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Volumn 42, Issue 3, 2012, Pages 526-534

Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome

(16)  Witchel, Selma F a   Recabarren, Sergio E b   González, Frank c   Diamanti Kandarakis, Evanthia d   Cheang, Kai I e   Duleba, Antoni J f   Legro, Richard S g   Homburg, Roy h   Pasquali, Renato i   Lobo, Rogerio A j   Zouboulis, Christos C k   Kelestimur, Fahrettin l   Fruzzetti, Franca m   Futterweit, Walter n   Norman, Robert J o   Abbott, David H p  


Author keywords

Advanced glycated end products; Aromatase inhibitors; Clomiphene citrate; Congenital adrenal hyperplasia; Developmental programming; Hirsutism; Inflammation; Lifestyle intervention; Metformin; Statins

Indexed keywords

ANASTROZOLE; ANDROGEN; AROMATASE INHIBITOR; CLOMIFENE CITRATE; CYPROTERONE ACETATE; EFLORNITHINE; FINASTERIDE; FLUTAMIDE; INSULIN SENSITIZING AGENT; LETROZOLE; METFORMIN; ORAL CONTRACEPTIVE AGENT; SPIRONOLACTONE;

EID: 84878250104     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-012-9701-4     Document Type: Article
Times cited : (26)

References (112)
  • 2
    • 69349084968 scopus 로고    scopus 로고
    • Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys
    • 19367587 1:CAS:528:DC%2BD1MXhtFKnu7jP 10.1002/ajp.20679
    • D.H. Abbott, A.F. Tarantal, D.A. Dumesic, Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am. J. Primatol. 71, 776-784 (2009)
    • (2009) Am. J. Primatol. , vol.71 , pp. 776-784
    • Abbott, D.H.1    Tarantal, A.F.2    Dumesic, D.A.3
  • 3
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • 7651477 1:STN:280:DyaK2MznvF2jug%3D%3D 10.1056/NEJM199509283331307
    • S. Franks, Polycystic ovary syndrome. N. Engl. J. Med. 333, 853-861 (1995)
    • (1995) N. Engl. J. Med. , vol.333 , pp. 853-861
    • Franks, S.1
  • 4
    • 38149096151 scopus 로고    scopus 로고
    • Impact of obesity on the risk for polycystic ovary syndrome
    • 17925334 1:CAS:528:DC%2BD1cXnsVyisA%3D%3D 10.1210/jc.2007-1834
    • B.O. Yildiz, E.S. Knochenhauer, R. Azziz, Impact of obesity on the risk for polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 93, 162-168 (2008)
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 162-168
    • Yildiz, B.O.1    Knochenhauer, E.S.2    Azziz, R.3
  • 5
    • 23844453653 scopus 로고    scopus 로고
    • Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span
    • 15944216 1:CAS:528:DC%2BD2MXnvVWlu74%3D 10.1210/jc.2005-0628
    • R. Azziz, C. Marin, L. Hoq, E. Badamgarav, P. Song, Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J. Clin. Endocrinol. Metab. 90, 4650-4658 (2005)
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 4650-4658
    • Azziz, R.1    Marin, C.2    Hoq, L.3    Badamgarav, E.4    Song, P.5
  • 6
    • 34047242577 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome (PCOS): A significant contributor to the overall burden of type 2 diabetes in women
    • 10.1089/jwh.2006.0098
    • E.O. Talbott, J.V. Zborowski, J.R. Rager, K.E. Kip, X. Xu, T.J. Orchard, Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women. J. Womens Health (Larchmt) 16, 191-197 (2007)
    • (2007) J. Womens Health (Larchmt) , vol.16 , pp. 191-197
    • Talbott, E.O.1    Zborowski, J.V.2    Rager, J.R.3    Kip, K.E.4    Xu, X.5    Orchard, T.J.6
  • 7
    • 33750333937 scopus 로고    scopus 로고
    • Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women
    • 17060537 10.1001/archinte.166.19.2081
    • F. Alvarez-Blasco, J.I. Botella-Carretero, J.L. San Millan, H.F. Escobar-Morreale, Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch. Intern. Med. 166, 2081-2086 (2006)
    • (2006) Arch. Intern. Med. , vol.166 , pp. 2081-2086
    • Alvarez-Blasco, F.1    Botella-Carretero, J.I.2    San Millan, J.L.3    Escobar-Morreale, H.F.4
  • 8
    • 77952787136 scopus 로고    scopus 로고
    • Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: A consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society
    • 20375205 1:CAS:528:DC%2BC3cXmtFegtb4%3D 10.1210/jc.2009-2724
    • R.A. Wild, E. Carmina, E. Diamanti-Kandarakis, A. Dokras, H.F. Escobar-Morreale, W. Futterweit, R. Lobo, R.J. Norman, E. Talbott, D.A. Dumesic, Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J. Clin. Endocrinol. Metab. 95, 2038-2049 (2010)
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2038-2049
    • Wild, R.A.1    Carmina, E.2    Diamanti-Kandarakis, E.3    Dokras, A.4    Escobar-Morreale, H.F.5    Futterweit, W.6    Lobo, R.7    Norman, R.J.8    Talbott, E.9    Dumesic, D.A.10
  • 9
    • 79960023595 scopus 로고    scopus 로고
    • Cardiovascular disease risk characteristics of the main polycystic ovary syndrome phenotypes
    • 21547513 1:CAS:528:DC%2BC3MXivFCrs7s%3D 10.1007/s12020-011-9437-6
    • B. Dilbaz, E. Ozkaya, M. Cinar, E. Cakir, S. Dilbaz, Cardiovascular disease risk characteristics of the main polycystic ovary syndrome phenotypes. Endocrine 39, 272-277 (2011)
    • (2011) Endocrine , vol.39 , pp. 272-277
    • Dilbaz, B.1    Ozkaya, E.2    Cinar, M.3    Cakir, E.4    Dilbaz, S.5
  • 12
    • 83755185526 scopus 로고    scopus 로고
    • Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
    • 22081247 1:CAS:528:DC%2BC3MXhs1Cqtr3P 10.1093/humrep/der379
    • H. Zhao, X. Xu, X. Xing, J. Wang, L. He, Y. Shi, Y. Shi, Y. Zhao, Z.J. Chen, Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Hum. Reprod. 27, 294-298 (2012)
    • (2012) Hum. Reprod. , vol.27 , pp. 294-298
    • Zhao, H.1    Xu, X.2    Xing, X.3    Wang, J.4    He, L.5    Shi, Y.6    Shi, Y.7    Zhao, Y.8    Chen, Z.J.9
  • 13
    • 84855192731 scopus 로고    scopus 로고
    • Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome
    • 21720879 1:CAS:528:DC%2BC3MXotlKntbw%3D 10.1007/s12020-011-9495-9
    • W. Hu, J. Qiao, Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome. Endocrine 40, 196-202 (2011)
    • (2011) Endocrine , vol.40 , pp. 196-202
    • Hu, W.1    Qiao, J.2
