Crossover inhibition as an indicator of convergent evolution of enzyme mechanisms: A β-lactamase and a N-terminal nucleophile hydrolase

FEBS Letters

Volumn 586, Issue 23, 2012, Pages 4186-4189

  Adediran, S A ^a   Lin, G ^b   Pelto, R B ^a   Pratt, R F ^a  

^a WESLEYAN UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Lactamase; Convergent evolution; Enzyme; Inhibitors; Proteasome

Indexed keywords

1,3,4 OXATHIAZOL 2 ONE DERIVATIVE; AMINO TERMINAL TELOPEPTIDE; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; HYDROLASE; O ARYLOXYCARBONYL HYDROXYMATE DERIVATIVE; PROTEASOME; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONVERGENT EVOLUTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

AMIDOHYDROLASES; BETA-LACTAMASES; CATALYTIC DOMAIN; ENZYME INHIBITORS; EVOLUTION, MOLECULAR; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84869498256     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.10.019     Document Type: Article

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