Structure-function paradigm in human myoglobin: How a single-residue substitution affects NO reactivity at low pO2

Journal of the American Chemical Society

Volumn 135, Issue 20, 2013, Pages 7534-7544

  Scorciapino, Mariano Andrea ^a,c   Spiga, Enrico ^a,b   Vezzoli, Alessandra ^d   Mrakic Sposta, Simona ^e   Russo, Rosaria ^e   Fink, Bruno ^f   Casu, Mariano ^a   Gussoni, Maristella ^d,e   Ceccarelli, Matteo ^a,c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b EPFL   (Switzerland)

^c IOM CNR LABORATORIO TASC   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f Noxygen Science Transfer and Diagnostics GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOND INTERACTIONS; ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; HEME ELECTRONIC STRUCTURE; MOLECULAR DYNAMICS SIMULATIONS; OVER-EXPRESSION; SINGLE MUTATION; STRUCTURE FUNCTIONS; SUBSTITUTION AFFECTS;

AMINO ACIDS; DYNAMICS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONIC STRUCTURE; MAGNETIC RESONANCE; MOLECULAR DYNAMICS; PARAMAGNETISM; PORPHYRINS;

DRUG PRODUCTS;

HEME; HISTIDINE; IRON; MYOGLOBIN; NITRIC OXIDE; OXYGEN;

ARTICLE; BINDING SITE; BLOOD OXYGEN TENSION; ELECTRON SPIN RESONANCE; MOLECULAR DYNAMICS; NITROSYLATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MYOGLOBIN; NITRIC OXIDE; OXYGEN; PROTEIN CONFORMATION;

EID: 84878263394     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja400213t     Document Type: Article

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