  • 14
    • 84867361684 scopus 로고    scopus 로고
    • Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: A meta-analysis
    • doi: 10.1007/s12020-012-9605-3
    • H. Jia, L. Yu, X. Guo, W. Gao, Z. Jiang, Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis. Endocrine (2012). doi: 10.1007/s12020-012-9605-3
    • (2012) Endocrine
    • Jia, H.1    Yu, L.2    Guo, X.3    Gao, W.4    Jiang, Z.5
  • 15
    • 84867335315 scopus 로고    scopus 로고
    • Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes
    • Epub ahead of print
    • R. Saxena, C.K. Welt, Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes. Acta Diabetol. (2012) [Epub ahead of print]
    • (2012) Acta Diabetol
    • Saxena, R.1    Welt, C.K.2
  • 16
    • 0032428506 scopus 로고    scopus 로고
    • Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome
    • 9843997 1:CAS:528:DyaK1cXotVGlsr0%3D 10.1073/pnas.95.25.14956
    • R.S. Legro, D. Driscoll, J.F. Strauss 3rd, J. Fox, A. Dunaif, Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc. Natl. Acad. Sci. U.S.A. 95, 14956-14960 (1998)
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 14956-14960
    • Legro, R.S.1    Driscoll, D.2    Strauss III, J.F.3    Fox, J.4    Dunaif, A.5
  • 17
    • 33744956385 scopus 로고    scopus 로고
    • Heritability of polycystic ovary syndrome in a Dutch twin-family study
    • 16219714 1:CAS:528:DC%2BD28XlvVCgs70%3D 10.1210/jc.2005-1494
    • J.M. Vink, S. Sadrzadeh, C.B. Lambalk, D.I. Boomsma, Heritability of polycystic ovary syndrome in a Dutch twin-family study. J. Clin. Endocrinol. Metab. 91, 2100-2104 (2006)
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 2100-2104
    • Vink, J.M.1    Sadrzadeh, S.2    Lambalk, C.B.3    Boomsma, D.I.4
  • 18
    • 32544457993 scopus 로고    scopus 로고
    • Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance
    • 16249280 1:CAS:528:DC%2BD28XhsFKntbw%3D 10.1210/jc.2005-1666
    • A.D. Coviello, R.S. Legro, A. Dunaif, Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J. Clin. Endocrinol. Metab. 91, 492-497 (2006)
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 492-497
    • Coviello, A.D.1    Legro, R.S.2    Dunaif, A.3
  • 19
    • 32544437005 scopus 로고    scopus 로고
    • Obesity in adolescent girls: Is excess androgen the real bad actor?
    • 16461952 10.1210/jc.2005-2665 1:CAS:528:DC%2BD28XhsFKnt7g%3D
    • J.C. Marshall, Obesity in adolescent girls: is excess androgen the real bad actor? J. Clin. Endocrinol. Metab. 91, 393-395 (2006)
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 393-395
    • Marshall, J.C.1
  • 20
    • 0031912265 scopus 로고    scopus 로고
    • Health consequences of obesity in youth: Childhood predictors of adult disease
    • 12224658 1:STN:280:DC%2BD38vmsFOrtQ%3D%3D
    • W.H. Dietz, Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics 101, 518-525 (1998)
    • (1998) Pediatrics , vol.101 , pp. 518-525
    • Dietz, W.H.1
  • 21
    • 2942554887 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002
    • 1:CAS:528:DC%2BD2cXkvFKnsbw%3D 10.1001/jama.291.23.2847
    • A.A. Hedley, C.L. Ogden, C.L. Johnson, M.D. Carroll, L.R. Curtin, K.M. Flegal, Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. J. Am. Med. Assoc. 291, 2847-2850 (2004)
    • (2004) J. Am. Med. Assoc. , vol.291 , pp. 2847-2850
    • Hedley, A.A.1    Ogden, C.L.2    Johnson, C.L.3    Carroll, M.D.4    Curtin, L.R.5    Flegal, K.M.6
  • 22
    • 33646410148 scopus 로고    scopus 로고
    • The association of obesity and hyperandrogenemia during the pubertal transition in girls: Obesity as a potential factor in the genesis of postpubertal hyperandrogenism
    • 16492701 1:CAS:528:DC%2BD28XkslCnt7c%3D 10.1210/jc.2005-1852
    • C.R. McCartney, K.A. Prendergast, S. Chhabra, C.A. Eagleson, R. Yoo, R.J. Chang, C.M. Foster, J.C. Marshall, The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J. Clin. Endocrinol. Metab. 91, 1714-1722 (2006)
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1714-1722
    • McCartney, C.R.1    Prendergast, K.A.2    Chhabra, S.3    Eagleson, C.A.4    Yoo, R.5    Chang, R.J.6    Foster, C.M.7    Marshall, J.C.8
  • 23
    • 77954157910 scopus 로고    scopus 로고
    • Maturation of sleep-wake gonadotrophin-releasing hormone secretion across puberty in girls: Potential mechanisms and relevance to the pathogenesis of polycystic ovary syndrome
    • 20492363 1:CAS:528:DC%2BC3cXovFejsL8%3D
    • C.R. McCartney, Maturation of sleep-wake gonadotrophin-releasing hormone secretion across puberty in girls: potential mechanisms and relevance to the pathogenesis of polycystic ovary syndrome. J. Neuroendocrinol. 22, 701-709 (2010)
    • (2010) J. Neuroendocrinol. , vol.22 , pp. 701-709
    • McCartney, C.R.1
  • 24
    • 34548309030 scopus 로고    scopus 로고
    • Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty
    • 17710731 1:CAS:528:DC%2BD2sXhtVyns73J 10.1055/s-2007-984741
    • S.K. Blank, C.R. McCartney, K.D. Helm, J.C. Marshall, Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty. Semin. Reprod. Med. 25, 352-359 (2007)
    • (2007) Semin. Reprod. Med. , vol.25 , pp. 352-359
    • Blank, S.K.1    McCartney, C.R.2    Helm, K.D.3    Marshall, J.C.4
  • 25
    • 33745249573 scopus 로고    scopus 로고
    • The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
    • 16670102 1:CAS:528:DC%2BD28Xmt1Wkurs%3D 10.1093/humupd/dml017
    • S.K. Blank, C.R. McCartney, J.C. Marshall, The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Hum. Reprod. Update 12, 351-361 (2006)
    • (2006) Hum. Reprod. Update , vol.12 , pp. 351-361
    • Blank, S.K.1    McCartney, C.R.2    Marshall, J.C.3
  • 27
    • 33947530021 scopus 로고    scopus 로고
    • Clinical review: Identifying children at risk for polycystic ovary syndrome
    • 17179197 1:CAS:528:DC%2BD2sXjtlGntb8%3D 10.1210/jc.2006-2012
    • R.L. Rosenfield, Clinical review: identifying children at risk for polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 92, 787-796 (2007)
