Caffeic acid phenethyl ester induces E2F-1-mediated growth inhibition and cell-cycle arrest in human cervical cancer cells

FEBS Journal

Volumn 280, Issue 11, 2013, Pages 2581-2593

  Hsu, Tzu Hui ^a   Chu, Chin Chen ^b,c   Hung, Mei Whey ^d   Lee, Hwei Jen ^a   Hsu, Hsien Jun ^a   Chang, Tsu Chung ^a,e  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

apoptosis; caffeic acid phenethyl ester; cell cycle arrest; cervical cancer cells; E2F 1 factor

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CAFFEIC ACID PHENETHYL ESTER; CYCLIN A; CYCLIN B; CYCLIN E; PROTEIN MCL 1; TRANSCRIPTION FACTOR E2F1;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APOPTOTIC PROTEASE ACTIVATING FACTOR 1 GENE; ARTICLE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL CYCLE ARREST; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIN B GENE; DNA TRANSCRIPTION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN 1 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION; UTERINE CERVIX CANCER;

APOPTOSIS; CAFFEIC ACIDS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOSTATIC AGENTS; E2F1 TRANSCRIPTION FACTOR; FEMALE; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; PHENYLETHYL ALCOHOL; PROMOTER REGIONS, GENETIC; UTERINE CERVICAL NEOPLASMS;

EID: 84878245521     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12242     Document Type: Article

References (37)

1. Chen MF, Wu CT, Chen YJ, Keng PC, &, Chen WC, (2004) Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J Radiat Res 45, 253-260.
2. Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, &, Tseng TH, (2003) Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol 15, 2281-2289.
3. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, &, Barrett JC, (1995) Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cell. Cancer Res 16, 3576-3583.
4. 2 induced oxidative and inflammatory responses in human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol 76, 675-679.
5. Korish AA, &, Arafa MM, (2011) Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock. Braz J Infect Dis 15, 332-338.
6. Boudreau LH, Maillet J, LeBlanc LM, Jean-François J, Touaibia M, Flamand N, &, Surette ME, (2011) Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes. PLoS One 7, e31833.
7. Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, &, Kohn KW, (1994) Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 48, 595-608.
8. Sud'ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, &, Varfolomeev SD, (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 329, 21-24.
9. Jin UH, Song KH, Motomura M, Suzuki I, Gu YH, Kang YJ, Moon TC, &, Kim CH, (2008) Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Mol Cell Biochem 310, 43-48.
10. Eşrefoǧlu M, Gül M, Ateş B, &, Erdoǧan A, (2011) The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage. Fundam Clin Pharmacol 25, 580-590.
11. Su ZZ, Lin J, Grunberger D, &, Fisher PB, (1994) Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res 54, 1865-1870.
12. Kudugunti SK, Vad NM, Whiteside AJ, Naik BU, Yusuf MA, Srivenugopal KS, &, Moridani MY, (2010) Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines. Chem Biol Interact 188, 1-14.
13. Bhimani RS, Troll W, Grunberger D, &, Frenkel K, (1993) Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res 53, 4528-4533.
14. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, &, Nakaki T, (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NF-κB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279, 6017-6026.
15. DeGregori J, &, Johnson DG, (2006) Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6, 739-748.
16. Holmberg C, Helin K, Sehested M, &, Karlstrom O, (1998) E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-155.
17. Hershko T, Chaussepied M, Oren M, &, Ginsberg D, (2005) Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ 12, 377-383.
18. Tamrakar S, Rubin E, &, Ludlow JW, (2000) Role of pRB dephosphorylation in cell cycle regulation. Front Biosci 1, D121-D137.
19. Ivanova IA, D'Souza SJ, &, Dagnino L, (2005) Signalling in the epidermis: the E2F cell cycle regulatory pathway in epidermal morphogenesis, regeneration and transformation. Int J Biol Sci 1, 87-95.
20. 2 checkpoint through cyclin B1. Proc Natl Acad Sci USA 96, 2147-2152.
21. 2/M transcription. EMBO J 23, 4615-4626.
22. Chen MJ, Chang WH, Lin CC, Liu CY, Wang TE, Chu CH, Shih SC, &, Chen YJ, (2008) Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. Pancreatology 8, 566-576.
23. Burd EM, (2003) Human papillomavirus and cervical cancer. Clin Microbiol Rev 16, 1-17.
24. Moroni MC, Hickman ES, Denchi EL, Caprara G, Coli E, Cecconi F, Muller H, &, Helin K, (2001) Apaf-1 is a transcriptional target for E2F1 and p53. Nat Cell Biol 3, 552-558.
25. Croxton R, Ma Y, Song L, Haura E, &, Cress WD, (2002) Direct repression of the Mcl-1 promoter by E2F1. Oncogene 21, 1359-1369.
26. Hsu LY, Lin CF, Hsu WC, Hsu WL, &, Chang TC, (2005) Evaluation of polyphenolic acid esters as potential antioxidants. Biol Pharm Bull 28, 1211-1215.
27. Pecoraro G, Morgan D, &, Defendi V, (1989) Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells. Proc Natl Acad Sci USA 86, 563-567.
28. Chou CY, Shen MR, &, Wu SN, (1995) Volume-sensitive chloride channels associated with human cervical carcinogenesis. Cancer Res 55, 6077-6083.
29. Ding DC, Chiang MH, Lai HC, Hsiung CA, Hsieh CY, &, Chu TY, (2009) Methylation of the long control region of Hpv16 is related to the severity of cervical neoplasia. Eur J Obstet Gynecol Reprod Biol 147, 215-220.
30. Mundle SD, &, Saberwal G, (2003) Evolving intricacies and implications of E2F1 regulation. FASEB J 17, 569-574.
31. Hallstrom TC, &, Nevins JR, (2003) Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci USA 100, 10845-10848.
32. Pützer BM, (2007) E2F1 death pathways as targets for cancer therapy. J Cell Mol Med 11, 239-251.
33. Stanelle J, &, Pützer BM, (2006) E2F1-induced apoptosis: turning killers into therapeutics. Trends Mol Med 12, 177-185.
34. Meng RD, Phillips P, &, El-Deiry WS, (1999) p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin. Int J Oncol 14, 5-14.
35. Dong YB, Yang HL, Elliott MJ, &, McMasters KM, (2002) Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors. Cancer Res 62, 1776-1783.
36. Chang TC, Tsai LC, Hung MW, Chu LL, Chu JT, &, Chen YT, (1997) Effects of transcriptional and translational inhibitors on a human gastric cancer cell line: potential role of Bcl-Xs in apoptosis triggered by these inhibitors. Biochem Pharmacol 53, 969-977.
37. Kirch HC, Pützer B, Schwabe G, Gnauck HK, &, Schulte HH, (1993) Regulation of adenovirus 12 E1A transcription: E2F and ATF motifs in the E1A promoter bind nuclear protein complexes including E2F1, DP-1, cyclin A and/or RB and mediate transcriptional (auto)activation. Cell Mol Biol Res 39, 705-716.