Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock

Brazilian Journal of Infectious Diseases

Volumn 15, Issue 4, 2011, Pages 332-338

  Korish, Aida Abdelhamid ^a   Arafa, Maha Mohamed ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cytokines; Lipopolysaccharides; Septic shock; Systemic inflammatory response syndrome

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; GALACTOSAMINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN TISSUE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG MECHANISM; ENDOTOXEMIA; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; LIVER CELL; LIVER HEMORRHAGE; LIVER INJURY; LIVER NECROSIS; LIVER PARENCHYMA; LIVER PROTECTION; MALE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TISSUE INJURY;

ANIMALS; BRAIN; CAFFEIC ACIDS; CYTOKINES; ENDOTOXEMIA; GALACTOSAMINE; LIPOPOLYSACCHARIDES; LIVER; MALE; PHENYLETHYL ALCOHOL; RATS; RATS, WISTAR; SHOCK, SEPTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 80052393337     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1590/S1413-86702011000400006     Document Type: Article

References (34)

1. Martin G.S., Mannino D.M., Eaton S., Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348(16):1546-1554.
2. Shapiro N., Howell M.D., Bates D.W., Angus D.C., Ngo L., Talmor D. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med 2006, 48(5):583-590.
3. Morikawa A., Sugiyama T., Kato Y., Koide N., Jiang G.Z., Takahashi K., Tamada Y., Yokochi T. Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect Immun 1996, 64:737-738.
4. Galanos C., Freudenberg M.A., Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 1979, 76:5939-5943.
5. Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol 1974, 71:77-106.
6. Pinzani M., Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001, 21:397-416.
7. Hanada T., Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2003, 13:413-421.
8. Mitchell J.A., Larkin S., Williams T.J. Cyclooxygenase 2 regulation and relevance in inflammation. Biochem Pharmacol 1995, 50:1535-1542.
9. Punyadeera C., Schneider E.M., Schaffer D., et al. A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsios severity. J Emerg Trauma Shock 2010, 3(10):26-35.
10. Gutteridge J.M.C., Mitchell J. Redox imbalance in the critically ill. Br Med Bull 1999, 55(1):49-75.
11. Mercer-Jones M.A., Heinzelmann M., Peyton J.C., Wickel D., Cook M., Cheadle W.G. Inhibition of neutrophil migration at the site of infection increases remote organ neutrophil sequestration and injury. Shock 1997, 8(3):193-199.
12. Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006, 6:173-182.
13. Thiemermann C. Nitric oxide and septic shock. Gen Pharmacol 1997, 29:159-166.
14. Nagai T., Inoue R., Inoue H., Suzuki N. Preparations and antioxidant properties of water extract of propolis. Food Chem 2003, 80:29-33.
15. Russo, Long R., Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethylester and galangin. Fitoterapia 2002, 73(Suppl1):S21-S29.
16. Yildiz Y., Serter M., Ek R.O., et al. Protective effects of caffeic acid phenethyl ester on intestinal ischemia-reperfusion injury. Dig Dis Sci 2009, 54(4):738-744.
17. Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 1996, 93:9090-9095.
18. Makarov S.S. NF-κB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 2000, 6:441-448.
19. Lee K.J., Choi J.H., Khanal T., Hwang Y.P., Chung Y.C., Jeong H.G. Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology 2008, 248:18-24.
20. Iraz M., Ozerol E., Gulec M., et al. Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat. Cell Biochem Funct 2006, 24(4):357-361.
21. Korish A.A. Effect of caffeic acid phenethyl ester on the hemostatic alterations associated with toxic-induced acute liver failure. Blood Coag Fibrinol 2010, 21:158-163.
22. Liu S.F., Malik A.B. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol 2006, 290:L622-L645.
23. Victor V.M., Espulgues J.V., Hernández-Mijares A., Rocha M. Oxidative stress and mitochondrial dysfunction in sepsis: a potential therapy with mitochondria-targeted antioxidants. Infect Disord Drug Targets 2009, 9(4):376-389.
24. Yachida S., Kokudo Y., Wakabayashi H., Maeba T., Kaneda K., Maeta H. Morphological and functional alterations to sinusoidal endothelial cells in early phase endotoxin-induced liver failure after partial hepatectomy in rats. Virchows Arch 1998, 433:173-181.
25. Secchi A., Ortanderl J.M., Schmidt W., Gebhard M.M., Martin E., Schmidt H. Effect of endotoximea on hepatic portal and sinusoidal blood flow in rats. J Surg Res 2000, 89:26-30.
26. Pils M.C., Pisano F., Fasnacht N., et al. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 2010, 40(2):443-448.
27. Doughty L., Clark R.S., Kaplan S.S., Sasser H., Carcillo J. sFas and sFas ligand and pediatric sepsis-induced multiple organ failure syndrome. Pediatr Res 2002, 52(6):922-927.
28. Essani N.A., Fisher M.A., Farhood A., Manning A.M., Smith C.W., Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 1995, 21:1632-1639.
29. Antoniades C.G., Berry P.A., Wendon J.A., Vergani D. The importance of immune dysfunction in determining outcome in acute liver failure. J Hepatol 2008, 49(5):845-861.
30. Koksel O., Ozdulger A., Tamer L., et al. Effects of caffeic acid phenethyl ester on lipopolysaccharide-induced lung injury in rats. Pulm Pharmacol Ther 2006, 19(2):90-95.
31. Henderson W.R., Chi E.Y., Teo J.L., Nguyen C., Kahn M. A small molecule inhibitor of redox-regulated NF kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model. J Immunol 2002, 169:5294-5299.
32. Barnes P.J. Nuclear factor-kappa B. Int J Biochem Cell Biol 1997, 29:867-870.
33. Ozyurt H., Ozyurt B., Koca K., Ozgocmen S. Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia-reperfusion-induced oxidative stress. Vascul Pharmacol 2007, 47(2-3):108-112.
34. Choi K., Han Y.H., Cho C. N-Acetyl cysteine and caffeic acid phenethylester sensitize astrocytoma cells to Fasmediated cell death in a redox-dependent manner. Cancer Lett 2007, 257:79-86.