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 787-796
    • Rosenfield, R.L.1
  • 28
    • 84858408683 scopus 로고    scopus 로고
    • State of the art review: Emerging therapies: The use of insulin sensitizers in the treatment of adolescents with polycystic ovary syndrome (PCOS)
    • of the Drug and Therapeutics Committee of the Pediatric Endocrine Society 21899727 10.1186/1687-9856-2011-9 1:CAS:528:DC%2BC38Xlsl2ru70%3D
    • D.H. Geller, D. Pacaud, C.M. Gordon, M. Misra, of the Drug and Therapeutics Committee of the Pediatric Endocrine Society, State of the art review: emerging therapies: the use of insulin sensitizers in the treatment of adolescents with polycystic ovary syndrome (PCOS). Int. J. Pediatr. Endocrinol. 2011, 9 (2011)
    • (2011) Int. J. Pediatr. Endocrinol. , vol.2011 , pp. 9
    • Geller, D.H.1    Pacaud, D.2    Gordon, C.M.3    Misra, M.4
  • 29
    • 79956131423 scopus 로고    scopus 로고
    • Congenital adrenal hyperplasia
    • 21601808 10.1016/j.jpag.2010.10.001
    • S.F. Witchel, R. Azziz, Congenital adrenal hyperplasia. J. Pediatr. Adolesc. Gynecol. 24, 116-126 (2011)
    • (2011) J. Pediatr. Adolesc. Gynecol. , vol.24 , pp. 116-126
    • Witchel, S.F.1    Azziz, R.2
  • 30
    • 83155190148 scopus 로고    scopus 로고
    • Guidelines for the development of comprehensive care centers for congenital adrenal hyperplasia: Guidance from the CARES foundation initiative
    • Epub 2011 Jan 10
    • R.J. Auchus, S.F. Witchel, K.R. Leight, J. Aisenberg, R. Azziz et al., Guidelines for the development of comprehensive care centers for congenital adrenal hyperplasia: guidance from the CARES foundation initiative. Int. J. Pediatr. Endocrinol. (2011) [Epub 2011 Jan 10]
    • (2011) Int. J. Pediatr. Endocrinol
    • Auchus, R.J.1    Witchel, S.F.2    Leight, K.R.3    Aisenberg, J.4    Azziz, R.5
  • 31
    • 77951490412 scopus 로고    scopus 로고
    • Hormones and the pilosebaceous unit
    • 1:CAS:528:DC%2BD1MXpsFGqtbo%3D 10.4161/derm.1.2.8354
    • W.C. Chen, C.C. Zouboulis, Hormones and the pilosebaceous unit. Dermatoendocrinology 1, 81-86 (2009)
    • (2009) Dermatoendocrinology , vol.1 , pp. 81-86
    • Chen, W.C.1    Zouboulis, C.C.2
  • 32
    • 84856379035 scopus 로고    scopus 로고
    • Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
    • Guideline Development Groups 21929505 10.5694/mja11.10915
    • H.J. Teede, M.L. Misso, A.A. Deeks, L.J. Moran, B.G. Stuckey, J.L. Wong, R.J. Norman, Guideline Development Groups, Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. Med. J. Aust. 195, S65-S112 (2011)
    • (2011) Med. J. Aust. , vol.195
    • Teede, H.J.1    Misso, M.L.2    Deeks, A.A.3    Moran, L.J.4    Stuckey, B.G.5    Wong, J.L.6    Norman, R.J.7
  • 33
    • 34548771778 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and its developmental origins
    • 17659447 10.1007/s11154-007-9046-0
    • D.A. Dumesic, D.H. Abbott, V. Padmanabhan, Polycystic ovary syndrome and its developmental origins. Rev. Endocr. Metab. Disord. 8, 127-141 (2007)
    • (2007) Rev. Endocr. Metab. Disord. , vol.8 , pp. 127-141
    • Dumesic, D.A.1    Abbott, D.H.2    Padmanabhan, V.3
  • 34
    • 74949096775 scopus 로고    scopus 로고
    • Developmental programming: Impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females
    • 19966179 1:CAS:528:DC%2BC3cXhsVOqtbc%3D 10.1210/en.2009-1015
    • V. Padmanabhan, A. Veiga-Lopez, D.H. Abbott, S.E. Recabarren, C. Herkimer, Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females. Endocrinology 151, 595-605 (2010)
    • (2010) Endocrinology , vol.151 , pp. 595-605
    • Padmanabhan, V.1    Veiga-Lopez, A.2    Abbott, D.H.3    Recabarren, S.E.4    Herkimer, C.5
  • 35
    • 78049388028 scopus 로고    scopus 로고
    • Prenatal androgen exposure programs metabolic dysfunction in female mice
    • 20713501 1:CAS:528:DC%2BC3cXhsVWgtLjL 10.1677/JOE-10-0217
    • A.V. Roland, C.S. Nunemaker, S.R. Keller, S.M. Moenter, Prenatal androgen exposure programs metabolic dysfunction in female mice. J. Endocrinol. 207, 213-223 (2010)
    • (2010) J. Endocrinol. , vol.207 , pp. 213-223
    • Roland, A.V.1    Nunemaker, C.S.2    Keller, S.R.3    Moenter, S.M.4
  • 36
    • 78649864843 scopus 로고    scopus 로고
    • Developmental programming: Impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep
    • 20739662 1:CAS:528:DC%2BC3MXlvVegur8%3D 10.1095/biolreprod.110.086686
    • A. Veiga-Lopez, T.L. Steckler, D.H. Abbott, K.B. Welch, P.S. MohanKumar, D.J. Phillips, K. Refsal, V. Padmanabhan, Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol. Reprod. 84, 87-89 (2011)
    • (2011) Biol. Reprod. , vol.84 , pp. 87-89
    • Veiga-Lopez, A.1    Steckler, T.L.2    Abbott, D.H.3    Welch, K.B.4    Mohankumar, P.S.5    Phillips, D.J.6    Refsal, K.7    Padmanabhan, V.8
  • 37
    • 10344240900 scopus 로고    scopus 로고
    • Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys
    • 15579780 1:CAS:528:DC%2BD2cXhtFSit7zJ 10.1210/jc.2004-0918
    • C.M. Bruns, S.T. Baum, R.J. Colman, J.R. Eisner, J.W. Kemnitz, R. Weindruch, D.H. Abbott, Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys. J. Clin. Endocrinol. Metab. 89, 6218-6223 (2004)
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 6218-6223
    • Bruns, C.M.1    Baum, S.T.2    Colman, R.J.3    Eisner, J.R.4    Kemnitz, J.W.5    Weindruch, R.6    Abbott, D.H.7
  • 40
    • 70449131024 scopus 로고    scopus 로고
    • High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity
    • 19837913 1:CAS:528:DC%2BD1MXhsVejtLfN 10.1210/jc.2009-1333
    • A.D. Coviello, S. Sam, R.S. Legro, A. Dunaif, High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity. J. Clin. Endocrinol. Metab. 94, 4361-4366 (2009)
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 4361-4366
    • Coviello, A.D.1    Sam, S.2    Legro, R.S.3    Dunaif, A.4
  • 41
    • 48649090906 scopus 로고    scopus 로고
