A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 6, 2013, Pages 1115-1123

  Lemke, Christopher T ^a   Titolo, Steve ^a,b   Goudreau, Nathalie ^a   Faucher, Anne Marie ^a,c   Mason, Stephen W ^a,d   Bonneau, Pierre ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b AL G Technologies   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

capsid assembly inhibitor; cocrystallization; dimerization; HIV 1

Indexed keywords

ANTIVIRUS AGENT; CAPSID PROTEIN;

ARTICLE; BINDING SITE; CAPSID-ASSEMBLY INHIBITOR; CHEMICAL STRUCTURE; CHEMISTRY; COCRYSTALLIZATION; CRYSTALLIZATION; DIMERIZATION; DRUG ANTAGONISM; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; VIRUS CAPSID; X RAY DIFFRACTION;

CAPSID-ASSEMBLY INHIBITOR; COCRYSTALLIZATION; DIMERIZATION; HIV-1;

ANTIVIRAL AGENTS; BINDING SITES; CAPSID; CAPSID PROTEINS; CRYSTALLIZATION; HIV-1; MODELS, MOLECULAR; X-RAY DIFFRACTION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

EID: 84878285234     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913006409     Document Type: Article

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