-
1
-
-
0034897709
-
Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution
-
Anisimova, M., Bielawski, J.P., and Yang, Z. (2001). Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution. Mol. Biol. Evol. 18: 1585-1592.
-
(2001)
Mol. Biol. Evol
, vol.18
, pp. 1585-1592
-
-
Anisimova, M.1
Bielawski, J.P.2
Yang, Z.3
-
2
-
-
34547793042
-
Multiple hypothesis testing to detect lineages under positive selection that affects only a few sites
-
Anisimova, M., and Yang, Z. (2007). Multiple hypothesis testing to detect lineages under positive selection that affects only a few sites. Mol. Biol. Evol. 24: 1219-1228.
-
(2007)
Mol. Biol. Evol
, vol.24
, pp. 1219-1228
-
-
Anisimova, M.1
Yang, Z.2
-
3
-
-
16644372406
-
Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase
-
Anke, S., Niemüller, D., Moll, S., Hänsch, R., and Ober, D. (2004). Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase. Plant Physiol. 136: 4037-4047.
-
(2004)
Plant Physiol
, vol.136
, pp. 4037-4047
-
-
Anke, S.1
Niemüller, D.2
Moll, S.3
Hänsch, R.4
Ober, D.5
-
4
-
-
0037323728
-
Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase
-
Barkman, T.J. (2003). Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase. Mol. Biol. Evol. 20: 168-172.
-
(2003)
Mol. Biol. Evol
, vol.20
, pp. 168-172
-
-
Barkman, T.J.1
-
5
-
-
33745159638
-
Positive selection driving diversification in plant secondary metabolism
-
Benderoth, M., Textor, S., Windsor, A.J., Mitchell-Olds, T., Gershenzon, J., and Kroymann, J. (2006). Positive selection driving diversification in plant secondary metabolism. Proc. Natl. Acad. Sci. USA 103: 9118-9123.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 9118-9123
-
-
Benderoth, M.1
Textor, S.2
Windsor, A.J.3
Mitchell-Olds, T.4
Gershenzon, J.5
Kroymann, J.6
-
6
-
-
0035733108
-
The control of the false discovery rate in multiple testing under dependency
-
Benjamini, Y., and Yekutieli, D. (2001). The control of the false discovery rate in multiple testing under dependency. Ann. Stat. 29: 1165-1188.
-
(2001)
Ann. Stat
, vol.29
, pp. 1165-1188
-
-
Benjamini, Y.1
Yekutieli, D.2
-
7
-
-
0034625046
-
Rapid evolution in plant chitinases: Molecular targets of selection in plantpathogen coevolution
-
Bishop, J.G., Dean, A.M., and Mitchell-Olds, T. (2000). Rapid evolution in plant chitinases: Molecular targets of selection in plantpathogen coevolution. Proc. Natl. Acad. Sci. USA 97: 5322-5327.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5322-5327
-
-
Bishop, J.G.1
Dean, A.M.2
Mitchell-Olds, T.3
-
8
-
-
17444363904
-
Biosynthetic precursors of fungal pyrrolizidines, the loline alkaloids
-
Blankenship, J.D., Houseknecht, J.B., Pal, S., Bush, L.P., Grossman, R.B., and Schardl, C.L. (2005). Biosynthetic precursors of fungal pyrrolizidines, the loline alkaloids. ChemBioChem 6: 1016-1022.
-
(2005)
ChemBioChem
, vol.6
, pp. 1016-1022
-
-
Blankenship, J.D.1
Houseknecht, J.B.2
Pal, S.3
Bush, L.P.4
Grossman, R.B.5
Schardl, C.L.6
-
9
-
-
0001643085
-
Homospermidine synthase, the first pathway-specific enzyme in pyrrolizidine alkaloid biosynthesis
-
Böttcher, F., Adolph, R.D., and Hartmann, T. (1993). Homospermidine synthase, the first pathway-specific enzyme in pyrrolizidine alkaloid biosynthesis. Phytochemistry 32: 679-689.
-
(1993)
Phytochemistry
, vol.32
, pp. 679-689
-
-
Böttcher, F.1
Adolph, R.D.2
Hartmann, T.3
-
10
-
-
0028316283
-
Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essential substrates of enzymatic homospermidine formation
-
Böttcher, F., Ober, D., and Hartmann, T. (1994). Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation. Can. J. Chem. 72: 80-85.
-
(1994)
Can. J. Chem
, vol.72
, pp. 80-85
-
-
Böttcher, F.1
Ober, D.2
Hartmann, T.3
-
11
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
-
(1976)
Anal. Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
12
-
-
52949135190
-
Evolution of a new function by degenerative mutation in cephalochordate steroid receptors
-
Bridgham, J.T., Brown, J.E., Rodríguez-Marí, A., Catchen, J.M., and Thornton, J.W. (2008). Evolution of a new function by degenerative mutation in cephalochordate steroid receptors. PLoS Genet. 4: e1000191.
-
(2008)
PLoS Genet
, vol.4
-
-
Bridgham, J.T.1
Brown, J.E.2
Rodríguez-Marí, A.3
Catchen, J.M.4
Thornton, J.W.5
-
13
-
-
0030817535
-
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A
-
Chen, K.Y., and Liu, A.Y. (1997). Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A. Biol. Signals 6: 105-109.