    • Metabolic phenotype in the brothers of women with polycystic ovary syndrome
    • 18332151 1:CAS:528:DC%2BD1cXotVant74%3D 10.2337/dc07-2190
    • S. Sam, A.D. Coviello, Y.A. Sung, R.S. Legro, A. Dunaif, Metabolic phenotype in the brothers of women with polycystic ovary syndrome. Diabetes Care 31, 1237-1241 (2008)
    • (2008) Diabetes Care , vol.31 , pp. 1237-1241
    • Sam, S.1    Coviello, A.D.2    Sung, Y.A.3    Legro, R.S.4    Dunaif, A.5
  • 42
    • 36849057669 scopus 로고    scopus 로고
    • Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome
    • 18078863 1:CAS:528:DC%2BD2sXhsVeqtbrK 10.1016/j.metabol.2007.08.010
    • S. Sam, Y.A. Sung, R.S. Legro, A. Dunaif, Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome. Metabolism 57, 84-89 (2008)
    • (2008) Metabolism , vol.57 , pp. 84-89
    • Sam, S.1    Sung, Y.A.2    Legro, R.S.3    Dunaif, A.4
  • 43
    • 0036090267 scopus 로고    scopus 로고
    • Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome
    • 11994353 1:CAS:528:DC%2BD38XjsFGhtbw%3D 10.1210/jc.87.5.2134
    • R.S. Legro, A.R. Kunselman, L. Demers, S.C. Wang, R. Bentley-Lewis, A. Dunaif, Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 87, 2134-2138 (2002)
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2134-2138
    • Legro, R.S.1    Kunselman, A.R.2    Demers, L.3    Wang, S.C.4    Bentley-Lewis, R.5    Dunaif, A.6
  • 45
    • 78349244087 scopus 로고    scopus 로고
    • Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring
    • 20682841 1:CAS:528:DC%2BC3cXhsFSgu7bJ 10.1152/ajpendo.00058.2010
    • D.H. Abbott, C.R. Bruns, D.K. Barnett, A. Dunaif, T.L. Goodfriend, D.A. Dumesic, A.F. Tarantal, Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring. Am. J. Physiol. Endocrinol. Metab. 299, E741-E751 (2010)
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Abbott, D.H.1    Bruns, C.R.2    Barnett, D.K.3    Dunaif, A.4    Goodfriend, T.L.5    Dumesic, D.A.6    Tarantal, A.F.7
  • 46
    • 43249084675 scopus 로고    scopus 로고
    • Hyperandrogenism and hyperinsulinism in children of women with polycystic ovary syndrome: A controlled study
    • 18270257 1:CAS:528:DC%2BD1cXlvFWgsrY%3D 10.1210/jc.2007-1958
    • S.C. Kent, C.L. Gnatuk, A.R. Kunselman, L.M. Demers, P.A. Lee, R.S. Legro, Hyperandrogenism and hyperinsulinism in children of women with polycystic ovary syndrome: a controlled study. J. Clin. Endocrinol. Metab. 93, 1662-1669 (2008)
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1662-1669
    • Kent, S.C.1    Gnatuk, C.L.2    Kunselman, A.R.3    Demers, L.M.4    Lee, P.A.5    Legro, R.S.6
  • 48
    • 77954478324 scopus 로고    scopus 로고
    • Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels
    • 20604643 1:CAS:528:DC%2BC3cXotl2hsL4%3D 10.3109/01443615.2010.485254
    • J.A. Barry, A.R. Kay, R. Navaratnarajah, S. Iqbal, J.E. Bamfo, A.L. David, M. Hines, P.J. Hardiman, Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels. J. Obstet. Gynaecol. 30, 444-446 (2010)
    • (2010) J. Obstet. Gynaecol. , vol.30 , pp. 444-446
    • Barry, J.A.1    Kay, A.R.2    Navaratnarajah, R.3    Iqbal, S.4    Bamfo, J.E.5    David, A.L.6    Hines, M.7    Hardiman, P.J.8
  • 49
    • 77952747569 scopus 로고    scopus 로고
    • Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels
    • 20228162 1:CAS:528:DC%2BC3cXmtFegurc%3D 10.1210/jc.2009-2651
    • H. Anderson, N. Fogel, S.K. Grebe, R.J. Singh, R.L. Taylor, A. Dunaif, Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels. J. Clin. Endocrinol. Metab. 95, 2180-2186 (2010)
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2180-2186
    • Anderson, H.1    Fogel, N.2    Grebe, S.K.3    Singh, R.J.4    Taylor, R.L.5    Dunaif, A.6
  • 50
    • 80455156236 scopus 로고    scopus 로고
    • Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys
    • 22076147 1:CAS:528:DC%2BC3MXhsFejsrbN 10.1371/journal.pone.0027286
    • N. Xu, S. Kwon, D.H. Abbott, D.H. Geller, D.A. Dumesic, R. Azziz, X. Guo, M.O. Goodarzi, Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PLoS One 6(11), e27286 (2011)
    • (2011) PLoS One , vol.6 , Issue.11 , pp. 27286
    • Xu, N.1    Kwon, S.2    Abbott, D.H.3    Geller, D.H.4    Dumesic, D.A.5    Azziz, R.6    Guo, X.7    Goodarzi, M.O.8
  • 55
    • 79953144610 scopus 로고    scopus 로고
    • Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: Extracellular matrix interactions and growth factor bioavailability
    • 21135108 1:CAS:528:DC%2BC3MXhvVeqtLc%3D 10.1074/jbc.M110.188615
    • G. Sengle, R.N. Ono, T. Sasaki, L.Y. Sakai, Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability. J. Biol. Chem. 286, 5087-5099 (2011)
    • (2011) J. Biol. Chem. , vol.286 , pp. 5087-5099
    • Sengle, G.1    Ono, R.N.2    Sasaki, T.3    Sakai, L.Y.4
  • 57
    • 40949095384 scopus 로고    scopus 로고
    • Congenital adrenal hyperplasia: Adolescence and transition
    • 18174736 10.1159/000110614
    • G.S. Conway, Congenital adrenal hyperplasia: adolescence and transition. Horm. Res. 68(suppl 5), 155-157 (2007)
    • (2007) Horm. Res. , vol.68 , Issue.SUPPL. 5 , pp. 155-157
    • Conway, G.S.1
  • 58
    • 59449086020 scopus 로고    scopus 로고
    • Models of comprehensive multidisciplinary care for individuals in the United States with genetic disorders
    • 19117908 10.1542/peds.2007-2875
    • S.D. Grosse, M.S. Schechter, R. Kulkarni, M.A. Lloyd-Puryear, B. Strickland, E. Trevathan, Models of comprehensive multidisciplinary care for individuals in the United States with genetic disorders. Pediatrics 123, 407-412 (2009)
    • (2009) Pediatrics , vol.123 , pp. 407-412
    • Grosse, S.D.1    Schechter, M.S.2    Kulkarni, R.3    Lloyd-Puryear, M.A.4    Strickland, B.5    Trevathan, E.6
  • 59
    • 0029130845 scopus 로고
    • Between two worlds: Bridging the cultures of child health and adult medicine
    • 7578156 1:STN:280:DyaK28%2FnvVKmuw%3D%3D 10.1016/1054-139X(95)00077-6
