Molecular evolution by change of function: Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5a precursor protein

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 12805-12812

  Ober, Dietrich ^a   Harms, Reiner ^a   Witte, Ludger ^a   Hartmann, Thomas ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; GENES; SUBSTRATES;

PRECURSORS;

BIOCHEMISTRY;

ALKALOID; DEOXYHYPUSINE SYNTHASE; HOMOSPERMIDINE SYNTHASE; INITIATION FACTOR 5A; LYSINE; POLYAMINE; PUTRESCINE; PYRROLIZIDINE ALKALOID; SPERMIDINE; SYNTHETASE; UNCLASSIFIED DRUG; EIF-5A; HOMOSPERMIDINE SYNTHETASE; INITIATION FACTOR; OXIDOREDUCTASE; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; RNA BINDING PROTEIN; TRANSFERASE;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; HERBIVORY; MICHAEL ADDITION; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; MASS FRAGMENTOGRAPHY; METABOLISM; MOLECULAR CLONING; PH; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; SENECIO VERNALIS;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CLONING, MOLECULAR; EVOLUTION, MOLECULAR; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROGEN-ION CONCENTRATION; KINETICS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEPTIDE INITIATION FACTORS; PROTEIN PRECURSORS; PUTRESCINE; RECOMBINANT PROTEINS; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SPERMIDINE; SUBSTRATE SPECIFICITY;

EID: 0038305967     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207112200     Document Type: Article

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