-
(1997)
Biol. Signals
, vol.6
, pp. 105-109
-
-
Chen, K.Y.1
Liu, A.Y.2
-
14
-
-
0037015010
-
Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
-
Chou, H.-H., Hayakawa, T., Diaz, S., Krings, M., Indriati, E., Leakey, M., Paabo, S., Satta, Y., Takahata, N., and Varki, A. (2002). Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proc. Natl. Acad. Sci. USA 99: 11736-11741.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11736-11741
-
-
Chou, H.-H.1
Hayakawa, T.2
Diaz, S.3
Krings, M.4
Indriati, E.5
Leakey, M.6
Paabo, S.7
Satta, Y.8
Takahata, N.9
Varki, A.10
-
15
-
-
56549119570
-
Turning a hobby into a job: How duplicated genes find new functions
-
Conant, G.C., and Wolfe, K.H. (2008). Turning a hobby into a job: How duplicated genes find new functions. Nat. Rev. Genet. 9: 938-950.
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 938-950
-
-
Conant, G.C.1
Wolfe, K.H.2
-
16
-
-
78650751202
-
Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict
-
Deng, C., Cheng, C.-H.C., Ye, H., He, X., and Chen, L. (2010). Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA 107: 21593-21598.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21593-21598
-
-
Deng, C.1
Cheng, C.-H.C.2
Ye, H.3
He, X.4
Chen, L.5
-
17
-
-
49349085897
-
The subtle benefits of being promiscuous: Adaptive evolution potentiated by enzyme promiscuity
-
Depristo, M.A. (2007). The subtle benefits of being promiscuous: Adaptive evolution potentiated by enzyme promiscuity. HFSP J. 1: 94-98.
-
(2007)
HFSP J
, vol.1
, pp. 94-98
-
-
Depristo, M.A.1
-
18
-
-
49649114289
-
Escape from adaptive conflict after duplication in an anthocyanin pathway gene
-
Des Marais, D.L., and Rausher, M.D. (2008). Escape from adaptive conflict after duplication in an anthocyanin pathway gene. Nature 454: 762-765.
-
(2008)
Nature
, vol.454
, pp. 762-765
-
-
des Marais, D.L.1
Rausher, M.D.2
-
19
-
-
0000635952
-
Feeding deterrency of some pyrrolizidine, indolizidine, and quinolizidine alkaloids towards pea aphid (Acyrthosiphon pisum) and evidence for phloem transport of indolizidine alkaloid swainsonine
-
Dreyer, D.L., Jones, K.C., and Molyneux, R.J. (1985). Feeding deterrency of some pyrrolizidine, indolizidine, and quinolizidine alkaloids towards pea aphid (Acyrthosiphon pisum) and evidence for phloem transport of indolizidine alkaloid swainsonine. J. Chem. Ecol. 11: 1045-1051.
-
(1985)
J. Chem. Ecol
, vol.11
, pp. 1045-1051
-
-
Dreyer, D.L.1
Jones, K.C.2
Molyneux, R.J.3
-
20
-
-
30744464824
-
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis
-
Duarte, J.M., Cui, L., Wall, P.K., Zhang, Q., Zhang, X., Leebens-Mack, J., Ma, H., Altman, N., and dePamphilis, C.W. (2006). Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol. 23: 469-478.
-
(2006)
Mol. Biol. Evol
, vol.23
, pp. 469-478
-
-
Duarte, J.M.1
Cui, L.2
Wall, P.K.3
Zhang, Q.4
Zhang, X.5
Leebens-Mack, J.6
Ma, H.7
Altman, N.8
Depamphilis, C.W.9
-
21
-
-
77951473217
-
Solanaceae and Convolvulaceae: Secondary Metabolites. Biosynthesis, Chemotaxonomy, Biological and Economic Significance
-
(Berlin, Heidelberg: Springer)
-
Eich, E. (2008). Solanaceae and Convolvulaceae: Secondary Metabolites. Biosynthesis, Chemotaxonomy, Biological and Economic Significance. A Handbook. (Berlin, Heidelberg: Springer).
-
(2008)
A Handbook
, vol.3
, Issue.6
-
-
Eich, E.1
-
23
-
-
0032893932
-
Preservation of duplicate genes by complementary, degenerative mutations
-
Force, A., Lynch, M., Pickett, F.B., Amores, A., Yan, Y.L., and Postlethwait, J. (1999). Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151: 1531-1545.
-
(1999)
Genetics
, vol.151
, pp. 1531-1545
-
-
Force, A.1
Lynch, M.2
Pickett, F.B.3
Amores, A.4
Yan, Y.L.5
Postlethwait, J.6
-
24
-
-
33745610025
-
Gene-balanced duplications, like tetraploidy, provide predictable drive to increase morphological complexity
-
Freeling, M., and Thomas, B.C. (2006). Gene-balanced duplications, like tetraploidy, provide predictable drive to increase morphological complexity. Genome Res. 16: 805-814.
-
(2006)
Genome Res
, vol.16
, pp. 805-814
-
-
Freeling, M.1
Thomas, B.C.2
-
25
-
-
37049134898
-
The structure of ipalbine, a new hexahydroindolizine alkaloid, isolated from Ipomoea alba L
-
Gourley, J.M., Heacock, R.A., McInnes, A.G., Nikolin, B., and Smith, D.G. (1969). The structure of ipalbine, a new hexahydroindolizine alkaloid, isolated from Ipomoea alba L. J. Chem. Soc. Chem. Commun. 709-710.