    • D. Rosen, Between two worlds: bridging the cultures of child health and adult medicine. J. Adolesc. Health 17, 10-16 (1995)
    • (1995) J. Adolesc. Health , vol.17 , pp. 10-16
    • Rosen, D.1
  • 60
    • 0034236427 scopus 로고    scopus 로고
    • Supporting development of children with chronic conditions: From compliance toward shared management
    • 12026469 1:STN:280:DC%2BD383otFCltg%3D%3D
    • G.M. Kieckhefer, C.M. Trahms, Supporting development of children with chronic conditions: from compliance toward shared management. Pediatr. Nurs. 26, 354-363 (2000)
    • (2000) Pediatr. Nurs. , vol.26 , pp. 354-363
    • Kieckhefer, G.M.1    Trahms, C.M.2
  • 61
  • 62
    • 79957468917 scopus 로고    scopus 로고
    • No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls
    • 21478181 1:CAS:528:DC%2BC3MXms1ajur8%3D 10.1093/humrep/der096
    • A. Lindholm, C. Blomquist, M. Bixo, I. Dahlbom, T. Hansson, I. Sundström Poromaa, J. Burén, No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls. Hum. Reprod. 26, 1478-1485 (2011)
    • (2011) Hum. Reprod. , vol.26 , pp. 1478-1485
    • Lindholm, A.1    Blomquist, C.2    Bixo, M.3    Dahlbom, I.4    Hansson, T.5    Sundström Poromaa, I.6    Burén, J.7
  • 63
    • 70349696503 scopus 로고    scopus 로고
    • Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment
    • 10.1111/j.1365-2265.2009.03523.x 1:CAS:528:DC%2BD1MXhtlynsrbN
    • D. Glintborg, M. Andersen, B. Richelsen, J.M. Bruun, Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment. Clin. Endocrinol. (Oxf) 715, 652-658 (2009)
    • (2009) Clin. Endocrinol. (Oxf) , vol.715 , pp. 652-658
    • Glintborg, D.1    Andersen, M.2    Richelsen, B.3    Bruun, J.M.4
  • 64
    • 79951956890 scopus 로고    scopus 로고
    • Circulating inflammatory markers in polycystic ovary symdrome: A systematic review and metaanalysis
    • H.F. Escobar-Morreale, M. Luque-Ramírez, F. González, Circulating inflammatory markers in polycystic ovary symdrome: a systematic review and metaanalysis. Fertil. Steril. 95, 1048-1058.e1-2 (2011)
    • (2011) Fertil. Steril , vol.95
    • Escobar-Morreale, H.F.1
  • 66
    • 84857063256 scopus 로고    scopus 로고
    • Inflammation in polycystic ovary syndrome: Underpinning of insulin resistance and ovarian dysfunction
    • 22178787 10.1016/j.steroids.2011.12.003 1:CAS:528:DC%2BC38XitFCqs78%3D
    • F. González, Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids 77, 300-305 (2012)
    • (2012) Steroids , vol.77 , pp. 300-305
    • González, F.1
  • 67
    • 84856143275 scopus 로고    scopus 로고
    • Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
    • 22045316 1:CAS:528:DC%2BC38XjsFKhurY%3D 10.1152/ajpendo.00416.2011
    • F. Gonzalez, K.S. Nair, J.K. Daniels, E. Basal, J.M. Schimke, Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Am. J. Physiol. Endocrinol. Metab. 302, E297-E306 (2012)
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302
    • Gonzalez, F.1    Nair, K.S.2    Daniels, J.K.3    Basal, E.4    Schimke, J.M.5
  • 68
    • 26444478269 scopus 로고    scopus 로고
    • Advanced glycation end products and RAGE: A common threat in aging, diabetes, neurodegeneretion, and inflammation
    • 15764591 1:CAS:528:DC%2BD2MXlvFSrtrk%3D 10.1093/glycob/cwi053
    • R. Ramasamy, S.J. Vannucci, S.S. Yan, K. Herold, S.F. Yan, A.M. Schmidt, Advanced glycation end products and RAGE: a common threat in aging, diabetes, neurodegeneretion, and inflammation. Glycobiology 15, 16R-28R (2005)
    • (2005) Glycobiology , vol.15
    • Ramasamy, R.1    Vannucci, S.J.2    Yan, S.S.3    Herold, K.4    Yan, S.F.5    Schmidt, A.M.6
  • 70
    • 65549168984 scopus 로고    scopus 로고
    • Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome
    • 19208775 1:CAS:528:DC%2BC3cXit1Gq 10.1530/EJE-08-0510
    • E. Diamanti-Kandarakis, A. Piouka, S. Livadas, C. Piperi, I. Katsikis, A.G. Papavassillou, D. Panidis, Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome. Eur. J. Endocrinol. 160, 847-853 (2009)
    • (2009) Eur. J. Endocrinol. , vol.160 , pp. 847-853
    • Diamanti-Kandarakis, E.1    Piouka, A.2    Livadas, S.3    Piperi, C.4    Katsikis, I.5    Papavassillou, A.G.6    Panidis, D.7
  • 71
  • 73
    • 73349125101 scopus 로고    scopus 로고
    • Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat
    • 19571257 1:CAS:528:DC%2BD1MXhtlWrtr%2FJ 10.1095/biolreprod.109.078667
    • I.J. Rzepczynska, P.C. Piotrowski, D.H. Wong, A.B. Cress, J. Villanueva, A.J. Duleba, Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. Biol. Reprod. 81, 850-855 (2009)
    • (2009) Biol. Reprod. , vol.81 , pp. 850-855
    • Rzepczynska, I.J.1    Piotrowski, P.C.2    Wong, D.H.3    Cress, A.B.4    Villanueva, J.5    Duleba, A.J.6
  • 74
    • 5044235633 scopus 로고    scopus 로고
    • Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis
    • 15474095 1:CAS:528:DC%2BD2MXitFCqs74%3D 10.1016/j.fertnstert.2004.03.037
    • D. Izquierdo, N. Foyouzi, J. Kwintkiewicz, A.J. Duleba, Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. Fertil. Steril. 82(Suppl 3), 1193-1197 (2004)
    • (2004) Fertil. Steril. , vol.82 , Issue.SUPPL. 3 , pp. 1193-1197
    • Izquierdo, D.1    Foyouzi, N.2    Kwintkiewicz, J.3    Duleba, A.J.4
  • 75
    • 78650065826 scopus 로고    scopus 로고
    • Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability
    • 20826585 1:CAS:528:DC%2BC3cXhs1arsLnN 10.1210/jc.2010-0770
    • A. Sokalska, P.C. Piotrowski, I.J. Rzepczynska, A. Cress, A.J. Duleba, Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. J. Clin. Endocrinol. Metab. 95, 5390-5394 (2010)
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 5390-5394
    • Sokalska, A.1    Piotrowski, P.C.2    Rzepczynska, I.J.3    Cress, A.4    Duleba, A.J.5
  • 76
    • 80655137134 scopus 로고    scopus 로고
    • Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment
    • 21865358 1:CAS:528:DC%2BC3MXhsV2ntbfE 10.1210/jc.2011-0501
