healthy young male adults
    • Presented at:, Chicago, IL, USA, 16 September
    • Merdjan H, Tarral A, Girard AM et al. Safety, single dose pharmacokinetics and pharmacodynamics of β-lactamase inhibitor NXL 104 in healthy young male adults. Presented at: 47th Intericience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • (2007) 47th Intericience Conference on Antimicrobial Agents and Chemotherapeutics
    • Merdjan, H.1    Tarral, A.2    Girard, A.M.3
  • 98
    • 3042617004 scopus 로고    scopus 로고
    • The discovery and development of modified penicillin- and cephalosporin-derived β-lactamase inhibitors
    • Buynak JD. The discovery and development of modified penicillin- and cephalosporin-derived β-lactamase inhibitors. Curr. Med. Chem. 11(14), 1951-1964 (2004).
    • (2004) Curr. Med. Chem , vol.11 , Issue.14 , pp. 1951-1964
    • Buynak, J.D.1
  • 99
    • 49449114425 scopus 로고    scopus 로고
    • SA-1-204, a novel 6 alkylidene penam sulfone β-lactamase inhibitor, is effective again Escherichia coli, expressing SHV β-lactamases
    • Presented at:, Chicago, IL, USA, 16 September
    • Buynak JD, Kalp M, Bethel CR, Carey MP, Bonomo RA. SA-1-204, a novel 6 alkylidene penam sulfone β-lactamase inhibitor, is effective again Escherichia coli, expressing SHV β-lactamases. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics
    • Buynak, J.D.1    Kalp, M.2    Bethel, C.R.3    Carey, M.P.4    Bonomo, R.A.5
  • 100
    • 33749526875 scopus 로고    scopus 로고
    • Rational design of a β-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penain sulfone
    • Padayatti PS, Sheri A, Totir MA et al. Rational design of a β-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penain sulfone. J. Am. Chem. Soc. 128(40), 13235-13242 (2006).
    • (2006) J. Am. Chem. Soc , vol.128 , Issue.40 , pp. 13235-13242
    • Padayatti, P.S.1    Sheri, A.2    Totir, M.A.3
  • 101
    • 49449101181 scopus 로고    scopus 로고
    • Petersen PJ, Jones CH, Bradfbrd PA. In vitro activity of piperacillin in combination with the penem β-lactamase inhibitor bli-489 against a predictor panel of characterized β-lactamase producing organisms. Presented at: 47th Intencience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Petersen PJ, Jones CH, Bradfbrd PA. In vitro activity of piperacillin in combination with the penem β-lactamase inhibitor bli-489 against a predictor panel of characterized β-lactamase producing organisms. Presented at: 47th Intencience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 102
    • 49449100809 scopus 로고    scopus 로고
    • Petersen PJ, Jones CH, Bradford PA. In vivo efficacy of the penem β-lactamase inhibitor BLI-489 in combination with piperacillin in murine infection models. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Petersen PJ, Jones CH, Bradford PA. In vivo efficacy of the penem β-lactamase inhibitor BLI-489 in combination with piperacillin in murine infection models. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 103
    • 49449107405 scopus 로고    scopus 로고
    • Bowker KE, Noel AR, Macgowan AP. In vitro potency of BAL 30376 against Gram-negative bacilli (GNR). Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
    • Bowker KE, Noel AR, Macgowan AP. In vitro potency of BAL 30376 against Gram-negative bacilli (GNR). Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapeutics. Chicago, IL, USA, 16 September 2007.
  • 110
    • 0024389916 scopus 로고
    • Antimicrobial activity of RO 23-9424, a novel ester-linked codrug of fleroxacin and desacetylcefotaxime
    • Jones RN, Barry AL, Thornsberry C. Antimicrobial activity of RO 23-9424, a novel ester-linked codrug of fleroxacin and desacetylcefotaxime. Antimicrob. Agents Chemother. 33(6), 944-950 (1989).
    • (1989) Antimicrob. Agents Chemother , vol.33 , Issue.6 , pp. 944-950
    • Jones, R.N.1    Barry, A.L.2    Thornsberry, C.3
  • 111
    • 0028198876 scopus 로고
    • β-lactamase hydrolysis of cephalosporin 3′-quinolone esters, carbamates, and tertiary amines
    • Georgopapadakou NH, McCaffrey C. β-lactamase hydrolysis of cephalosporin 3′-quinolone esters, carbamates, and tertiary amines. Antimicrob. Agents Chemother. 38(5), 959-962 (1994).
    • (1994) Antimicrob. Agents Chemother , vol.38 , Issue.5 , pp. 959-962
    • Georgopapadakou, N.H.1    McCaffrey, C.2
  • 112
    • 42549086795 scopus 로고    scopus 로고
    • The research agenda of the national institute of allergy and infectious diseases for antimicrobial resistance
    • Peters NK, Dixon DM, Holland SM, Fauci AS. The research agenda of the national institute of allergy and infectious diseases for antimicrobial resistance. J. Infect. Dis. 197(8), 1087-1093 (2008).
    • (2008) J. Infect. Dis , vol.197 , Issue.8 , pp. 1087-1093
    • Peters, N.K.1    Dixon, D.M.2    Holland, S.M.3    Fauci, A.S.4
  • 113
    • 42549171131 scopus 로고    scopus 로고
    • Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE
    • Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J. Infect. Dis. 197(8), 1079-1081 (2008).
    • (2008) J. Infect. Dis , vol.197 , Issue.8 , pp. 1079-1081
    • Rice, L.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.