-
(1969)
J. Chem. Soc. Chem. Commun
, pp. 709-710
-
-
Gourley, J.M.1
Heacock, R.A.2
McInnes, A.G.3
Nikolin, B.4
Smith, D.G.5
-
26
-
-
13744255893
-
Plant metabolic diversity: A regulatory perspective
-
Grotewold, E. (2005). Plant metabolic diversity: A regulatory perspective. Trends Plant Sci. 10: 57-62.
-
(2005)
Trends Plant Sci
, vol.10
, pp. 57-62
-
-
Grotewold, E.1
-
27
-
-
0036890022
-
Rapid divergence in expression between duplicate genes inferred from microarray data
-
Gu, Z., Nicolae, D., Lu, H.H.S., and Li, W.-H. (2002). Rapid divergence in expression between duplicate genes inferred from microarray data. Trends Genet. 18: 609-613.
-
(2002)
Trends Genet
, vol.18
, pp. 609-613
-
-
Gu, Z.1
Nicolae, D.2
Lu, H.H.S.3
Li, W.-H.4
-
28
-
-
0002051540
-
BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
-
Hall, T.A. (1999). BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp. Ser. 41: 95-98.
-
(1999)
Nucleic Acids Symp. Ser
, vol.41
, pp. 95-98
-
-
Hall, T.A.1
-
30
-
-
36549024989
-
From waste products to ecochemicals: Fifty years research of plant secondary metabolism
-
Hartmann, T. (2007). From waste products to ecochemicals: fifty years research of plant secondary metabolism. Phytochemistry 68: 2831-2846.
-
(2007)
Phytochemistry
, vol.68
, pp. 2831-2846
-
-
Hartmann, T.1
-
31
-
-
84919715694
-
Defense By Pyrrolizidine Alkaloids: Developed By Plants and Recruited By Insects
-
In A. Schaller, ed Berlin: Springer Science and Business Media
-
Hartmann, T., and Ober, D. (2008). Defense by pyrrolizidine alkaloids: Developed by plants and recruited by insects. In Induced Plant Resistance to Herbivory, A. Schaller, ed (Berlin: Springer Science and Business Media), pp. 213-231.
-
(2008)
Induced Plant Resistance to Herbivory
, pp. 213-231
-
-
Hartmann, T.1
Ober, D.2
-
32
-
-
0000724877
-
Chemistry, biology and chemoecology of the pyrrolizidine alkaloids
-
In S.W. Pelletier, ed (Oxford, UK: Pergamon Press
-
Hartmann, T., and Witte, L. (1995). Chemistry, biology and chemoecology of the pyrrolizidine alkaloids. In Alkaloids: Chemical and Biological Perspectives, S.W. Pelletier, ed (Oxford, UK: Pergamon Press), pp. 155-233.
-
(1995)
Alkaloids: Chemical and Biological Perspectives
, pp. 155-233
-
-
Hartmann, T.1
Witte, L.2
-
33
-
-
35148863240
-
Gene duplication and the adaptive evolution of a classic genetic switch
-
Hittinger, C.T., and Carroll, S.B. (2007). Gene duplication and the adaptive evolution of a classic genetic switch. Nature 449: 677-681.
-
(2007)
Nature
, vol.449
, pp. 677-681
-
-
Hittinger, C.T.1
Carroll, S.B.2
-
34
-
-
18744413151
-
Effectiveness of tiger moth (Lepidoptera, Arctiidae) chemical defenses against an insectivorous bat (Eptesicus fuscus)
-
Hristov, N., and Conner, W.E. (2005). Effectiveness of tiger moth (Lepidoptera, Arctiidae) chemical defenses against an insectivorous bat (Eptesicus fuscus). Chemoecology 15: 105-113.
-
(2005)
Chemoecology
, vol.15
, pp. 105-113
-
-
Hristov, N.1
Conner, W.E.2
-
35
-
-
0028342845
-
The evolution of functionally novel proteins after gene duplication
-
Hughes, A.L. (1994). The evolution of functionally novel proteins after gene duplication. Proc. Biol. Sci. 256: 119-124.
-
(1994)
Proc. Biol. Sci
, vol.256
, pp. 119-124
-
-
Hughes, A.L.1
-
36
-
-
0036716752
-
Adaptive evolution after gene duplication
-
Hughes, A.L. (2002). Adaptive evolution after gene duplication. Trends Genet. 18: 433-434.
-
(2002)
Trends Genet
, vol.18
, pp. 433-434
-
-
Hughes, A.L.1
-
37
-
-
21144433991
-
Gene duplication and the origin of novel proteins
-
Hughes, A.L. (2005). Gene duplication and the origin of novel proteins. Proc. Natl. Acad. Sci. USA 102: 8791-8792.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8791-8792
-
-
Hughes, A.L.1
-
38
-
-
0345800607
-
Noveaux alcaloides indiliziniques isolés de Ipomoea alba
-
Ikhiri, K., Koulodo, D.D.D., Garba, M., Mamane, S., Ahond, A., Poupat, C., and Potier, P. (1987). Noveaux alcaloides indiliziniques isolés de Ipomoea alba. J. Nat. Prod. 50: 152-156.