    • B. Banaszewska, L. Pawelczyk, R.Z. Spaczynski, A.J. Duleba, Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment. J. Clin. Endocrinol. Metab. 96, 3493-3501 (2011)
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 3493-3501
    • Banaszewska, B.1    Pawelczyk, L.2    Spaczynski, R.Z.3    Duleba, A.J.4
  • 77
    • 33645403158 scopus 로고    scopus 로고
    • Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: Results of a prospective, randomized trial
    • 16580386 1:CAS:528:DC%2BD28XksVKnurc%3D 10.1016/j.fertnstert.2005.09.030
    • A.J. Duleba, B. Banaszewska, R.Z. Spaczynski, L. Pawelczyk, Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial. Fertil. Steril. 85, 996-1001 (2006)
    • (2006) Fertil. Steril. , vol.85 , pp. 996-1001
    • Duleba, A.J.1    Banaszewska, B.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 78
    • 67651099084 scopus 로고    scopus 로고
    • Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: A prospective randomized study
    • 18692805 1:CAS:528:DC%2BD1MXht1Gntb3L 10.1016/j.fertnstert.2008.06.006
    • C. Kaya, S.D. Cengiz, B. Berker, S. Demirtas, M. Cesur, G. Erdogan, Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study. Fertil. Steril. 92, 635-642 (2009)
    • (2009) Fertil. Steril. , vol.92 , pp. 635-642
    • Kaya, C.1    Cengiz, S.D.2    Berker, B.3    Demirtas, S.4    Cesur, M.5    Erdogan, G.6
  • 79
    • 58149394432 scopus 로고    scopus 로고
    • The effect of atorvastatin in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled study
    • 18940877 1:CAS:528:DC%2BD1MXptVKltw%3D%3D 10.1210/jc.2008-1750
    • T. Sathyapalan, E.S. Kilpatrick, A.M. Coady, S.L. Atkin, The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. J. Clin. Endocrinol. Metab. 94, 103-108 (2009)
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 103-108
    • Sathyapalan, T.1    Kilpatrick, E.S.2    Coady, A.M.3    Atkin, S.L.4
  • 80
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group 11832527 1:CAS:528: DC%2BD38XhtVWqurc%3D 10.1056/NEJMoa012512
    • W.C. Knowler, E. Barrett-Connor, S.E. Fowler, R.F. Hamman, J.M. Lachin, E.A. Walker, D.M. Nathan, Diabetes Prevention Program Research Group, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393-403 (2002)
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    Hamman, R.F.4    Lachin, J.M.5    Walker, E.A.6    Nathan, D.M.7
  • 81
    • 70749121763 scopus 로고    scopus 로고
    • Treatment of obesity in polycystic ovary syndrome: A position statement of the Androgen Excess and Polycystic Ovary Syndrome Society
    • 19062007 10.1016/j.fertnstert.2008.09.018
    • L.J. Moran, R. Pasquali, H.J. Teede, K.M. Hoeger, R.J. Norman, Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil. Steril. 92, 1966-1982 (2009)
    • (2009) Fertil. Steril. , vol.92 , pp. 1966-1982
    • Moran, L.J.1    Pasquali, R.2    Teede, H.J.3    Hoeger, K.M.4    Norman, R.J.5
  • 82
    • 35348965687 scopus 로고    scopus 로고
    • The use of anti-mullerian hormone in predicting menstrual response after weight loss in overweight women with polycystic ovary syndrome
    • 17652213 1:CAS:528:DC%2BD2sXht1SmtbjE 10.1210/jc.2007-1188
    • L.J. Moran, M. Noakes, P.M. Clifton, R.J. Norman, The use of anti-mullerian hormone in predicting menstrual response after weight loss in overweight women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 92, 3796-3802 (2007)
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 3796-3802
    • Moran, L.J.1    Noakes, M.2    Clifton, P.M.3    Norman, R.J.4
  • 83
    • 68349099934 scopus 로고    scopus 로고
    • Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome
    • 20368201 10.1177/1479164109336050
    • K.I. Cheang, J.M. Huszar, A.M. Best, S. Sharma, P.A. Essah, J.E. Nestler, Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome. Diab. Vasc. Dis. Res. 6, 110-119 (2009)
    • (2009) Diab. Vasc. Dis. Res. , vol.6 , pp. 110-119
    • Cheang, K.I.1    Huszar, J.M.2    Best, A.M.3    Sharma, S.4    Essah, P.A.5    Nestler, J.E.6
  • 84
    • 77957601724 scopus 로고    scopus 로고
    • Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
    • Diabetes Prevention Program Research Group 20682687 1:CAS:528: DC%2BC3cXhsVGhs7fF 10.2337/db10-0543
    • K.A. Jablonski, J.B. McAteer, P.I. de Bakker, P.W. Franks, T.I. Pollin, R.L. Hanson, R. Saxena, S. Fowler, A.R. Shuldiner, W.C. Knowler, D. Altshuler, J.C. Florez, Diabetes Prevention Program Research Group, Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes 59, 2672-2681 (2010)
    • (2010) Diabetes , vol.59 , pp. 2672-2681
    • Jablonski, K.A.1    McAteer, J.B.2    De Bakker, P.I.3    Franks, P.W.4    Pollin, T.I.5    Hanson, R.L.6    Saxena, R.7    Fowler, S.8    Shuldiner, A.R.9    Knowler, W.C.10    Altshuler, D.11    Florez, J.C.12
  • 86
    • 55949087098 scopus 로고    scopus 로고
    • A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): A randomized open-label parallel study
    • 1:CAS:528:DC%2BD1MXmtlOhsg%3D%3D 10.1111/j.1365-2265.2008.03260.x
    • T. Sathyapalan, L.W. Cho, E.S. Kilpatrick, A.M. Coady, S.L. Atkin, A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): a randomized open-label parallel study. Clin. Endocrinol. (Oxf) 69, 931-935 (2008)
    • (2008) Clin. Endocrinol. (Oxf) , vol.69 , pp. 931-935
    • Sathyapalan, T.1    Cho, L.W.2    Kilpatrick, E.S.3    Coady, A.M.4    Atkin, S.L.5
  • 88
    • 40349085776 scopus 로고    scopus 로고
    • Consensus on infertility treatment related to polycystic ovary syndrome
    • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 10.1016/j.fertnstert.2007.09.041
    • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Consensus on infertility treatment related to polycystic ovary syndrome. Fertil. Steril. 89, 505-522 (2008)
    • (2008) Fertil. Steril. , vol.89 , pp. 505-522
  • 89
    • 80052339190 scopus 로고    scopus 로고
    • Does laparoscopic ovarian diathermy change clomiphene-resistant PCOS into clomiphene-sensitive?
