메뉴 건너뛰기




Volumn 25, Issue 7, 2010, Pages 1675-1683

PCOSMIC: A multi-centre randomized trial in women with PolyCystic Ovary syndrome evaluating metformin for infertility with clomiphene

Author keywords

anovulation; clomiphene citrate; metformin; polycystic ovary syndrome; randomized controlled trial

Indexed keywords

CLOMIFENE; METFORMIN; PLACEBO;

EID: 77955895421     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deq100     Document Type: Article
Times cited : (63)

References (29)
  • 1
    • 33745699510 scopus 로고    scopus 로고
    • Drugs for anovulatory infertility in polycystic ovary syndrome: Reserve metformin for second line treatment for women with clomifene resistance
    • Al-Inany H, Johnson N. Drugs for anovulatory infertility in polycystic ovary syndrome: reserve metformin for second line treatment for women with clomifene resistance. Br Med J 2006;332:1461-1462.
    • (2006) Br Med J , vol.332 , pp. 1461-1462
    • Al-Inany, H.1    Johnson, N.2
  • 2
    • 5144220551 scopus 로고    scopus 로고
    • Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity
    • Baillargeon JP, Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Nestler JE. Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Fertil Steril 2004;82:893-902.
    • (2004) Fertil Steril , vol.82 , pp. 893-902
    • Baillargeon, J.P.1    Jakubowicz, D.J.2    Iuorno, M.J.3    Jakubowicz, S.4    Nestler, J.E.5
  • 3
    • 33644755377 scopus 로고    scopus 로고
    • Should obese women with polycystic ovary syndrome receive treatment for infertility?
    • Balen AH, Dresner M, Scott EM, Drife JO. Should obese women with polycystic ovary syndrome receive treatment for infertility? Br Med J 2006;332:434-435.
    • (2006) Br Med J , vol.332 , pp. 434-435
    • Balen, A.H.1    Dresner, M.2    Scott, E.M.3    Drife, J.O.4
  • 6
    • 33748748876 scopus 로고    scopus 로고
    • Prioritising for fertility treatments\the effect of excluding women with a high body mass index
    • Gillett W, Putt T, Farquhar CM. Prioritising for fertility treatments\the effect of excluding women with a high body mass index. Br J Obstet Gynaecol 2006;113:1218-1221.
    • (2006) Br J Obstet Gynaecol , vol.113 , pp. 1218-1221
    • Gillett, W.1    Putt, T.2    Farquhar, C.M.3
  • 7
    • 0025030576 scopus 로고
    • Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth
    • Gonen Y, Casper RF. Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth. Hum Reprod 1990;5:670-674.
    • (1990) Hum Reprod , vol.5 , pp. 670-674
    • Gonen, Y.1    Casper, R.F.2
  • 8
    • 25144483568 scopus 로고    scopus 로고
    • Clomiphene citrate\end of an era? A mini-review
    • Homburg R. Clomiphene citrate\end of an era? A mini-review. Hum Reprod 2005;20:2043-2051.
    • (2005) Hum Reprod , vol.20 , pp. 2043-2051
    • Homburg, R.1
  • 9
    • 0023412220 scopus 로고
    • Epidemiology of infertility and polycystic ovarian disease: Endocrinological and demographic studies
    • Hull MG. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol 1987; 1:235-245.
    • (1987) Gynecol Endocrinol , vol.1 , pp. 235-245
    • Hull, M.G.1
  • 10
    • 84881264956 scopus 로고    scopus 로고
    • Use of fertility drugs and risk of ovarian cancer: Danish population based study
    • JensenA, SharifH, Frederiksen K, Kruger Kjaer S. Use of fertility drugs and risk of ovarian cancer: Danish population based study. Br Med J 2009;338:b249.
    • (2009) Br Med J , vol.338
    • Sharifh, J.1    Frederiksen, K.2    Kruger Kjaer, S.3
  • 11
    • 33645364688 scopus 로고    scopus 로고
    • No more surrogate end-points in randomised trials\the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene
    • Johnson NP. No more surrogate end-points in randomised trials\the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene. Aust N Z J Obstet Gynaecol 2006;46:141-145.
    • (2006) Aust N Z J Obstet Gynaecol , vol.46 , pp. 141-145
    • Johnson, N.P.1
  • 13
    • 33644963762 scopus 로고    scopus 로고
    • Obesity, polycystic ovary syndrome, infertility treatment: Lifestyle modification in paramount
    • Lord JM, Norman R. Obesity, polycystic ovary syndrome, infertility treatment: lifestyle modification in paramount. Br Med J 2006;332:609.
    • (2006) Br Med J , vol.332 , pp. 609
    • Lord, J.M.1    Norman, R.2
  • 14
    • 0141724824 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome (Cochrane review)
    • Lord JM, Flight IHK, Norman RJ. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome (Cochrane review). Cochrane Database Syst Rev 2005; 4:CD003053.
    • (2005) Cochrane Database Syst Rev , vol.4
    • Lord, J.M.1    Ihk, F.2    Norman, R.J.3
  • 15