-
(1987)
J. Nat. Prod
, vol.50
, pp. 152-156
-
-
Ikhiri, K.1
Koulodo, D.D.D.2
Garba, M.3
Mamane, S.4
Ahond, A.5
Poupat, C.6
Potier, P.7
-
39
-
-
0000511303
-
Ipangulines, the first pyrrolizidine alkaloids from the Convolvulaceae
-
Jenett-Siems, K., Kaloga, M., and Eich, E. (1993). Ipangulines, the first pyrrolizidine alkaloids from the Convolvulaceae. Phytochemistry 34: 437-440.
-
(1993)
Phytochemistry
, vol.34
, pp. 437-440
-
-
Jenett-Siems, K.1
Kaloga, M.2
Eich, E.3
-
40
-
-
19944432558
-
Ipangulines and minalobines, chemotaxonomic markers of the infrageneric Ipomoea taxon subgenus Quamoclit, section Mina
-
Jenett-Siems, K., Ott, S.C., Schimming, T., Siems, K., Müller, F., Hilker, M., Witte, L., Hartmann, T., Austin, D.F., and Eich, E. (2005). Ipangulines and minalobines, chemotaxonomic markers of the infrageneric Ipomoea taxon subgenus Quamoclit, section Mina. Phytochemistry 66: 223-231.
-
(2005)
Phytochemistry
, vol.66
, pp. 223-231
-
-
Jenett-Siems, K.1
Ott, S.C.2
Schimming, T.3
Siems, K.4
Müller, F.5
Hilker, M.6
Witte, L.7
Hartmann, T.8
Austin, D.F.9
Eich, E.10
-
41
-
-
0032051797
-
Pyrrolizidine alkaloids of Ipomoea hederifolia and related species
-
Jenett-Siems, K., Schimming, T., Kaloga, M., Eich, E., Siems, K., Gupta, M.P., Witte, L., and Hartmann, T. (1998). Pyrrolizidine alkaloids of Ipomoea hederifolia and related species. Phytochemistry 47: 1551-1560.
-
(1998)
Phytochemistry
, vol.47
, pp. 1551-1560
-
-
Jenett-Siems, K.1
Schimming, T.2
Kaloga, M.3
Eich, E.4
Siems, K.5
Gupta, M.P.6
Witte, L.7
Hartmann, T.8
-
42
-
-
0026691182
-
The rapid generation of mutation data matrices from protein sequences
-
Jones, D.T., Taylor, W.R., and Thornton, J.M. (1992). The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 8: 275-282.
-
(1992)
Comput. Appl. Biosci
, vol.8
, pp. 275-282
-
-
Jones, D.T.1
Taylor, W.R.2
Thornton, J.M.3
-
43
-
-
0019296687
-
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
-
Kimura, M. (1980). A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J. Mol. Evol. 16: 111-120.
-
(1980)
J. Mol. Evol
, vol.16
, pp. 111-120
-
-
Kimura, M.1
-
44
-
-
79952015151
-
The evolution of pyrrolizidine alkaloid biosynthesis and diversity in the Senecioneae
-
Langel, D., Ober, D., and Pelser, P. (2011). The evolution of pyrrolizidine alkaloid biosynthesis and diversity in the Senecioneae. Phytochem. Rev. 10: 3-74.
-
(2011)
Phytochem. Rev
, vol.10
, pp. 3-74
-
-
Langel, D.1
Ober, D.2
Pelser, P.3
-
45
-
-
26444488575
-
Expression divergence between duplicate genes
-
Li, W.-H., Yang, J., and Gu, X. (2005). Expression divergence between duplicate genes. Trends Genet. 21: 602-607.
-
(2005)
Trends Genet
, vol.21
, pp. 602-607
-
-
Li, W.-H.1
Yang, J.2
Gu, X.3
-
46
-
-
0032518247
-
Crystal structure of the NAD complex of human deoxyhypusine synthase: An enzyme with a ball-and-chain mechanism for blocking the active site
-
Liao, D.I., Wolff, E.C., Park, M.H., and Davies, D.R. (1998). Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Structure 6: 23-32.
-
(1998)
Structure
, vol.6
, pp. 23-32
-
-
Liao, D.I.1
Wolff, E.C.2
Park, M.H.3
Davies, D.R.4
-
47
-
-
0242354129
-
The origin of new genes: Glimpses from the young and old
-
Long, M., Betrán, E., Thornton, K., and Wang, W. (2003). The origin of new genes: Glimpses from the young and old. Nat. Rev. Genet. 4: 865-875.
-
(2003)
Nat. Rev. Genet
, vol.4
, pp. 865-875
-
-
Long, M.1
Betrán, E.2
Thornton, K.3
Wang, W.4
-
48
-
-
0242497865
-
Evolutionary rate variation in anthocyanin pathway genes
-
Lu, Y., and Rausher, M.D. (2003). Evolutionary rate variation in anthocyanin pathway genes. Mol. Biol. Evol. 20: 1844-1853.
-
(2003)
Mol. Biol. Evol
, vol.20
, pp. 1844-1853
-
-
Lu, Y.1
Rausher, M.D.2
-
49
-
-
0033972072
-
The probability of duplicate gene preservation by subfunctionalization
-
Lynch, M., and Force, A. (2000). The probability of duplicate gene preservation by subfunctionalization. Genetics 154: 459-473.