    • 21594601 10.1007/s00404-011-1931-9
    • H. Abu Hashim, M. El-Shafei, A. Badawy, A. Wafa, H. Zaglol, Does laparoscopic ovarian diathermy change clomiphene-resistant PCOS into clomiphene-sensitive? Arch. Gynecol. Obstet. 284, 503-507 (2011)
    • (2011) Arch. Gynecol. Obstet. , vol.284 , pp. 503-507
    • Abu Hashim, H.1    El-Shafei, M.2    Badawy, A.3    Wafa, A.4    Zaglol, H.5
  • 90
    • 77955895421 scopus 로고    scopus 로고
    • PCOSMIC: A multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene
    • REACT-NZ (REproduction And Collaborative Trials in New Zealand), a multi-centre fertility trials group 20435692 1:CAS:528:DC%2BC3cXhtVWmtb7I 10.1093/humrep/deq100
    • N.P. Johnson, A.W. Stewart, J. Falkiner, C.M. Farquhar, S. Milsom, V.P. Singh, Q.L. Okonkwo, K.L. Buckingham, REACT-NZ (REproduction And Collaborative Trials in New Zealand), a multi-centre fertility trials group, PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene. Hum. Reprod. 25, 1675-1683 (2010)
    • (2010) Hum. Reprod. , vol.25 , pp. 1675-1683
    • Johnson, N.P.1    Stewart, A.W.2    Falkiner, J.3    Farquhar, C.M.4    Milsom, S.5    Singh, V.P.6    Okonkwo, Q.L.7    Buckingham, K.L.8
  • 91
    • 70449117327 scopus 로고    scopus 로고
    • Aromatase inhibitors for female infertility: A systematic review of the literature
    • 19909585 1:CAS:528:DC%2BD1MXhsVyis7jN 10.1016/j.rbmo.2009.06.008
    • N.P. Polyzos, S. Tzioras, A.M. Badawy, A. Valachis, C. Dritsas, D. Mauri, Aromatase inhibitors for female infertility: a systematic review of the literature. Reprod. Biomed. Online 19, 456-471 (2009)
    • (2009) Reprod. Biomed. Online , vol.19 , pp. 456-471
    • Polyzos, N.P.1    Tzioras, S.2    Badawy, A.M.3    Valachis, A.4    Dritsas, C.5    Mauri, D.6
  • 93
    • 79952903221 scopus 로고    scopus 로고
    • Anastrozole vs. Clomiphene citrate in infertile women with ovulatory dysfunction: A phase II, randomized, dose-finding study
    • D. Tredway, J.C. Schertz, D. Bock, G. Hemsey, M.P Diamond, Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study. Fertil. Steril. 95, 1720-4.e1-8 (2011)
    • (2011) Fertil. Steril , vol.95
    • Tredway, D.1    Schertz, J.C.2    Bock, D.3    Hemsey, G.4    Diamond, M.P.5
  • 94
    • 33744541255 scopus 로고    scopus 로고
    • Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate
    • 16650422 1:CAS:528:DC%2BD28XntVWhsb4%3D 10.1016/j.fertnstert.2006.03.014
    • T. Tulandi, J. Martin, R. Al-Fadhli, N. Kabli, R. Forman, J. Hitkari, C. Librach, E. Greenblatt, R.F. Casper, Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil. Steril. 85, 1761-1765 (2006)
    • (2006) Fertil. Steril. , vol.85 , pp. 1761-1765
    • Tulandi, T.1    Martin, J.2    Al-Fadhli, R.3    Kabli, N.4    Forman, R.5    Hitkari, J.6    Librach, C.7    Greenblatt, E.8    Casper, R.F.9
  • 95
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
    • 19056992 1:CAS:528:DC%2BD1MXjt1eru7g%3D 10.1210/er.2008-0030
    • S. Palomba, A. Falbo, F. Zullo, F. Orio Jr, Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr. Rev. 30, 1-50 (2009)
    • (2009) Endocr. Rev. , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio, Jr.F.4
  • 96
    • 33748751562 scopus 로고    scopus 로고
    • The impact of obesity on reproduction in women with polycystic ovary syndrome
    • 1:STN:280:DC%2BD28rkslOisA%3D%3D 10.1111/j.1471-0528.2006.00990.x
    • R. Pasquali, A. Gambineri, U. Pagotto, The impact of obesity on reproduction in women with polycystic ovary syndrome. Br. J. Obstet. Gynecol. 113, 1148-1159 (2006)
    • (2006) Br. J. Obstet. Gynecol. , vol.113 , pp. 1148-1159
    • Pasquali, R.1    Gambineri, A.2    Pagotto, U.3
  • 97
    • 75149162547 scopus 로고    scopus 로고
    • Metformin: An old medication of new fashion: Evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
    • 19841045 1:CAS:528:DC%2BC3cXit1KqtbY%3D 10.1530/EJE-09-0733
    • E. Diamanti-Kandarakis, C.D. Christakou, E. Kandaraki, F.N. Economou, Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome. Eur. J. Endocrinol. 162, 193-212 (2010)
    • (2010) Eur. J. Endocrinol. , vol.162 , pp. 193-212
    • Diamanti-Kandarakis, E.1    Christakou, C.D.2    Kandaraki, E.3    Economou, F.N.4
  • 99
    • 58549108971 scopus 로고    scopus 로고
    • Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): A systematic review of head-to-head randomized controlled studies and meta-analysis
    • 1:CAS:528:DC%2BD1MXjsVCht7c%3D 10.1111/j.1365-2265.2008.03369.x
    • S. Palomba, R. Pasquali, F. Orio Jr, J.E. Nestler, Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. Clin. Endocrinol. (Oxf) 70, 311-321 (2009)
    • (2009) Clin. Endocrinol. (Oxf) , vol.70 , pp. 311-321
    • Palomba, S.1    Pasquali, R.2    Orio, Jr.F.3    Nestler, J.E.4
  • 100
    • 41649090945 scopus 로고    scopus 로고
    • Use of metformin in polycystic ovary syndrome: A meta-analysis
    • 18378757 1:CAS:528:DC%2BD1cXkvVaktbg%3D 10.1097/AOG.0b013e31816a4ed4
    • A.A. Creanga, H.M. Bradley, C. McCormick, C.T. Witkop, Use of metformin in polycystic ovary syndrome: a meta-analysis. Obstet. Gynecol. 111, 959-968 (2008)
    • (2008) Obstet. Gynecol. , vol.111 , pp. 959-968
    • Creanga, A.A.1    Bradley, H.M.2    McCormick, C.3    Witkop, C.T.4
  • 101
    • 78651309029 scopus 로고    scopus 로고
    • When should an insulin sensitizing agent used in the treatment of polycystic ovary syndrome?