    • 33745713576 scopus 로고    scopus 로고
    • Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: Randomised double blind clinical trial
    • Moll E, Bossuyt PMM, Korevaar JC, Lambalk CB, van der Veen F. Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. Br Med J 2006; 332:1485-1489.
    • (2006) Br Med J , vol.332 , pp. 1485-1489
    • Moll, E.1    Pmm, B.2    Korevaar, J.C.3    Lambalk, C.B.4    Van Der Veen, F.5
  • 16
    • 45849151669 scopus 로고    scopus 로고
    • Metformin in the treatment of infertility in polycystic ovarian syndrome: An alternative perspective
    • Nestler JE. Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective. Fertil Steril 2008;90:14-16.
    • (2008) Fertil Steril , vol.90 , pp. 14-16
    • Nestler, J.E.1
  • 17
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998;338:1876-1880.
    • (1998) N Engl J Med , vol.338 , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3    Pasquali, R.4
  • 18
    • 23044513823 scopus 로고    scopus 로고
    • Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome
    • Palomba S, Orio F Jr, Falbo A, Manguso F, Russo T, Cascella T, Tolino A, Carmina E, Colao A, Zullo F et al. Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4068-4074.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4068-4074
    • Palomba, S.1    Orio Jr., F.2    Falbo, A.3    Manguso, F.4    Russo, T.5    Cascella, T.6    Tolino, A.7    Carmina, E.8    Colao, A.9    Zullo, F.10
  • 19
    • 58549108971 scopus 로고    scopus 로고
    • Clomiphene citrate metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): A systematic review of head-to-head tandomized controlled studies and meta-analysis
    • Palomba S, Pasquali R, Orio F Jr, Nestler JE. Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head tandomized controlled studies and meta-analysis. Clin Endocrinol (Oxf) 2009;70:311-321.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 311-321
    • Palomba, S.1    Pasquali, R.2    Orio Jr., F.3    Nestler, J.E.4
  • 21
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81:19-25.
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 22
    • 58749114766 scopus 로고    scopus 로고
    • Obesity and pregnancy
    • Stotland NE. Obesity and pregnancy. Br Med J 2008;337:a2450.
    • (2008) Br Med J , vol.337
    • Stotland, N.E.1
  • 23
    • 29144477303 scopus 로고    scopus 로고
    • Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study
    • Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH. Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study. Hum Reprod 2006;21:80-89.
    • (2006) Hum Reprod , vol.21 , pp. 80-89
    • Tang, T.1    Glanville, J.2    Hayden, C.J.3    White, D.4    Barth, J.H.5    Balen, A.H.6
  • 24
    • 84864521778 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
    • Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev 2010;1:CD003053
    • (2010) Cochrane Database Syst Rev , vol.1
    • Tang, T.1    Lord, J.M.2    Norman, R.J.3    Yasmin, E.4    Balen, A.H.5
  • 25
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-47
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 26
    • 40749085240 scopus 로고    scopus 로고
    • Consensus on infertility treatment related to polycystic ovary syndrome
    • The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod 2008;23:462-477
    • (2008) Hum Reprod , vol.23 , pp. 462-477
  • 27
    • 40349085776 scopus 로고    scopus 로고
    • Consensus on infertility treatment related to polycystic ovary syndrome
    • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Fertil Steril 2008;89:505-522.
    • (2008) Fertil Steril , vol.89 , pp. 505-522
  • 28
    • 33947573668 scopus 로고    scopus 로고
    • A randomized comparison of ovulation induction and hormone profile between the aromatase inhibitor anastrozole and clomiphene citrate in women with infertility
    • Wu HH, Wang NM, Cheng ML, Hsieh JN. A randomized comparison of ovulation induction and hormone profile between the aromatase inhibitor anastrozole and clomiphene citrate in women with infertility. Gynecol Endocrinol 2007;23:76-81.
    • (2007) Gynecol Endocrinol , vol.23 , pp. 76-81
    • Wu, H.H.1    Wang, N.M.2    Cheng, M.L.3    Hsieh, J.N.4
  • 29
    • 57149148369 scopus 로고    scopus 로고
    • Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: A randomized controlled trial
    • Zain MM, Jamaluddin R, Ibrahim A, Norman RJ. Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial. Fertil Steril 2008;85:1448-1451.
    • (2008) Fertil Steril , vol.85 , pp. 1448-1451
    • Zain, M.M.1    Jamaluddin, R.2    Ibrahim, A.3    Norman, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.