-
(2000)
Genetics
, vol.154
, pp. 459-473
-
-
Lynch, M.1
Force, A.2
-
50
-
-
0003586408
-
-
Cambridge, UK: Cambridge University Press)
-
Mabberley, D.J. (1987). The Plant Book. (Cambridge, UK: Cambridge University Press).
-
(1987)
The Plant Book
-
-
Mabberley, D.J.1
-
52
-
-
50649097975
-
Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus
-
Markert, A., Steffan, N., Ploss, K., Hellwig, S., Steiner, U., Drewke, C., Li, S.-M., Boland, W., and Leistner, E. (2008). Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus. Plant Physiol. 147: 296-305.
-
(2008)
Plant Physiol
, vol.147
, pp. 296-305
-
-
Markert, A.1
Steffan, N.2
Ploss, K.3
Hellwig, S.4
Steiner, U.5
Drewke, C.6
Li, S.-M.7
Boland, W.8
Leistner, E.9
-
53
-
-
84868365613
-
The spatial architecture of protein function and adaptation
-
McLaughlin, R.N., Jr., Poelwijk, F.J., Raman, A., Gosal, W.S., and Ranganathan, R. (2012). The spatial architecture of protein function and adaptation. Nature 491: 138-142.
-
(2012)
Nature
, vol.491
, pp. 138-142
-
-
McLaughlin Jr., R.N.1
Poelwijk, F.J.2
Raman, A.3
Gosal, W.S.4
Ranganathan, R.5
-
54
-
-
0036804707
-
An examination of the monophyly of morning glory taxa using Bayesian phylogenetic inference
-
Miller, R.E., Buckley, T.R., and Manos, P.S. (2002). An examination of the monophyly of morning glory taxa using Bayesian phylogenetic inference. Syst. Biol. 51: 740-753.
-
(2002)
Syst. Biol
, vol.51
, pp. 740-753
-
-
Miller, R.E.1
Buckley, T.R.2
Manos, P.S.3
-
55
-
-
15944415952
-
Systematics of Ipomoea subgenus Quamoclit (Convolvulaceae) based on ITS sequence data and a Bayesian phylogenetic analysis
-
Miller, R.E., McDonald, J.A., and Manos, P.S. (2004). Systematics of Ipomoea subgenus Quamoclit (Convolvulaceae) based on ITS sequence data and a Bayesian phylogenetic analysis. Am. J. Bot. 91: 1208-1218.
-
(2004)
Am. J. Bot
, vol.91
, pp. 1208-1218
-
-
Miller, R.E.1
McDonald, J.A.2
Manos, P.S.3
-
56
-
-
0036739727
-
Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase
-
Moll, S., Anke, S., Kahmann, U., Hänsch, R., Hartmann, T., and Ober, D. (2002). Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase. Plant Physiol. 130: 47-57.
-
(2002)
Plant Physiol
, vol.130
, pp. 47-57
-
-
Moll, S.1
Anke, S.2
Kahmann, U.3
Hänsch, R.4
Hartmann, T.5
Ober, D.6
-
57
-
-
0024245410
-
Australine a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australe
-
Molyneux, R.J., Benson, M., Wong, R.Y., Tropea, J.E., and Elbein, A.D. (1988). Australine a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australe. J. Nat. Prod. 51: 1198-1206.
-
(1988)
J. Nat. Prod
, vol.51
-
-
Molyneux, R.J.1
Benson, M.2
Wong, R.Y.3
Tropea, J.E.4
Elbein, A.D.5
-
58
-
-
33749238682
-
Beyond Bonferroni: Less conservative analyses for conservation genetics
-
Narum, S. (2006). Beyond Bonferroni: Less conservative analyses for conservation genetics. Conserv. Genet. 7: 783-787.
-
(2006)
Conserv. Genet
, vol.7
, pp. 783-787
-
-
Narum, S.1
-
59
-
-
84863713396
-
Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales
-
Niemüller, D., Reimann, A., and Ober, D. (2012). Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales. Plant Physiol. 159: 920-929.
-
(2012)
Plant Physiol
, vol.159
, pp. 920-929
-
-
Niemüller, D.1
Reimann, A.2
Ober, D.3
-
60
-
-
66149086564
-
Reliabilities of identifying positive selection by the branch-site and the site-prediction methods
-
Nozawa, M., Suzuki, Y., and Nei, M. (2009). Reliabilities of identifying positive selection by the branch-site and the site-prediction methods. Proc. Natl. Acad. Sci. USA 106: 6700-6705.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 6700-6705
-
-
Nozawa, M.1
Suzuki, Y.2
Nei, M.3
-
61
-
-
62549155756
-
Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: Identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes
-
Nurhayati, N., Gondé, D., and Ober, D. (2009). Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: Identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes. Phytochemistry 70: 508-516.
-
(2009)
Phytochemistry
, vol.70
, pp. 508-516
-
-
Nurhayati, N.1
Gondé, D.2
Ober, D.3
-
62
-
-
20444406073
-
Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity?
-
Nurhayati, N., and Ober, D. (2005). Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity? Phytochemistry 66: 1346-1357.
-
(2005)
Phytochemistry
, vol.66
, pp. 1346-1357
-
-
Nurhayati, N.1
Ober, D.2
-
63
-
-
27244432046
-
Seeing double: Gene duplication and diversification in plant secondary metabolism
-
Ober, D. (2005). Seeing double: Gene duplication and diversification in plant secondary metabolism. Trends Plant Sci. 10: 444-449.