    • 10.1111/j.1365-2265.2010.03934.x
    • S. Franks, When should an insulin sensitizing agent used in the treatment of polycystic ovary syndrome? Clin. Endocrinol. (Oxf) 74, 148-151 (2011)
    • (2011) Clin. Endocrinol. (Oxf) , vol.74 , pp. 148-151
    • Franks, S.1
  • 103
    • 10644286191 scopus 로고    scopus 로고
    • The human skin as a hormone target and an endocrine gland
    • C.C. Zouboulis, The human skin as a hormone target and an endocrine gland. Hormones (Athens) 3, 9-26 (2004)
    • (2004) Hormones (Athens) , vol.3 , pp. 9-26
    • Zouboulis, C.C.1
  • 104
    • 79955848243 scopus 로고    scopus 로고
    • The skin as an endocrine organ
    • 10.4161/derm.1.5.9499
    • C.C. Zouboulis, The skin as an endocrine organ. Dermatoendocrinology 1, 250-252 (2009)
    • (2009) Dermatoendocrinology , vol.1 , pp. 250-252
    • Zouboulis, C.C.1
  • 106
    • 77955869463 scopus 로고    scopus 로고
    • Quality of life, mental health and self-esteem in hirsute adolescent females
    • 20626242 10.3109/0167482X.2010.501398
    • A. Drosdzol, V. Skrzypulec, R. Plinta, Quality of life, mental health and self-esteem in hirsute adolescent females. J. Psychosom. Obstet. Gynaecol. 31, 168-175 (2010)
    • (2010) J. Psychosom. Obstet. Gynaecol. , vol.31 , pp. 168-175
    • Drosdzol, A.1    Skrzypulec, V.2    Plinta, R.3
  • 108
    • 84857037262 scopus 로고    scopus 로고
    • Mood and anxiety disorders in women with PCOS
    • 22178257 1:CAS:528:DC%2BC38XitFCqsLo%3D 10.1016/j.steroids.2011.12.008
    • A. Dokras, Mood and anxiety disorders in women with PCOS. Steroids 77, 338-341 (2012)
    • (2012) Steroids , vol.77 , pp. 338-341
    • Dokras, A.1
  • 109
    • 80054070917 scopus 로고    scopus 로고
    • The Hirsute woman: Challenges in evaluation and management
    • 21856600 10.4158/EP11117.RA
    • R. Paparodis, A. Dunaif, The Hirsute woman: challenges in evaluation and management. Endocr. Pract. 17, 807-818 (2011)
    • (2011) Endocr. Pract. , vol.17 , pp. 807-818
    • Paparodis, R.1    Dunaif, A.2
  • 110
    • 77955652371 scopus 로고    scopus 로고
    • Medical treatment of hirsutism in women
    • 20491644 1:CAS:528:DC%2BC3cXpslSksLo%3D 10.2174/092986710791556005
    • F. Lumachi, S.M. Basso, Medical treatment of hirsutism in women. Curr. Med. Chem. 17, 2530-2538 (2010)
    • (2010) Curr. Med. Chem. , vol.17 , pp. 2530-2538
    • Lumachi, F.1    Basso, S.M.2
  • 111
    • 83755220903 scopus 로고    scopus 로고
    • Hair loss in women: Medical and cosmetic approaches to increase scalp hair fullness
    • 22171680 1:CAS:528:DC%2BC38XhtlOrtb8%3D 10.1111/j.1365-2133.2011.10630.x
    • R. Sinclair, M. Patel, T.L. Dawson Jr, A. Yazdabadi, L. Yip, A. Perez, N.W. Rufaut, Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. Br. J. Dermatol. 165(Suppl 3), 12-18 (2011)
    • (2011) Br. J. Dermatol. , vol.165 , Issue.SUPPL. 3 , pp. 12-18
    • Sinclair, R.1    Patel, M.2    Dawson, Jr.T.L.3    Yazdabadi, A.4    Yip, L.5    Perez, A.6    Rufaut, N.W.7
  • 112
    • 84858228703 scopus 로고    scopus 로고
    • Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
    • 22249003 1:CAS:528:DC%2BC38Xjs1GhtLg%3D 10.1016/j.jsbmb.2012.01.001
    • M. Yamaoka, T. Hara, T. Hitaka, T. Kaku, T. Takeuchi, J. Takahashi, S. Asahi, H. Miki, A. Tasaka, M. Kusaka, Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J. Steroid. Biochem. Mol. Biol. 129, 115-128 (2012)
    • (2012) J. Steroid. Biochem. Mol. Biol. , vol.129 , pp. 115-128
    • Yamaoka, M.1    Hara, T.2    Hitaka, T.3    Kaku, T.4    Takeuchi, T.5    Takahashi, J.6    Asahi, S.7    Miki, H.8    Tasaka, A.9    Kusaka, M.10


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