Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

International Journal of Pediatric Otorhinolaryngology

Volumn 76, Issue 5, 2012, Pages 675-679

  Song, Jae Jun ^a   Lim, Hyun Woo ^b   Kim, Kihyoung ^b   Kim, Kyoung Min ^b   Cho, Sunyoung ^b   Chae, Sung Won ^b  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

Acute otitis media; Caffeic acid phenethyl ester; H2O2; Human middle ear epithelial cells; N Acetyl cysteine

Indexed keywords

ACETYLCYSTEINE; CAFFEIC ACID PHENETHYL ESTER; CYCLOOXYGENASE 2; DICHLORODIHYDROFLUORESCEIN DIACETATE; HYDROGEN PEROXIDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MIDDLE EAR; OTITIS MEDIA; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIOXIDANTS; BLOTTING, WESTERN; CAFFEIC ACIDS; CELL CULTURE TECHNIQUES; CYTOKINES; EAR, MIDDLE; EPITHELIAL CELLS; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84862823889     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2012.01.041     Document Type: Article

References (24)

1. Barrett T.Q., Kristiansen L.H., Ovesen T. NF-kappaB in cultivated middle ear epithelium. Int. J. Pediatr. Otorhinolaryngol. 2003, 67:895-903.
2. Bluestone C.D., Hebda P.A., Alper C.M., Sando I., Buchman C.A., Stangerup S.E., et al. Recent advances in otitis media. 2. Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis. Ann. Otol. Rhinol. Laryngol. Suppl. 2005, 194:16-30.
3. Butler C.C., Williams R.G. The etiology, pathophysiology, and management of otitis media with effusion. Curr. Infect. Dis. Rep. 2003, 5:205-212.
4. Pelton S.I. New concepts in the pathophysiology and management of middle ear disease in childhood. Drugs 1996, 52(Suppl. 2):62-66. discussion 66-67.
5. Doner F., Delibas N., Dogru H., Yariktas M., Demirci M. The role of free oxygen radicals in experimental otitis media. J. Basic Clin. Physiol. Pharmacol. 2002, 13:33-40.
6. Parks R.R., Huang C.C., Haddad J. Evidence of oxygen radical injury in experimental otitis media. Laryngoscope 1994, 104:1389-1392.
7. Yilmaz T., Kocan E.G., Besler H.T., Yilmaz G., Gursel B. The role of oxidants and antioxidants in otitis media with effusion in children. Otolaryngol. Head Neck Surg. 2004, 131:797-803.
8. Gargouri B., Nasr R., Ben Mansour R., Lassoued S., Mseddi M., Attia H., et al. Reactive oxygen species production and antioxidant enzyme expression after Epstein-Barr virus lytic cycle induction in Raji cell line. Biol. Trace Elem. Res. 2011, 144(1-3):1449-1457.
9. Koyu A., Ozguner F., Yilmaz H., Uz E., Cesur G., Ozcelik N. The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative stress in rat liver exposed to the 900MHz electromagnetic field. Toxicol. Ind. Health 2009, 25:429-434.
10. Dobrowolski J.W., Vohora S.B., Sharma K., Shah S.A., Naqvi S.A., Dandiya P.C. Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products. J. Ethnopharmacol. 1991, 35:77-82.
11. Su Z.Z., Lin J., Grunberger D., Fisher P.B. Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression. Cancer Res. 1994, 54:1865-1870.
12. Michaluart P., Masferrer J.L., Carothers A.M., Subbaramaiah K., Zweifel B.S., Koboldt C., et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999, 59:2347-2352.
13. Mirzoeva O.K., Calder P.C. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot. Essent. Fatty Acids 1996, 55:441-449.
14. Song J.J., Cho J.G., Hwang S.J., Cho C.G., Park S.W., Chae S.W. Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells. Acta Otolaryngol. 2008, 128:1303-1307.
15. Chun Y.M., Moon S.K., Lee H.Y., Webster P., Brackmann D.E., Rhim J.S., et al. Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16. Ann. Otol. Rhinol. Laryngol. 2002, 111:507-517.
16. Long J.P., Tong H.H., Shannon P.A., DeMaria T.F. Differential expression of cytokine genes and inducible nitric oxide synthase induced by opacity phenotype variants of Streptococcus pneumoniae during acute otitis media in the rat. Infect. Immun. 2003, 71:5531-5540.
17. Yariktas M., Doner F., Dogru H., Yasan H., Delibas N. The role of free oxygen radicals on the development of otitis media with effusion. Int. J. Pediatr. Otorhinolaryngol. 2004, 68:889-894.
18. McCord J.M., Roy R.S. The pathophysiology of superoxide: roles in inflammation and ischemia. Can. J. Physiol. Pharmacol. 1982, 60:1346-1352.
19. Goossens V., Grooten J., De Vos K., Fiers W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:8115-8119.
20. Song J.J., Kwon S.K., Cho C.G., Park S.W., Chae S.W. Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC). Int. J. Pediatr. Otorhinolaryngol. 2010, 74:1384-1387.
21. Cho J.G., Lee E.S., Woo J.S., Lee H.M., Jung H.H., Hwang S.J., et al. Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat. Int. J. Pediatr. Otorhinolaryngol. 2007, 71:101-106.
22. Kakiuchi M., Tsujigiwa H., Orita Y., Nagatsuka H., Yoshinobu J., Kariya S., et al. Cyclooxygenase 2 expression in otitis media with effusion. Am. J. Otolaryngol. 2006, 27:81-85.
23. Ben Mansour R., Gargouri B., Bouaziz M., Elloumi N., Belhadj Jilani I., Ghrabi Z., et al. Antioxidant activity of ethanolic extract of inflorescence of Ormenis Africana in vitro and in cell cultures. Lipids Health Dis. 2011, 10:78.
24. Aladag I., Guven M., Eyibilen A., Sahin S., Koseoglu D. Efficacy of vitamin A in experimentally induced acute otitis media. Int. J. Pediatr. Otorhinolaryngol. 2007, 71:623-628.