-
(2005)
Trends Plant Sci
, vol.10
, pp. 444-449
-
-
Ober, D.1
-
64
-
-
77955935755
-
Gene duplications and the time thereafter Examples from plant secondary metabolism
-
Ober, D. (2010). Gene duplications and the time thereafter Examples from plant secondary metabolism. Plant Biol (Stuttg) 12: 570-577.
-
(2010)
Plant Biol (Stuttg)
, vol.12
, pp. 570-577
-
-
Ober, D.1
-
65
-
-
0037308193
-
Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase
-
Ober, D., Gibas, L., Witte, L., and Hartmann, T. (2003a). Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase. Phytochemistry 62: 339-344.
-
(2003)
Phytochemistry
, vol.62
, pp. 339-344
-
-
Ober, D.1
Gibas, L.2
Witte, L.3
Hartmann, T.4
-
66
-
-
0038305967
-
Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein
-
Ober, D., Harms, R., Witte, L., and Hartmann, T. (2003b). Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein. J. Biol. Chem. 278: 12805-12812.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 12805-12812
-
-
Ober, D.1
Harms, R.2
Witte, L.3
Hartmann, T.4
-
67
-
-
0033593052
-
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase
-
Ober, D., and Hartmann, T. (1999a). Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase. Proc. Natl. Acad. Sci. USA 96: 14777-14782.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14777-14782
-
-
Ober, D.1
Hartmann, T.2
-
68
-
-
0033527751
-
Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity
-
Ober, D., and Hartmann, T. (1999b). Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity. J. Biol. Chem. 274: 32040-32047.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 32040-32047
-
-
Ober, D.1
Hartmann, T.2
-
69
-
-
70350739109
-
Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism
-
Ober, D., and Kaltenegger, E. (2009). Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism. Phytochemistry 70: 1687-1695.
-
(2009)
Phytochemistry
, vol.70
, pp. 1687-1695
-
-
Ober, D.1
Kaltenegger, E.2
-
70
-
-
0023691425
-
Genetic applications of an inverse polymerase chain reaction
-
Ochman, H., Gerber, A.S., and Hartl, D.L. (1988). Genetic applications of an inverse polymerase chain reaction. Genetics 120: 621-623.
-
(1988)
Genetics
, vol.120
, pp. 621-623
-
-
Ochman, H.1
Gerber, A.S.2
Hartl, D.L.3
-
72
-
-
0006806047
-
Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae
-
Park, M.H., Joe, Y.A., and Kang, K.R. (1998). Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 273: 1677-1683.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 1677-1683
-
-
Park, M.H.1
Joe, Y.A.2
Kang, K.R.3
-
73
-
-
0030767387
-
Hypusine is essential for eukaryotic cell proliferation
-
Park, M.H., Lee, Y.B., and Joe, Y.A. (1997). Hypusine is essential for eukaryotic cell proliferation. Biol. Signals 6: 115-123.
-
(1997)
Biol. Signals
, vol.6
, pp. 115-123
-
-
Park, M.H.1
Lee, Y.B.2
Joe, Y.A.3
-
74
-
-
0026326815
-
The recruitment of crystallins: New functions precede gene duplication
-
Piatigorsky, J., and Wistow, G. (1991). The recruitment of crystallins: New functions precede gene duplication. Science 252: 1078-1079.
-
(1991)
Science
, vol.252
, pp. 1078-1079
-
-
Piatigorsky, J.1
Wistow, G.2
-
75
-
-
0033779923
-
Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective
-
Pichersky, E., and Gang, D.R. (2000). Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective. Trends Plant Sci. 5: 439-445.
-
(2000)
Trends Plant Sci
, vol.5
, pp. 439-445
-
-
Pichersky, E.1
Gang, D.R.2
-
76
-
-
16644387127
-
Repeated evolution of the pyrrolizidine alkaloid-mediated defense system in separate angiosperm lineages
-
Reimann, A., Nurhayati, N., Backenköhler, A., and Ober, D. (2004). Repeated evolution of the pyrrolizidine alkaloid-mediated defense system in separate angiosperm lineages. Plant Cell 16: 2772-2784.
-
(2004)
Plant Cell
, vol.16
, pp. 2772-2784
-
-
Reimann, A.1
Nurhayati, N.2
Backenköhler, A.3
Ober, D.4
-
77
-
-
70350394850
-
Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera)
-
Reinhard, A., Janke, M., von der Ohe, W., Kempf, M., Theuring, C., Hartmann, T., Schreier, P., and Beuerle, T. (2009). Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera). J. Chem. Ecol. 35: 1086-1095.
-
(2009)
J. Chem. Ecol
, vol.35
, pp. 1086-1095
-
-
Reinhard, A.1
Janke, M.2
von der Ohe, W.3
Kempf, M.4
Theuring, C.5
Hartmann, T.6
Schreier, P.7
Beuerle, T.8
-
78
-
-
25144435946
-
Repositioning-dependent fate of duplicate genes
-
Rodin, S.N., Parkhomchuk, D.V., Rodin, A.S., Holmquist, G.P., and Riggs, A.D. (2005). Repositioning-dependent fate of duplicate genes. DNA Cell Biol. 24: 529-542.
