Lipoplex formation under equilibrium conditions reveals a three-step mechanism

Biophysical Journal

Volumn 79, Issue 3, 2000, Pages 1447-1454

  Oberle, Volker ^a   Bakowsky, Udo ^a   Zuhorn, Inge S ^a   Hoekstra, Dick ^a,b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE;

ARTICLE; COMPLEX FORMATION; GENE CLUSTER; GENE FUSION; GENE TARGETING; GENETIC ORGANIZATION; GENETIC TRANSCRIPTION; PLASMID; REGULATORY MECHANISM;

EID: 0033863232     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76396-X     Document Type: Article

References (5)

1. Behr, J.-P. 1986. DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants. Tetrahedron Lett. 27:58-61.
2. Dowty, M. E., P. Williams, G. Zhang, J. E. Hagstrom, and J. A. Wolff. 1995. Plasmid DNA entry into postmitotic nuclei of primary rat myotubes. Proc. Natl. Acad. Sci. USA. 92:4572-4576.
3. Eastman, S. J., C. Siegel, J. Tousignant, A. E. Smith, S. H. Cheng, and R. K. Scheule. 1997. Biophysical characterization of cationic lipid: DNA complexes. Biochim. Biophys. Acta. 1325:41-62.
4. Escriou, V., C. Ciolina, F. Lacroix, G. Byk, D. Scherman, and P. Wils. 1998. Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes. Biochim. Biophys. Acta. 1368:276-288.
5. Felgner, P. L. 1996. Improvements in cationic liposomes for in vivo gene transfer. Hum. Gene Ther. 7:1791-1793.