-
(2005)
DNA Cell Biol
, vol.24
, pp. 529-542
-
-
Rodin, S.N.1
Parkhomchuk, D.V.2
Rodin, A.S.3
Holmquist, G.P.4
Riggs, A.D.5
-
79
-
-
0344824014
-
Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene
-
Rodríguez-Trelles, F., Tarrío, R., and Ayala, F.J. (2003). Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene. Proc. Natl. Acad. Sci. USA 100: 13413-13417.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13413-13417
-
-
Rodríguez-Trelles, F.1
Tarrío, R.2
Ayala, F.J.3
-
80
-
-
84878260065
-
Fungal Endophytes In Lolium and Festuca Species
-
In Yamada and G. Spangenberg, eds (New York: Springer
-
Schardl, C.L. (2009). Fungal endophytes in Lolium and Festuca species. In Molecular Breeding of Forage and Turf, T. Yamada and G. Spangenberg, eds (New York: Springer), pp. 285-298.
-
(2009)
Molecular Breeding of Forage and Turf
, pp. 285-298
-
-
Schardl, C.L.1
-
81
-
-
33947251674
-
Loline alkaloids: Currencies of mutualism
-
Schardl, C.L., Grossman, R.B., Nagabhyru, P., Faulkner, J.R., and Mallik, U.P. (2007). Loline alkaloids: Currencies of mutualism. Phytochemistry 68: 980-996.
-
(2007)
Phytochemistry
, vol.68
, pp. 980-996
-
-
Schardl, C.L.1
Grossman, R.B.2
Nagabhyru, P.3
Faulkner, J.R.4
Mallik, U.P.5
-
82
-
-
21844444294
-
Pyrrolizidine alkaloids from Anchusa strigosa and their antifeedant activity
-
Siciliano, T., Leo, M.D., Bader, A., Tommasi, N.D., Vrieling, K., Braca, A., and Morelli, I. (2005). Pyrrolizidine alkaloids from Anchusa strigosa and their antifeedant activity. Phytochemistry 66: 1593-1600.
-
(2005)
Phytochemistry
, vol.66
, pp. 1593-1600
-
-
Siciliano, T.1
Leo, M.D.2
Bader, A.3
Tommasi, N.D.4
Vrieling, K.5
Braca, A.6
Morelli, I.7
-
83
-
-
0013443483
-
Does anti-parasitoid defense explain host-plant selection by a polyphagous caterpillar?
-
Singer, M.S., and Stireman, J.O., III., (2003). Does anti-parasitoid defense explain host-plant selection by a polyphagous caterpillar? Oikos 100: 554-562.
-
(2003)
Oikos
, vol.100
, pp. 554-562
-
-
Singer, M.S.1
Stireman, J.O.2
-
84
-
-
84873571934
-
Functional evolution of an anthocyanin pathway enzyme during a flower color transition
-
Smith, S.D., Wang, S., and Rausher, M.D. (2013). Functional evolution of an anthocyanin pathway enzyme during a flower color transition. Mol. Biol. Evol. 30: 602-612.
-
(2013)
Mol. Biol. Evol
, vol.30
, pp. 602-612
-
-
Smith, S.D.1
Wang, S.2
Rausher, M.D.3
-
85
-
-
0344099535
-
Classification of Convolvulaceae: A phylogenetic approach
-
Stefanovic, S., Austin, D.F., and Olmstead Richard, G. (2003). Classification of Convolvulaceae: A phylogenetic approach. Syst. Bot. 28: 791-806.
-
(2003)
Syst. Bot
, vol.28
, pp. 791-806
-
-
Stefanovic, S.1
Austin, D.F.2
Olmstead Richard, G.3
-
86
-
-
0036743053
-
Monophyly of the Convolvulaceae and circumscription of their major lineages based on DNA sequences of multiple chloroplast loci
-
Stefanovic, S., Krueger, L., and Olmstead, R.G. (2002). Monophyly of the Convolvulaceae and circumscription of their major lineages based on DNA sequences of multiple chloroplast loci. Am. J. Bot. 89: 1510-1522.
-
(2002)
Am. J. Bot
, vol.89
, pp. 1510-1522
-
-
Stefanovic, S.1
Krueger, L.2
Olmstead, R.G.3
-
87
-
-
33746896974
-
Molecular characterization of a seed transmitted clavicipitaceous fungus occurring on dicotyledoneous plants (Convolvulaceae)
-
Steiner, U., et al. (2006). Molecular characterization of a seed transmitted clavicipitaceous fungus occurring on dicotyledoneous plants (Convolvulaceae). Planta 224: 533-544.
-
(2006)
Planta
, vol.224
, pp. 533-544
-
-
Steiner, U.1
-
89
-
-
0031574072
-
The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
-
Thompson, J.D., Gibson, T.J., Plewniak, F., Jeanmougin, F., and Higgins, D.G. (1997). The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25: 4876-4882.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 4876-4882
-
-
Thompson, J.D.1
Gibson, T.J.2
Plewniak, F.3
Jeanmougin, F.4
Higgins, D.G.5
-
91
-
-
0032813852
-
Occurrence of loline alkaloids in Argyreia mollis (Convolvulaceae)
-
Tofern, B., Kaloga, M., Witte, L., Hartmann, T., and Eich, E. (1999). Occurrence of loline alkaloids in Argyreia mollis (Convolvulaceae). Phytochemistry 51: 1177-1180.
-
(1999)
Phytochemistry
, vol.51
, pp. 1177-1180
-
-
Tofern, B.1
Kaloga, M.2
Witte, L.3
Hartmann, T.4
Eich, E.5
-
92
-
-
3142543751
-
A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme-NAD-inhibitor ternary complex
-
Umland, T.C., Wolff, E.C., Park, M.H., and Davies, D.R. (2004). A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme-NAD-inhibitor ternary complex. J. Biol. Chem. 279: 28697-28705.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 28697-28705
-
-
Umland, T.C.1
Wolff, E.C.2
Park, M.H.3
Davies, D.R.4
-
93
-
-
0038988554
-
Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants
-
von Borstel, K., and Hartmann, T. (1986). Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants. Plant Cell Rep. 5: 39-42.
-
(1986)
Plant Cell Rep
, vol.5
, pp. 39-42
-
-
von Borstel, K.1
Hartmann, T.2
-
94
-
-
0037423828
-
How the global structure of protein interaction networks evolves
-
Wagner, A. (2003). How the global structure of protein interaction networks evolves. Proc. Biol. Sci. 270: 457-466.
-
(2003)
Proc. Biol. Sci
, vol.270
, pp. 457-466
-
-
Wagner, A.1
-
95
-
-
34548501747
-
Natural history and evolutionary principles of gene duplication in fungi
-
Wapinski, I., Pfeffer, A., Friedman, N., and Regev, A. (2007). Natural history and evolutionary principles of gene duplication in fungi. Nature 449: 54-61.
-
(2007)
Nature
, vol.449
, pp. 54-61
-
-
Wapinski, I.1
Pfeffer, A.2
Friedman, N.3
Regev, A.4
-
96
-
-
0030683599
-
PAML: A program package for phylogenetic analysis by maximum likelihood
-
Yang, Z. (1997). PAML: A program package for phylogenetic analysis by maximum likelihood. Comput. Appl. Biosci. 13: 555-556.
-
(1997)
Comput. Appl. Biosci
, vol.13
, pp. 555-556
-
-
Yang, Z.1
-
97
-
-
0031897964
-
Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
-
Yang, Z. (1998). Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol. Biol. Evol. 15: 568-573.
-
(1998)
Mol. Biol. Evol
, vol.15
, pp. 568-573
-
-
Yang, Z.1
-
98
-
-
34547803197
-
PAML 4: Phylogenetic analysis by maximum likelihood
-
Yang, Z. (2007). PAML 4: Phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24: 1586-1591.
-
(2007)
Mol. Biol. Evol
, vol.24
, pp. 1586-1591
-
-
Yang, Z.1
-
99
-
-
79952136825
-
Statistical properties of the branch-site test of positive selection
-
Yang, Z., and dos Reis, M. (2011). Statistical properties of the branch-site test of positive selection. Mol. Biol. Evol. 28: 1217-1228.
-
(2011)
Mol. Biol. Evol
, vol.28
, pp. 1217-1228
-
-
Yang, Z.1
dos Reis, M.2
-
100
-
-
0031960185
-
Synonymous and nonsynonymous rate variation in nuclear genes of mammals
-
Yang, Z., and Nielsen, R. (1998). Synonymous and nonsynonymous rate variation in nuclear genes of mammals. J. Mol. Evol. 46: 409-418.
-
(1998)
J. Mol. Evol
, vol.46
, pp. 409-418
-
-
Yang, Z.1
Nielsen, R.2
-
101
-
-
0036270185
-
Codon-substitution models for detecting molecular adaptation at individual sites along spe cific lineages
-
Yang, Z., and Nielsen, R. (2002). Codon-substitution models for detecting molecular adaptation at individual sites along spe cific lineages. Mol. Biol. Evol. 19: 908-917.
-
(2002)
Mol. Biol. Evol
, vol.19
, pp. 908-917
-
-
Yang, Z.1
Nielsen, R.2
-
102
-
-
0034097381
-
Codon-substitution models for heterogeneous selection pressure at amino acid sites
-
Yang, Z., Nielsen, R., Goldman, N., and Pedersen, A.M.K. (2000). Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 155: 431-449.
-
(2000)
Genetics
, vol.155
, pp. 431-449
-
-
Yang, Z.1
Nielsen, R.2
Goldman, N.3
Pedersen, A.M.K.4
-
103
-
-
16344378246
-
Bayes empirical bayes inference of amino acid sites under positive selection
-
Yang, Z., Wong, W.S.W., and Nielsen, R. (2005). Bayes empirical bayes inference of amino acid sites under positive selection. Mol. Biol. Evol. 22: 1107-1118.
-
(2005)
Mol. Biol. Evol
, vol.22
, pp. 1107-1118
-
-
Yang, Z.1
Wong, W.S.W.2
Nielsen, R.3
-
104
-
-
0037500141
-
Evolution by gene duplication: An update
-
Zhang, J. (2003). Evolution by gene duplication: An update. Trends Ecol. Evol. 18: 292-298.
-
(2003)
Trends Ecol. Evol
, vol.18
, pp. 292-298
-
-
Zhang, J.1
-
105
-
-
27844439855
-
Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level
-
Zhang, J., Nielsen, R., and Yang, Z. (2005). Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level. Mol. Biol. Evol. 22: 2472-2479.
-
(2005)
Mol. Biol. Evol
, vol.22
, pp. 2472-2479
-
-
Zhang, J.1
Nielsen, R.2
Yang, Z.3
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